growth hormone receptor (GHR) - coding DNA reference sequence

(used for variant description)

(last modified August 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000163.4 in the GHR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011688.1, covering GHR transcript NM_000163.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4863
                                                 cggcggcggcgg       c.-181

 .         .         .         .         .         .                g.4923
 cggcagcggcagcagcagctgctacagtggcggtggcggcggcggctgctgctgagcccg       c.-121

 .         .         .         .         .         .                g.4983
 ggcggcggcggggaccccgggctggggccacgcgggccggaggccccggcaccattggcc       c.-61

 .         .         .         .         .         | 02             g.146951
 ccagcgcagacgcgaacccgcgctctctgatcagaggcgaagctcggag | gtcctacaggt    c.-1

          .         .         .         .         .         .       g.147011
 ATGGATCTCTGGCAGCTGCTGTTGACCTTGGCACTGGCAGGATCAAGTGATGCTTTTTCT       c.60
 M  D  L  W  Q  L  L  L  T  L  A  L  A  G  S  S  D  A  F  S         p.20

          . | 03       .         .         .         .         .    g.210164
 GGAAGTGAGG | CCACAGCAGCTATCCTTAGCAGAGCACCCTGGAGTCTGCAAAGTGTTAAT    c.120
 G  S  E  A |   T  A  A  I  L  S  R  A  P  W  S  L  Q  S  V  N      p.40

          .       | 04 .         .         .         .         .    g.270010
 CCAGGCCTAAAGACAA | ATTCTTCTAAGGAGCCTAAATTCACCAAGTGCCGTTCACCTGAG    c.180
 P  G  L  K  T  N |   S  S  K  E  P  K  F  T  K  C  R  S  P  E      p.60

          .         .         .         .         .         .       g.270070
 CGAGAGACTTTTTCATGCCACTGGACAGATGAGGTTCATCATGGTACAAAGAACCTAGGA       c.240
 R  E  T  F  S  C  H  W  T  D  E  V  H  H  G  T  K  N  L  G         p.80

          .         .       | 05 .         .         .         .    g.276027
 CCCATACAGCTGTTCTATACCAGAAG | GAACACTCAAGAATGGACTCAAGAATGGAAAGAA    c.300
 P  I  Q  L  F  Y  T  R  R  |  N  T  Q  E  W  T  Q  E  W  K  E      p.100

          .         .         .         .         .         .       g.276087
 TGCCCTGATTATGTTTCTGCTGGGGAAAACAGCTGTTACTTTAATTCATCGTTTACCTCC       c.360
 C  P  D  Y  V  S  A  G  E  N  S  C  Y  F  N  S  S  F  T  S         p.120

          .         .         .         .         .         .       g.276147
 ATCTGGATACCTTATTGTATCAAGCTAACTAGCAATGGTGGTACAGTGGATGAAAAGTGT       c.420
 I  W  I  P  Y  C  I  K  L  T  S  N  G  G  T  V  D  E  K  C         p.140

          .          | 06        .         .         .         .    g.280941
 TTCTCTGTTGATGAAATAG | TGCAACCAGATCCACCCATTGCCCTCAACTGGACTTTACTG    c.480
 F  S  V  D  E  I  V |   Q  P  D  P  P  I  A  L  N  W  T  L  L      p.160

          .         .         .         .         .         .       g.281001
 AACGTCAGTTTAACTGGGATTCATGCAGATATCCAAGTGAGATGGGAAGCACCACGCAAT       c.540
 N  V  S  L  T  G  I  H  A  D  I  Q  V  R  W  E  A  P  R  N         p.180

          .         .         .         .         .         .       g.281061
 GCAGATATTCAGAAAGGATGGATGGTTCTGGAGTATGAACTTCAATACAAAGAAGTAAAT       c.600
 A  D  I  Q  K  G  W  M  V  L  E  Y  E  L  Q  Y  K  E  V  N         p.200

          .         | 07         .         .         .         .    g.292325
 GAAACTAAATGGAAAATG | ATGGACCCTATATTGACAACATCAGTTCCAGTGTACTCATTG    c.660
 E  T  K  W  K  M   | M  D  P  I  L  T  T  S  V  P  V  Y  S  L      p.220

