GDP-mannose pyrophosphorylase B (GMPPB) - coding DNA reference sequence

(used for variant description)

(last modified November 10, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_021971.2 in the GMPPB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering GMPPB transcript NM_021971.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.4985
                                                     actgcccg       c.-241

 .         .         .         .         .         .                g.5045
 cgccgggtccggcctgagttcggggccagcagccgtctacccggtgtcgcgttctgtgtt       c.-181

 .         .         .         .         .         .                g.5105
 gtggcggccctggatccggcgtcagggcgaccgggcggacgaggtggagccagagtctgt       c.-121

 .         .         .         .         .         .                g.5165
 caggcgggttggtgaagggcgcggggccgggcacggcgttgggagtgcgcggcagggacc       c.-61

 .         .         .         .         .         .                g.5225
 ggccaggcgggctgcaggcacctcagagcccgggacaccccctcaacgtccgcaggcgcg       c.-1

          .         .         .         .         .         .       g.5285
 ATGAAGGCACTGATCTTAGTGGGGGGCTATGGGACGCGGCTACGGCCGCTGACGCTGAGC       c.60
 M  K  A  L  I  L  V  G  G  Y  G  T  R  L  R  P  L  T  L  S         p.20

          .         .         .         .         .         .       g.5345
 ACCCCGAAGCCACTGGTGGACTTCTGCAATAAGCCCATCTTGCTGCACCAAGTGGAGGCG       c.120
 T  P  K  P  L  V  D  F  C  N  K  P  I  L  L  H  Q  V  E  A         p.40

           | 02        .         .         .         .         .    g.5530
 CTAGCCGCG | GCAGGCGTGGACCACGTGATCCTGGCCGTGAGCTACATGTCGCAGGTGCTG    c.180
 L  A  A   | A  G  V  D  H  V  I  L  A  V  S  Y  M  S  Q  V  L      p.60

          .         .         . | 03       .         .         .    g.5679
 GAGAAGGAAATGAAGGCACAGGAGCAGAGG | CTGGGAATCCGAATCTCCATGTCCCATGAA    c.240
 E  K  E  M  K  A  Q  E  Q  R   | L  G  I  R  I  S  M  S  H  E      p.80

          .          | 04        .         .         .         .    g.5878
 GAGGAGCCTTTGGGGACAG | CTGGGCCCCTGGCGCTGGCCCGTGACCTACTCTCTGAGACT    c.300
 E  E  P  L  G  T  A |   G  P  L  A  L  A  R  D  L  L  S  E  T      p.100

          .         .         .         .         .         .       g.5938
 GCAGACCCTTTCTTCGTCCTCAACAGTGACGTGATCTGCGATTTCCCCTTCCAAGCCATG       c.360
 A  D  P  F  F  V  L  N  S  D  V  I  C  D  F  P  F  Q  A  M         p.120

          .         .         .         .   | 05     .         .    g.6215
 GTGCAGTTCCACCGGCACCATGGCCAGGAGGGCTCCATCCTG | GTGACCAAGGTGGAGGAA    c.420
 V  Q  F  H  R  H  H  G  Q  E  G  S  I  L   | V  T  K  V  E  E      p.140

          .         .         .         .         .         .       g.6275
 CCCTCCAAGTACGGTGTGGTGGTGTGTGAGGCTGACACAGGCCGCATTCACCGGTTCGTG       c.480
 P  S  K  Y  G  V  V  V  C  E  A  D  T  G  R  I  H  R  F  V         p.160

          .         .         .         .         .         .       g.6335
 GAGAAGCCACAGGTGTTTGTGTCCAATAAGATCAACGCAGGCATGTACATCCTGAGCCCT       c.540
 E  K  P  Q  V  F  V  S  N  K  I  N  A  G  M  Y  I  L  S  P         p.180

          .         .  | 06      .         .         .         .    g.6480
 GCAGTGCTGCAGCGCATCCAG | CTGCAGCCTACGTCCATTGAGAAGGAGGTCTTCCCCATT    c.600
 A  V  L  Q  R  I  Q   | L  Q  P  T  S  I  E  K  E  V  F  P  I      p.200

          .         .         .         . | 07       .         .    g.6613
 ATGGCCAAGGAGGGGCAGCTATATGCCATGGAGTTACAGG | GCTTCTGGATGGACATTGGG    c.660
 M  A  K  E  G  Q  L  Y  A  M  E  L  Q  G |   F  W  M  D  I  G      p.220

          .         .         .         .         .         .       g.6673
 CAGCCCAAGGACTTCCTCACTGGCATGTGCCTCTTCCTGCAGTCACTGAGGCAGAAGCAG       c.720
 Q  P  K  D  F  L  T  G  M  C  L  F  L  Q  S  L  R  Q  K  Q         p.240

          .         .         .         .         | 08         .    g.6816
 CCTGAGCGGCTGTGCTCAGGCCCTGGCATTGTGGGCAACGTGCTGGTG | GACCCAAGTGCC    c.780
 P  E  R  L  C  S  G  P  G  I  V  G  N  V  L  V   | D  P  S  A      p.260

          .         .         .         .         .         .       g.6876
 CGCATCGGCCAGAACTGCAGCATTGGCCCCAATGTGAGCCTGGGACCTGGCGTGGTGGTC       c.840
 R  I  G  Q  N  C  S  I  G  P  N  V  S  L  G  P  G  V  V  V         p.280

          .         .         .         .         .         .       g.6936
 GAAGATGGTGTGTGTATCCGGCGGTGCACGGTGCTGCGGGATGCCCGGATCCGTTCCCAT       c.900
 E  D  G  V  C  I  R  R  C  T  V  L  R  D  A  R  I  R  S  H         p.300

          .         .         .         .         .  | 09      .    g.7077
 TCCTGGCTTGAGTCCTGCATTGTGGGCTGGCGCTGCCGCGTGGGTCAGTGG | GTACGCATG    c.960
 S  W  L  E  S  C  I  V  G  W  R  C  R  V  G  Q  W   | V  R  M      p.320

          .         .         .         .         .         .       g.7137
 GAGAACGTGACAGTGCTGGGTGAGGACGTCATAGTTAATGATGAGCTCTACCTCAACGGA       c.1020
 E  N  V  T  V  L  G  E  D  V  I  V  N  D  E  L  Y  L  N  G         p.340

          .         .         .         .         .         .       g.7197
 GCCAGCGTGCTGCCCCACAAGTCTATTGGCGAGTCAGTGCCAGAGCCTCGTATCATCATG       c.1080
 A  S  V  L  P  H  K  S  I  G  E  S  V  P  E  P  R  I  I  M         p.360

                                                                    g.7200
 TGA                                                                c.1083
 X                                                                  p.360

          .         .         .         .         .         .       g.7260
 ggggatgcagtggggctggccgagccccggttttcccatcagcaaggggagtgctggcct       c.*60

          .         .         .         .         .         .       g.7320
 gacacatcagaagaccctggacttgtcattatttgtctggggggcactgggtgaagctga       c.*120

          .         .         .         .         .         .       g.7380
 agctgttggacacctgccttctcatgtggacatcatctggcaggatccctgctgggcaca       c.*180

          .         .         .         .         .         .       g.7440
 ccccacaaaccccactccctcaagaagggccagggccagggctgtatggaataataattt       c.*240

          .         .         .                                     g.7476
 aatgctcactgtggccctgactgaaagtcaagctca                               c.*276

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GDP-mannose pyrophosphorylase B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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