glypican 4 (GPC4) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001448.2 in the GPC4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012498.1, covering GPC4 transcript NM_001448.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                             gcctggcaccggggaccgttgcctgacgcgag       c.-181

 .         .         .         .         .         .                g.5092
 gcccagctctacttttcgccccgcgtctcctccgcctgctcgcctcttccaccaactcca       c.-121

 .         .         .         .         .         .                g.5152
 actccttctccctccagctccactcgctagtccccgactccgccagccctcggcccgctg       c.-61

 .         .         .         .         .         .                g.5212
 ccgtagcgccgcttcccgtccggtcccaaaggtgggaacgcgtccgccccggcccgcacc       c.-1

          .         .         .         .         .         .       g.5272
 ATGGCACGGTTCGGCTTGCCCGCGCTTCTCTGCACCCTGGCAGTGCTCAGCGCCGCGCTG       c.60
 M  A  R  F  G  L  P  A  L  L  C  T  L  A  V  L  S  A  A  L         p.20

          .         .         .         .         .         .       g.5332
 CTGGCTGCCGAGCTCAAGTCGAAAAGTTGCTCGGAAGTGCGACGTCTTTACGTGTCCAAA       c.120
 L  A  A  E  L  K  S  K  S  C  S  E  V  R  R  L  Y  V  S  K         p.40

          .         .         .         . | 02       .         .    g.80856
 GGCTTCAACAAGAACGATGCCCCCCTCCACGAGATCAACG | GTGATCATTTGAAGATCTGT    c.180
 G  F  N  K  N  D  A  P  L  H  E  I  N  G |   D  H  L  K  I  C      p.60

          .         .         .         .         .         .       g.80916
 CCCCAGGGTTCTACCTGCTGCTCTCAAGAGATGGAGGAGAAGTACAGCCTGCAAAGTAAA       c.240
 P  Q  G  S  T  C  C  S  Q  E  M  E  E  K  Y  S  L  Q  S  K         p.80

          .         .         .         .         .         .       g.80976
 GATGATTTCAAAAGTGTGGTCAGCGAACAGTGCAATCATTTGCAAGCTGTCTTTGCTTCA       c.300
 D  D  F  K  S  V  V  S  E  Q  C  N  H  L  Q  A  V  F  A  S         p.100

          .          | 03        .         .         .         .    g.95682
 CGTTACAAGAAGTTTGATG | AATTCTTCAAAGAACTACTTGAAAATGCAGAGAAATCCCTG    c.360
 R  Y  K  K  F  D  E |   F  F  K  E  L  L  E  N  A  E  K  S  L      p.120

          .         .         .         .         .         .       g.95742
 AATGATATGTTTGTGAAGACATATGGCCATTTATACATGCAAAATTCTGAGCTATTTAAA       c.420
 N  D  M  F  V  K  T  Y  G  H  L  Y  M  Q  N  S  E  L  F  K         p.140

          .         .         .         .         .         .       g.95802
 GATCTCTTCGTAGAGTTGAAACGTTACTACGTGGTGGGAAATGTGAACCTGGAAGAAATG       c.480
 D  L  F  V  E  L  K  R  Y  Y  V  V  G  N  V  N  L  E  E  M         p.160

          .         .         .         .         .         .       g.95862
 CTAAATGACTTCTGGGCTCGCCTCCTGGAGCGGATGTTCCGCCTGGTGAACTCCCAGTAC       c.540
 L  N  D  F  W  A  R  L  L  E  R  M  F  R  L  V  N  S  Q  Y         p.180

          .         .         .         .         .         .       g.95922
 CACTTTACAGATGAGTATCTGGAATGTGTGAGCAAGTATACGGAGCAGCTGAAGCCCTTC       c.600
 H  F  T  D  E  Y  L  E  C  V  S  K  Y  T  E  Q  L  K  P  F         p.200

          .         .         .         .         .         .       g.95982
 GGAGATGTCCCTCGCAAATTGAAGCTCCAGGTTACTCGTGCTTTTGTAGCAGCCCGTACT       c.660
 G  D  V  P  R  K  L  K  L  Q  V  T  R  A  F  V  A  A  R  T         p.220

          .         .         .         .         .  | 04      .    g.108763
 TTCGCTCAAGGCTTAGCGGTTGCGGGAGATGTCGTGAGCAAGGTCTCCGTG | GTAAACCCC    c.720
 F  A  Q  G  L  A  V  A  G  D  V  V  S  K  V  S  V   | V  N  P      p.240

          .         .         .         .         .         .       g.108823
 ACAGCCCAGTGTACCCATGCCCTGTTGAAGATGATCTACTGCTCCCACTGCCGGGGTCTC       c.780
 T  A  Q  C  T  H  A  L  L  K  M  I  Y  C  S  H  C  R  G  L         p.260

