guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1) - coding DNA reference sequence

(used for variant description)

(last modified August 14, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_138736.2 in the GNAO1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering GNAO1 transcript NM_138736.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    gctgacgtcagctggcggcccgcggagccgggtgcgcagagccgctggcgcactcgc       c.-841

 .         .         .         .         .         .                g.5117
 gcgctgcgctggcctcctccccgccccgggcccaggcgcgcgcgcgcttgttcgctctcc       c.-781

 .         .         .         .         .         .                g.5177
 cattttttttttcccctccctccctgcctctctctctctccctctccctcgagctcccgg       c.-721

 .         .         .         .         .         .                g.5237
 ctggctgcggctccctggcgctctccctctctctccggtaggctcaccgagcgatgcgag       c.-661

 .         .         .         .         .         .                g.5297
 ctctgggagacagcgacgccgcctcccgctagagacctgcccctcggcccggccccctgc       c.-601

 .         .         .         .         .         .                g.5357
 ccaaccctgcccagcgcgcgggggtcggcgaaggcgccgcggacgcaccgacggctgaag       c.-541

 .         .         .         .         .         .                g.5417
 agcggcgatgcacatgcactagcagcaccccctaactcactccctccacatcccgcgccg       c.-481

 .         .         .         .         .         .                g.5477
 ccgccgccgcctcctccacctcctcctccgccgccgccgcctcctcctcctccggcagcc       c.-421

 .         .         .         .         .         .                g.5537
 gcggcagcaggacccaccctgccccccaccccaccctctgtcggctccggctgcggctcc       c.-361

 .         .         .         .         .         .                g.5597
 agcctcgactattattttatttattttgggtcgtgcacaagcctcagtgcctgcagtccg       c.-301

 .         .         .         .         .         .                g.5657
 cgcctcctcggcccgcgggcgcctcctcccttggctccggagccccagaccccggccacc       c.-241

 .         .         .         .         .         .                g.5717
 ctcgattcgacaaccccagacccctgccagctgccgcgagtctccgctgctggaatcttg       c.-181

 .         .         .         .         .         .                g.5777
 ttagcggctgtctttttggagggttctggtttcccgacatttttgtttccagcccaggag       c.-121

 .         .         .         .         .         .                g.5837
 aggatatcgtgattttccccccttgagcccaggctctgctctctgggggggtggggggcg       c.-61

 .         .         .         .         .         .                g.5897
 ctccaagccggggagccgtgccagccgagtcgtgcgggctgtggcagggaaggggccacc       c.-1

          .         .         .         .         .         .       g.5957
 ATGGGATGTACTCTGAGCGCAGAGGAGAGAGCCGCCCTCGAGCGGAGCAAGGCGATTGAG       c.60
 M  G  C  T  L  S  A  E  E  R  A  A  L  E  R  S  K  A  I  E         p.20

          .         .         .         .         .         | 02    g.6237
 AAAAACCTCAAAGAGGATGGCATCAGCGCCGCCAAAGACGTGAAATTACTCCTGCTCG | GG    c.120
 K  N  L  K  E  D  G  I  S  A  A  K  D  V  K  L  L  L  L  G |       p.40

          .         .         .         .  | 03      .         .    g.89611
 GCTGGAGAATCAGGAAAAAGCACCATTGTGAAGCAGATGAA | GATCATCCATGAAGATGGC    c.180
 A  G  E  S  G  K  S  T  I  V  K  Q  M  K  |  I  I  H  E  D  G      p.60

          .         .         .         .         .         .       g.89671
 TTCTCCGGAGAAGACGTGAAACAGTACAAGCCTGTTGTCTACAGCAACACTATCCAGTCC       c.240
 F  S  G  E  D  V  K  Q  Y  K  P  V  V  Y  S  N  T  I  Q  S         p.80

          .         .         .         .         .         .       g.89731
 CTGGCAGCCATCGTCCGGGCCATGGACACTTTGGGCATCGAATATGGTGATAAGGAGAGA       c.300
 L  A  A  I  V  R  A  M  D  T  L  G  I  E  Y  G  D  K  E  R         p.100

     | 04    .         .         .         .         .         .    g.142349
 AAG | GCTGACGCCAAGATGGTGTGTGATGTGGTGAGTCGGATGGAAGACACCGAGCCCTTC    c.360
 K   | A  D  A  K  M  V  C  D  V  V  S  R  M  E  D  T  E  P  F      p.120

          .         .         .         .         .         .       g.142409
 TCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGC       c.420
 S  A  E  L  L  S  A  M  M  R  L  W  G  D  S  G  I  Q  E  C         p.140

          .         .         .         .     | 05   .         .    g.148406
 TTCAACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATA | CTACCTGGACAGCCTG    c.480
 F  N  R  S  R  E  Y  Q  L  N  D  S  A  K  Y  |  Y  L  D  S  L      p.160

