guanine nucleotide binding protein (G protein), beta 5 (GNB5) - coding DNA reference sequence

(used for variant description)

(last modified October 20, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_016194.3 in the GNB5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering GNB5 transcript NM_016194.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        tcacc       c.-61

 .         .         .         .         .  | 02      .             g.11692
 tctcaccatctgctctgtggctcccagtgctgactctggaag | ctttatcttgggtaaaag    c.-1

          .         .         .         .         .         .       g.11752
 ATGTGTGATCAGACCTTTCTCGTTAATGTATTTGGCTCATGTGACAAATGTTTCAAACAA       c.60
 M  C  D  Q  T  F  L  V  N  V  F  G  S  C  D  K  C  F  K  Q         p.20

          .         .         .         .         .         .       g.11812
 CGAGCTCTGAGACCAGTTTTCAAGAAGTCTCAACAACTCAGCTACTGTTCAACATGTGCA       c.120
 R  A  L  R  P  V  F  K  K  S  Q  Q  L  S  Y  C  S  T  C  A         p.40

        | 03 .         .         .         .         .         .    g.16543
 GAAATT | ATGGCAACCGAGGGGCTGCACGAGAACGAGACGCTGGCGTCGCTGAAGAGCGAG    c.180
 E  I   | M  A  T  E  G  L  H  E  N  E  T  L  A  S  L  K  S  E      p.60

          .         .         .         .         .         | 04    g.42294
 GCCGAGAGCCTCAAGGGCAAGCTGGAGGAGGAGCGAGCCAAGCTGCACGATGTGGAGC | TG    c.240
 A  E  S  L  K  G  K  L  E  E  E  R  A  K  L  H  D  V  E  L |       p.80

          .         .         .         .         .         .       g.42354
 CACCAGGTGGCGGAGCGGGTGGAGGCCCTGGGGCAGTTTGTCATGAAGACCAGAAGGACC       c.300
 H  Q  V  A  E  R  V  E  A  L  G  Q  F  V  M  K  T  R  R  T         p.100

          .         .         .         .         .         .       g.42414
 CTCAAAGGCCACGGGAACAAAGTCCTGTGCATGGACTGGTGCAAAGATAAGAGGAGGATC       c.360
 L  K  G  H  G  N  K  V  L  C  M  D  W  C  K  D  K  R  R  I         p.120

          .      | 05  .         .         .         .        | 06. g.48836
 GTGAGCTCGTCACAG | GATGGGAAGGTGATCGTGTGGGATTCCTTCACCACAAACAAG | GAG c.420
 V  S  S  S  Q   | D  G  K  V  I  V  W  D  S  F  T  T  N  K   | E   p.140

          .         .         .         .         .         .       g.48896
 CACGCGGTCACCATGCCCTGCACGTGGGTGATGGCATGTGCTTATGCCCCATCGGGATGT       c.480
 H  A  V  T  M  P  C  T  W  V  M  A  C  A  Y  A  P  S  G  C         p.160

          .     | 07   .         .         .         .         .    g.55142
 GCCATTGCTTGTGG | TGGTTTGGATAATAAGTGTTCTGTGTACCCCTTGACGTTTGACAAA    c.540
 A  I  A  C  G  |  G  L  D  N  K  C  S  V  Y  P  L  T  F  D  K      p.180

          .         .         .         .         .         .       g.55202
 AATGAAAACATGGCTGCCAAAAAGAAGTCTGTTGCTATGCACACCAACTACCTGTCGGCC       c.600
 N  E  N  M  A  A  K  K  K  S  V  A  M  H  T  N  Y  L  S  A         p.200

          .         .        | 08.         .         .         .    g.60645
 TGCAGCTTCACCAACTCTGACATGCAG | ATCCTGACAGCGAGCGGCGATGGCACATGTGCC    c.660
 C  S  F  T  N  S  D  M  Q   | I  L  T  A  S  G  D  G  T  C  A      p.220

