gap junction protein, gamma 2, 47kDa (GJC2) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_020435.3 in the GJC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011838.1, covering GJC2 transcript NM_020435.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4875
                                                gcccccggtcgct       c.-301

 .         .         .         .         .         .                g.4935
 tgctccagggcaggtggactgagcttcggaggctggggctggcctctgacctgcttgggc       c.-241

 .         .         .         .         .         .                g.4995
 ttggagagccctgcccgctgccctgccccccaggacaatcagggattcagaccctgaggc       c.-181

 .         .         .         .         .         .                g.5055
 cgaggggggaacaatggggcccttgagggcccctcctccagcccccattgtgcttggtgg       c.-121

 .         .         .         .         .         .                g.5115
 tgagaggtggccctggctcggccacacaccctcggggaggaccagcatccaagcaggtgg       c.-61

 .         .         .         .         . | 02       .             g.12907
 aagggctctgagggagactggaattttctggcctggagaag | gacccgcccgcccgcccct    c.-1

          .         .         .         .         .         .       g.12967
 ATGACCAACATGAGCTGGAGCTTCCTGACGCGGCTGCTGGAGGAGATCCACAACCACTCC       c.60
 M  T  N  M  S  W  S  F  L  T  R  L  L  E  E  I  H  N  H  S         p.20

          .         .         .         .         .         .       g.13027
 ACCTTCGTGGGCAAGGTGTGGCTCACGGTGCTGGTGGTCTTCCGCATCGTGCTGACGGCT       c.120
 T  F  V  G  K  V  W  L  T  V  L  V  V  F  R  I  V  L  T  A         p.40

          .         .         .         .         .         .       g.13087
 GTGGGCGGCGAGGCCATCTACTCGGACGAGCAGGCCAAGTTCACTTGCAACACGCGGCAG       c.180
 V  G  G  E  A  I  Y  S  D  E  Q  A  K  F  T  C  N  T  R  Q         p.60

          .         .         .         .         .         .       g.13147
 CCAGGCTGCGACAACGTCTGCTATGACGCCTTCGCGCCCCTGTCGCACGTGCGCTTCTGG       c.240
 P  G  C  D  N  V  C  Y  D  A  F  A  P  L  S  H  V  R  F  W         p.80

          .         .         .         .         .         .       g.13207
 GTCTTCCAGATTGTGGTCATCTCCACGCCCTCGGTCATGTACCTGGGCTACGCCGTGCAC       c.300
 V  F  Q  I  V  V  I  S  T  P  S  V  M  Y  L  G  Y  A  V  H         p.100

          .         .         .         .         .         .       g.13267
 CGCCTGGCCCGTGCGTCTGAGCAGGAGCGGCGCCGCGCCCTCCGCCGCCGCCCGGGGCCA       c.360
 R  L  A  R  A  S  E  Q  E  R  R  R  A  L  R  R  R  P  G  P         p.120

          .         .         .         .         .         .       g.13327
 CGCCGCGCGCCCCGAGCGCACCTGCCGCCCCCGCACGCCGGCTGGCCTGAGCCCGCCGAC       c.420
 R  R  A  P  R  A  H  L  P  P  P  H  A  G  W  P  E  P  A  D         p.140

          .         .         .         .         .         .       g.13387
 CTGGGCGAGGAGGAGCCCATGCTGGGCCTGGGCGAGGAGGAGGAGGAGGAGGAGACGGGG       c.480
 L  G  E  E  E  P  M  L  G  L  G  E  E  E  E  E  E  E  T  G         p.160

          .         .         .         .         .         .       g.13447
 GCAGCCGAGGGCGCCGGCGAGGAAGCGGAGGAGGCAGGCGCGGAGGAGGCGTGCACTAAG       c.540
 A  A  E  G  A  G  E  E  A  E  E  A  G  A  E  E  A  C  T  K         p.180

          .         .         .         .         .         .       g.13507
 GCGGTCGGCGCTGACGGCAAGGCGGCAGGGACCCCGGGCCCGACCGGGCAACACGATGGG       c.600
 A  V  G  A  D  G  K  A  A  G  T  P  G  P  T  G  Q  H  D  G         p.200

          .         .         .         .         .         .       g.13567
 CGGAGGCGCATCCAGCGGGAGGGCCTGATGCGCGTGTACGTGGCCCAGCTGGTGGCCAGG       c.660
 R  R  R  I  Q  R  E  G  L  M  R  V  Y  V  A  Q  L  V  A  R         p.220

          .         .         .         .         .         .       g.13627
 GCAGCTTTCGAGGTGGCCTTCCTGGTGGGCCAGTACCTGCTGTACGGCTTCGAGGTGCGA       c.720
 A  A  F  E  V  A  F  L  V  G  Q  Y  L  L  Y  G  F  E  V  R         p.240

          .         .         .         .         .         .       g.13687
 CCGTTCTTTCCCTGCAGCCGCCAGCCCTGCCCGCACGTGGTGGACTGCTTCGTGTCGCGC       c.780
 P  F  F  P  C  S  R  Q  P  C  P  H  V  V  D  C  F  V  S  R         p.260