          .         .         .         .         .         .       g.292385
 AAAGTGGATAAGGAATATGAAGTGCGTGTGAGATCCAAACAACGAAACTCTGGAAATTAT       c.720
 K  V  D  K  E  Y  E  V  R  V  R  S  K  Q  R  N  S  G  N  Y         p.240

          .         .         .         .         .         .       g.292445
 GGCGAGTTCAGTGAGGTGCTCTATGTAACACTTCCTCAGATGAGCCAATTTACATGTGAA       c.780
 G  E  F  S  E  V  L  Y  V  T  L  P  Q  M  S  Q  F  T  C  E         p.260

      | 08   .         .         .         .         .         .    g.294561
 GAAG | ATTTCTACTTTCCATGGCTCTTAATTATTATCTTTGGAATATTTGGGCTAACAGTG    c.840
 E  D |   F  Y  F  P  W  L  L  I  I  I  F  G  I  F  G  L  T  V      p.280

          .         .         .      | 09  .         .         .    g.299153
 ATGCTATTTGTATTCTTATTTTCTAAACAGCAAAG | GATTAAAATGCTGATTCTGCCCCCA    c.900
 M  L  F  V  F  L  F  S  K  Q  Q  R  |  I  K  M  L  I  L  P  P      p.300

          .         .         .         .      | 10  .         .    g.299544
 GTTCCAGTTCCAAAGATTAAAGGAATCGATCCAGATCTCCTCAAG | GAAGGAAAATTAGAG    c.960
 V  P  V  P  K  I  K  G  I  D  P  D  L  L  K   | E  G  K  L  E      p.320

          .         .         .         .         .         .       g.299604
 GAGGTGAACACAATCTTAGCCATTCATGATAGCTATAAACCCGAATTCCACAGTGATGAC       c.1020
 E  V  N  T  I  L  A  I  H  D  S  Y  K  P  E  F  H  S  D  D         p.340

          .         .         .         .         .         .       g.299664
 TCTTGGGTTGAATTTATTGAGCTAGATATTGATGAGCCAGATGAAAAGACTGAGGAATCA       c.1080
 S  W  V  E  F  I  E  L  D  I  D  E  P  D  E  K  T  E  E  S         p.360

          .         .         .         .         .         .       g.299724
 GACACAGACAGACTTCTAAGCAGTGACCATGAGAAATCACATAGTAACCTAGGGGTGAAG       c.1140
 D  T  D  R  L  L  S  S  D  H  E  K  S  H  S  N  L  G  V  K         p.380

          .         .         .         .         .         .       g.299784
 GATGGCGACTCTGGACGTACCAGCTGTTGTGAACCTGACATTCTGGAGACTGATTTCAAT       c.1200
 D  G  D  S  G  R  T  S  C  C  E  P  D  I  L  E  T  D  F  N         p.400

          .         .         .         .         .         .       g.299844
 GCCAATGACATACATGAGGGTACCTCAGAGGTTGCTCAGCCACAGAGGTTAAAAGGGGAA       c.1260
 A  N  D  I  H  E  G  T  S  E  V  A  Q  P  Q  R  L  K  G  E         p.420

          .         .         .         .         .         .       g.299904
 GCAGATCTCTTATGCCTTGACCAGAAGAATCAAAATAACTCACCTTATCATGATGCTTGC       c.1320
 A  D  L  L  C  L  D  Q  K  N  Q  N  N  S  P  Y  H  D  A  C         p.440

          .         .         .         .         .         .       g.299964
 CCTGCTACTCAGCAGCCCAGTGTTATCCAAGCAGAGAAAAACAAACCACAACCACTTCCT       c.1380
 P  A  T  Q  Q  P  S  V  I  Q  A  E  K  N  K  P  Q  P  L  P         p.460

          .         .         .         .         .         .       g.300024
 ACTGAAGGAGCTGAGTCAACTCACCAAGCTGCCCATATTCAGCTAAGCAATCCAAGTTCA       c.1440
 T  E  G  A  E  S  T  H  Q  A  A  H  I  Q  L  S  N  P  S  S         p.480

          .         .         .         .         .         .       g.300084
 CTGTCAAACATCGACTTTTATGCCCAGGTGAGCGACATTACACCAGCAGGTAGTGTGGTC       c.1500
 L  S  N  I  D  F  Y  A  Q  V  S  D  I  T  P  A  G  S  V  V         p.500

