gliomedin (GLDN) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_181789.2 in the GLDN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_054933.1, covering GLDN transcript NM_181789.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            ctctgggctgctcgggcgccaccactactgtccccatcccgccccgcca       c.-121

 .         .         .         .         .         .                g.5109
 gctgggccaaagggtgacttgactcacgacgctgccaccagcccacggcttgcccgaggc       c.-61

 .         .         .         .         .         .                g.5169
 gtataaaggctgccagggccgcaggctgccaagccctgccctgcccaaggcgcatagagc       c.-1

          .         .         .         .         .         .       g.5229
 ATGGCCCGAGGCGCTGAGGGAGGCCGTGGGGACGCGGGTTGGGGCCTGCGTGGCGCCCTG       c.60
 M  A  R  G  A  E  G  G  R  G  D  A  G  W  G  L  R  G  A  L         p.20

          .         .         .         .         .         .       g.5289
 GCGGCCGTGGCGCTGCTCTCGGCGCTCAACGCTGCGGGCACGGTGTTCGCGCTGTGCCAG       c.120
 A  A  V  A  L  L  S  A  L  N  A  A  G  T  V  F  A  L  C  Q         p.40

          .         .         .         .         .         .       g.5349
 TGGCGCGGGCTGAGCTCGGCGCTGCGGGCTTTGGAGGCGCAGCGGGGCCGGGAGCAGCGC       c.180
 W  R  G  L  S  S  A  L  R  A  L  E  A  Q  R  G  R  E  Q  R         p.60

          .         .         .         .         .         .       g.5409
 GAGGACAGTGCCCTGCGCTCCTTCCTGGCCGAGTTGAGCCGCGCGCCGCGCGGGGCGTCC       c.240
 E  D  S  A  L  R  S  F  L  A  E  L  S  R  A  P  R  G  A  S         p.80

          .         .         .         .         .         .       g.5469
 GCACCACCCCAAGACCCGGCCAGCTCAGCTCGCAACAAGCGCAGCCACAGCGGCGAGCCC       c.300
 A  P  P  Q  D  P  A  S  S  A  R  N  K  R  S  H  S  G  E  P         p.100

          .         .         .         .         .         .       g.5529
 GCGCCGCATATCCGCGCCGAGAGCCATGACATGCTGATGATGATGACCTACTCCATGGTG       c.360
 A  P  H  I  R  A  E  S  H  D  M  L  M  M  M  T  Y  S  M  V         p.120

     | 02    .         .         .         .         .      | 03  . g.46925
 CCG | ATCCGAGTGATGGTGGACCTGTGCAACAGCACCAAGGGCATCTGCCTCACAG | GACCT c.420
 P   | I  R  V  M  V  D  L  C  N  S  T  K  G  I  C  L  T  G |   P   p.140

          .    | 04    .         .         .         .         .    g.47316
 TCTGGACCACCAG | GACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGA    c.480
 S  G  P  P  G |   P  P  G  A  G  G  L  P  G  H  N  G  L  D  G      p.160

          .         .         .         .         .         .       g.47376
 CAGCCTGGTCCTCAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATG       c.540
 Q  P  G  P  Q  G  P  K  G  E  K  G  A  N  G  K  R  G  K  M         p.180

   | 05      .         .         .         .         .         .    g.58378
 G | GGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAAAAGGGAGACCATGGTGAA    c.600
 G |   I  P  G  A  A  G  N  P  G  E  R  G  E  K  G  D  H  G  E      p.200

          .         .         .         .         .         .       g.58438
 CTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGA       c.660
 L  G  L  Q  G  N  E  G  P  P  G  Q  K  G  E  K  G  D  K  G         p.220

          .         .         | 06         .         .         .    g.60986
 GATGTGTCCAACGACGTGCTCCTGGCAG | GTGCCAAAGGTGACCAAGGCCCACCCGGTCCA    c.720
 D  V  S  N  D  V  L  L  A  G |   A  K  G  D  Q  G  P  P  G  P      p.240