          .         .         .         .         .         .       g.148466
 GATCGGATTGGGGCCGCCGACTACCAGCCCACCGAGCAGGACATCCTCCGAACCAGGGTC       c.540
 D  R  I  G  A  A  D  Y  Q  P  T  E  Q  D  I  L  R  T  R  V         p.180

          .         .         .         .         .    | 06    .    g.150399
 AAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAG | GCTGTTT    c.600
 K  T  T  G  I  V  E  T  H  F  T  F  K  N  L  H  F  R  |  L  F      p.200

          .         .         .         .         .         .       g.150459
 GACGTCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACG       c.660
 D  V  G  G  Q  R  S  E  R  K  K  W  I  H  C  F  E  D  V  T         p.220

          .         .         .         .         .         .       g.150519
 GCCATCATTTTCTGTGTCGCGCTCAGCGGCTATGACCAGGTGCTCCACGAAGACGAAACC       c.720
 A  I  I  F  C  V  A  L  S  G  Y  D  Q  V  L  H  E  D  E  T         p.240

     | 07    .         .         .         .         .         .    g.154552
 ACG | AACCGCATGCACGAATCCCTGAAGCTTTTTGACAGCATCTGCAACAACAAATGGTTC    c.780
 T   | N  R  M  H  E  S  L  K  L  F  D  S  I  C  N  N  K  W  F      p.260

          .         .         .         .         .         .       g.154612
 ACAGACACGTCCATCATCCTGTTTCTTAACAAGAAGGACATATTTGAAGAGAAGATCAAG       c.840
 T  D  T  S  I  I  L  F  L  N  K  K  D  I  F  E  E  K  I  K         p.280

          .         .         .        | 08.         .         .    g.157447
 AAGTCCCCGCTCACCATCTGCTTTCCTGAATATACAG | GCCCCAGCGCCTTCACAGAAGCC    c.900
 K  S  P  L  T  I  C  F  P  E  Y  T  G |   P  S  A  F  T  E  A      p.300

          .         .         .         .         .         .       g.157507
 GTGGCTTACATCCAGGCCCAGTACGAGAGCAAGAACAAGTCAGCCCACAAAGAGATCTAC       c.960
 V  A  Y  I  Q  A  Q  Y  E  S  K  N  K  S  A  H  K  E  I  Y         p.320

          .         .         .         .         .         .       g.157567
 ACCCACGTCACCTGCGCCACGGACACCAACAACATCCAGTTTGTCTTTGATGCTGTGACG       c.1020
 T  H  V  T  C  A  T  D  T  N  N  I  Q  F  V  F  D  A  V  T         p.340

          .         .         .         .                           g.157612
 GACGTCATCATCGCCAAAAACCTGCGGGGCTGTGGACTCTACTGA                      c.1065
 D  V  I  I  A  K  N  L  R  G  C  G  L  Y  X                        p.354

          .         .         .         .         .         .       g.157672
 gcccagccgccctgcccggcacccttgccctgcctggcctgccgccccccctcccctgga       c.*60

          .         .         .         .         .         .       g.157732
 accaggctccaccactctcagaccactctttgcacttgaggaagaagacctcagaggctg       c.*120

          .         .         .         .         .         .       g.157792
 gcaccaagggagggaggagggagcatcctccacccgcaccccccaacagaacttgtggta       c.*180

          .         .         .         .         .         .       g.157852
 acgcaggggcggggcggggctgctgagtgcatgctgcaaggccaggagactccacgctca       c.*240

          .         .         .         .         .         .       g.157912
 cagcctctgtgtcatctctgagtgcttgatcgggaagctggggggacagggcagggccca       c.*300

          .         .         .         .         .         .       g.157972
 gatgggcacaccctgcacctgatgactcactggaagcctcggagtgtcctcctgtcatct       c.*360

          .         .         .         .         .         .       g.158032
 tgggtggtgcaggggcgcagatggccctgcagcagggtgctggcagggtggggtcatagg       c.*420

          .         .         .         .         .         .       g.158092
 agccatccttcagctttgcctggggtctctggtggagggcagttccgtcaacaaaagcca       c.*480

          .         .         .         .         .         .       g.158152
 gggtgggatcaggccaacttggtgtgggttggaggactcaggccttggcgatggcctccg       c.*540

          .         .         .         .         .         .       g.158212
 tctccctgctccctcccctgggtctcagcccttccttctctgggtcatcctcccttgcct       c.*600

          .         .         .         .         .         .       g.158272
 ttgctctcccagagaactcccatccctgactcctccgagttctggaaatgcttcttgaga       c.*660

