glutaminase (GLS) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_014905.4 in the GLS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering GLS transcript NM_014905.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     agtgcggagccttaggcggagcga       c.-241

 .         .         .         .         .         .                g.5084
 agagaaccggtcgcggcaatcctagcgcgcagcagcagcagcagcagcagcagcagcagc       c.-181

 .         .         .         .         .         .                g.5144
 agcagcagcagcagcacccgcatccgctgcgggagtccgagccggaaccacacccaagta       c.-121

 .         .         .         .         .         .                g.5204
 gctgccctttcctcttctgtcatctcaccgccccaccacagaccgcgttccccgaggaaa       c.-61

 .         .         .         .         .         .                g.5264
 ccggccgcccacgcccggagcatcctcccctgttgagcgggcgctgacggacccggcggc       c.-1

          .         .         .         .         .         .       g.5324
 ATGATGCGGCTGCGAGGCTCGGGGATGCTGCGGGACCTGCTCCTGCGGTCGCCCGCCGGC       c.60
 M  M  R  L  R  G  S  G  M  L  R  D  L  L  L  R  S  P  A  G         p.20

          .         .         .         .         .         .       g.5384
 GTGAGCGCGACTCTGCGGCGGGCACAGCCCTTGGTCACCCTGTGCCGGCGTCCCCGAGGC       c.120
 V  S  A  T  L  R  R  A  Q  P  L  V  T  L  C  R  R  P  R  G         p.40

          .         .         .         .         .         .       g.5444
 GGGGGACGGCCGGCCGCGGGCCCGGCTGCCGCCGCGCGACTCCACCCGTGGTGGGGCGGG       c.180
 G  G  R  P  A  A  G  P  A  A  A  A  R  L  H  P  W  W  G  G         p.60

          .         .         .         .         .         .       g.5504
 GGCGGCTGGCCGGCGGAGCCCCTCGCGCGGGGCCTGTCCAGCTCTCCTTCGGAGATCTTG       c.240
 G  G  W  P  A  E  P  L  A  R  G  L  S  S  S  P  S  E  I  L         p.80

          .         .         .         .         .         .       g.5564
 CAGGAGCTGGGCAAGGGGAGCACGCATCCGCAGCCCGGGGTGTCGCCACCCGCTGCCCCG       c.300
 Q  E  L  G  K  G  S  T  H  P  Q  P  G  V  S  P  P  A  A  P         p.100

          .         .         .         .         .         .       g.5624
 GCGGCGCCCGGCCCCAAGGACGGCCCCGGGGAGACGGACGCGTTTGGCAACAGCGAGGGC       c.360
 A  A  P  G  P  K  D  G  P  G  E  T  D  A  F  G  N  S  E  G         p.120

          .         .       | 02 .         .         .         .    g.19365
 AAAGAGCTGGTGGCCTCAGGTGAAAA | TAAAATAAAACAGGGTCTGTTACCTAGCTTGGAA    c.420
 K  E  L  V  A  S  G  E  N  |  K  I  K  Q  G  L  L  P  S  L  E      p.140

          .         .         .         .         .         .       g.19425
 GATTTGCTGTTCTATACAATTGCTGAAGGACAAGAGAAAATACCTGTTCATAAATTTATT       c.480
 D  L  L  F  Y  T  I  A  E  G  Q  E  K  I  P  V  H  K  F  I         p.160

     | 03    .         .         .         .         .         .    g.19840
 ACA | GCACTCAAATCTACAGGATTGCGAACGTCTGATCCCAGGTTGAAAGAGTGTATGGAT    c.540
 T   | A  L  K  S  T  G  L  R  T  S  D  P  R  L  K  E  C  M  D      p.180

          .         .         .         .         .         .       g.19900
 ATGTTAAGATTAACTCTTCAAACAACATCAGATGGTGTCATGCTAGACAAAGATCTTTTT       c.600
 M  L  R  L  T  L  Q  T  T  S  D  G  V  M  L  D  K  D  L  F         p.200

       | 04  .         .         .         .         .         .    g.24798
 AAAAA | ATGTGTTCAGAGCAACATTGTTTTGTTGACACAAGCATTTAGAAGAAAGTTTGTG    c.660
 K  K  |  C  V  Q  S  N  I  V  L  L  T  Q  A  F  R  R  K  F  V      p.220

