glutamate-ammonia ligase (GLUL) - coding DNA reference sequence

(used for variant description)

(last modified April 19, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001033044.2 in the GLUL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering GLUL transcript NM_001033044.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-541

 .         .         .         .         .         .                g.5061
 taaaactattccccgtgaaggcggcagggcagaggtccagggcgggctttgctgggagcc       c.-481

 .         .         .         .         .         .                g.5121
 tcgggaccccgggttgggggccgtggggcggcacctggcgagctggcgggtgggcggcga       c.-421

 .         .         .         .         .         .                g.5181
 gccgaggcttcccggcctggcggcaactcgcccctctgccctcagccctcccggctccgc       c.-361

 .         .         .         .         .         .                g.5241
 tcccttcccccacgccgccctgcccctcccccacgcccctttctctttctttctttcttt       c.-301

 .         .         .         .         .         .                g.5301
 cccagttcgcttgcccccaccccagcggcgcccgccgggctcctcgcccaatggccgcgg       c.-241

 .         .         .         .         .         .                g.5361
 ggcccgggaccgcatcagctgatcggcccgggctcctggccgctgggagccaatcagggc       c.-181

 .         .         .         .         .         .                g.5421
 accgggggcggccccgggccgcggataaagggtgcggggctgctggcggctctgcagagt       c.-121

 .         .         .         .         .         .                g.5481
 cgagagtgggagaagagcggagcgtgtgagcagtactgcggcctcctctcctctcctaac       c.-61

 .         .         .         .         .       | 02 .             g.8469
 ctcgctctcgcggcctagctttacccgcccgcctgctcggcgaccag | aacaccttccacc    c.-1

          .         .         .         .         .         .       g.8529
 ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG       c.60
 M  T  T  S  A  S  S  H  L  N  K  G  I  K  Q  V  Y  M  S  L         p.20

          .         .         .         .         .         .       g.8589
 CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG       c.120
 P  Q  G  E  K  V  Q  A  M  Y  I  W  I  D  G  T  G  E  G  L         p.40

          .         .         .         .       | 03 .         .    g.9928
 CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAG | AGTTGCCTGAGTGG    c.180
 R  C  K  T  R  T  L  D  S  E  P  K  C  V  E  E |   L  P  E  W      p.60

          .         .         .         .         .         .       g.9988
 AATTTCGATGGCTCTAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG       c.240
 N  F  D  G  S  S  T  L  Q  S  E  G  S  N  S  D  M  Y  L  V         p.80

          .         .         .         .         .         .       g.10048
 CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA       c.300
 P  A  A  M  F  R  D  P  F  R  K  D  P  N  K  L  V  L  C  E         p.100

          .         .         | 04         .         .         .    g.10836
 GTTTTCAAGTACAATCGAAGGCCTGCAG | AGACCAATTTGAGGCACACCTGTAAACGGATA    c.360
 V  F  K  Y  N  R  R  P  A  E |   T  N  L  R  H  T  C  K  R  I      p.120

          .         .         .         .         .         .       g.10896
 ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG       c.420
 M  D  M  V  S  N  Q  H  P  W  F  G  M  E  Q  E  Y  T  L  M         p.140

          .         .         .         .         .      | 05  .    g.11324
 GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGG | GTCCA    c.480
 G  T  D  G  H  P  F  G  W  P  S  N  G  F  P  G  P  Q  G |   P      p.160

          .         .         .         .         .         .       g.11384
 TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC       c.540
 Y  Y  C  G  V  G  A  D  R  A  Y  G  R  D  I  V  E  A  H  Y         p.180

          .         .         .         .         .         .       g.11444
 CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC       c.600
 R  A  C  L  Y  A  G  V  K  I  A  G  T  N  A  E  V  M  P  A         p.200

     | 06    .         .         .         .         .         .    g.11707
 CAG | TGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG    c.660
 Q   | W  E  F  Q  I  G  P  C  E  G  I  S  M  G  D  H  L  W  V      p.220

          .         .         .         .         .         .       g.11767
 GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT       c.720
 A  R  F  I  L  H  R  V  C  E  D  F  G  V  I  A  T  F  D  P         p.240