          .         .         .         .         .         .       g.61046
 CCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGAAGCAGAAGAGCCAAAGGC       c.780
 P  G  P  P  G  P  P  G  P  P  G  P  P  G  S  R  R  A  K  G         p.260

          .         .         .        | 07.         .         .    g.63699
 CCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAG | GTGAGACTTGTGCCATACCAAAT    c.840
 P  R  Q  P  S  M  F  N  G  Q  C  P  G |   E  T  C  A  I  P  N      p.280

          .         .         .         .         .         .       g.63759
 GATGATACCTTGGTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCA       c.900
 D  D  T  L  V  G  K  A  D  E  K  A  S  E  H  H  S  P  Q  A         p.300

   | 08      .         .         .         .         .         .    g.63916
 G | AATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTGAAAGTGACAGAGACATTT    c.960
 E |   S  M  I  T  S  I  G  N  P  V  Q  V  L  K  V  T  E  T  F      p.320

          .         .         .         .         .         .       g.63976
 GGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCAT       c.1020
 G  T  W  I  R  E  S  A  N  K  S  D  D  R  I  W  V  T  E  H         p.340

         | 09.         .         .         .         .         .    g.65130
 TTTTCAG | GCATCATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTAC    c.1080
 F  S  G |   I  M  V  K  E  F  K  D  Q  P  S  L  L  N  G  S  Y      p.360

          .         .         .         .         .         .       g.65190
 ACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCACGTTGTTTACAACAACTCT       c.1140
 T  F  I  H  L  P  Y  Y  F  H  G  C  G  H  V  V  Y  N  N  S         p.380

          .         .         .         | 10         .         .    g.67783
 CTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAG | ATTTGAATTTGGCCAGGAAACA    c.1200
 L  Y  Y  H  K  G  G  S  N  T  L  V  R  |  F  E  F  G  Q  E  T      p.400

          .         .         .         .         .         .       g.67843
 TCCCAAACTCTGAAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAAT       c.1260
 S  Q  T  L  K  L  E  N  A  L  Y  F  D  R  K  Y  L  F  A  N         p.420

          .         .         .         .         .         .       g.67903
 TCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTTTGGATTATCTATGCGTCA       c.1320
 S  K  T  Y  F  N  L  A  V  D  E  K  G  L  W  I  I  Y  A  S         p.440

          .         .         .         .         .         .       g.67963
 AGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTG       c.1380
 S  V  D  G  S  S  I  L  V  A  Q  L  D  E  R  T  F  S  V  V         p.460

          .         .         .         .         .         .       g.68023
 CAACACGTCAATACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGA       c.1440
 Q  H  V  N  T  T  Y  P  K  S  K  A  G  N  A  F  I  A  R  G         p.480

          .         .         .         .         .         .       g.68083
 ATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTTGCCTTTGATTTGTTAGGA       c.1500
 I  L  Y  V  T  D  T  K  D  M  R  V  T  F  A  F  D  L  L  G         p.500

          .         .         .         .         .         .       g.68143
 GGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTA       c.1560
 G  K  Q  I  N  A  N  F  D  L  R  T  S  Q  S  V  L  A  M  L         p.520

          .         .         .         .         .         .       g.68203
 GCATACAACATGAGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTAT       c.1620
 A  Y  N  M  R  D  Q  H  L  Y  S  W  E  D  G  H  L  M  L  Y         p.540

          .         .         .                                     g.68239
 CCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGA                               c.1656
 P  V  Q  F  L  S  T  T  L  N  Q  X                                 p.551

          .         .         .         .         .         .       g.68299
 tgtgctgcattcggctcccttcagcaaatttcaggggttttctgggaccagttctccccc       c.*60

          .         .         .         .         .         .       g.68359
 aacaggaaacttgtttttttaacgtcagccagatatttagaaaataacctcaaaagtgtt       c.*120

          .         .         .         .         .         .       g.68419
 tatatggtcagtgagccccgcttagtgaaatagcaacagattggaagttgaaatggctga       c.*180

          .         .         .         .         .         .       g.68479
 gatttggtgatctccccacagctggctctgcaagttacctctttctccttgggccttagt       c.*240