          .         .         .         .         .         .       g.108883
 GTGACTGTGAAGCCATGTTACAACTACTGCTCAAACATCATGAGAGGCTGTTTGGCCAAC       c.840
 V  T  V  K  P  C  Y  N  Y  C  S  N  I  M  R  G  C  L  A  N         p.280

          .         .         .        | 05.         .         .    g.114046
 CAAGGGGATCTCGATTTTGAATGGAACAATTTCATAG | ATGCTATGCTGATGGTGGCAGAG    c.900
 Q  G  D  L  D  F  E  W  N  N  F  I  D |   A  M  L  M  V  A  E      p.300

          .         .         .         .         .         .       g.114106
 AGGCTAGAGGGTCCTTTCAACATTGAATCGGTCATGGATCCCATCGATGTGAAGATTTCT       c.960
 R  L  E  G  P  F  N  I  E  S  V  M  D  P  I  D  V  K  I  S         p.320

          .         .         .         .         | 06         .    g.114271
 GATGCTATTATGAACATGCAGGATAATAGTGTTCAAGTGTCTCAGAAG | GTTTTCCAGGGA    c.1020
 D  A  I  M  N  M  Q  D  N  S  V  Q  V  S  Q  K   | V  F  Q  G      p.340

          .         .         .         .         .         .       g.114331
 TGTGGACCCCCCAAGCCCCTCCCAGCTGGACGAATTTCTCGTTCCATCTCTGAAAGTGCC       c.1080
 C  G  P  P  K  P  L  P  A  G  R  I  S  R  S  I  S  E  S  A         p.360

          .         .         .         .         .         .       g.114391
 TTCAGTGCTCGCTTCAGACCACATCACCCCGAGGAACGCCCAACCACAGCAGCTGGCACT       c.1140
 F  S  A  R  F  R  P  H  H  P  E  E  R  P  T  T  A  A  G  T         p.380

          .      | 07  .         .         .         .         .    g.115361
 AGTTTGGACCGACTG | GTTACTGATGTCAAGGAGAAACTGAAACAGGCCAAGAAATTCTGG    c.1200
 S  L  D  R  L   | V  T  D  V  K  E  K  L  K  Q  A  K  K  F  W      p.400

          .         .         .         .         .         .       g.115421
 TCCTCCCTTCCGAGCAACGTTTGCAACGATGAGAGGATGGCTGCAGGAAACGGCAATGAG       c.1260
 S  S  L  P  S  N  V  C  N  D  E  R  M  A  A  G  N  G  N  E         p.420

          .         .         .   | 08     .         .         .    g.116864
 GATGACTGTTGGAATGGGAAAGGCAAAAGCAG | GTACCTGTTTGCAGTGACAGGAAATGGA    c.1320
 D  D  C  W  N  G  K  G  K  S  R  |  Y  L  F  A  V  T  G  N  G      p.440

          .         .         .         .         .         .       g.116924
 TTAGCCAACCAGGGCAACAACCCAGAGGTCCAGGTTGACACCAGCAAACCAGACATACTG       c.1380
 L  A  N  Q  G  N  N  P  E  V  Q  V  D  T  S  K  P  D  I  L         p.460

          .         .         .         .         .         .       g.116984
 ATCCTTCGTCAAATCATGGCTCTTCGAGTGATGACCAGCAAGATGAAGAATGCATACAAT       c.1440
 I  L  R  Q  I  M  A  L  R  V  M  T  S  K  M  K  N  A  Y  N         p.480

          .         .         | 09         .         .         .    g.117140
 GGGAACGACGTGGACTTCTTTGATATCA | GTGATGAAAGTAGTGGAGAAGGAAGTGGAAGT    c.1500
 G  N  D  V  D  F  F  D  I  S |   D  E  S  S  G  E  G  S  G  S      p.500

          .         .         .         .         .         .       g.117200
 GGCTGTGAGTATCAGCAGTGCCCTTCAGAGTTTGACTACAATGCCACTGACCATGCTGGG       c.1560
 G  C  E  Y  Q  Q  C  P  S  E  F  D  Y  N  A  T  D  H  A  G         p.520

          .         .         .         .         .         .       g.117260
 AAGAGTGCCAATGAGAAAGCCGACAGTGCTGGTGTCCGTCCTGGGGCACAGGCCTACCTC       c.1620
 K  S  A  N  E  K  A  D  S  A  G  V  R  P  G  A  Q  A  Y  L         p.540

          .         .         .         .         .                 g.117311
 CTCACTGTCTTCTGCATCTTGTTCCTGGTTATGCAGAGAGAGTGGAGATAA                c.1671
 L  T  V  F  C  I  L  F  L  V  M  Q  R  E  W  R  X                  p.556

