gonadotropin-releasing hormone receptor (GNRHR) - coding DNA reference sequence

(used for variant description)

(last modified April 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000406.2 in the GNRHR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009293.1, covering GNRHR transcript NM_000406.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  ttggttgctgg       c.-1741

 .         .         .         .         .         .                g.5071
 tccacttacaaacacttttcatatttgtatgtctttccaatggttatcctgttttgttca       c.-1681

 .         .         .         .         .         .                g.5131
 tttcaggcatatggccctgatcagattaactgacatgatgtatatgcaaagccttttgag       c.-1621

 .         .         .         .         .         .                g.5191
 ttcttcagaaaaataaattatcttattcaagactgattgcttataaggaacttattatag       c.-1561

 .         .         .         .         .         .                g.5251
 ctaatatagtaggcacaattttttttttgtaattctcctagatgagtcagaacttagttt       c.-1501

 .         .         .         .         .         .                g.5311
 tgacgtaggtaaaaattttatggtcacaaatctcaggtgtgagaaaatctctttccttga       c.-1441

 .         .         .         .         .         .                g.5371
 tactctatataaatagaggatataaatatttcaagtctggaagtagtgagagaagctggt       c.-1381

 .         .         .         .         .         .                g.5431
 aattctggacatatagtgacagtcaaaaaggagctcaggtacaggactggtctaagctgc       c.-1321

 .         .         .         .         .         .                g.5491
 tcaagattcaggagacagccagtacacagagaagctgaggagatacataagatatatcta       c.-1261

 .         .         .         .         .         .                g.5551
 aaacatttatctaaccttctgtggtaacaagctccttaaaggggctggatgatgttgtgt       c.-1201

 .         .         .         .         .         .                g.5611
 tcactttttatcaccagcaaaggctaagataatgtatatagtaaatatttagtaactatt       c.-1141

 .         .         .         .         .         .                g.5671
 tattaaataaataaatatttaagacagaataaacaagtataataaatgaaccaataagaa       c.-1081

 .         .         .         .         .         .                g.5731
 tgcaccatctaagtcaaaatagccacttttatccttaacattgtacctgctttggctgct       c.-1021

 .         .         .         .         .         .                g.5791
 gcagaagcaaacttgttggcattagacaaatcaagctggtgatttaataaattccaatgt       c.-961

 .         .         .         .         .         .                g.5851
 aagtcttaccagtattgatgaataactatccagcactcaccatgaaagttaaagaaacaa       c.-901

 .         .         .         .         .         .                g.5911
 cacagaaaaagttcctaagtggtcccaatttgaaatgatcagataacctataaaagaaca       c.-841

 .         .         .         .         .         .                g.5971
 tattcatattatactaacataaacacatataaatgcacttacagcagttacacagtattc       c.-781

 .         .         .         .         .         .                g.6031
 tcttcaataactagtttccttatgcattaatgtgtaataacagcaactacaatatttaga       c.-721

 .         .         .         .         .         .                g.6091
 taattataaaaaccaaggcaataatttaaaaactgattaaccgttttactctaacttaag       c.-661

 .         .         .         .         .         .                g.6151
 catggattggatcagtaagattgattaataaatttgaatgcagtcagttggattgattct       c.-601

 .         .         .         .         .         .                g.6211
 aatttaaagttttaatttgttgtagaataattttaagtgaatatatttgtccagtgttcg       c.-541

 .         .         .         .         .         .                g.6271
 agtgctcaacagtgtgtttgaaaaggaaaacaaagaaatgtttttgagaaatgtgttaat       c.-481

 .         .         .         .         .         .                g.6331
 tccttaagacaatggattttaattggatctagttgttttcatttttcttcattatcatta       c.-421

 .         .         .         .         .         .                g.6391
 tacatctgtatgttggacagaacactaacactaaatagtttttagaaaaattttttaaag       c.-361

 .         .         .         .         .         .                g.6451
 ttatttaaatcataatatcatgactgacttttaaattcaaaattaggctgtgactatcct       c.-301

 .         .         .         .         .         .                g.6511
 tcttcacttaggaagagtgttgtgaaagccagaccatctgctgaggtgctacagttacat       c.-241

 .         .         .         .         .         .                g.6571
 gtggccctcagaatgcatttggcctgctctgttttagcactctgttggattaccaataca       c.-181

 .         .         .         .         .         .                g.6631
 caaaacaagttaaccttgatctttcacattaagtatctcagggacaaaatttgacatacg       c.-121