          .         .         .         .         .         .       g.13747
 CCTACTGAAAAGACGGTCTTCCTGCTGGTTATGTACGTGGTCAGCTGCCTGTGCCTGCTG       c.840
 P  T  E  K  T  V  F  L  L  V  M  Y  V  V  S  C  L  C  L  L         p.280

          .         .         .         .         .         .       g.13807
 CTCAACCTCTGTGAGATGGCCCACCTGGGCTTGGGCAGCGCGCAGGACGCGGTGCGCGGC       c.900
 L  N  L  C  E  M  A  H  L  G  L  G  S  A  Q  D  A  V  R  G         p.300

          .         .         .         .         .         .       g.13867
 CGCCGCGGCCCCCCGGCCTCCGCCCCCGCCCCCGCGCCGCGGCCCCCGCCCTGCGCCTTC       c.960
 R  R  G  P  P  A  S  A  P  A  P  A  P  R  P  P  P  C  A  F         p.320

          .         .         .         .         .         .       g.13927
 CCTGCGGCGGCCGCTGGCTTGGCCTGCCCGCCCGACTACAGCCTGGTGGTGCGGGCGGCC       c.1020
 P  A  A  A  A  G  L  A  C  P  P  D  Y  S  L  V  V  R  A  A         p.340

          .         .         .         .         .         .       g.13987
 GAGCGCGCTCGGGCGCATGACCAGAACCTGGCAAACCTGGCCCTGCAGGCGCTGCGCGAC       c.1080
 E  R  A  R  A  H  D  Q  N  L  A  N  L  A  L  Q  A  L  R  D         p.360

          .         .         .         .         .         .       g.14047
 GGGGCAGCGGCTGGGGACCGCGACCGGGACAGTTCGCCGTGCGTCGGCCTCCCTGCGGCC       c.1140
 G  A  A  A  G  D  R  D  R  D  S  S  P  C  V  G  L  P  A  A         p.380

          .         .         .         .         .         .       g.14107
 TCCCGGGGGCCCCCCAGAGCAGGCGCCCCCGCGTCCCGGACGGGCAGTGCTACCTCTGCG       c.1200
 S  R  G  P  P  R  A  G  A  P  A  S  R  T  G  S  A  T  S  A         p.400

          .         .         .         .         .         .       g.14167
 GGCACTGTCGGGGAGCAGGGCCGGCCCGGCACCCACGAGCGGCCAGGAGCCAAGCCCAGG       c.1260
 G  T  V  G  E  Q  G  R  P  G  T  H  E  R  P  G  A  K  P  R         p.420

          .         .         .         .         .         .       g.14227
 GCTGGCTCCGAGAAGGGCAGTGCCAGCAGCAGGGACGGGAAGACCACCGTGTGGATCTGA       c.1320
 A  G  S  E  K  G  S  A  S  S  R  D  G  K  T  T  V  W  I  X         p.439

          .         .         .         .         .         .       g.14287
 gggcgctggcttgcgagctgggccagggaggaggagggttggggggctccggtggaaacc       c.*60

          .         .         .         .         .         .       g.14347
 tgcgaccccttctcctcagccttctccttagccggtggcctcaggcagactctgcccaga       c.*120

          .         .         .         .         .         .       g.14407
 ggggcagccaggctgctcagggaaggggctgaaagcggcagaggagtgccctggcttggt       c.*180

          .         .         .         .         .         .       g.14467
 caccactggggccaaggtggggtggagagaggcctaggagccagaaagggccctctgctg       c.*240

          .         .         .         .         .         .       g.14527
 tggtctgaaccccagggggagtggggcattgactccacccctgtcctgagctggaatagg       c.*300

          .         .         .         .         .         .       g.14587
 tcctctgggatgccagctctcccctttgtgcttccctgcagcaacccatggagggcccag       c.*360

          .         .         .         .         .         .       g.14647
 ggtgcctggtatgggcatcagttggtgggggtgcgggggtgcgtgtccccattccctgca       c.*420

          .         .         .         .         .         .       g.14707
 acagcaaatggggctccttcttcagccctccccttcccagccccaaactgagacagactg       c.*480

          .         .         .         .         .         .       g.14767
 ggagctgggagcctggggtggacaggaccataccctctttgagcttctgcgatgccggcc       c.*540

          .         .         .         .         .         .       g.14827
 ttccgttcctctgggaggcttgaagttctgcaaagatgttgatatgccttgcagcttgga       c.*600

          .         .         .         .         .         .       g.14887
 cccaatgggtggtggtcagggcctgggggcttggccatgctgggggaatggggctctggg       c.*660

          .         .         .         .         .         .       g.14947
 ttcctgcctgtggcctgtctgtcctcctccctaattcagacccagcctcaagaggaaagg       c.*720

          .         .                                               g.14975
 gagtaaaataaaactaacttgtttataa                                       c.*748

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gap junction protein, gamma 2, 47kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 14
©2004-2015 Leiden University Medical Center