          .         .         .         .         .         .       g.11827
 AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC       c.780
 K  P  I  P  G  N  W  N  G  A  G  C  H  T  N  F  S  T  K  A         p.260

          .         .    | 07    .         .         .         .    g.12520
 ATGCGGGAGGAGAATGGTCTGAA | GTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG    c.840
 M  R  E  E  N  G  L  K  |  Y  I  E  E  A  I  E  K  L  S  K  R      p.280

          .         .         .         .         .         .       g.12580
 CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA       c.900
 H  Q  Y  H  I  R  A  Y  D  P  K  G  G  L  D  N  A  R  R  L         p.300

          .         .         .         .         .         .       g.12640
 ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGC       c.960
 T  G  F  H  E  T  S  N  I  N  D  F  S  A  G  V  A  N  R  S         p.320

          .         .         .         .         .         .       g.12700
 GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT       c.1020
 A  S  I  R  I  P  R  T  V  G  Q  E  K  K  G  Y  F  E  D  R         p.340

          .         .         .         .         .         .       g.12760
 CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT       c.1080
 R  P  S  A  N  C  D  P  F  S  V  T  E  A  L  I  R  T  C  L         p.360

          .         .         .         .                           g.12802
 CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA                         c.1122
 L  N  E  T  G  D  E  P  F  Q  Y  K  N  X                           p.373

          .         .         .         .         .         .       g.12862
 gtggactagacctccagctgttgagcccctcctagttcttcatcccactccaactcttcc       c.*60

          .         .         .         .         .         .       g.12922
 ccctctcccagttgtcccgattgtaactcaaagggtggaatatcaaggtcgtttttttca       c.*120

          .         .         .         .         .         .       g.12982
 ttccatgtgcccagttaatcttgctttctttgtttggctgggatagaggggtcaagttat       c.*180

          .         .         .         .         .         .       g.13042
 taatttcttcacacctaccctcctttttttccctatcactgaagctttttagtgcattag       c.*240

          .         .         .         .         .         .       g.13102
 tggggaggagggtggggagacataaccactgcttccatttaatggggtgcacctgtccaa       c.*300

          .         .         .         .         .         .       g.13162
 taggcgtagctatccggacagagcacgtttgcagaagggggtctcttcttccaggtagct       c.*360

          .         .         .         .         .         .       g.13222
 gaaaggggaagacctgacgtactctggttaggttaggacttgccctcgtggtggaaactt       c.*420

          .         .         .         .         .         .       g.13282
 ttcttaaaaagttataaccaacttttctattaaaagtgggaattaggagagaaggtaggg       c.*480

          .         .         .         .         .         .       g.13342
 gttgggaatcagagagaatggctttggtctcttgcttgtgggactagcctggcttgggac       c.*540

          .         .         .         .         .         .       g.13402
 taaatgccctgctctgaacacgaagcttagtataaactgatggatatccctaccttgaaa       c.*600

          .         .         .         .         .         .       g.13462
 gaagaaaaggttcttactgcttggtccttgatttatcacacaaagcagaatagtattttt       c.*660

          .         .         .         .         .         .       g.13522
 atatttaaatgtaaagacaaaaaactatatgtatggttttgtggattatgtgtgttttgc       c.*720

          .         .         .         .         .         .       g.13582
 taaaggaaaaaaccatccaggtcacggggcaccaaatttgagacaaatagtcggattaga       c.*780

          .         .         .         .         .         .       g.13642
 aataaagcatctcattttgagtagagagcaagggaagtggttcttagatggtgatctggg       c.*840

          .         .         .         .         .         .       g.13702
 attaggccctcaagacccttttgggtttctgccctgcccaccctctggagaaggtgggca       c.*900

          .         .         .         .         .         .       g.13762
 ctggattagttaacagacaacacgttactagcagtcacttgatctccgtggctttggttt       c.*960

          .         .         .         .         .         .       g.13822
 aaaagacacacttgtccacataggtttagagataagagttggctggtcaacttgagcatg       c.*1020

          .         .         .         .         .         .       g.13882
 ttactgacagagggggtattggggttattttctggtaggaatagcatgtcactaaagcag       c.*1080

          .         .         .         .         .         .       g.13942
 gccttttgatattaaattttttaaaaagcaaaattatagaagtttagattttaatcaaat       c.*1140

