guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1) - coding DNA reference sequence

(used for variant description)

(last modified May 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_002074.3 in the GNB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering GNB1 transcript NM_002074.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          agg       c.-361

 .         .         .         .         .         .                g.5063
 ggcccgccgcgcccatcccgatggctggaggcgtctgaggggcggacggaggcggcggcg       c.-301

 .         .         .         .         .         .                g.5123
 gcggcggcgggagcgggagcgggcggcgagtggggagcggggccgggagtggagcagccg       c.-241

 .         .         .         .         .         .                g.5183
 ccgcggcgggactggaccgagcctcgccggcgcgcacctgcccgcagcgcccgcggagcg       c.-181

 .         .         .         .         .         .                g.5243
 cgcagcgcggcccgagcgcgacgacctgccgagcggcggccgaggcggcggtgtgggcgc       c.-121

 .         .         .     | 02   .         .         .             g.56884
 gtcaggccgcgacgagggcgctgag | acaaatttacatgtattggagaccagaccagaagc    c.-61

 .         .    | 03    .         .         .         .             g.70634
 ccttctgaattaag | atctcacattcttgaaggtggcattgaagagcactaagatcggaag    c.-1

          .         .         .         .         .        | 04.    g.78215
 ATGAGTGAGCTTGACCAGTTACGGCAGGAGGCCGAGCAACTTAAGAACCAGATTCGA | GAC    c.60
 M  S  E  L  D  Q  L  R  Q  E  A  E  Q  L  K  N  Q  I  R   | D      p.20

          .         .         .       | 05 .         .         .    g.80249
 GCCAGGAAAGCATGTGCAGATGCAACTCTCTCTCAG | ATCACAAACAACATCGACCCAGTG    c.120
 A  R  K  A  C  A  D  A  T  L  S  Q   | I  T  N  N  I  D  P  V      p.40

          .         .         .         .         .         .       g.80309
 GGAAGAATCCAAATGCGCACGAGGAGGACACTGCGGGGGCACCTGGCCAAGATCTACGCC       c.180
 G  R  I  Q  M  R  T  R  R  T  L  R  G  H  L  A  K  I  Y  A         p.60

          .         .    | 06    .         .         .         .    g.89586
 ATGCACTGGGGCACAGACTCCAG | GCTTCTCGTCAGTGCCTCGCAGGATGGTAAACTTATC    c.240
 M  H  W  G  T  D  S  R  |  L  L  V  S  A  S  Q  D  G  K  L  I      p.80

          .         .        | 07.         .         .         .    g.91539
 ATCTGGGACAGCTACACCACCAACAAG | GTCCACGCCATCCCTCTGCGCTCCTCCTGGGTC    c.300
 I  W  D  S  Y  T  T  N  K   | V  H  A  I  P  L  R  S  S  W  V      p.100

          .         .         .         .         .         .       g.91599
 ATGACCTGTGCATATGCCCCTTCTGGGAACTATGTGGCCTGCGGTGGCCTGGATAACATT       c.360
 M  T  C  A  Y  A  P  S  G  N  Y  V  A  C  G  G  L  D  N  I         p.120

          .         .         .         .         .         .       g.91659
 TGCTCCATTTACAATCTGAAAACTCGTGAGGGGAACGTGCGCGTGAGTCGTGAGCTGGCA       c.420
 C  S  I  Y  N  L  K  T  R  E  G  N  V  R  V  S  R  E  L  A         p.140

          . | 08       .         .         .         .         .    g.102826
 GGACACACAG | GTTACCTGTCCTGCTGCCGATTCCTGGATGACAATCAGATCGTCACCAGC    c.480
 G  H  T  G |   Y  L  S  C  C  R  F  L  D  D  N  Q  I  V  T  S      p.160

          .        | 09.         .         .         .         .    g.105534
 TCTGGAGACACCACGTG | TGCCCTGTGGGACATCGAGACCGGCCAGCAGACGACCACGTTT    c.540
 S  G  D  T  T  C  |  A  L  W  D  I  E  T  G  Q  Q  T  T  T  F      p.180

          .         .         .         .         .         .       g.105594
 ACCGGACACACTGGAGATGTCATGAGCCTTTCTCTTGCTCCTGACACCAGACTGTTCGTC       c.600
 T  G  H  T  G  D  V  M  S  L  S  L  A  P  D  T  R  L  F  V         p.200

          .         .         .         .         .         .       g.105654
 TCTGGTGCTTGTGATGCTTCAGCCAAACTCTGGGATGTGCGAGAAGGCATGTGCCGGCAG       c.660
 S  G  A  C  D  A  S  A  K  L  W  D  V  R  E  G  M  C  R  Q         p.220

          .         .         .          | 10        .         .    g.106839
 ACCTTCACTGGCCACGAGTCTGACATCAATGCCATTTGC | TTCTTTCCAAATGGCAATGCA    c.720
 T  F  T  G  H  E  S  D  I  N  A  I  C   | F  F  P  N  G  N  A      p.240

          .         .         .         .         .         .       g.106899
 TTTGCCACTGGCTCAGACGACGCCACCTGCAGGCTGTTTGACCTTCGTGCTGACCAGGAG       c.780
 F  A  T  G  S  D  D  A  T  C  R  L  F  D  L  R  A  D  Q  E         p.260

          .         .         .         .         .         .       g.106959
 CTCATGACTTACTCCCATGACAACATCATCTGCGGGATCACCTCTGTCTCCTTCTCCAAG       c.840
 L  M  T  Y  S  H  D  N  I  I  C  G  I  T  S  V  S  F  S  K         p.280

