gamma-glutamyltransferase 1 (GGT1) - coding DNA reference sequence

(used for variant description)

(last modified December 15, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_013430.2 in the GGT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008111.1, covering GGT1 transcript NM_013430.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      gcctgga       c.-481

 .         .         .         .         .         .  | 02          g.29211
 ttctcccagagattgcctggaacaccagctcgggtcctcgcacaccatcctg | cgggtgca    c.-421

 .         .         .         .         .         .                g.29271
 gcccagaactgtcttctgaggaagaggtgctctcctgggcccccactgtccccaggcctc       c.-361

 .  | 03      .         .         .         .         .             g.31272
 ag | caaggcaagtgaggtgctgccgtcatccaggctggacagttcagtgatttgcctgagg    c.-301

 .         . | 04       .         .         .         .             g.31548
 ccccacagcag | agttcaactggagacagagaaaccagctagaggcagagggaggtaacac    c.-241

 .         .         .         .         .         .                g.31608
 ggagtcccccagaaaggtctgggctgcgcgtgcttcaggtaacctcccttgaccttcagg       c.-181

 .         .         .         .         .         .                g.31668
 agaacgagaaggctgcctgatcagagagtccctgaagaagattctgtggctacaggcttc       c.-121

 .         .         .         .         .         .                g.31728
 agcagagtgtgagggagaccccggttatttcctcagctatttccaccaaatcctcctgtc       c.-61

 .         .         .         .         .         .   | 05         g.32331
 tttcgtggccaacaccccaggcaaggcttggggcccccgtctgctgctggacg | cagagcc    c.-1

          .         .         .         .         .         .       g.32391
 ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGTC       c.60
 M  K  K  K  L  V  V  L  G  L  L  A  V  V  L  V  L  V  I  V         p.20

          .         .         .         .         .         .       g.32451
 GGCCTCTGTCTCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCAGG       c.120
 G  L  C  L  W  L  P  S  A  S  K  E  P  D  N  H  V  Y  T  R         p.40

          .         .         .         .     | 06   .         .    g.36041
 GCTGCCGTGGCCGCGGATGCCAAGCAGTGCTCGAAGATTGGGAG | GGATGCACTGCGGGAC    c.180
 A  A  V  A  A  D  A  K  Q  C  S  K  I  G  R  |  D  A  L  R  D      p.60

          .         .         .         .         .         .       g.36101
 GGTGGCTCTGCGGTGGATGCAGCCATTGCAGCCCTGTTGTGTGTGGGGCTCATGAATGCC       c.240
 G  G  S  A  V  D  A  A  I  A  A  L  L  C  V  G  L  M  N  A         p.80

          .         .         .         .         .      | 07  .    g.36295
 CACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCTACAACAGCACCACAC | GAAAA    c.300
 H  S  M  G  I  G  G  G  L  F  L  T  I  Y  N  S  T  T  R |   K      p.100

          .         .         .         .         .         .       g.36355
 GCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCACCATGTTCAAC       c.360
 A  E  V  I  N  A  R  E  V  A  P  R  L  A  F  A  T  M  F  N         p.120

          .         .   | 08     .         .         .         .    g.41615
 AGCTCGGAGCAGTCCCAGAAGG | GGGGGCTGTCGGTGGCGGTGCCTGGGGAGATCCGAGGC    c.420
 S  S  E  Q  S  Q  K  G |   G  L  S  V  A  V  P  G  E  I  R  G      p.140

          .         .         .         .         .         .       g.41675
 TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCAGCCCAGC       c.480
 Y  E  L  A  H  Q  R  H  G  R  L  P  W  A  R  L  F  Q  P  S         p.160

          .         .         .         .         .         .       g.41735
 ATCCAGCTGGCCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCCTGGAAAAC       c.540
 I  Q  L  A  R  Q  G  F  P  V  G  K  G  L  A  A  A  L  E  N         p.180

          .         .         .      | 09  .         .         .    g.42187
 AAGCGGACCGTCATCGAGCAGCAGCCTGTCTTGTG | TGAGGTGTTCTGCCGGGATAGAAAG    c.600
 K  R  T  V  I  E  Q  Q  P  V  L  C  |  E  V  F  C  R  D  R  K      p.200

          .         .         .         .         .         .       g.42247
 GTGCTTCGGGAGGGGGAGAGACTGACCCTGCCGCAGCTGGCTGACACCTACGAGACGCTG       c.660
 V  L  R  E  G  E  R  L  T  L  P  Q  L  A  D  T  Y  E  T  L         p.220

          .         .         .         .         .         .       g.42307
 GCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCACGGCCCAGATTGTGAAGGAC       c.720
 A  I  E  G  A  Q  A  F  Y  N  G  S  L  T  A  Q  I  V  K  D         p.240

          .    | 10    .         .         .         .         .    g.44403
 ATCCAGGCGGCCG | GGGGCATTGTGACAGCTGAGGACCTGAACAACTACCGTGCTGAGCTG    c.780
 I  Q  A  A  G |   G  I  V  T  A  E  D  L  N  N  Y  R  A  E  L      p.260

