galactosidase, beta 1 (GLB1) - coding DNA reference sequence

(used for variant description)

(last modified March 17, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000404.2 in the GLB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering GLB1 transcript NM_000404.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    aggcgcgagggctggctgctgggccgacgaggggcggtgccaggccgtgggtcctta       c.-61

 .         .         .         .         .         .                g.5117
 gtcaagtgacgcgaagcggccggcctgggcgccgactgcagagccgggaggctggtggtc       c.-1

          .         .         .         .         .         .       g.5177
 ATGCCGGGGTTCCTGGTTCGCATCCTCCCTCTGTTGCTGGTTCTGCTGCTTCTGGGCCCT       c.60
 M  P  G  F  L  V  R  I  L  P  L  L  L  V  L  L  L  L  G  P         p.20

          .      | 02  .         .         .         .         .    g.29534
 ACGCGCGGCTTGCGC | AATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCC    c.120
 T  R  G  L  R   | N  A  T  Q  R  M  F  E  I  D  Y  S  R  D  S      p.40

          .         .         .         .         .         .       g.29594
 TTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTG       c.180
 F  L  K  D  G  Q  P  F  R  Y  I  S  G  S  I  H  Y  S  R  V         p.60

          .         .         .         .         .         .       g.29654
 CCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATC       c.240
 P  R  F  Y  W  K  D  R  L  L  K  M  K  M  A  G  L  N  A  I         p.80

       | 03  .         .         .         .         .         .    g.33287
 CAGAC | GTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAG    c.300
 Q  T  |  Y  V  P  W  N  F  H  E  P  W  P  G  Q  Y  Q  F  S  E      p.100

          .         .         .         .         .         .       g.33347
 GACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTG       c.360
 D  H  D  V  E  Y  F  L  R  L  A  H  E  L  G  L  L  V  I  L         p.120

          .         .         .       | 04 .         .         .    g.33936
 AGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATG | GGAGGATTACCTGCTTGGCTGCTA    c.420
 R  P  G  P  Y  I  C  A  E  W  E  M   | G  G  L  P  A  W  L  L      p.140

          .         .         .        | 05.         .         .    g.36668
 GAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAG | ATTACCTGGCAGCTGTGGACAAG    c.480
 E  K  E  S  I  L  L  R  S  S  D  P  D |   Y  L  A  A  V  D  K      p.160

          .         .         .         .         .         .       g.36728
 TGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTT       c.540
 W  L  G  V  L  L  P  K  M  K  P  L  L  Y  Q  N  G  G  P  V         p.180

          .   | 06     .         .         .         .         .    g.43981
 ATAACAGTGCAG | GTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTG    c.600
 I  T  V  Q   | V  E  N  E  Y  G  S  Y  F  A  C  D  F  D  Y  L      p.200

          .         .         .         .         .         .       g.44041
 CGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACT       c.660
 R  F  L  Q  K  R  F  R  H  H  L  G  D  D  V  V  L  F  T  T         p.220

          .         .         .         .         .         .       g.44101
 GATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTG       c.720
 D  G  A  H  K  T  F  L  K  C  G  A  L  Q  G  L  Y  T  T  V         p.240

          .    | 07    .         .         .         .         .    g.48700
 GACTTTGGAACAG | GCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCC    c.780
 D  F  G  T  G |   S  N  I  T  D  A  F  L  S  Q  R  K  C  E  P      p.260

          .   | 08     .         .         .         .         .    g.50246
 AAAGGACCCTTG | ATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCT    c.840
 K  G  P  L   | I  N  S  E  F  Y  T  G  W  L  D  H  W  G  Q  P      p.280

          .         .         .         .         .         .       g.50306
 CACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGG       c.900
 H  S  T  I  K  T  E  A  V  A  S  S  L  Y  D  I  L  A  R  G         p.300

          .     | 09   .         .         .         .      | 10  . g.55975
 GCGAGTGTGAACTT | GTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATG | GGGCC c.960
 A  S  V  N  L  |  Y  M  F  I  G  G  T  N  F  A  Y  W  N  G |   A   p.320

          .         .         .         .         .         .       g.56035
 AACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCT       c.1020
 N  S  P  Y  A  A  Q  P  T  S  Y  D  Y  D  A  P  L  S  E  A         p.340

          .         .         .         .         | 11         .    g.77889
 GGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAG | TTTGAAAAAGTA    c.1080
 G  D  L  T  E  K  Y  F  A  L  R  N  I  I  Q  K   | F  E  K  V      p.360