 .         .         .         .         .         .                g.6691
 tctaaacctgtgacgtttccatctaaagaaggcagaaataaaacaggactttagattcgg       c.-61

 .         .         .         .         .         .                g.6751
 ttacaataaaatatcagatgcaccagagacacaaggcttgaagctctgtcctgggaaaat       c.-1

          .         .         .         .         .         .       g.6811
 ATGGCAAACAGTGCCTCTCCTGAACAGAATCAAAATCACTGTTCAGCCATCAACAACAGC       c.60
 M  A  N  S  A  S  P  E  Q  N  Q  N  H  C  S  A  I  N  N  S         p.20

          .         .         .         .         .         .       g.6871
 ATCCCACTGATGCAGGGCAACCTCCCCACTCTGACCTTGTCTGGAAAGATCCGAGTGACG       c.120
 I  P  L  M  Q  G  N  L  P  T  L  T  L  S  G  K  I  R  V  T         p.40

          .         .         .         .         .         .       g.6931
 GTTACTTTCTTCCTTTTTCTGCTCTCTGCGACCTTTAATGCTTCTTTCTTGTTGAAACTT       c.180
 V  T  F  F  L  F  L  L  S  A  T  F  N  A  S  F  L  L  K  L         p.60

          .         .         .         .         .         .       g.6991
 CAGAAGTGGACACAGAAGAAAGAGAAAGGGAAAAAGCTCTCAAGAATGAAGCTGCTCTTA       c.240
 Q  K  W  T  Q  K  K  E  K  G  K  K  L  S  R  M  K  L  L  L         p.80

          .         .         .         .         .         .       g.7051
 AAACATCTGACCTTAGCCAACCTGTTGGAGACTCTGATTGTCATGCCACTGGATGGGATG       c.300
 K  H  L  T  L  A  N  L  L  E  T  L  I  V  M  P  L  D  G  M         p.100

          .         .         .         .         .         .       g.7111
 TGGAACATTACAGTCCAATGGTATGCTGGAGAGTTACTCTGCAAAGTTCTCAGTTATCTA       c.360
 W  N  I  T  V  Q  W  Y  A  G  E  L  L  C  K  V  L  S  Y  L         p.120

          .         .         .         .         .         .       g.7171
 AAGCTTTTCTCCATGTATGCCCCAGCCTTCATGATGGTGGTGATCAGCCTGGACCGCTCC       c.420
 K  L  F  S  M  Y  A  P  A  F  M  M  V  V  I  S  L  D  R  S         p.140

          .         .         .         .         .         .       g.7231
 CTGGCTATCACGAGGCCCCTAGCTTTGAAAAGCAACAGCAAAGTCGGACAGTCCATGGTT       c.480
 L  A  I  T  R  P  L  A  L  K  S  N  S  K  V  G  Q  S  M  V         p.160

          .         .         .         .   | 02     .         .    g.16317
 GGCCTGGCCTGGATCCTCAGTAGTGTCTTTGCAGGACCACAG | TTATACATCTTCAGGATG    c.540
 G  L  A  W  I  L  S  S  V  F  A  G  P  Q   | L  Y  I  F  R  M      p.180

          .         .         .         .         .         .       g.16377
 ATTCATCTAGCAGACAGCTCTGGACAGACAAAAGTTTTCTCTCAATGTGTAACACACTGC       c.600
 I  H  L  A  D  S  S  G  Q  T  K  V  F  S  Q  C  V  T  H  C         p.200

          .         .         .         .         .         .       g.16437
 AGTTTTTCACAATGGTGGCATCAAGCATTTTATAACTTTTTCACCTTCAGCTGCCTCTTC       c.660
 S  F  S  Q  W  W  H  Q  A  F  Y  N  F  F  T  F  S  C  L  F         p.220

          .         .         .         .         .         .       g.16497
 ATCATCCCTCTTTTCATCATGCTGATCTGCAATGCAAAAATCATCTTCACCCTGACACGG       c.720
 I  I  P  L  F  I  M  L  I  C  N  A  K  I  I  F  T  L  T  R         p.240

          .         .   | 03     .         .         .         .    g.20400
 GTCCTTCATCAGGACCCCCACG | AACTACAACTGAATCAGTCCAAGAACAATATACCAAGA    c.780
 V  L  H  Q  D  P  H  E |   L  Q  L  N  Q  S  K  N  N  I  P  R      p.260

          .         .         .         .         .         .       g.20460
 GCACGGCTGAAGACTCTAAAAATGACGGTTGCATTTGCCACTTCATTTACTGTCTGCTGG       c.840
 A  R  L  K  T  L  K  M  T  V  A  F  A  T  S  F  T  V  C  W         p.280