          .         .         .         .         .         .       g.300144
 CTTTCCCCGGGCCAAAAGAATAAGGCAGGGATGTCCCAATGTGACATGCACCCGGAAATG       c.1560
 L  S  P  G  Q  K  N  K  A  G  M  S  Q  C  D  M  H  P  E  M         p.520

          .         .         .         .         .         .       g.300204
 GTCTCACTCTGCCAAGAAAACTTCCTTATGGACAATGCCTACTTCTGTGAGGCAGATGCC       c.1620
 V  S  L  C  Q  E  N  F  L  M  D  N  A  Y  F  C  E  A  D  A         p.540

          .         .         .         .         .         .       g.300264
 AAAAAGTGCATCCCTGTGGCTCCTCACATCAAGGTTGAATCACACATACAGCCAAGCTTA       c.1680
 K  K  C  I  P  V  A  P  H  I  K  V  E  S  H  I  Q  P  S  L         p.560

          .         .         .         .         .         .       g.300324
 AACCAAGAGGACATTTACATCACCACAGAAAGCCTTACCACTGCTGCTGGGAGGCCTGGG       c.1740
 N  Q  E  D  I  Y  I  T  T  E  S  L  T  T  A  A  G  R  P  G         p.580

          .         .         .         .         .         .       g.300384
 ACAGGAGAACATGTTCCAGGTTCTGAGATGCCTGTCCCAGACTATACCTCCATTCATATA       c.1800
 T  G  E  H  V  P  G  S  E  M  P  V  P  D  Y  T  S  I  H  I         p.600

          .         .         .         .         .         .       g.300444
 GTACAGTCCCCACAGGGCCTCATACTCAATGCGACTGCCTTGCCCTTGCCTGACAAAGAG       c.1860
 V  Q  S  P  Q  G  L  I  L  N  A  T  A  L  P  L  P  D  K  E         p.620

          .         .         .         .         .                 g.300501
 TTTCTCTCATCATGTGGCTATGTGAGCACAGACCAACTGAACAAAATCATGCCTTAG          c.1917
 F  L  S  S  C  G  Y  V  S  T  D  Q  L  N  K  I  M  P  X            p.638

          .         .         .         .         .         .       g.300561
 cctttctttggtttcccaagagctacgtatttaatagcaaagaattgactggggcaataa       c.*60

          .         .         .         .         .         .       g.300621
 cgtttaagccaaaacaatgtttaaaccttttttgggggagtgacaggatggggtatggat       c.*120

          .         .         .         .         .         .       g.300681
 tctaaaatgccttttcccaaaatgttgaaatatgatgttaaaaaaataagaagaatgctt       c.*180

          .         .         .         .         .         .       g.300741
 aatcagatagatattcctattgtgcaatgtaaatattttaaagaattgtgtcagactgtt       c.*240

          .         .         .         .         .         .       g.300801
 tagtagcagtgattgtcttaatattgtgggtgttaatttttgatactaagcattgaatgg       c.*300

          .         .         .         .         .         .       g.300861
 ctatgtttttaatgtatagtaaatcacgctttttgaaaaagcgaaaaaatcaggtggctt       c.*360

          .         .         .         .         .         .       g.300921
 ttgcggttcaggaaaattgaatgcaaaccatagcacaggctaattttttgttgtttctta       c.*420

          .         .         .         .         .         .       g.300981
 aataagaaacttttttatttaaaaaactaaaaactagaggtgagaaatttaaactataag       c.*480

          .         .         .         .         .         .       g.301041
 caagaaggcaaaaatagtttggatatgtaaaacatttattttgacataaagttgataaag       c.*540

          .         .         .         .         .         .       g.301101
 attttttaataatttagacttcaagcatggctattttatattacactacacactgtgtac       c.*600

          .         .         .         .         .         .       g.301161
 tgcagttggtatgacccctctaaggagtgtagcaactacagtctaaagctggtttaatgt       c.*660

          .         .         .         .         .         .       g.301221
 tttggccaatgcacctaaagaaaaacaaactcgttttttacaaagcccttttatacctcc       c.*720

          .         .         .         .         .         .       g.301281
 ccagactccttcaacaattctaaaatgattgtagtaatctgcattattggaatataattg       c.*780

          .         .         .         .         .         .       g.301341
 ttttatctgaatttttaaacaagtatttgttaatttagaaaactttaaagcgtttgcaca       c.*840

