gap junction protein, alpha 5, 40kDa (GJA5) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005266.6 in the GJA5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009369.2, covering GJA5 transcript NM_005266.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5036
                                     gaggaacaactgacaggctcaaga       c.-121

 .         .         .         .         .         .                g.5096
 gcaaaaagcgtgggcagttggagaagaagcagccagagtgtgaagaagcccacggaagga       c.-61

 .         .         .       | 02 .         .         .             g.19136
 aagtccagggaggaggaaaagaagcag | aagttttggcatctgttccctggctgtgccaag    c.-1

          .         .         .         .         .         .       g.19196
 ATGGGCGATTGGAGCTTCCTGGGAAATTTCCTGGAGGAAGTACACAAGCACTCGACCGTG       c.60
 M  G  D  W  S  F  L  G  N  F  L  E  E  V  H  K  H  S  T  V         p.20

          .         .         .         .         .         .       g.19256
 GTAGGCAAGGTCTGGCTCACTGTCCTCTTCATATTCCGTATGCTCGTGCTGGGCACAGCT       c.120
 V  G  K  V  W  L  T  V  L  F  I  F  R  M  L  V  L  G  T  A         p.40

          .         .         .         .         .         .       g.19316
 GCTGAGTCTTCCTGGGGGGATGAGCAGGCTGATTTCCGGTGTGATACGATTCAGCCTGGC       c.180
 A  E  S  S  W  G  D  E  Q  A  D  F  R  C  D  T  I  Q  P  G         p.60

          .         .         .         .         .         .       g.19376
 TGCCAGAATGTCTGCTACGACCAGGCTTTCCCCATCTCCCACATTCGCTACTGGGTGCTG       c.240
 C  Q  N  V  C  Y  D  Q  A  F  P  I  S  H  I  R  Y  W  V  L         p.80

          .         .         .         .         .         .       g.19436
 CAGATCATCTTCGTCTCCACGCCCTCTCTGGTGTACATGGGCCACGCCATGCACACTGTG       c.300
 Q  I  I  F  V  S  T  P  S  L  V  Y  M  G  H  A  M  H  T  V         p.100

          .         .         .         .         .         .       g.19496
 CGCATGCAGGAGAAGCGCAAGCTACGGGAGGCCGAGAGGGCCAAAGAGGTCCGGGGCTCT       c.360
 R  M  Q  E  K  R  K  L  R  E  A  E  R  A  K  E  V  R  G  S         p.120

          .         .         .         .         .         .       g.19556
 GGCTCTTACGAGTACCCGGTGGCAGAGAAGGCAGAACTGTCCTGCTGGGAGGAAGGGAAT       c.420
 G  S  Y  E  Y  P  V  A  E  K  A  E  L  S  C  W  E  E  G  N         p.140

          .         .         .         .         .         .       g.19616
 GGAAGGATTGCCCTCCAGGGCACTCTGCTCAACACCTATGTGTGCAGCATCCTGATCCGC       c.480
 G  R  I  A  L  Q  G  T  L  L  N  T  Y  V  C  S  I  L  I  R         p.160

          .         .         .         .         .         .       g.19676
 ACCACCATGGAGGTGGGCTTCATTGTGGGCCAGTACTTCATCTACGGAATCTTCCTGACC       c.540
 T  T  M  E  V  G  F  I  V  G  Q  Y  F  I  Y  G  I  F  L  T         p.180

          .         .         .         .         .         .       g.19736
 ACCCTGCATGTCTGCCGCAGGAGTCCCTGTCCCCACCCGGTCAACTGTTACGTATCCCGG       c.600
 T  L  H  V  C  R  R  S  P  C  P  H  P  V  N  C  Y  V  S  R         p.200

          .         .         .         .         .         .       g.19796
 CCCACAGAGAAGAATGTCTTCATTGTCTTTATGCTGGCTGTGGCTGCACTGTCCCTCCTC       c.660
 P  T  E  K  N  V  F  I  V  F  M  L  A  V  A  A  L  S  L  L         p.220

          .         .         .         .         .         .       g.19856
 CTTAGCCTGGCTGAACTCTACCACCTGGGCTGGAAGAAGATCAGACAGCGATTTGTCAAA       c.720
 L  S  L  A  E  L  Y  H  L  G  W  K  K  I  R  Q  R  F  V  K         p.240

          .         .         .         .         .         .       g.19916
 CCGCGGCAGCACATGGCTAAGTGCCAGCTTTCTGGCCCCTCTGTGGGCATAGTCCAGAGC       c.780
 P  R  Q  H  M  A  K  C  Q  L  S  G  P  S  V  G  I  V  Q  S         p.260

          .         .         .         .         .         .       g.19976
 TGCACACCACCCCCCGACTTTAATCAGTGCCTGGAGAATGGCCCTGGGGGAAAATTCTTC       c.840
 C  T  P  P  P  D  F  N  Q  C  L  E  N  G  P  G  G  K  F  F         p.280

          .         .         .         .         .         .       g.20036
 AATCCCTTCAGCAATAATATGGCCTCCCAACAAAACACAGACAACCTGGTCACCGAGCAA       c.900
 N  P  F  S  N  N  M  A  S  Q  Q  N  T  D  N  L  V  T  E  Q         p.300

          .         .         .         .         .         .       g.20096
 GTACGAGGTCAGGAGCAGACTCCTGGGGAAGGTTTCATCCAGGTTCGTTATGGCCAGAAG       c.960
 V  R  G  Q  E  Q  T  P  G  E  G  F  I  Q  V  R  Y  G  Q  K         p.320