          .         .         .         .         .         .       g.77949
 CCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAA       c.1140
 P  E  G  P  I  P  P  S  T  P  K  F  A  Y  G  K  V  T  L  E         p.380

     | 12    .         .         .         .         .         .    g.80604
 AAG | TTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGC    c.1200
 K   | L  K  T  V  G  A  A  L  D  I  L  C  P  S  G  P  I  K  S      p.400

          .         .         .    | 13    .         .         .    g.83668
 CTTTATCCCTTGACATTTATCCAGGTGAAACAG | CATTATGGGTTTGTGCTGTACCGGACA    c.1260
 L  Y  P  L  T  F  I  Q  V  K  Q   | H  Y  G  F  V  L  Y  R  T      p.420

          .         .         .         .         .         .       g.83728
 ACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCAC       c.1320
 T  L  P  Q  D  C  S  N  P  A  P  L  S  S  P  L  N  G  V  H         p.440

          .         .        | 14.         .         .         .    g.85395
 GATCGAGCATATGTTGCTGTGGATGGG | ATCCCCCAGGGAGTCCTTGAGCGAAACAATGTG    c.1380
 D  R  A  Y  V  A  V  D  G   | I  P  Q  G  V  L  E  R  N  N  V      p.460

          .         .         .         .         .         .       g.85455
 ATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATG       c.1440
 I  T  L  N  I  T  G  K  A  G  A  T  L  D  L  L  V  E  N  M         p.480

          .         .         .          | 15        .         .    g.87913
 GGACGTGTGAACTATGGTGCATATATCAACGATTTTAAG | GGTTTGGTTTCTAACCTGACT    c.1500
 G  R  V  N  Y  G  A  Y  I  N  D  F  K   | G  L  V  S  N  L  T      p.500

          .         .         .         .         .         .       g.87973
 CTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTG       c.1560
 L  S  S  N  I  L  T  D  W  T  I  F  P  L  D  T  E  D  A  V         p.520

          .         .         .         .         .         .       g.88033
 TGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCC       c.1620
 C  S  H  L  G  G  W  G  H  R  D  S  G  H  H  D  E  A  W  A         p.540

          .         .         .         .         .         .       g.88093
 CACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGT       c.1680
 H  N  S  S  N  Y  T  L  P  A  F  Y  M  G  N  F  S  I  P  S         p.560

          .         .         .         .         .     | 16   .    g.104864
 GGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAG | GGCCAG    c.1740
 G  I  P  D  L  P  Q  D  T  F  I  Q  F  P  G  W  T  K   | G  Q      p.580

          .         .         .         .         .         .       g.104924
 GTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACC       c.1800
 V  W  I  N  G  F  N  L  G  R  Y  W  P  A  R  G  P  Q  L  T         p.600

          .         .         .         .         .         .       g.104984
 TTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAA       c.1860
 L  F  V  P  Q  H  I  L  M  T  S  A  P  N  T  I  T  V  L  E         p.620

          .         .         .         .         .         .       g.105044
 CTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGAC       c.1920
 L  E  W  A  P  C  S  S  D  D  P  E  L  C  A  V  T  F  V  D         p.640

          .         .         .         .         .         .       g.105104
 AGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGA       c.1980
 R  P  V  I  G  S  S  V  T  Y  D  H  P  S  K  P  V  E  K  R         p.660

          .         .         .         .         .                 g.105158
 CTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGA             c.2034
 L  M  P  P  P  P  Q  K  N  K  D  S  W  L  D  H  V  X               p.677

          .         .         .         .         .         .       g.105218
 tgatgaaagcctgtgtctttgagggattctaccctgaacatacctcacagatcctccctg       c.*60

          .         .         .         .         .         .       g.105278
 tcatgccacatttcactgattggaatgtggaaatggaaaaggaatttaggatgtgcattt       c.*120

          .         .         .         .         .         .       g.105338
 tcacctgaggtttccctgcatccctgcagtgccaaagccccaccttcagggaccacctgg       c.*180

          .         .         .         .         .         .       g.105398
 aatgtgtgaggggctgacagcacagtaacgtgcatacatatctgcagggctggaatggaa       c.*240

          .         .         .         .         .         .       g.105458
 gctttaaaggtggtagtgatttttattttggaagaatcatgttacctttttgttaaataa       c.*300

          .         .         .         .         .         .       g.105518
 aatttgtactcaaatgatgatgtcactgtttttaatgtgcaggtattgaattatatggtc       c.*360

          .         .         .         .         .         .       g.105578
 tgacttaaatcataactagacttgagtgggctgaataaaccacttcactaacttgaagtt       c.*420

          .                                                         g.105595
 caaaaggatggaaaata                                                  c.*437

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Galactosidase, beta 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2022 Leiden University Medical Center