GLIS family zinc finger 2 (GLIS2) - coding DNA reference sequence

(used for variant description)

(last modified November 20, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_032575.2 in the GLIS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016391.2, covering GLIS2 transcript NM_032575.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.22520
    tgaagaccagctgggagcccactgcctgctgccacctccaactccggccccctcacc       c.-1

          .         .         .         .         .         .       g.22580
 ATGCACTCCCTGGACGAGCCGCTCGACCTGAAGCTGAGTATCACCAAGCTCCGGGCGGCA       c.60
 M  H  S  L  D  E  P  L  D  L  K  L  S  I  T  K  L  R  A  A         p.20

          .         .         .         .         .         .       g.22640
 AGAGAGAAGCGGGAGAGGACGCTGGGTGTGGTCCGGCCCCGTGCTCTGCACAGGGAGCTG       c.120
 R  E  K  R  E  R  T  L  G  V  V  R  P  R  A  L  H  R  E  L         p.40

          .         .         .         .         .   | 02     .    g.23594
 GGCCTGGTGGATGACAGCCCCACACCTGGCTCTCCAGGCTCCCCGCCCTCAG | GCTTCCTG    c.180
 G  L  V  D  D  S  P  T  P  G  S  P  G  S  P  P  S  G |   F  L      p.60

          .         .         .         .         .         .       g.23654
 CTGAACTCCAAGTTCCCCGAGAAGGTGGAGGGACGCTTTTCAGCAGCCCCTCTCGTGGAC       c.240
 L  N  S  K  F  P  E  K  V  E  G  R  F  S  A  A  P  L  V  D         p.80

          .         .         .         .         .         .       g.23714
 CTCAGCCTGTCACCACCATCTGGGCTGGACTCCCCCAATGGCAGCAGCTCGCTGTCCCCC       c.300
 L  S  L  S  P  P  S  G  L  D  S  P  N  G  S  S  S  L  S  P         p.100

          .         .         .         .      | 03  .         .    g.25055
 GAGCGCCAGGGCAACGGGGACCTGCCTCCAGTGCCCAGTGCCTCG | GACTTCCAGCCACTG    c.360
 E  R  Q  G  N  G  D  L  P  P  V  P  S  A  S   | D  F  Q  P  L      p.120

          .         .         .         .         .         .       g.25115
 CGCTATTTGGATGGTGTCCCCAGCTCCTTCCAGTTCTTCCTGCCCCTCGGCTCCGGGGGG       c.420
 R  Y  L  D  G  V  P  S  S  F  Q  F  F  L  P  L  G  S  G  G         p.140

          .         .         .         .         .         .       g.25175
 GCCCTGCACCTGCCTGCCTCCTCCTTCCTTACCCCTCCCAAGGACAAGTGCCTCTCGCCA       c.480
 A  L  H  L  P  A  S  S  F  L  T  P  P  K  D  K  C  L  S  P         p.160

          .         .         .         .   | 04     .         .    g.25317
 GACCTGCCCCTGCCCAAGCAGCTGGTGTGTCGCTGGGCCAAG | TGTAACCAGCTCTTTGAG    c.540
 D  L  P  L  P  K  Q  L  V  C  R  W  A  K   | C  N  Q  L  F  E      p.180

          .         .         .         .         .         .       g.25377
 CTCCTGCAAGACCTGGTGGACCATGTCAACGATTACCATGTCAAGCCCGAGAAGGATGCG       c.600
 L  L  Q  D  L  V  D  H  V  N  D  Y  H  V  K  P  E  K  D  A         p.200

          .         .         .         .         .       | 05 .    g.25518
 GGGTACTGCTGCCACTGGGAGGGCTGCGCCCGCCATGGCCGAGGTTTCAACGCCAG | GTAC    c.660
 G  Y  C  C  H  W  E  G  C  A  R  H  G  R  G  F  N  A  R  |  Y      p.220

          .         .         .         .         .         .       g.25578
 AAGATGCTCATCCACATCCGCACACACACCAACGAGAAGCCACACCGCTGTCCGACCTGC       c.720
 K  M  L  I  H  I  R  T  H  T  N  E  K  P  H  R  C  P  T  C         p.240