          .         .         .         .         .         .       g.20156
 CCTGAGGTGCCCAATGGAGTCTCACCAGGTCACCGCCTTCCCCATGGCTATCATAGTGAC       c.1020
 P  E  V  P  N  G  V  S  P  G  H  R  L  P  H  G  Y  H  S  D         p.340

          .         .         .         .         .                 g.20213
 AAGCGACGTCTTAGTAAGGCCAGCAGCAAGGCAAGGTCAGATGACCTATCAGTGTGA          c.1077
 K  R  R  L  S  K  A  S  S  K  A  R  S  D  D  L  S  V  X            p.358

          .         .         .         .         .         .       g.20273
 ccctcctttatgggaggatcaggaccaggtgggaacaaaggaggctcagagaggaaagac       c.*60

          .         .         .         .         .         .       g.20333
 gtgtcccttctgaactgatgctttctcactgtcatcactgcttggctcctttgagccccg       c.*120

          .         .         .         .         .         .       g.20393
 ggtctcaatgacgttgctcattaattctagaaactataaccagggctctgggatagtaag       c.*180

          .         .         .         .         .         .       g.20453
 agaggtgacaacccacccagactgcagttccctccccaccctctacccagtatacgaagc       c.*240

          .         .         .         .         .         .       g.20513
 ctttcagattactcatgaaacagggtagagggaaagaagggaagcatggcaaaagctggc       c.*300

          .         .         .         .         .         .       g.20573
 ctggaagggatagccagagggatagaatgactctctctctacataccagcagcataccaa       c.*360

          .         .         .         .         .         .       g.20633
 atgcgttctctaagttcctacctccttgacctgatcaccctccctcctccaaggaagagc       c.*420

          .         .         .         .         .         .       g.20693
 tcaaagttcccagccaatagacagcatgaatcaaggaacttgcattatatgtgctcttga       c.*480

          .         .         .         .         .         .       g.20753
 atctgttgtctccatggaccattcctcggagtagtggtgagatggccttgggttgccctt       c.*540

          .         .         .         .         .         .       g.20813
 ggcttctcctccctctactcagccttaaaaagggcttcttggaactttaccagcagcctc       c.*600

          .         .         .         .         .         .       g.20873
 agctttacaaatgccttggtatgtacctctggcaaatgccctggtatgtacctctggcaa       c.*660

          .         .         .         .         .         .       g.20933
 atgccccaccttggtgatgttgcaacctttccttctgctagggtgtacacctagcctgtg       c.*720

          .         .         .         .         .         .       g.20993
 caggtgtcagccctgctagggagtcactgtacacacaaactctactggaattcctgccaa       c.*780

          .         .         .         .         .         .       g.21053
 catctgtcaccctgcagctcctttacagttcaatccaatgatagaaaccatcccttccct       c.*840

          .         .         .         .         .         .       g.21113
 ttctcccttggctgttcacccagccattccctgaaggccttaccaacaggaatatccaag       c.*900

          .         .         .         .         .         .       g.21173
 aagctgttgtcctctctcgaaccctgaccagatcatcagccactgaggccagtggaattt       c.*960

          .         .         .         .         .         .       g.21233
 ccccaggccttgttaaaacaaagaaagcattgtacttctcagattccccttgtggaaaaa       c.*1020

          .         .         .         .         .         .       g.21293
 aaaattctgctgtgaagatgaaaataaaaatggagagaaaacactggaaaactattttcc       c.*1080

          .         .         .         .         .         .       g.21353
 cctcctatttacttcctttgctgactgccaacttagtgccaagaggaggtgtgatgacag       c.*1140

          .         .         .         .         .         .       g.21413
 ctatggaggcccccagatctctctctcctggaggctttagcaggggcaaggaaatagtag       c.*1200

          .         .         .         .         .         .       g.21473
 gggaatctccagctctcttggcagggcctttatttaaagagcgcagagattcctatgtct       c.*1260

          .         .         .         .         .         .       g.21533
 ccctagtgcccctaatgagactgccaagtgggggctgtagaaaagccttgccttccccag       c.*1320

          .         .         .         .         .         .       g.21593
 ggattggcctggtctctgtattcactggatccataatgggttgctgttgttttggatgaa       c.*1380

          .         .         .         .         .         .       g.21653
 ggtaaacgatgcttggaattggaaactgagacttatagagggattattacattattaaaa       c.*1440

          .         .         .         .         .         .       g.21713
 tgcacgtgtgtgtgtgtgtgggtgctgatgggatgggtaaaggcttggggagtcctgaaa       c.*1500

          .         .         .         .         .         .       g.21773
 taaggaaaggaaaccacagagaaacttgtgtcttcctgctctcctctccggctgcctggc       c.*1560

          .         .         .         .         .         .       g.21833
 agttattaacctaaacagatagccacaagaggttgggacagaggagggtaaaggctcaga       c.*1620

          .         .         .         .         .         .       g.21893
 aggaggttcaacctctgactcacctgcccatctctgggccctctgctgacacttggatgc       c.*1680

          .         .         .         .         .         .       g.21953
 tattgttgggtggaaagataaatgagagtggagaggtggaggaaagtgactaggatgcca       c.*1740

          .         .         .         .         .         .       g.22013
 tttaggaaggaatgtctgatcatcccgggtccctggaggggacaccttttaatctattgc       c.*1800

          .         .         .         .         .         .       g.22073
 ctagcattaatattttctctccttctatctctgaaatgttttatgaaatgagtgttcttg       c.*1860

          .         .         .         .         .         .       g.22133
 aattagaaattctgtgggatcaatctttgatggtgagggttttagaaaggaaaaatatag       c.*1920

          .         .         .         .                           g.22176
 taaaatgtgtaatttgtcttaataaaatctatctctacatcta                        c.*1963

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gap junction protein, alpha 5, 40kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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