G protein-coupled receptor, family C, group 5, member B (GPRC5B) - coding DNA reference sequence

(used for variant description)

(last modified November 9, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_016235.1 in the GPRC5B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering GPRC5B transcript NM_016235.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 cgcaggcgggcgtgcgtggagcgggggccgcggccgcgccgcag       c.-61

 .         .         .         .         .         .         | 02    g.16984
 agatgtgactcgggccgaaggccagctggagcgtcggcgctgcggggccgcgggggtcg | a    c.-1

          .         .         .         .         .         .       g.17044
 ATGTTCGTGGCATCAGAGAGAAAGATGAGAGCTCACCAGGTGCTCACCTTCCTCCTGCTC       c.60
 M  F  V  A  S  E  R  K  M  R  A  H  Q  V  L  T  F  L  L  L         p.20

          .         .         .         .         .         .       g.17104
 TTCGTGATCACCTCGGTGGCCTCTGAAAACGCCAGCACATCCCGAGGCTGTGGGCTGGAC       c.120
 F  V  I  T  S  V  A  S  E  N  A  S  T  S  R  G  C  G  L  D         p.40

          .         .         .         .         .         .       g.17164
 CTCCTCCCTCAGTACGTGTCCCTGTGCGACCTGGACGCCATCTGGGGCATTGTGGTGGAG       c.180
 L  L  P  Q  Y  V  S  L  C  D  L  D  A  I  W  G  I  V  V  E         p.60

          .         .         .         .         .         .       g.17224
 GCGGTGGCCGGGGCGGGCGCCCTGATCACACTGCTCCTGATGCTCATCCTCCTGGTGCGG       c.240
 A  V  A  G  A  G  A  L  I  T  L  L  L  M  L  I  L  L  V  R         p.80

          .         .         .         .         .         .       g.17284
 CTGCCCTTCATCAAGGAGAAGGAGAAGAAGAGCCCTGTGGGCCTCCACTTTCTGTTCCTC       c.300
 L  P  F  I  K  E  K  E  K  K  S  P  V  G  L  H  F  L  F  L         p.100

          .         .         .         .         .         .       g.17344
 CTGGGGACCCTGGGCCTCTTTGGGCTGACGTTTGCCTTCATCATCCAGGAGGACGAGACC       c.360
 L  G  T  L  G  L  F  G  L  T  F  A  F  I  I  Q  E  D  E  T         p.120

          .         .         .         .         .         .       g.17404
 ATCTGCTCTGTCCGCCGCTTCCTCTGGGGCGTCCTCTTTGCGCTCTGCTTCTCCTGCCTG       c.420
 I  C  S  V  R  R  F  L  W  G  V  L  F  A  L  C  F  S  C  L         p.140

          .         .         .         .         .         .       g.17464
 CTGAGCCAGGCATGGCGCGTGCGGAGGCTGGTGCGGCATGGCACGGGCCCCGCGGGCTGG       c.480
 L  S  Q  A  W  R  V  R  R  L  V  R  H  G  T  G  P  A  G  W         p.160

          .         .         .         .         .         .       g.17524
 CAGCTGGTGGGCCTGGCGCTGTGCCTGATGCTGGTGCAAGTCATCATCGCTGTGGAGTGG       c.540
 Q  L  V  G  L  A  L  C  L  M  L  V  Q  V  I  I  A  V  E  W         p.180

          .         .         .         .         .         .       g.17584
 CTGGTGCTCACCGTGCTGCGTGACACAAGGCCAGCCTGCGCCTACGAGCCCATGGACTTT       c.600
 L  V  L  T  V  L  R  D  T  R  P  A  C  A  Y  E  P  M  D  F         p.200

          .         .         .         .         .         .       g.17644
 GTGATGGCCCTCATCTACGACATGGTACTGCTTGTGGTCACCCTGGGGCTGGCCCTCTTC       c.660
 V  M  A  L  I  Y  D  M  V  L  L  V  V  T  L  G  L  A  L  F         p.220

          .         .         .         .         .         .       g.17704
 ACTCTGTGCGGCAAGTTCAAGAGGTGGAAGCTGAACGGGGCCTTCCTCCTCATCACAGCC       c.720
 T  L  C  G  K  F  K  R  W  K  L  N  G  A  F  L  L  I  T  A         p.240

          .         .         .         .         .         .       g.17764
 TTCCTCTCTGTGCTCATCTGGGTGGCCTGGATGACCATGTACCTCTTCGGCAATGTCAAG       c.780
 F  L  S  V  L  I  W  V  A  W  M  T  M  Y  L  F  G  N  V  K         p.260

          .         .         .         .         .         .       g.17824
 CTGCAGCAGGGGGATGCCTGGAACGACCCCACCTTGGCCATCACGCTGGCGGCCAGCGGC       c.840
 L  Q  Q  G  D  A  W  N  D  P  T  L  A  I  T  L  A  A  S  G         p.280

          .         .         .         .         .         .       g.17884
 TGGGTCTTCGTCATCTTCCACGCCATCCCTGAGATCCACTGCACCCTTCTGCCAGCCCTG       c.900
 W  V  F  V  I  F  H  A  I  P  E  I  H  C  T  L  L  P  A  L         p.300

          .         .         .         .         .         .       g.17944
 CAGGAGAACACGCCCAACTACTTCGACACGTCGCAGCCCAGGATGCGGGAGACGGCCTTC       c.960
 Q  E  N  T  P  N  Y  F  D  T  S  Q  P  R  M  R  E  T  A  F         p.320