          .         .         .         .         .      | 06  .    g.26969
 AGCAAGAGCTTCTCCCGCCTGGAGAACCTGAAGATCCACAACCGGTCGCACACAG | GTGAG    c.780
 S  K  S  F  S  R  L  E  N  L  K  I  H  N  R  S  H  T  G |   E      p.260

          .         .         .         .         .         .       g.27029
 AAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGC       c.840
 K  P  Y  V  C  P  Y  E  G  C  N  K  R  Y  S  N  S  S  D  R         p.280

          .         .         .         .         .         .       g.27089
 TTTAAGCACACGCGCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGC       c.900
 F  K  H  T  R  T  H  Y  V  D  K  P  Y  Y  C  K  M  P  G  C         p.300

          .         .         .         .         .         .       g.27149
 CACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGGCCCATGGCCACTTT       c.960
 H  K  R  Y  T  D  P  S  S  L  R  K  H  I  K  A  H  G  H  F         p.320

          .         .         .         .         .         .       g.27209
 GTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCC       c.1020
 V  S  H  E  Q  Q  E  L  L  Q  L  R  P  P  P  K  P  P  L  P         p.340

          .         .         .         .         .         .       g.27269
 GCCCCCGACGGCGGCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCC       c.1080
 A  P  D  G  G  P  Y  V  S  G  A  Q  I  I  I  P  N  P  A  A         p.360

          .         .         .         .         .         .       g.27329
 CTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCCCCGGCCCCCTTGAC       c.1140
 L  F  G  G  P  G  L  P  G  L  P  L  P  L  A  P  G  P  L  D         p.380

          .         .         .         .         .         .       g.27389
 CTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCT       c.1200
 L  S  A  L  A  C  G  N  G  G  G  S  G  G  G  G  G  M  G  P         p.400

          .         .         .         .         .         .       g.27449
 GGGCTGCCAGGCCCCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCC       c.1260
 G  L  P  G  P  V  L  P  L  N  L  A  K  N  P  L  L  P  S  P         p.420

          .         .         .         .         .         .       g.27509
 TTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTGGCGCAGCTGGTGGC       c.1320
 F  G  A  G  G  L  G  L  P  V  V  S  L  L  A  G  A  A  G  G         p.440

          .         .         .         .         .         .       g.27569
 AAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGC       c.1380
 K  A  E  G  E  K  G  R  G  S  V  P  T  R  A  L  G  M  E  G         p.460

          .         .         .         .         .         .       g.27629
 CACAAGACGCCCCTTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTC       c.1440
 H  K  T  P  L  E  R  T  E  S  S  C  S  R  P  S  P  D  G  L         p.480

          .         .         .         .         .         .       g.27689
 CCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACTCAGCTGCCAGCAGC       c.1500
 P  L  L  P  G  T  V  L  D  L  S  T  G  V  N  S  A  A  S  S         p.500

          .         .         .         .         .         .       g.27749
 CCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAAACCG       c.1560
 P  E  A  L  A  P  G  W  V  V  I  P  P  G  S  V  L  L  K  P         p.520

          .                                                         g.27764
 GCTGTGGTGAACTGA                                                    c.1575
 A  V  V  N  X                                                      p.524

          .         .         .         .         .         .       g.27824
 gcccatcctgcggacagttgtggtgcccccccggcagctcccggcactgcccccgacgaa       c.*60

          .         .         .         .         .         .       g.27884
 cggaaactcttctgtgaaatagcaataatgtcctactgcccgggcagccccagcccagcc       c.*120

          .         .         .         .         .         .       g.27944
 cgccgggagcaaggatggtgctaggtcattcatggctggcctcccagcccccgggtgggg       c.*180

          .         .         .         .         .         .       g.28004
 acctggcctgtcatgcagggagagctgtgctcctgggtgctgaagcctcgctcctgtctg       c.*240

          .         .         .         .         .         .       g.28064
 tcccccaccacctggccctcagcttctgagaggctttcccctgcccgacctcctcccgtt       c.*300

          .         .         .         .         .         .       g.28124
 tccctctcccaccctggcacctccctcacctagtgaccacccatggcaagttgccctctc       c.*360

          .         .         .         .         .         .       g.28184
 ccagcagagggggtgggtggggtggcatctgccctccctgctagcaccaggctccccctt       c.*420

          .         .         .         .         .         .       g.28244
 cctgagaggagcccccagggaccagaggcctgcccttccctcctaggcttacccagcccc       c.*480