          .         .         .         .         .         .       g.68539
 ttccccattggtaatctgaattggctaagatgattggggagattttctgtacctgtaggt       c.*300

          .         .         .         .         .         .       g.68599
 aatttggtgattcttggtggctgctcttctcacaacttttatgtatctgcttctgtcgtt       c.*360

          .         .         .         .         .         .       g.68659
 tagcttttttagccacatgctgaccaaatttacctttgagttgataagtccagtggcttg       c.*420

          .         .         .         .         .         .       g.68719
 agtagtgaatccctcagtgctgacttatatcttgttctttgaaaaaatgcattgactctt       c.*480

          .         .         .         .         .         .       g.68779
 taagacatctaaagtatcacattatccataatttattgcttttctttgcatctgcacctg       c.*540

          .         .         .         .         .         .       g.68839
 ccaccacagaataaccattaccctcagctgctgattgggcagctctgagattagcaaaag       c.*600

          .         .         .         .         .         .       g.68899
 ccagggacagctacatgttcaggtttttttttttttttttttttcaataagctatttttt       c.*660

          .         .         .         .         .         .       g.68959
 ttcttttcttattttaaatagagagagagtcttgctatgtttcccaggctggtcttgaac       c.*720

          .         .         .         .         .         .       g.69019
 tcctggggctcaagtgatcctcctgccttggcctcccaaaatgctggattacaggcatgt       c.*780

          .         .         .         .         .         .       g.69079
 gtgcctggcccaggtttcttaataaaacagaatcatgatcttccaggttccccccagttt       c.*840

          .         .         .         .         .         .       g.69139
 ctgatcatgttgatttgtagctgtggatcatgaacactgaatcctcagatcactctgact       c.*900

          .         .         .         .         .         .       g.69199
 tcttatgcttctcctgtggatccactatcaaagtactaaatgctgtgtaagtagacgtta       c.*960

          .         .         .         .         .         .       g.69259
 atctggctggaaccatgggaagcactttgcagtgttcagaagagaggctccatttgtggc       c.*1020

          .         .         .         .         .         .       g.69319
 tattatgtagaactgggccagagccagtccattgcctgtttttttaaataaggttttact       c.*1080

          .         .         .         .         .         .       g.69379
 gagcacagccacactcatttgtttatgcagtacggcctgacattgcttttgctctgcaac       c.*1140

          .         .         .         .         .         .       g.69439
 agcagagtcgagtcattgcaacaaagagcatatggccccacagtgcctaaaatattgacc       c.*1200

          .         .         .         .         .         .       g.69499
 agctacccctttatggaaaaagattgctgactcctgataaagaatataaagtgagcctga       c.*1260

          .         .         .         .         .         .       g.69559
 ttcttgaaaaaatcagaaccagagcctgttttgttttgttctaaactaagaagccgcata       c.*1320

          .         .         .         .         .         .       g.69619
 ggatgtgacttgcgttttgagtagaggggaaggctgataacggcgtaagatgaagtggcc       c.*1380

          .         .         .         .         .         .       g.69679
 ctccacaaaggctggttaggggacagttctttctctaacatagttttaaaggatgtgatc       c.*1440

          .         .         .         .         .         .       g.69739
 tggtccccttggatgccaggagagaatccagttgaacttgctcctaaatgctcttaaata       c.*1500

          .         .         .         .         .         .       g.69799
 tgcatattttctgccaactcacttctttaaacatctttcagcccagcgctgcggccccgg       c.*1560

          .         .         .         .         .         .       g.69859
 gaagggccactgcgaatagagaggaagctggaaaagttcctggggctctgcagccaggaa       c.*1620

          .         .         .         .         .         .       g.69919
 ggggaaccagggcaaatcttatgtaaagatttttcagcaacttgtcccaatttgtgtgta       c.*1680

          .         .         .         .         .         .       g.69979
 ttctgaaactttctctttgggaccaaattcattctcaatggccctgagttcaatatatta       c.*1740