          .         .         .         .         .         .       g.107019
 AGCGGGCGCCTCCTCCTTGCTGGGTACGACGACTTCAACTGCAACGTCTGGGATGCACTC       c.900
 S  G  R  L  L  L  A  G  Y  D  D  F  N  C  N  V  W  D  A  L         p.300

          .       | 11 .         .         .         .         .    g.108694
 AAAGCCGACCGGGCAG | GTGTCTTGGCTGGGCATGACAACCGCGTCAGCTGCCTGGGCGTG    c.960
 K  A  D  R  A  G |   V  L  A  G  H  D  N  R  V  S  C  L  G  V      p.320

          .         .         .         .         .         .       g.108754
 ACTGACGATGGCATGGCTGTGGCGACAGGGTCCTGGGATAGCTTCCTCAAGATCTGGAAC       c.1020
 T  D  D  G  M  A  V  A  T  G  S  W  D  S  F  L  K  I  W  N         p.340

                                                                g.108757
 TAA |                                                             c.1024
 X                                                               p.340

           | 12        .         .         .         .         .    g.109085
 cgccagtag | catgtggatgccatggagactggaagaccattccaacttggacgcgttacc    c.*60

          .         .         .         .         .         .       g.109145
 atgagagcatatcctatccaaccgtactaacgtggacaccctacacctcccctcagaact       c.*120

          .         .         .         .         .         .       g.109205
 tcaaaagggcaagatcttttttccttcacttattgctgaaaccaagagcacaattcccat       c.*180

          .         .         .         .         .         .       g.109265
 tgagagaaagatctctgtgctgtaaactaaaacaaattgtgcattccttccggggccatc       c.*240

          .         .         .         .         .         .       g.109325
 gtctttgttttcttttttgtcttgaatgaattttaaaaggaaatatataataaaaatgtt       c.*300

          .         .         .         .         .         .       g.109385
 aaccagaaggtaaacttgagtgtaattgtcagacagacacacttttccaccagtgtattt       c.*360

          .         .         .         .         .         .       g.109445
 gaattttagaccagtgaccctgttttgtggcattcatgcaaaacatgctgagggctttgt       c.*420

          .         .         .         .         .         .       g.109505
 tcatctggtcatcgtgtccaaatttcagtcatgtttgtagcaagattttggaagcattca       c.*480

          .         .         .         .         .         .       g.109565
 tatttcctttttaaaatgtattcctttgtgttcaacagttaatcaaaaccagagagtcta       c.*540

          .         .         .         .         .         .       g.109625
 gggcagcctctctgatgttgtcaatgatgtaaattcagtccctggtttttaattttctgt       c.*600

          .         .         .         .         .         .       g.109685
 ctgatgtcacagatcattgttgcacacaaacgtggcatagaaaagaacatgttcagaagc       c.*660

          .         .         .         .         .         .       g.109745
 catggggccaagcacatgcggggacggtctcaaatgcgtgatcagagaatccttcacctt       c.*720

          .         .         .         .         .         .       g.109805
 tgctgaaaagtgagctcagatccagcaccatgttcctcctgacccatcctgtctatcttc       c.*780

          .         .         .         .         .         .       g.109865
 tcagttgagtttttaatctcactttgggtttccttgtgaagttggagggaagtttataat       c.*840

          .         .         .         .         .         .       g.109925
 agcctaacactaccccacccccaactaggaggaacctctgttttcaagagagatgcctgt       c.*900

          .         .         .         .         .         .       g.109985
 cctgtgcttggatagtcagtcaattatttgtgtatgaaacaatgtacaaatcaatgtttt       c.*960

          .         .         .         .         .         .       g.110045
 gaaaataatgatctcagactttctaagttaaattttaaaaattttgattgtttgccatat       c.*1020

          .         .         .         .         .         .       g.110105
 tgggtgggtttactcttagaatcgcatgctgtagaaatgctcaaaagtgcatatgggact       c.*1080

          .         .         .         .         .         .       g.110165
 cagtccttaggtgttctttttcttttaagaaataacctcttacagttgtaaccattgcgg       c.*1140

          .         .         .         .         .         .       g.110225
 ctctgtccacttctcgttgctgctctgtggcacatatcggaagcagtacagcgcgcggct       c.*1200

          .         .         .         .         .         .       g.110285
 ctacacgcttgggtagcgggataagtcactgttttctttatttctttaaaaaaaaaaaag       c.*1260

          .         .         .         .         .         .       g.110345
 ttctgttgcaaacgactgctgttggattctgagggtggggagggagagagagggagggag       c.*1320

          .         .         .         .         .         .       g.110405
 agggagtgaagagcctgccctcctatatggattcttcagggccctccacatctgaggtgg       c.*1380

          .         .         .         .         .         .       g.110465
 ctcattcccatcacacacagattgtcctggtgttcatttcaaggccagtgttcagcagca       c.*1440

          .         .         .         .         .         .       g.110525
 gcgtttggaaagcaggttctgtgggaccccccgccccgccccccgcactccttcatagca       c.*1500

          .         .         .         .         .         .       g.110585
 gcagtagtggcttctccatcctgttttctgcaacattctatacaaaactgtgctgtgacc       c.*1560

          .         .         .         .         .         .       g.110645
 ttgcggtaggcctggatctggcaaagagaatacaaatgaaaccccttctttctctttccg       c.*1620

          .         .         .         .         .         .       g.110705
 tccaacaactctgtagagctctctgcacccttacccctttccaccttttgtatttaattt       c.*1680

          .         .         .         .         .         .       g.110765
 taaagtcagtgtactgcaaggaagctggatgcaagatagatactatattaaactgtactg       c.*1740

          .         .         .                                     g.110802
 ttatttaagatgtaataaagcagtttgacatgaggga                              c.*1777

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Guanine nucleotide binding protein (G protein), beta polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 15
©2004-2016 Leiden University Medical Center