          .         .         .         .         .         .       g.24858
 ATTCCTGACTTTATGTCTTTTACCTCACACATTGATGAGTTATATGAAAGTGCTAAAAAG       c.720
 I  P  D  F  M  S  F  T  S  H  I  D  E  L  Y  E  S  A  K  K         p.240

          .      | 05  .         .         .         .         .    g.26171
 CAGTCTGGAGGAAAG | GTTGCAGATTATATTCCTCAACTGGCCAAATTCAGTCCCGATTTG    c.780
 Q  S  G  G  K   | V  A  D  Y  I  P  Q  L  A  K  F  S  P  D  L      p.260

          .         .         .      | 06  .         .         .    g.29208
 TGGGGTGTGTCTGTTTGTACAGTAGATGGACAGAG | GCATTCTACTGGAGATACCAAAGTT    c.840
 W  G  V  S  V  C  T  V  D  G  Q  R  |  H  S  T  G  D  T  K  V      p.280

          .         .         .         .         .         .       g.29268
 CCCTTCTGTCTTCAGTCCTGTGTAAAACCTTTGAAATATGCCATTGCTGTTAATGATCTT       c.900
 P  F  C  L  Q  S  C  V  K  P  L  K  Y  A  I  A  V  N  D  L         p.300

          .         .         .         .         .         .       g.29328
 GGAACTGAATATGTGCATCGATATGTTGGAAAAGAGCCGAGTGGACTAAGATTCAACAAA       c.960
 G  T  E  Y  V  H  R  Y  V  G  K  E  P  S  G  L  R  F  N  K         p.320

          .          | 07        .         .         .         .    g.34483
 CTATTTTTGAATGAAGATG | ATAAACCACATAATCCTATGGTAAATGCTGGAGCAATTGTT    c.1020
 L  F  L  N  E  D  D |   K  P  H  N  P  M  V  N  A  G  A  I  V      p.340

          .         | 08         .         .         .  | 09      . g.45333
 GTGACTTCACTAATAAAG | CAAGGAGTAAATAATGCTGAAAAATTTGACTAT | GTCATGCAG c.1080
 V  T  S  L  I  K   | Q  G  V  N  N  A  E  K  F  D  Y   | V  M  Q   p.360

          .         .         .         .         . | 10       .    g.48106
 TTTTTGAATAAGATGGCTGGTAATGAATATGTTGGATTCAGTAATGCAAC | GTTTCAGTCT    c.1140
 F  L  N  K  M  A  G  N  E  Y  V  G  F  S  N  A  T  |  F  Q  S      p.380

          .         .         .         .         .        | 11.    g.48725
 GAAAGAGAAAGTGGAGATCGAAATTTTGCAATAGGATATTACTTAAAAGAAAAGAAG | TGT    c.1200
 E  R  E  S  G  D  R  N  F  A  I  G  Y  Y  L  K  E  K  K   | C      p.400

          .         .         .         .         | 12         .    g.51497
 TTTCCAGAAGGCACAGACATGGTTGGTATATTAGACTTCTACTTCCAG | CTGTGCTCCATT    c.1260
 F  P  E  G  T  D  M  V  G  I  L  D  F  Y  F  Q   | L  C  S  I      p.420

          .         .         .         .         .         .       g.51557
 GAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCTGC       c.1320
 E  V  T  C  E  S  A  S  V  M  A  A  T  L  A  N  G  G  F  C         p.440

          .         .         .         .         .         .       g.51617
 CCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATG       c.1380
 P  I  T  G  E  R  V  L  S  P  E  A  V  R  N  T  L  S  L  M         p.460

          .         .         .         .      | 13  .         .    g.54631
 CATTCCTGTGGCATGTATGACTTCTCAGGGCAGTTTGCTTTCCAT | GTTGGTCTTCCTGCA    c.1440
 H  S  C  G  M  Y  D  F  S  G  Q  F  A  F  H   | V  G  L  P  A      p.480

          .         .         .         .         .         .       g.54691
 AAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGTGC       c.1500
 K  S  G  V  A  G  G  I  L  L  V  V  P  N  V  M  G  M  M  C         p.500

          .         .         .         .         .        | 14.    g.55727
 TGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCAC | GAT    c.1560
 W  S  P  P  L  D  K  M  G  N  S  V  K  G  I  H  F  C  H   | D      p.520

          .         .         .         .         .         .       g.55787
 CTTGTTTCTCTGTGTAATTTCCATAACTATGATAATTTGAGACACTTTGCAAAAAAACTT       c.1620
 L  V  S  L  C  N  F  H  N  Y  D  N  L  R  H  F  A  K  K  L         p.540