          .         .         .         .         .         .       g.44463
 ATCGAGCACCCGCTGAACATCAGCCTGGGAGACGTGGTGCTGTACATGCCCAGTGCGCCG       c.840
 I  E  H  P  L  N  I  S  L  G  D  V  V  L  Y  M  P  S  A  P         p.280

          .         .         .         .    | 11    .         .    g.45046
 CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAG | GGTACAACTTCTCCCGG    c.900
 L  S  G  P  V  L  A  L  I  L  N  I  L  K  G |   Y  N  F  S  R      p.300

          .         .         .         .         .         .       g.45106
 GAGAGCGTGGAGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCATCGTAGAGGCTTTC       c.960
 E  S  V  E  S  P  E  Q  K  G  L  T  Y  H  R  I  V  E  A  F         p.320

          .         .         .         .         .         .       g.45166
 CGGTTTGCCTACGCCAAGAGGACCCTGCTTGGGGACCCCAAGTTTGTGGATGTGACTGAG       c.1020
 R  F  A  Y  A  K  R  T  L  L  G  D  P  K  F  V  D  V  T  E         p.340

  | 12       .         .         .         .         .         .    g.48741
  | GTGGTCCGCAACATGACCTCCGAGTTCTTCGCTGCCCAGCTCCGGGCCCAGATCTCTGAC    c.1080
  | V  V  R  N  M  T  S  E  F  F  A  A  Q  L  R  A  Q  I  S  D      p.360

          .         .         .         .         .         .       g.48801
 GACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCTACACGCCGGATGACGGGGGC       c.1140
 D  T  T  H  P  I  S  Y  Y  K  P  E  F  Y  T  P  D  D  G  G         p.380

          .         .         .         .         .         .       g.48861
 ACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGTCCGCCACCAGCACCATC       c.1200
 T  A  H  L  S  V  V  A  E  D  G  S  A  V  S  A  T  S  T  I         p.400

          | 13         .         .         .         .         .    g.49153
 AACCTCTA | CTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGGATCCTGTTCAATAATGAA    c.1260
 N  L  Y  |  F  G  S  K  V  R  S  P  V  S  G  I  L  F  N  N  E      p.420

          .         .         .         .         .         .       g.49213
 ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGGGGTACCCCCCTCACCTGCC       c.1320
 M  D  D  F  S  S  P  S  I  T  N  E  F  G  V  P  P  S  P  A         p.440

          .       | 14 .         .         .         .         .    g.49374
 AATTTCATCCAGCCAG | GGAAGCAGCCGCTCTCGTCCATGTGCCCGACGATCATGGTGGGC    c.1380
 N  F  I  Q  P  G |   K  Q  P  L  S  S  M  C  P  T  I  M  V  G      p.460

          .         .         .         .         .         .       g.49434
 CAGGACGGCCAGGTCCGGATGGTGGTGGGAGCTGCTGGGGGCACACAGATCACCACGGCC       c.1440
 Q  D  G  Q  V  R  M  V  V  G  A  A  G  G  T  Q  I  T  T  A         p.480

           | 15        .         .         .         .         .    g.49575
 ACTGCACTG | GCCATCATCTACAACCTCTGGTTCGGCTATGACGTGAAGCGGGCCGTGGAG    c.1500
 T  A  L   | A  I  I  Y  N  L  W  F  G  Y  D  V  K  R  A  V  E      p.500

          .         .         .         .         .         .       g.49635
 GAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCACGACAGTGGAGAGAAACATTGAC       c.1560
 E  P  R  L  H  N  Q  L  L  P  N  V  T  T  V  E  R  N  I  D         p.520

     | 16    .         .         .         .         .         .    g.49999
 CAG | GCAGTGACTGCAGCCCTGGAGACCCGGCACCATCACACCCAGATCGCGTCCACCTTC    c.1620
 Q   | A  V  T  A  A  L  E  T  R  H  H  H  T  Q  I  A  S  T  F      p.540

          .         .         .         .         .         .       g.50059
 ATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGTGGCTGGGCAGCTGCCTCGGACTCC       c.1680
 I  A  V  V  Q  A  I  V  R  T  A  G  G  W  A  A  A  S  D  S         p.560

          .         .         .                                     g.50089
 AGGAAAGGCGGGGAGCCTGCCGGCTACTGA                                     c.1710
 R  K  G  G  E  P  A  G  Y  X                                       p.569

          .         .         .         .         .         .       g.50149
 gtgctccaggaggacaaggctgacaagcaatccagggacaagatactcaccaggaccagg       c.*60

          .         .         .         .         .         .       g.50209
 aaggggactctgggggaccggcttcccctgtgagcagcagagcagcacaataaatgaggc       c.*120

          .         .         .         .                           g.50255
 cactgtgccaggctccaggtggcctccctggcctgtctccccactc                     c.*166

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gamma-glutamyltransferase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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