          .         .         .         .         .         .       g.14002
 ttgtagggtttctaggtaatttttacagaattgcttgtttgcttcaactgtctcctacct       c.*1200

          .         .         .         .         .         .       g.14062
 ctgctcttggaggagatggggacagggctggagtcaaaacacttgtaattttgtatcttg       c.*1260

          .         .         .         .         .         .       g.14122
 atgtctttgttaagactgctgaagaattattttttttcttttataataaggaataaaccc       c.*1320

          .         .         .         .         .         .       g.14182
 cacctttattccttcatttcatctaccattttctggttcttgtgttggctgtggcaggcc       c.*1380

          .         .         .         .         .         .       g.14242
 agctgtggttttcttttgccatgacaacttctaattgccatgtacagtatgttcaaagtc       c.*1440

          .         .         .         .         .         .       g.14302
 aaataactcctcattgtaaacaaactgtgtaactgcccaaagcagcacttataaatcagc       c.*1500

          .         .         .         .         .         .       g.14362
 ctaacataagatctctctgatgtgtttgtgattctttcaaatccctatgtgccattatat       c.*1560

          .         .         .         .         .         .       g.14422
 ttctttatttcctaaaacaggcaaaataagctcaagtttatgtactctgagtttttaaaa       c.*1620

          .         .         .         .         .         .       g.14482
 cactggagtgatgttgctgaccagccgtttcctgtacctctctaagttgggtatttggga       c.*1680

          .         .         .         .         .         .       g.14542
 cttaagggattaagtttttcacctagacttagttacacacaatcttggcatttcctagcc       c.*1740

          .         .         .         .         .         .       g.14602
 tagaggtttgtagcagggtacaagccccactcctcccccttcctttgctcccctgagttt       c.*1800

          .         .         .         .         .         .       g.14662
 ggttttggcttaccataacattgttttgaccattcctagcctaatacaatagcctaacat       c.*1860

          .         .         .         .         .         .       g.14722
 aatgtaagattaactggctttacgatttctattctctgctctcagtgataagaaacaaat       c.*1920

          .         .         .         .         .         .       g.14782
 attagctaccctgctaccctggttgaagccttccaaggctggctatgccctaggcatggg       c.*1980

          .         .         .         .         .         .       g.14842
 ctcatccttgggtgtatcttgccttgcaggaagaccagtggaccgattgtgattctcaaa       c.*2040

          .         .         .         .         .         .       g.14902
 agctctgtgttgtcacctgtgcccttgccccttgctcttatcttggtccgtgtatctggg       c.*2100

          .         .         .         .         .         .       g.14962
 agttcttccaccttatcttggccaattcctaccttcgttcattcctcatgaggttgggta       c.*2160

          .         .         .         .         .         .       g.15022
 aaagctccctccggctcccatgatgctgtgcatatacctagcaaaaagcaattattggac       c.*2220

          .         .         .         .         .         .       g.15082
 acattggagtgcaatattattaatagcattaatactactaataatgtgggcaatagtgat       c.*2280

          .         .         .         .         .         .       g.15142
 tgtttttaaaaggcagtatactcttaccagtgcgaggtagctggggcctgtgatagtttt       c.*2340

          .         .         .         .         .         .       g.15202
 tagagataagttcttcaggcaactgtgtattttacactagtcaagtaatcctagatatcc       c.*2400

          .         .         .         .         .         .       g.15262
 gtggtttttcttaagaaagttggctcgtaatatgatttaatattcaaagtagagtcatct       c.*2460

          .         .         .         .         .         .       g.15322
 acctattagcttgctggcgtggtcctagtttatgcctgtttcagcatgattgttgagtac       c.*2520

          .         .         .         .         .         .       g.15382
 cctgtttcatccttagcattttcttgattttgttgttaaatgatgtatacccttatttcc       c.*2580

          .         .         .         .         .         .       g.15442
 attgaatctgtgcttccacccccccaactgaagttgtcttccctttgcttggccaccctt       c.*2640

          .         .         .         .         .         .       g.15502
 acagcctcttggatggtgtatcctacagtgtaagcactaaactgaagaggcagtgacctg       c.*2700

                                                                    g.15503
 a                                                                  c.*2701

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate-ammonia ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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