          .         .         .         .         .         .       g.117371
 ttctcaaactctgagaaaaagtgttcatcaaaaagttaaaaggcaccagttatcactttt       c.*60

          .         .         .         .         .         .       g.117431
 ctaccatcctagtgactttgctttttaaatgaatggacaacaatgtacagtttttactat       c.*120

          .         .         .         .         .         .       g.117491
 gtggccactggtttaagaagtgctgactttgttttctcattcagttttgggaggaaaagg       c.*180

          .         .         .         .         .         .       g.117551
 gactgtgcattgagttggttcctgctcccccaaaccatgttaaacgtggctaacagtgta       c.*240

          .         .         .         .         .         .       g.117611
 ggtacagaactatagttagttgtgcatttgtgattttatcactctattatttgtttgtat       c.*300

          .         .         .         .         .         .       g.117671
 gtttttttctcatttcgtttgtgggtttttttttccaactgtgatctcgccttgtttctt       c.*360

          .         .         .         .         .         .       g.117731
 acaagcaaaccagggtcccttcttggcacgtaacatgtacgtatttctgaaatattaaat       c.*420

          .         .         .         .         .         .       g.117791
 agctgtacagaagcaggttttatttatcatgttatcttattaaaagaaaaagcccaaaaa       c.*480

          .         .         .         .         .         .       g.117851
 gcagtaaaatttccatttctccctgttattttagttgccttatctggagagacgtggagg       c.*540

          .         .         .         .         .         .       g.117911
 tgattttcttttttttaaattattattaagacagaatgtgagggcacaagcaggcttctg       c.*600

          .         .         .         .         .         .       g.117971
 agccacttgtcagattgtattcaaagcatcaatccaagaaggaggttatgtgtacttcat       c.*660

          .         .         .         .         .         .       g.118031
 ttattggtgatagttggaagagactgcagactactgctttgaatgagttgaattacataa       c.*720

          .         .         .         .         .         .       g.118091
 gctaagatcactataggtccatttcttgaacccacttatacataaaatgtaacccattta       c.*780

          .         .         .         .         .         .       g.118151
 gaaaaagattctggatatcatcccccttgaaagatagaaagcattcaggatgtcccagtt       c.*840

          .         .         .         .         .         .       g.118211
 atcacatgttcacacttgggtttaggggtgtttttttttaaaaccaggcaggttagctag       c.*900

          .         .         .         .         .         .       g.118271
 cccaccctgtgctagttttcatgttcacactgaccctatttgaattaatatcctttgtta       c.*960

          .         .         .         .         .         .       g.118331
 gagtggtcgagatttcaaacccaattatgtacagggagctgtctgagagctagccagaac       c.*1020

          .         .         .         .         .         .       g.118391
 tggggtacagcctgggctcagggaatagctgtcaacactcgggcaaagtttttgtctgtg       c.*1080

          .         .         .         .         .         .       g.118451
 catgtgtatctccatttgttttgggatcccagtttttgttttaagagagtataaggtgtc       c.*1140

          .         .         .         .         .         .       g.118511
 tcatttgagtctttttcttacctagccccctcttatcagtaaaacaaaggacttgccatg       c.*1200

          .         .         .         .         .         .       g.118571
 gttcacagcaatgtgctacgatccaagatatcagccaaggagcccacttaggggagaact       c.*1260

          .         .         .         .         .         .       g.118631
 aggtgtccagatttttgtatgtgttgtttttcttgggggatggggtggggtgggagtagg       c.*1320

          .         .         .         .         .         .       g.118691
 tagagctgagaatactacatcttagtggtgacctttagccacgtgggtgaagtggcaaag       c.*1380

          .         .         .         .         .         .       g.118751
 gccatggccatatctgttgtcccaggccaaagactaacaactgccttgggaatcccttcc       c.*1440

          .         .         .         .         .         .       g.118811
 ttgtgtccttaccaaatgatagctcataaaactctgataatgtaacaaatcactttcaaa       c.*1500

          .         .         .         .         .         .       g.118871
 ggagttcccagaagtcttcagaaagactaaaattctgtctcttcctgctttagacagcca       c.*1560

          .         .         .         .         .         .       g.118931
 ttaagatcccaactaattttaccgaacctaaaacccacaaagaggttgtttgtgttattg       c.*1620

          .         .         .         .         .         .       g.118991
 ttcaatcttcagttgtaagagtaattctctatttttatattgaaacataattacttgata       c.*1680

          .         .         .         .         .         .       g.119051
 gctcagggtctacatttcattcaactttttacaccaaattctgcagagtggtcaaaatgg       c.*1740

          .         .         .         .         .         .       g.119111
 aatattgggggctgttgtaaacagaggcttaattttattagaagtagccagttatttatt       c.*1800

          .         .         .                                     g.119142
 aaagcatgatgttaataaaataggcatattc                                    c.*1831

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glypican 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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