          .         .         . | 15       .         .         .    g.77774
 GATCCTCGAAGAGAAGGTGGTGATCAAAGG | GTAAAGTCAGTGATAAATCTTTTGTTTGCT    c.1680
 D  P  R  R  E  G  G  D  Q  R   | V  K  S  V  I  N  L  L  F  A      p.560

          .         .         .   | 16     .         .         .    g.78791
 GCATATACTGGAGATGTGTCTGCACTTCGAAG | ATTTGCTTTGTCAGCTATGGACATGGAA    c.1740
 A  Y  T  G  D  V  S  A  L  R  R  |  F  A  L  S  A  M  D  M  E      p.580

          .         .         .         .          | 17        .    g.78945
 CAGCGGGACTATGATTCTAGAACAGCACTCCATGTAGCTGCTGCAGAGG | GTCATGTTGAA    c.1800
 Q  R  D  Y  D  S  R  T  A  L  H  V  A  A  A  E  G |   H  V  E      p.600

          .         .         .         .         .    | 18    .    g.87016
 GTTGTTAAATTTTTGCTGGAAGCCTGCAAAGTAAACCCTTTCCCCAAGGACAG | GTGGAAT    c.1860
 V  V  K  F  L  L  E  A  C  K  V  N  P  F  P  K  D  R  |  W  N      p.620

          .         .         .         .         .         .       g.87076
 AACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTCCAA       c.1920
 N  T  P  M  D  E  A  L  H  F  G  H  H  D  V  F  K  I  L  Q         p.640

          .         .         .         .         .         .       g.87136
 GAATACCAAGTCCAGTACACACCTCAAGGAGATTCTGACAACGGGAAGGAAAATCAAACC       c.1980
 E  Y  Q  V  Q  Y  T  P  Q  G  D  S  D  N  G  K  E  N  Q  T         p.660

          .         .         .                                     g.87166
 GTCCATAAGAATCTTGATGGATTGTTGTAA                                     c.2010
 V  H  K  N  L  D  G  L  L  X                                       p.669

          .         .         .         .         .         .       g.87226
 tggtctcaaatcccaagatttaaatcacttacctatttaattgtggaaaatgattatgaa       c.*60

          .         .         .         .         .         .       g.87286
 gaacatgtgtatttctatctggtagtgatgtatattttacatttgtcatttcagtgttac       c.*120

          .         .         .         .         .         .       g.87346
 tggagttttcttcattgtgcacacaggacaaatctgatctctttgggaaaaaatagaaat       c.*180

          .         .         .         .         .         .       g.87406
 aaaacaatctccctccataatgtgagcaatattacctcgtgcattgtataatttgatgta       c.*240

          .         .         .         .         .         .       g.87466
 aaagaaatagttaccaatgctagcttgtgtggtcttccatgatttatttgtgttttgtga       c.*300

          .         .         .         .         .         .       g.87526
 attttcaatttatggtgatgatctgctgatatgcatttataaagtaagctctgttgtaca       c.*360

          .         .         .         .         .         .       g.87586
 gtctgtccaaatgggtcaaggttgcctttagaagcaaatagtgtgattttcaagacttca       c.*420

          .         .         .         .         .         .       g.87646
 aatacaaatttagtttaagtgtttgaacaactatatgcacttacggttgtgtgtttaaaa       c.*480

          .         .         .         .         .         .       g.87706
 tgtctctctcaccccctagcttcatgatgtgactcttaaaaaactataatagttaacaac       c.*540

          .         .         .         .         .         .       g.87766
 tgttagtaagatagaccaattctgattagactttatcagggaatctgtttaagatatgtt       c.*600

          .         .         .         .         .         .       g.87826
 tggtgaccaaaacgtatgtgtgaatgtagttataatgcttttgaaaaattttcctttttc       c.*660

          .         .         .         .         .         .       g.87886
 tatatccccttagtccagcctctcttctcagacatttagctatctgcctctttcctttag       c.*720

          .         .         .         .         .         .       g.87946
 ctgggaaagtgagagctggcatactatgcagtttttatgttttccatagtaagtcagaaa       c.*780

          .         .         .         .         .         .       g.88006
 atgcctcctatttctggcatcagaactttgccatttgtctacagaagacgaaccagagac       c.*840

          .         .         .         .         .         .       g.88066
 aaaattactaagtataaattagtcaagtttatcagtctaaaaaacgaagggatgtgcaac       c.*900

