glutamate receptor, ionotropic, AMPA 1 (GRIA1) - coding DNA reference sequence

(used for variant description)

(last modified October 16, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000827.3 in the GRIA1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047078.1, covering GRIA1 transcript NM_000827.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        ataga       c.-361

 .         .         .         .         .         .                g.5065
 gcttgctgcctgtgtgagtgtgagggggagagcgagagagagcaagggagggagagagag       c.-301

 .         .         .         .         .         .                g.5125
 gcaggctgcgaggggagaggagagggagtgggggagccagcgctccagctagcatgagga       c.-241

 .         .         .         .         .         .                g.5185
 cgggcttcttttcccgtgctcagttaatctggctgtcagttggtgttaacgctgcagttt       c.-181

 .         .         .         .         .         .                g.5245
 aagtgttcggattccaagggaaacagacaaacctcacgaaaggaaggaagcaagcaagca       c.-121

 .         .         .         .         .         .                g.5305
 aggaaggaactgcaggaggaaaagaacaggcagaacagcgagaagaataaagggaaaggg       c.-61

 .         .         .         .         .         .                g.5365
 ggggaaacaccaaatctatgattggacctgggcttctttttcgccaatgcaaaaaggaat       c.-1

          .         .         .         .         .         .       g.5425
 ATGCAGCACATTTTTGCCTTCTTCTGCACCGGTTTCCTAGGCGCGGTAGTAGGTGCCAAT       c.60
 M  Q  H  I  F  A  F  F  C  T  G  F  L  G  A  V  V  G  A  N         p.20

          .         .   | 02     .         .         .         .    g.8442
 TTCCCCAACAATATCCAGATCG | GGGGATTATTTCCAAACCAGCAGTCACAGGAACATGCT    c.120
 F  P  N  N  I  Q  I  G |   G  L  F  P  N  Q  Q  S  Q  E  H  A      p.40

          .         .         .         .         .         .       g.8502
 GCTTTTAGATTTGCTTTGTCGCAACTCACAGAGCCCCCGAAGCTGCTCCCCCAGATTGAT       c.180
 A  F  R  F  A  L  S  Q  L  T  E  P  P  K  L  L  P  Q  I  D         p.60

          .         .         .         . | 03       .         .    g.161424
 ATTGTGAACATCAGCGACAGCTTTGAGATGACCTATAGAT | TCTGTTCCCAGTTCTCCAAA    c.240
 I  V  N  I  S  D  S  F  E  M  T  Y  R  F |   C  S  Q  F  S  K      p.80

          .         .         .         .         .         .       g.161484
 GGAGTCTATGCCATCTTTGGGTTTTATGAACGTAGGACTGTCAACATGCTGACCTCCTTT       c.300
 G  V  Y  A  I  F  G  F  Y  E  R  R  T  V  N  M  L  T  S  F         p.100

          .         .         .         .         .         .       g.161544
 TGTGGGGCCCTCCACGTCTGCTTCATTACGCCGAGCTTTCCCGTTGATACATCCAATCAG       c.360
 C  G  A  L  H  V  C  F  I  T  P  S  F  P  V  D  T  S  N  Q         p.120

          .         .         .         .         .         .       g.161604
 TTTGTCCTTCAGCTGCGCCCTGAACTGCAGGATGCCCTCATCAGCATCATTGACCATTAC       c.420
 F  V  L  Q  L  R  P  E  L  Q  D  A  L  I  S  I  I  D  H  Y         p.140

          .         .         .         . | 04       .         .    g.164826
 AAGTGGCAGAAATTTGTCTACATTTATGATGCCGACCGGG | GCTTATCCGTCCTGCAGAAA    c.480
 K  W  Q  K  F  V  Y  I  Y  D  A  D  R  G |   L  S  V  L  Q  K      p.160

          .         .         .         .         .         .       g.164886
 GTCCTGGATACAGCTGCTGAGAAGAACTGGCAGGTGACAGCAGTCAACATTTTGACAACC       c.540
 V  L  D  T  A  A  E  K  N  W  Q  V  T  A  V  N  I  L  T  T         p.180

          .         .         .         .         .         .       g.164946
 ACAGAGGAGGGATACCGGATGCTCTTTCAGGACCTGGAGAAGAAAAAGGAGCGGCTGGTG       c.600
 T  E  E  G  Y  R  M  L  F  Q  D  L  E  K  K  K  E  R  L  V         p.200

          .         .         .         .      | 05  .         .    g.170310
 GTGGTGGACTGTGAATCAGAACGCCTCAATGCTATCTTGGGCCAG | ATTATAAAGCTAGAG    c.660
 V  V  D  C  E  S  E  R  L  N  A  I  L  G  Q   | I  I  K  L  E      p.220