          .         .         .         .         .         .       g.158332
 ctgatttatggctcagatagatggtggcgtggagcggggggagggagagatgggaggtgc       c.*720

          .         .         .         .         .         .       g.158392
 ggggaagggaggtggaagctcctgtgtcacctgggctggggcctcccgcccagtcctcgc       c.*780

          .         .         .         .         .         .       g.158452
 aggccaaagggtgacccatttcttttttccagtcaccaggagctcggatggtcactctga       c.*840

          .         .         .         .         .         .       g.158512
 ggtgtgaatagatatgtttttccttcagtccacactgaattcaactcaaaccagcaaagg       c.*900

          .         .         .         .         .         .       g.158572
 cctttgggctggggattctgtggttgcagaggtctagagggggtggacttttgcagccag       c.*960

          .         .         .         .         .         .       g.158632
 tgcctccgcctcaccgtcttggtgaagaaatcagcgagtttgttcacagccgttggtgtc       c.*1020

          .         .         .         .         .         .       g.158692
 ttcccagcccctggggacagaggacagcagggggatggagctgacaccctggagtatttg       c.*1080

          .         .         .         .         .         .       g.158752
 gacccaggccagcacaaacacacccccctgtccccaactctaaagggagagtcctaggac       c.*1140

          .         .         .         .         .         .       g.158812
 tccttagaggaggcttcactgcggagatccctgagcagaagggggcggggtagcttctcc       c.*1200

          .         .         .         .         .         .       g.158872
 cggtgacggtgacgcaggtctggctggccttgggcaaccaacacacctctcccactccaa       c.*1260

          .         .         .         .         .         .       g.158932
 gatgcctccaggtggctgaggccaacgcccacacccaggccagtcgtgtgcttgtacagc       c.*1320

          .         .         .         .         .         .       g.158992
 aggctgtgcctggggacctagatgtgccatgggagggaggagggtacccactgacaggcc       c.*1380

          .         .         .         .         .         .       g.159052
 tctgcctccctcctcaagccctctgttctccctgcccccactctggacactgcttagtcc       c.*1440

          .         .         .         .         .         .       g.159112
 ccagccaggcagggcccctgggtttccacttgcagcccccggactgccccagagccggga       c.*1500

          .         .         .         .         .         .       g.159172
 agcaccagtgccaacagctctggacttgttggacccacaggcacagagctctgagtggtg       c.*1560

          .         .         .         .         .         .       g.159232
 cccaggagacccaggaaccttccctagtgccaaatgcctgcagggaccggtgcctgggga       c.*1620

          .         .         .         .         .         .       g.159292
 gcctctggcagccggactgcaggagccaccccatcagcccaagtccacctctgttttgtt       c.*1680

          .         .         .         .         .         .       g.159352
 cacctcggtcatgttttggaccttgcaccaggtgctgggacgtggcagaggacaggccct       c.*1740

          .         .         .         .         .         .       g.159412
 gggaaccaacagtgtcctaccatggacagccagggccagctaagctaagccatcccgccc       c.*1800

          .         .         .         .         .         .       g.159472
 aacacagaagacatggcagttatttctcagcagcaccacgctgggtgaggccagttgttc       c.*1860

          .         .         .         .         .         .       g.159532
 cgcttactctgctccgaactgtaaccccaggctcagaagcagccggcaaaagggggatgc       c.*1920

          .         .         .         .         .         .       g.159592
 tggccacgccccacctctaaggccatcaccctggaggtggaagtcactgggctggagggc       c.*1980

          .         .         .         .         .         .       g.159652
 tctccatgtcccccagcagccgccctcagaacacagtggccagagcaccaggctgggtcc       c.*2040

          .         .         .         .         .         .       g.159712
 aggcctccaatccaggccttccctgtccctagaactggggctggaggagtgggtgctcag       c.*2100

          .         .         .         .         .         .       g.159772
 cccttcctgccctccatccccagcctgcctttctcttcctttggatgctccatcctcctt       c.*2160

          .         .         .         .         .         .       g.159832
 ggtttcttgcactgctctcaatcctcccaccctagcctgggggtggtccttggtcctcag       c.*2220

          .         .         .         .         .         .       g.159892
 gggtatccggggagaaattctctccctgtgcatgacacctgtcatccatgtcgtaaccag       c.*2280

          .         .         .         .         .         .       g.159952
 cggctccatcttgtggggtggtgactgagggtgacaaatgagatttggctccgtcgtgga       c.*2340

          .         .         .         .         .         .       g.160012
 tgtggatgtgggaggaatgttgcgagtgacacgtgtgggtttctaatccacagtggtcct       c.*2400

          .         .         .         .         .         .       g.160072
 gcgtgtgccctgaggggccatggtaacctctccgatggctcggatttagcaggccaagca       c.*2460