          .         .         .         .         .         .       g.28304
 tgccctgggggctccttggacccctttccctctgaccctgcctccagagggaaagcaaga       c.*540

          .         .         .         .         .         .       g.28364
 cagatgcaggcccctgcaaagccccaggtagaagcatgccccccaggacaaggcgcctcc       c.*600

          .         .         .         .         .         .       g.28424
 cactagttaggaggaggcccgctctgcagccgccgtcctcaccccaggccaggcctgcag       c.*660

          .         .         .         .         .         .       g.28484
 taccagacgggatagctggccactccacccctgcaccccagggtctcctccctctacctt       c.*720

          .         .         .         .         .         .       g.28544
 ttggggcaccctgggagcgtgggaagcaggtccgagggcccctgagctggcaaggggagg       c.*780

          .         .         .         .         .         .       g.28604
 tgccaggccagctgtggtgccaagatactgagtgacctgggccctggctcagggagcatg       c.*840

          .         .         .         .         .         .       g.28664
 tggggccaggcccagcgccccgtcttcctccttctacccccgctgggcctggcctgggca       c.*900

          .         .         .         .         .         .       g.28724
 gcgccccctgcagaggcctttgggtccttggtcctgtaacaggaagggggaggctggctg       c.*960

          .         .         .         .         .         .       g.28784
 gggacgaccgaccacaggctgggacacagctcctggtctgggggctccaagtgacagcat       c.*1020

          .         .         .         .         .         .       g.28844
 gcaggggagggggctcccagtcagtgctgtgttgggagctttctggaggctgtggactga       c.*1080

          .         .         .         .         .         .       g.28904
 aggccttgagggaagcagtggctggaggagggtgctggacccatgacacgttgcttcctc       c.*1140

          .         .         .         .         .         .       g.28964
 tggcttttccctgctgggccgctttctcagaggcacttccccacccctaacacccagtgg       c.*1200

          .         .         .         .         .         .       g.29024
 gcccccccaggttctgtgccactcagagggaccctggcaggggccagaaccacttaaggg       c.*1260

          .         .         .         .         .         .       g.29084
 tggtgctggagggccttgtgccccagtcccatcccaggacgccctgagggatggacgcag       c.*1320

          .         .         .         .         .         .       g.29144
 ccatgcaccccccatctggggcctctccctgctccctctcccacctggcagctgggagtt       c.*1380

          .         .         .         .         .         .       g.29204
 ctggcttctaggcctgccctgtcaccaggcctctgagtggccaggcccttccacctcccc       c.*1440

          .         .         .         .         .         .       g.29264
 atctgtaaaacgaggcagctgcccggacagccttggggtccttagtggccctgcaggtcc       c.*1500

          .         .         .         .         .         .       g.29324
 tctggcagctctgctgaccccaccctctcccggactgcccttctgtcccagaggggtcac       c.*1560

          .         .         .         .         .         .       g.29384
 cctgacccggcccaccttgccactgggctttggactccagccctgacagggcccagccac       c.*1620

          .         .         .         .         .         .       g.29444
 actggctctgcccctcgaaggggctatgagcaaggtaggagggagctggtctcctttctt       c.*1680

          .         .         .         .         .         .       g.29504
 cgggccccacccaggccctgagcaccccccacccctgtgagggccccaggccttaagtcc       c.*1740

          .         .         .         .         .         .       g.29564
 ctggcggggtcatgggtttgcgacttgagcagagcggaggaacagggcactggaaggccg       c.*1800

          .         .         .         .         .         .       g.29624
 acgagctcagcatgcgactcggtgacggaccaggctcggcagggccggtgtactttttgt       c.*1860

          .         .         .         .         .         .       g.29684
 ggttgtcattggtgtgttgttgcacattccaggacgtcagtattttaacaggttctaagt       c.*1920

          .         .         .         .         .         .       g.29744
 gcctttctatcgtagcttatgttttcctcctcttggctccattgctgttagcatagagtt       c.*1980

          .         .         .         .         .         .       g.29804
 ttaaaaaaagagataagctaatgactataacaatatattcctccatgggagaggaagttt       c.*2040

          .         .         .                                     g.29837
 ataaagaaacaataaaagtgagttgcaaagatg                                  c.*2073

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GLIS family zinc finger 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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