          .         .         .          | 06        .         .    g.188997
 AAGAATGGCATCGGCTACCACTACATTCTTGCAAATCTG | GGCTTCATGGACATTGACTTA    c.720
 K  N  G  I  G  Y  H  Y  I  L  A  N  L   | G  F  M  D  I  D  L      p.240

          .         .         .         .         .         .       g.189057
 AACAAATTCAAGGAGAGTGGCGCCAATGTGACAGGTTTCCAGCTGGTGAACTACACAGAC       c.780
 N  K  F  K  E  S  G  A  N  V  T  G  F  Q  L  V  N  Y  T  D         p.260

          .         .         .         .         .         .       g.189117
 ACTATTCCGGCCAAGATCATGCAGCAGTGGAAGAATAGTGATGCTCGAGACCACACACGG       c.840
 T  I  P  A  K  I  M  Q  Q  W  K  N  S  D  A  R  D  H  T  R         p.280

          .         .  | 07      .         .         .         .    g.191509
 GTGGACTGGAAGAGACCCAAG | TACACCTCTGCGCTCACCTACGATGGGGTGAAGGTGATG    c.900
 V  D  W  K  R  P  K   | Y  T  S  A  L  T  Y  D  G  V  K  V  M      p.300

          .         .         .         .         .         .       g.191569
 GCTGAGGCTTTCCAGAGCCTGCGGAGGCAGAGAATTGATATATCTCGCCGGGGGAATGCT       c.960
 A  E  A  F  Q  S  L  R  R  Q  R  I  D  I  S  R  R  G  N  A         p.320

          .         .         .         .         .         .       g.191629
 GGGGATTGTCTGGCTAACCCAGCTGTTCCCTGGGGCCAAGGGATCGACATCCAGAGAGCT       c.1020
 G  D  C  L  A  N  P  A  V  P  W  G  Q  G  I  D  I  Q  R  A         p.340

           | 08        .         .         .         .         .    g.200752
 CTGCAGCAG | GTGCGATTTGAAGGTTTAACAGGAAACGTGCAGTTTAATGAGAAAGGACGC    c.1080
 L  Q  Q   | V  R  F  E  G  L  T  G  N  V  Q  F  N  E  K  G  R      p.360

          .         .         .         .         .     | 09   .    g.212526
 CGGACCAACTACACGCTCCACGTGATTGAAATGAAACATGACGGCATCCGAAAG | ATTGGT    c.1140
 R  T  N  Y  T  L  H  V  I  E  M  K  H  D  G  I  R  K   | I  G      p.380

          .         .         .         .         .         .       g.212586
 TACTGGAATGAAGATGATAAGTTTGTCCCTGCAGCCACCGATGCCCAAGCTGGGGGCGAT       c.1200
 Y  W  N  E  D  D  K  F  V  P  A  A  T  D  A  Q  A  G  G  D         p.400

          .         .         .         .      | 10  .         .    g.213358
 AATTCAAGTGTTCAGAACAGAACATACATCGTCACAACAATCCTA | GAAGATCCTTATGTG    c.1260
 N  S  S  V  Q  N  R  T  Y  I  V  T  T  I  L   | E  D  P  Y  V      p.420

          .         .         .         .         .         .       g.213418
 ATGCTCAAGAAGAACGCCAATCAGTTTGAGGGCAATGACCGTTACGAGGGCTACTGTGTA       c.1320
 M  L  K  K  N  A  N  Q  F  E  G  N  D  R  Y  E  G  Y  C  V         p.440

          .         .         .         .         .         .       g.213478
 GAGCTGGCGGCAGAGATTGCCAAGCACGTGGGCTACTCCTACCGTCTGGAGATTGTCAGT       c.1380
 E  L  A  A  E  I  A  K  H  V  G  Y  S  Y  R  L  E  I  V  S         p.460

          .         .         .         .         .         .       g.213538
 GATGGAAAATACGGAGCCCGAGACCCTGACACGAAGGCCTGGAATGGCATGGTGGGAGAG       c.1440
 D  G  K  Y  G  A  R  D  P  D  T  K  A  W  N  G  M  V  G  E         p.480

          .   | 11     .         .         .         .         .    g.220221
 CTGGTCTATGGA | AGAGCAGATGTGGCTGTGGCTCCCTTAACTATCACTTTGGTCCGGGAA    c.1500
 L  V  Y  G   | R  A  D  V  A  V  A  P  L  T  I  T  L  V  R  E      p.500

          .         .         .         .         .         .       g.220281
 GAAGTTATAGATTTCTCCAAACCATTTATGAGTTTGGGGATCTCCATCATGATTAAAAAA       c.1560
 E  V  I  D  F  S  K  P  F  M  S  L  G  I  S  I  M  I  K  K         p.520

          .         .         .         .         .         .       g.220341
 CCACAGAAATCCAAGCCGGGTGTCTTCTCCTTCCTTGATCCTTTGGCTTATGAGATTTGG       c.1620
 P  Q  K  S  K  P  G  V  F  S  F  L  D  P  L  A  Y  E  I  W         p.540