          .         .         .         .         .         .       g.70039
 ttaacagcagtattttaaaacttagggttgaactgggcatggtggcacataactgcaatc       c.*1800

          .         .         .         .         .         .       g.70099
 ccagctactttggaggcagggatgggaggatcacttgaggccaggatctcaggaccagcc       c.*1860

          .         .         .         .         .         .       g.70159
 tagagagatcccatctctaaaaaataaaatataagaaaataaaacttaggggatatacag       c.*1920

          .         .         .         .         .         .       g.70219
 atttaaatattcaaatctccctgctcccctgaaagtccccaggcagctgtcaatgacttg       c.*1980

          .         .         .         .         .         .       g.70279
 tttgttgtgttctcaatatgatggctatttgaaacttcacctacttttcattagattggt       c.*2040

          .         .         .         .         .         .       g.70339
 tgtaccatgtcaccttagcttttaaaaatactcttttcagattcacgttctctaacaaag       c.*2100

          .         .         .         .         .         .       g.70399
 agtctcatgttcaagatcaatatgtctaataagtgctggtgtccttttaaagtatttaaa       c.*2160

          .         .         .         .         .         .       g.70459
 tatatatgttgctgttgctgaatacaggagaccaggttaggaatatagtttcataataat       c.*2220

          .         .         .         .         .         .       g.70519
 agtacatacaatactaattgtatataaggtagcaaccaaaagaggttgttaattagcaca       c.*2280

          .         .         .         .         .         .       g.70579
 tattccttttagaaaaatgtttcagaaacctcagtcttgatatctgagctatctgggctc       c.*2340

          .         .         .         .         .         .       g.70639
 ccttacttgtgagtaagggatcatgctcaccactggagaagcttacaccgggactttttt       c.*2400

          .         .         .         .         .         .       g.70699
 tcttttttcttttttttttgctatgacagagtaatgctaacgtaaggacaactgagtttg       c.*2460

          .         .         .         .         .         .       g.70759
 atcagtgtttaatcgcagtgggtaatcttatctgattgtctttaaaagtgaaaaggatta       c.*2520

          .         .         .         .         .         .       g.70819
 agattttattctttcttgtaaacattacttgattttttaaagaagttttgggctcactgc       c.*2580

          .         .         .         .         .         .       g.70879
 taaaatagagtatacaactgaatgtttttaagtcaagatactgttttaggagtttaccct       c.*2640

          .         .         .         .         .         .       g.70939
 ctcatttataaccaaagttgctctaaaacactttccaaatatctgcacttctgatgtcag       c.*2700

          .         .         .         .         .         .       g.70999
 aatcaaaccagataattctctaattcttctttaatctaaagtagatagcttcccactgga       c.*2760

          .         .         .         .         .         .       g.71059
 aagtaaacaaaaccatccctcccaacctcaaagctaggccacactctatttcaaggcatt       c.*2820

          .         .         .         .         .         .       g.71119
 ttctttcagctgataaggtgtcctcctgaagccaagtaggtggttctggtctccaagtat       c.*2880

          .         .         .         .         .         .       g.71179
 cgttaagcacaggtgctatgacagaaaaagttctggggtggaagttttaagatgaggagt       c.*2940

          .         .         .         .         .         .       g.71239
 tctgatcttaggcatcttaacagtcacaaggtgaaaagtcaaatgaaacagtacaattct       c.*3000

          .         .         .         .         .         .       g.71299
 tgatgagtgaggtgtcatcttccaaccacacagaggacgttttggctatgatcatctgat       c.*3060

          .         .         .         .         .         .       g.71359
 ggcaagtgaaggagaaatgagtgatagggctttgcgttttcatccagatgctgtggccct       c.*3120

          .         .         .         .         .         .       g.71419
 gtgtttcacagcattaagagccataatttccaacctgcacagatcctgaacaacaaatga       c.*3180

          .         .         .         .         .         .       g.71479
 ataacgatgaatgtctttttggttgtaatttaacaagtcaaataaaataatcattgctga       c.*3240

          .                                                         g.71498
 gcacaatcacatgttgaaa                                                c.*3259

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gliomedin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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