          .         .         .         .         .         .       g.88126
 tgcagctctttaagaagttttttttttttagcttctagggtaaagataaattcagaaatg       c.*960

          .         .         .         .         .         .       g.88186
 ctctaagctaccaaagttattctgaaagtatgggaactgctacaactaacaaacatttgt       c.*1020

          .         .         .         .         .         .       g.88246
 ttccaagcctgtcattaagagtctgcatcaagagatttgtcctccttgggggaccactgg       c.*1080

          .         .         .         .         .         .       g.88306
 atcattccagatttcttgtgatttttctattgtgtaattcttggtgggctctgtagttta       c.*1140

          .         .         .         .         .         .       g.88366
 ataataagaaaaaggccatttcattttaaattgtgacctataattctttgtcttgggttg       c.*1200

          .         .         .         .         .         .       g.88426
 gtaattcaggattcatttggaaagtgggtaaaaggggcttcaaaaaacggatagaacagg       c.*1260

          .         .         .         .         .         .       g.88486
 attttctaggagttacacatacattttatcctgtcatacctcgagataaagtggcatgtt       c.*1320

          .         .         .         .         .         .       g.88546
 agtgaggagttctgatattaagcacacacacacatgcacacaaatggacttctctgaagc       c.*1380

          .         .         .         .         .         .       g.88606
 tgtgtttagtgaaatgagctcaagtacatgaatgttagttgttatcacatacagcaaatt       c.*1440

          .         .         .         .         .         .       g.88666
 cctttttttttctttttctatgagcacactctgctgcttctaaactttacatgcctgatg       c.*1500

          .         .         .         .         .         .       g.88726
 gcaccttactccagcagcctccaggtgctttcattttcacttccagtctaagccagtggc       c.*1560

          .         .         .         .         .         .       g.88786
 tcctgccactgccctcccattacctagatggcacctcctttggtgaaaccacggccaatg       c.*1620

          .         .         .         .         .         .       g.88846
 ttccttagctgcaccaggcccgaagctgttcccatgcttgagcttccatggggaggatgc       c.*1680

          .         .         .         .         .         .       g.88906
 tgagtgagcagtttcctaccccgtggatctagcaagccatggagacaggtagcatttgta       c.*1740

          .         .         .         .         .         .       g.88966
 agatgctgcacaggagcagcattatccccaaagatattacagggtagacacgttttaact       c.*1800

          .         .         .         .         .         .       g.89026
 gaaatcaatcaagataactttattcaaagagcagcccgctttgtgtgactaaaatgaaac       c.*1860

          .         .         .         .         .         .       g.89086
 aagacagttgaattgtgtgacttgaagattaccaatgattttgaggcttttctataataa       c.*1920

          .         .         .         .         .         .       g.89146
 aaagaggttctaaccattatttgggaacaaagagagttttcatcttttttcagatcaaaa       c.*1980

          .         .         .         .         .         .       g.89206
 ccattctgtaaaatctttgttgtttaattaaatgtgccgttatttacccctgatgttatt       c.*2040

          .         .         .         .         .         .       g.89266
 tatgactatgtgccgattcctgctcgggctgtttgctgttggctggtaataatatatttg       c.*2100

          .         .         .         .         .         .       g.89326
 atttaaatgctgttgactgtgctattaactgctgccgtcagtaaactccaaagatctttt       c.*2160

          .         .         .         .         .         .       g.89386
 tgttttggctttagtatcatatgtgctttttctgtatcctgagcgctctatatgatcatg       c.*2220

          .         .         .         .         .         .       g.89446
 ttaatttaaagctttatacacattgttgtttttgctggtctcatctttggtaatatgcta       c.*2280

          .         .         .         .         .         .       g.89506
 taccccactgctgcccgacactgccctttagctgcagagctggattagctgttgaccatt       c.*2340

          .         .         .         .         .         .       g.89566
 tgatgctgttgtctgtctggcagggactgaatgacctgatgtcagatttagattcttcct       c.*2400

          .         .         .         .         .         .       g.89626
 ggggattacacagctatgaatgtatttgcttctaaaacctcccaaagtgaatctaatctt       c.*2460

          .         .         .         .         .         .       g.89686
 aaaactacaagttgtaagtattctgaaattgggaaacatttattttaaatgcaatcaggt       c.*2520

          .         .         .         .                           g.89732
 agtgttgctttttacagcataataaatatatgtatcaaaaaaaaaa                     c.*2566

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutaminase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2021 Leiden University Medical Center