          .         .         .         .         .         .       g.20520
 ACTCCCTACTATGTCCTAGGAATTTGGTATTGGTTTGATCCTGAAATGTTAAACAGGTTG       c.900
 T  P  Y  Y  V  L  G  I  W  Y  W  F  D  P  E  M  L  N  R  L         p.300

          .         .         .         .         .         .       g.20580
 TCAGACCCAGTAAATCACTTCTTCTTTCTCTTTGCCTTTTTAAACCCATGCTTTGATCCA       c.960
 S  D  P  V  N  H  F  F  F  L  F  A  F  L  N  P  C  F  D  P         p.320

          .         .                                               g.20607
 CTTATCTATGGATATTTTTCTCTGTGA                                        c.987
 L  I  Y  G  Y  F  S  L  X                                          p.328

          .         .         .         .         .         .       g.20667
 ttgatagactacacaagaagtcatatgaagaagggtaaggtaatgaatctctccatctgg       c.*60

          .         .         .         .         .         .       g.20727
 gaatgattaacacaaatgttggagcatgtttacatacaaacaaagtaggatttacactta       c.*120

          .         .         .         .         .         .       g.20787
 agttatcattcttttagaaactcagtcttcagagcctcaattattaaggaaaagtcttca       c.*180

          .         .         .         .         .         .       g.20847
 ggaaaaatactaaaatattttctcttcctcataagcttctaaattaatctctgccttttc       c.*240

          .         .         .         .         .         .       g.20907
 tgacctcatataacacattatgtaggtttcttatcactttctctttgcataataatgtac       c.*300

          .         .         .         .         .         .       g.20967
 taatatttaaaataccttcagcctaaggcacaaggatgccaaaaaaacaaaggtgagaaa       c.*360

          .         .         .         .         .         .       g.21027
 ccacaacacaggtctaaactcagcatgctttggtgagtttttctccaaaaggggcatatt       c.*420

          .         .         .         .         .         .       g.21087
 agcaattagagttgtatgctatataatacatagagcacagagccctttgcccataatatc       c.*480

          .         .         .         .         .         .       g.21147
 aactttccctcctatagttaaaaagaaaaaaaatgaatctatttttctctttggcttcaa       c.*540

          .         .         .         .         .         .       g.21207
 aagcattctgacatttggaggagtcagtaaccaatcccaccaaccactccagcaacctga       c.*600

          .         .         .         .         .         .       g.21267
 caagactatgagtagttctccttcatcctatttatgtggtacaggttgtgaagtatctct       c.*660

          .         .         .         .         .         .       g.21327
 atataaagggaaattttagaggggttaggatttggacaggggtttagaacattcctctaa       c.*720

          .         .         .         .         .         .       g.21387
 gctatctagtctgtggagtttgtggcaattaattgccataaaataacaatgtttccaaat       c.*780

          .         .         .         .         .         .       g.21447
 gcaactaagaaaatactcatagtgagtacgctctatgcatagtatgacttctattttaat       c.*840

          .         .         .         .         .         .       g.21507
 gtgaagaattttttgtctctctcctgatcttactaaatccatatttcataaataactgag       c.*900

          .         .         .         .         .         .       g.21567
 aataattaaaacaaaattaagcaaatgcacaagcaaaaagatgcttgatacacaaaagga       c.*960

          .         .         .         .         .         .       g.21627
 actctggagagaaaactacagcttcagtctgtacagatcaaagaagacagaacatgtcag       c.*1020

          .         .         .         .         .         .       g.21687
 gggaaggagggaaagatcttgatgcagggtttcttaacctgcagtctatgcacaacacta       c.*1080

          .         .         .         .         .         .       g.21747
 tatttccatgtaatgtttttatttcagccctatttgtattattttgtgcatttaaaaaac       c.*1140

          .         .         .         .         .         .       g.21807
 acaatcttaaggggatagactagactgccacagcagcccatggcacaactaacacctact       c.*1200

          .         .         .         .         .         .       g.21867
 gatattcacattaaatagtatggtttccaaaatatgtctgcacaacaagacctctttatg       c.*1260

          .         .         .         .         .         .       g.21927
 taattcaggcttgtgtctacctcttccatgaaaaatggaaagggatgaaaataatgggag       c.*1320

          .         .         .         .         .         .       g.21987
 tataatacccatttaatgtgaaaaacataagagtcttaaaagaaattaagccatttaaca       c.*1380