          .         .         .         .         .         .       g.60705
 CTGTGGGACGTGGAGAGCGGGCAGCTGCTGCAGAGCTTCCACGGACATGGGGCTGACGTC       c.720
 L  W  D  V  E  S  G  Q  L  L  Q  S  F  H  G  H  G  A  D  V         p.240

          .         .         .         .         .  | 09      .    g.62908
 CTCTGCTTGGACCTGGCCCCCTCAGAAACTGGAAACACCTTCGTGTCTGGG | GGATGTGAC    c.780
 L  C  L  D  L  A  P  S  E  T  G  N  T  F  V  S  G   | G  C  D      p.260

          .         .         .         .         .         .       g.62968
 AAGAAAGCCATGGTGTGGGACATGCGCTCCGGCCAGTGCGTGCAGGCCTTTGAAACACAT       c.840
 K  K  A  M  V  W  D  M  R  S  G  Q  C  V  Q  A  F  E  T  H         p.280

          .         .    | 10    .         .         .         .    g.68161
 GAATCTGACATCAACAGTGTCCG | GTACTACCCCAGTGGAGATGCCTTTGCTTCAGGGTCA    c.900
 E  S  D  I  N  S  V  R  |  Y  Y  P  S  G  D  A  F  A  S  G  S      p.300

          .   | 11     .         .         .         .         .    g.70372
 GATGACGCTACG | TGTCGCCTCTATGACCTGCGGGCAGATAGGGAGGTTGCCATCTATTCC    c.960
 D  D  A  T   | C  R  L  Y  D  L  R  A  D  R  E  V  A  I  Y  S      p.320

          .         .         .         .          | 12        .    g.71740
 AAAGAAAGCATCATATTTGGAGCATCCAGCGTGGACTTCTCCCTCAGTG | GTCGCCTGCTG    c.1020
 K  E  S  I  I  F  G  A  S  S  V  D  F  S  L  S  G |   R  L  L      p.340

          .         .         .         .         .         .       g.71800
 TTTGCTGGATACAATGATTACACTATCAACGTCTGGGATGTTCTCAAAGGGTCCCGGGTC       c.1080
 F  A  G  Y  N  D  Y  T  I  N  V  W  D  V  L  K  G  S  R  V         p.360

          .         .         .         .         .         .       g.71860
 TCCATCCTGTTTGGACATGAAAACCGCGTTAGCACTCTACGAGTTTCCCCCGATGGGACT       c.1140
 S  I  L  F  G  H  E  N  R  V  S  T  L  R  V  S  P  D  G  T         p.380

          .         .         .       | 13 .                        g.73624
 GCTTTCTGCTCTGGATCATGGGATCATACCCTCAGA | GTCTGGGCCTAA                c.1188
 A  F  C  S  G  S  W  D  H  T  L  R   | V  W  A  X                  p.395

          .         .         .         .         .         .       g.73684
 tcatcttctgacagtgcactcatgtatacctgagaatttgaaatcttcacatgtaaatag       c.*60

          .         .         .         .         .         .       g.73744
 atattacttctagaggagcttagagtttattgcagtgtagcttaggggagcaacccatgg       c.*120

          .         .         .         .         .         .       g.73804
 ctcacaggtcactaagcgtctccaatatgactattaaaactgtcacctctggaaatacac       c.*180

          .         .         .         .         .         .       g.73864
 tagtgtgagccttcagcactgcgagaataccttcaagtacagtatttttcttttggaaca       c.*240

          .         .         .         .         .         .       g.73924
 ctttttaaaatgtatctgtttttaaggttattctaaattatagtagcctcaactcattct       c.*300

          .         .         .         .         .         .       g.73984
 gtcaccagtagaattcagcagttaatatattccatattatttctttgaatcaattcattt       c.*360

          .         .         .         .         .         .       g.74044
 tcagagcactttaaagtctgatatttctcgatgtgcactgtgatgcctggaaccttcctc       c.*420