          .         .         .         .         .         .       g.18004
 GAGGAGGACGTGCAGCTGCCGCGGGCCTATATGGAGAACAAGGCCTTCTCCATGGATGAA       c.1020
 E  E  D  V  Q  L  P  R  A  Y  M  E  N  K  A  F  S  M  D  E         p.340

          . | 03       .         .         .         .         .    g.27906
 CACAATGCAG | CTCTCCGAACAGCAGGATTTCCCAACGGCAGCTTGGGAAAAAGACCCAGT    c.1080
 H  N  A  A |   L  R  T  A  G  F  P  N  G  S  L  G  K  R  P  S      p.360

          .         .         .         .         .         .       g.27966
 GGCAGCTTGGGGAAAAGACCCAGCGCTCCGTTTAGAAGCAACGTGTATCAGCCAACTGAG       c.1140
 G  S  L  G  K  R  P  S  A  P  F  R  S  N  V  Y  Q  P  T  E         p.380

          .         .        | 04.         .         .         .    g.29318
 ATGGCCGTCGTGCTCAACGGTGGGACC | ATCCCAACTGCTCCGCCAAGTCACACAGGAAGA    c.1200
 M  A  V  V  L  N  G  G  T   | I  P  T  A  P  P  S  H  T  G  R      p.400

          .                                                         g.29330
 CACCTTTGGTGA                                                       c.1212
 H  L  W  X                                                         p.403

          .         .         .         .         .         .       g.29390
 aagactttaagttccagagaatcagaatttctcttaccgatttgcctccctggctgtgtc       c.*60

          .         .         .         .         .         .       g.29450
 tttcttgagggagaaatcggtaacagttgccgaaccaggccgcctcacagccaggaaatt       c.*120

          .         .         .         .         .         .       g.29510
 tggaaatcctagccaaggggatttcgtgtaaatgtgaacactgacgaactgaaaagctaa       c.*180

          .         .         .         .         .         .       g.29570
 caccgactgcccgcccctcccctgccacacacacagacacgtaataccagaccaacctca       c.*240

          .         .         .         .         .         .       g.29630
 atccccgcaaactaaagcaaagctaattgcaaatagtattaggctcactggaaaatgtgg       c.*300

          .         .         .         .         .         .       g.29690
 ctgggaagactgtttcatcctctgggggtagaacagaaccaaattcacagctggtgggcc       c.*360

          .         .         .         .         .         .       g.29750
 agactggtgttggttggaggtggggggctcccactcttatcacctctccccagcaagtgc       c.*420

          .         .         .         .         .         .       g.29810
 tggaccccaggtagcctcttggagatgaccgttgcgttgaggacaaatggggactttgcc       c.*480

          .         .         .         .         .         .       g.29870
 accggcttgcctggtggtttgcacatttcaggggggtcaggagagttaaggaggttgtgg       c.*540

          .         .         .         .         .         .       g.29930
 gtgggattccaaggtgaggcccaactgaatcgtggggtgagctttatagccagtagaggt       c.*600

          .         .         .         .         .         .       g.29990
 ggagggaccctggcatgtgccaaagaagaggccctctgggtgatgaagtgaccatcacat       c.*660

          .         .         .         .         .         .       g.30050
 ttggaaagtgatcaaccactgttccttctatggggctcttgctctagtgtctatggtgag       c.*720

          .         .         .         .         .         .       g.30110
 aacacaggccccgccccttcccttgtagagccatagaaatattctggcttggggcagcag       c.*780

          .         .         .         .         .         .       g.30170
 tcccttcttcccttgatcatctcgccctgttcctacacttacgggtgtatctccaaatcc       c.*840

          .         .         .         .         .         .       g.30230
 tctcccaattttattcccttattcatttcaagagctccaatggggtctccagctgaaagc       c.*900

          .         .         .         .         .         .       g.30290
 ccctccgggaggcaggttggaaggcaggcaccacggcaggttttccgcgatgatgtcacc       c.*960

          .         .         .         .         .         .       g.30350
 tagcagggcttcaggggttcccactaggatgcagagatgacctctcgctgcctcacaagc       c.*1020

          .         .         .         .         .         .       g.30410
 agtgacacctcgggtcctttccgttgctatggtgaaaattcctggatggaatggatcaca       c.*1080

          .         .         .         .         .         .       g.30470
 tgagggtttcttgttgcttttggagggtgtgggggatattttgttttggtttttctgcag       c.*1140

          .         .         .         .         .         .       g.30530
 gttccatgaaaacagcccttttccaagcccattgtttctgtcatggtttccatctgtcct       c.*1200

          .         .         .         .         .         .       g.30590
 gagcaagtcattcctttgttatttagcatttcgaacatctcggccattcaaagcccccat       c.*1260

          .         .         .         .         .         .       g.30650
 gttctctgcactgtttggccagcataacctctagcatcgattcaaagcagagttttaacc       c.*1320

          .         .         .         .         .         .       g.30710
 tgacggcatggaatgtataaatgagggtgggtccttctgcagatactctaatcactacat       c.*1380

          .         .         .         .         .         .       g.30770
 tgctttttctataaaactacccataagcctttaacctttaaagaaaaatgaaaaaggtta       c.*1440

          .         .         .         .         .         .       g.30830
 gtgtttgggggccgggggaggactgaccgcttcataagccagtacgtctgagctgagtat       c.*1500

          .         .                                               g.30859
 gtttcaataaaccttttgatatttctcaa                                      c.*1529

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The G protein-coupled receptor, family C, group 5, member B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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