          .         .         .         .         .         .       g.160132
 gaaactgatttctacgaagagcgtctttgccaaactcatgaaaattgtgcctgccacttt       c.*2520

          .         .         .         .         .         .       g.160192
 catgcctatgggccagttttgtgacctgcgccgctgaccatcctaagaaccaggtcttgg       c.*2580

          .         .         .         .         .         .       g.160252
 ccttccctctgagcactgatagaggtccccaaggctctctggcctgaggagggtgtgggg       c.*2640

          .         .         .         .         .         .       g.160312
 tctgcccagccccaagcagagagcacagtctgggcccctgaccaacagctttggcattct       c.*2700

          .         .         .         .         .         .       g.160372
 gggttccatggggaccctagagctcaggcacaagaacaacaccatacctgctgccaggac       c.*2760

          .         .         .         .         .         .       g.160432
 gcagctgtctcccaggccctccccacagcccagctcccactggcaggaactggacacatc       c.*2820

          .         .         .         .         .         .       g.160492
 cctgccctccatggtctgcactggtcttctctgagtattcttaggagcagaggcagcccc       c.*2880

          .         .         .         .         .         .       g.160552
 aagttccaacttgcaagccctgtaactaagctgtctataaaccccagcagggaaggccaa       c.*2940

          .         .         .         .         .         .       g.160612
 gggatggtctcacccatgcccttccctttggccaacatgagtcctgcagtggggagctta       c.*3000

          .         .         .         .         .         .       g.160672
 gcccctgctcccacctaacactctacagttagcacccaggggttgattcaggaagttctt       c.*3060

          .         .         .         .         .         .       g.160732
 cctttttctagcctgcatccttcctggccaccccctttatttctcagtctgacctggtgc       c.*3120

          .         .         .         .         .         .       g.160792
 actcttggcaagtgagtccattgcagtcccaggtggatatttaatgagcactcggactgt       c.*3180

          .         .         .         .         .         .       g.160852
 ttcctccaagtcagctagtggcctgccctcctccttttcaagaagtctggggcacagagc       c.*3240

          .         .         .         .         .         .       g.160912
 ctcctctggctgcctcttctcttctctgagcctctgggagccttcaggcaaaacctggca       c.*3300

          .         .         .         .         .         .       g.160972
 gttctcaggaacccagacctgaggctccagctccgcggccaccagagattcagtgtgcag       c.*3360

          .         .         .         .         .         .       g.161032
 tgccgaaggcagtcacccccaggcagttcctgctgtcaggccgcaagcctagagcgcagg       c.*3420

          .         .         .         .         .         .       g.161092
 atcccagcagcccagggaacagggccggcgtgtgagctgctgccgtggggtctgtggtag       c.*3480

          .         .         .         .         .         .       g.161152
 ggctccccatctcccacccctcagcaagaagagtcctgacccctgaccccaccctgccca       c.*3540

          .         .         .         .         .         .       g.161212
 gagaggagctggggcctccagacagaccccactgcagccagatgaaggcccctgtcaaag       c.*3600

          .         .         .         .         .         .       g.161272
 aaggggcaggctgggggaaaagcagaaagaatggcccccagtccaaactcctggatcccc       c.*3660

          .         .         .         .         .         .       g.161332
 tccatgagagaggggctccccctggaacagaagctctcatccccaggcccagtgcacaag       c.*3720

          .         .         .         .         .         .       g.161392
 accaccagcagagacccaccgcccttcctggcagagcaccacttcctggcagtgcagctc       c.*3780

          .         .         .         .         .         .       g.161452
 cgaggcaccactactgtcctccccttccctccccacccctcccctccctttccctcctct       c.*3840

          .         .         .         .         .         .       g.161512
 cccctcccctccacacctgccctgttactcccacagctctgggcagccaggccctcccct       c.*3900

          .         .         .         .         .         .       g.161572
 cctgcctcctggtcttctctactccgctggttctgacccatcccctggctctgcccgccg       c.*3960

          .         .         .         .         .         .       g.161632
 tcccccaccctgcccctgctgagtatcttcttcctccccacgcacccccctcccccatct       c.*4020

          .         .         .         .         .         .       g.161692
 aggcgaggtgggctcgggcgtcccaggccctccttagaaaagccgtctctctcgagtgca       c.*4080

          .         .         .         .         .         .       g.161752
 gtggtcccacctcccaaccccatcactgctgcccaccccatattaactgtaattttgtaa       c.*4140

          .         .         .         .         .         .       g.161812
 gaagagtgacttgttggtttaataaatctctagttattgtaataatttattggctgccat       c.*4200

          .         .         .         .                           g.161861
 aatgtatttattagtcgcctaccgttaataaaaagtgcccgctttccta                  c.*4249

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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