          .         .         .         .         .         .       g.74104
 tggaagtgctgattttatggactgaggactggtgactggtctgtgatagaagcaaattcc       c.*480

          .         .         .         .         .         .       g.74164
 aattccaaatgtaattagacaaaaatcatttttttagaatgtgtttttattgtaaaagta       c.*540

          .         .         .         .         .         .       g.74224
 tctttttcagcttcctgttctattgtcttttttcagatacaacatttttgtctatggtga       c.*600

          .         .         .         .         .         .       g.74284
 actgctgtaaatgacgcagagaaatgcctaaaaaggacaggtggtttgactcatggatga       c.*660

          .         .         .         .         .         .       g.74344
 tgatgatgtcactgtgccacttggacagggcgttttctctgaattgaagggaaagccaat       c.*720

          .         .         .         .         .         .       g.74404
 ggtgtttgtaaacaaatgcttctgagagcaaagaaaagtcttctgtgtgggaacacaaga       c.*780

          .         .         .         .         .         .       g.74464
 tagtaaacttatttaaaaacctattagtagaattagtggaaacacttaggttaaagtgaa       c.*840

          .         .         .         .         .         .       g.74524
 tcttgtccatataaattatattcatggccgggcgcggtggctcacgcttgtaatcccagc       c.*900

          .         .         .         .         .         .       g.74584
 actttgggaggccgaggcgggcggatcacgaggtcaggagttcgagaccacggtgaaacc       c.*960

          .         .         .         .         .         .       g.74644
 ctgtctctactaaaaaatacaaaaaattagccgggcgtggtggcgggcgcctgtagtccc       c.*1020

          .         .         .         .         .         .       g.74704
 agctactcggagaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagt       c.*1080

          .         .         .         .         .         .       g.74764
 gagccgaggtcgagccactgcagcctgggtgacaaagcgagactccgtctcaaaaaaaaa       c.*1140

          .         .         .         .         .         .       g.74824
 aaaaaattatattcatatgtattgcattgcaattataattacatatgcagattgattgat       c.*1200

          .         .         .         .         .         .       g.74884
 agtcatgaataataacgtctgctcctcttacatagaaaaacgatattaaaagaagatctt       c.*1260

          .         .         .         .         .         .       g.74944
 ctctttatttgagactcagaattccttctagaagaaggaagtgctttttgttataggatc       c.*1320

          .         .         .         .         .         .       g.75004
 ccttcttttcctttttttgtttttttgtaagatgtagatgcttattctttgctttagaaa       c.*1380

          .         .         .         .         .         .       g.75064
 acttctcacttaaaaagatggcatgcacctaggggaataaaaggtcacctcagacaccag       c.*1440

          .         .         .         .         .         .       g.75124
 gtgtcattcctggtgaggcctgcctcgtcggtggcctggggtctgccggcaggttctggc       c.*1500

          .         .         .         .         .         .       g.75184
 tgcacctgaaggctgcgtgcaccttgtcccctggacaggtctcctttcctggccctgctc       c.*1560

          .         .         .         .         .         .       g.75244
 cagcccagcccttcttctagtggtagctctggctttgcaggcccagctccaggccctgct       c.*1620

          .         .         .         .         .         .       g.75304
 cctcagagagactcttccagagctggagctgggcacagccataagacaggactggaccag       c.*1680

          .         .         .         .         .         .       g.75364
 atgctcctgtaaacatccaggggtgtgccaggcccaccctcacaactgcttgttcaggta       c.*1740

          .         .         .         .         .         .       g.75424
 tcgtgatgggccactcggtccaaaatcagccaggccatcttttccatcatctcacttcaa       c.*1800

          .         .         .                                     g.75455
 ataaacataataattatatttgatcatttgc                                    c.*1831

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Guanine nucleotide binding protein (G protein), beta 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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