          .         .         .         .         .         .       g.301401
 gatcaacttaccaggcaccaaaagaagtaaaagcaaaaaagaaaacctttcttcaccaaa       c.*900

          .         .         .         .         .         .       g.301461
 tcttggttgatgccaaaaaaaaatacatgctaagagaagtagaaatcatagctggttcac       c.*960

          .         .         .         .         .         .       g.301521
 actgaccaagatacttaagtgctgcaattgcacgcggagtgagttttttagtgcgtgcag       c.*1020

          .         .         .         .         .         .       g.301581
 atggtgagagataagatctatagcctctgcagcggaatctgttcacacccaacttggttt       c.*1080

          .         .         .         .         .         .       g.301641
 tgctacataattatccaggaagggaataaggtacaagaagcattttgtaagttgaagcaa       c.*1140

          .         .         .         .         .         .       g.301701
 atcgaatgaaattaactgggtaatgaaacaaagagttcaagaaataagtttttgtttcac       c.*1200

          .         .         .         .         .         .       g.301761
 agcctataaccagacacatactcatttttcatgataatgaacagaacatagacagaagaa       c.*1260

          .         .         .         .         .         .       g.301821
 acaaggttttcagtccccacagataactgaaaattatttaaaccgctaaaagaaactttc       c.*1320

          .         .         .         .         .         .       g.301881
 tttctcactaaatcttttataggatttatttaaaatagcaaaagaagaagtttcatcatt       c.*1380

          .         .         .         .         .         .       g.301941
 ttttacttcctctctgagtggactggcctcaaagcaagcattcagaagaaaaagaagcaa       c.*1440

          .         .         .         .         .         .       g.302001
 cctcagtaatttagaaatcattttgcaatcccttaatatcctaaacatcattcatttttg       c.*1500

          .         .         .         .         .         .       g.302061
 ttgttgttgttgttgttgagacagagtctcgctctgtcgccaggctagagtgcggtggcg       c.*1560

          .         .         .         .         .         .       g.302121
 cgatcttgactcactgcaatctccacctcccacaggttcaggcgattcccgtgcctcagc       c.*1620

          .         .         .         .         .         .       g.302181
 ctcctgagtagctgggactacaggcacgcaccaccatgccaggctaatttttttgtattt       c.*1680

          .         .         .         .         .         .       g.302241
 tagcagagacggggtttcaccatgttggccaggatggtctcgatctcctgacctcgtgat       c.*1740

          .         .         .         .         .         .       g.302301
 ccacccgactcggcctcccaaagtgctgggattacaggtgtaagccaccgtgcccagccc       c.*1800

          .         .         .         .         .         .       g.302361
 taaacatcattcttgagagcattgggatatctcctgaaaaggtttatgaaaaagaagaat       c.*1860

          .         .         .         .         .         .       g.302421
 ctcatctcagtgaagaatacttctcattttttaaaaaagcttaaaactttgaagttagct       c.*1920

          .         .         .         .         .         .       g.302481
 ttaacttaaatagtatttcccatttatcgcagaccttttttaggaagcaagcttaatggc       c.*1980

          .         .         .         .         .         .       g.302541
 tgataattttaaattctctctcttgcaggaaggactatgaaaagctagaattgagtgttt       c.*2040

          .         .         .         .         .         .       g.302601
 aaagttcaacatgttatttgtaatagatgtttgatagattttctgctactttgctgctat       c.*2100

          .         .         .         .         .         .       g.302661
 ggttttctccaagagctacataatttagtttcatataaagtatcatcagtgtagaaccta       c.*2160

          .         .         .         .         .         .       g.302721
 attcaattcaaagctgtgtgtttggaagactatcttactatttcacaacagcctgacaac       c.*2220

          .         .         .         .         .         .       g.302781
 atttctatagccaaaaatagctaaatacctcaatcagtctcagaatgtcattttggtact       c.*2280

          .         .         .         .         .         .       g.302841
 ttggtggccacataagccattattcactagtatgactagttgtgtctggcagtttatatt       c.*2340

          .         .         .         .         .         .       g.302901
 taactctctttatgtctgtggattttttccttcaaagtttaataaatttattttcttgga       c.*2400

          .         .         .         .         .                 g.302955
 ttcctgatagtgtgcttctgttatcaaacaccaacataaaaatgatctaaacca             c.*2454

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Growth hormone receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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