          .         .         .         .         .         .       g.22047
 ttttttaaataggtaagataccattatatttatatgagctatgtactgccacaaaaaaag       c.*1440

          .         .         .         .         .         .       g.22107
 atgaaatgtaatttctaaatactccaggtgtgtggtattatggaaagcaaattgccaact       c.*1500

          .         .         .         .         .         .       g.22167
 aatggcacgtcctttctttctttgattttctcctctcatacttcagttttatagtgttgt       c.*1560

          .         .         .         .         .         .       g.22227
 gttgttgtttttttcatatcctaccttactttccaattctgtctcaattgaactccctct       c.*1620

          .         .         .         .         .         .       g.22287
 gtctactcactctttcattcatagcttcttttccattaaactcatacctttaattaacca       c.*1680

          .         .         .         .         .         .       g.22347
 attcatggcccagttctacagttgaattggacaaggctaaaattctgtagtgtgctaaaa       c.*1740

          .         .         .         .         .         .       g.22407
 tgctcaagttggcacataaacccattccaagattttatagttcttgtagataacacaggg       c.*1800

          .         .         .         .         .         .       g.22467
 atgtagataagttgaaacaaaaccagtgtcctctaagtctctatcatatacttattccta       c.*1860

          .         .         .         .         .         .       g.22527
 aactgataattcttacttctggatttaaaatcaaaaataacacacttgtacagatacaat       c.*1920

          .         .         .         .         .         .       g.22587
 ctaagggctttatcacacacgtgttaacgaatgtatctcagcttggttcttcttgtgtgc       c.*1980

          .         .         .         .         .         .       g.22647
 tcattatggatctctctgtcttaggaattgcctcaggcattttttttttttacacattaa       c.*2040

          .         .         .         .         .         .       g.22707
 ctaaagggctattcgaaatcttgactcaggggttcttaacctacatttcatgcaaaaaat       c.*2100

          .         .         .         .         .         .       g.22767
 atatatatttcaatgtattttttattttagtcctatttgtattattttatgcatttaaaa       c.*2160

          .         .         .         .         .         .       g.22827
 acacagtcctgagagggatggaccagactgccacagcagctcatagcacaaaaaaaggtt       c.*2220

          .         .         .         .         .         .       g.22887
 aagaagtcctagttgactttgtatatatataaagaaatctattacaataaaaatataaca       c.*2280

          .         .         .         .         .         .       g.22947
 taatctattcatctatttatatgcaaacataaaaatgtaaatattgaaacaagattgctt       c.*2340

          .         .         .         .         .         .       g.23007
 caatatgcttattgttttcaaaccaacaaactctcttaaggttcaatatgtaataaaaaa       c.*2400

          .         .         .         .         .         .       g.23067
 cataacacaaataattattctatatgaatattatggttcataaattataatgtataatct       c.*2460

          .         .         .         .         .         .       g.23127
 atacattataatgtaatatataaactaaaatttatggcacaaaagataaatatggctttg       c.*2520

          .         .         .         .         .         .       g.23187
 aaattaaagatattccactcaacagacaatatttcatatttgatattacaatcatttatt       c.*2580

          .         .         .         .         .         .       g.23247
 ttatgtcctattataataaaaggtgaggactccttgtaaaaaaggaaatgttccacagag       c.*2640

          .         .         .         .         .         .       g.23307
 tcaatctaatatatcagatattggagattctatcttggtttctcttcctttacttagcct       c.*2700

          .         .         .         .         .         .       g.23367
 ataaaactagttaaaaatggaatttcttttagcaattcagtttagtacaggagtgacatt       c.*2760

          .         .         .         .         .         .       g.23427
 aactaatgacaataaattaaacaaagcctacattagttcaatttaagcctattcaacaga       c.*2820

          .         .         .         .         .         .       g.23487
 aatatagaaatatagtagctaaaaaaatactctggggaaggtaccacaaacattatctac       c.*2880

          .         .         .         .         .         .       g.23547
 cagggaacatagcataaattagtctgaaatttcctgagagtgactttgtcttagaactta       c.*2940

          .         .         .         .         .         .       g.23607
 ggtggtagtcatgaagagataatgtttttaggcagttaaaatacttctagaactccatct       c.*3000

          .         .         .         .         .         .       g.23667
 attttacctgtggtccactttcctacattgaaccaatgccttgggcttctctaattacta       c.*3060

          .         .         .         .                           g.23712
 tacattgtgctcatatgaataaaagaaattttaaaagaaaaaaaa                      c.*3105

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gonadotropin-releasing hormone receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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