          .         .         .         .         .         .       g.220401
 ATGTGCATTGTTTTTGCCTACATTGGAGTGAGTGTTGTCCTCTTCCTGGTCAGCCGCTTC       c.1680
 M  C  I  V  F  A  Y  I  G  V  S  V  V  L  F  L  V  S  R  F         p.560

          .         .         .         .         .         .       g.220461
 AGTCCCTATGAATGGCACAGTGAAGAGTTTGAGGAAGGACGGGACCAGACAACCAGTGAC       c.1740
 S  P  Y  E  W  H  S  E  E  F  E  E  G  R  D  Q  T  T  S  D         p.580

          .         .         .         .         .         .       g.220521
 CAGTCCAATGAGTTTGGGATATTCAACAGTTTGTGGTTCTCCCTGGGAGCCTTCATGCAG       c.1800
 Q  S  N  E  F  G  I  F  N  S  L  W  F  S  L  G  A  F  M  Q         p.600

          .         .    | 12    .         .         .         .    g.278947
 CAAGGATGTGACATTTCTCCCAG | GTCCCTGTCTGGTCGCATCGTTGGTGGCGTCTGGTGG    c.1860
 Q  G  C  D  I  S  P  R  |  S  L  S  G  R  I  V  G  G  V  W  W      p.620

          .         .         .         .         .         .       g.279007
 TTCTTCACCTTAATCATCATCTCCTCATATACAGCCAATCTGGCCGCCTTCCTGACCGTG       c.1920
 F  F  T  L  I  I  I  S  S  Y  T  A  N  L  A  A  F  L  T  V         p.640

          .         .         .         .         .         .       g.279067
 GAGAGGATGGTGTCTCCCATTGAGAGTGCAGAGGACCTAGCGAAGCAGACAGAAATTGCC       c.1980
 E  R  M  V  S  P  I  E  S  A  E  D  L  A  K  Q  T  E  I  A         p.660

          .         .         .         .   | 13     .         .    g.284662
 TACGGGACGCTGGAAGCAGGATCTACTAAGGAGTTCTTCAGG | AGGTCTAAAATTGCTGTG    c.2040
 Y  G  T  L  E  A  G  S  T  K  E  F  F  R   | R  S  K  I  A  V      p.680

          .         .         .         .         .         .       g.284722
 TTTGAGAAGATGTGGACATACATGAAGTCAGCAGAGCCATCAGTTTTTGTGCGGACCACA       c.2100
 F  E  K  M  W  T  Y  M  K  S  A  E  P  S  V  F  V  R  T  T         p.700

          .         .         .         .         .         .       g.284782
 GAGGAGGGGATGATTCGAGTGAGGAAATCCAAAGGCAAATATGCCTACCTCCTGGAGTCC       c.2160
 E  E  G  M  I  R  V  R  K  S  K  G  K  Y  A  Y  L  L  E  S         p.720

          .         .         .         .         .         .       g.284842
 ACCATGAATGAGTACATTGAGCAGCGGAAACCCTGTGACACCATGAAGGTGGGAGGTAAC       c.2220
 T  M  N  E  Y  I  E  Q  R  K  P  C  D  T  M  K  V  G  G  N         p.740

          .         .         .         .         . | 14       .    g.309107
 TTGGATTCCAAAGGCTATGGCATTGCAACACCCAAGGGGTCTGCCCTGAG | AAATCCAGTA    c.2280
 L  D  S  K  G  Y  G  I  A  T  P  K  G  S  A  L  R  |  N  P  V      p.760

          .         .         .         .         .         .       g.309167
 AACCTGGCAGTGTTAAAACTGAACGAGCAGGGGCTTTTGGACAAATTGAAAAACAAATGG       c.2340
 N  L  A  V  L  K  L  N  E  Q  G  L  L  D  K  L  K  N  K  W         p.780

          .         .         .         .      | 15  .         .    g.316847
 TGGTACGACAAGGGCGAGTGCGGCAGCGGGGGAGGTGATTCCAAG | GACAAGACAAGCGCT    c.2400
 W  Y  D  K  G  E  C  G  S  G  G  G  D  S  K   | D  K  T  S  A      p.800

          .         .         .         .         .         .       g.316907
 CTGAGCCTCAGCAATGTGGCAGGCGTGTTCTACATCCTGATCGGAGGACTTGGACTAGCC       c.2460
 L  S  L  S  N  V  A  G  V  F  Y  I  L  I  G  G  L  G  L  A         p.820

          .         .         .         .         .         .       g.316967
 ATGCTGGTTGCCTTAATCGAGTTCTGCTACAAATCCCGTAGTGAATCCAAGCGGATGAAG       c.2520
 M  L  V  A  L  I  E  F  C  Y  K  S  R  S  E  S  K  R  M  K         p.840

  | 16       .         .         .         .         .         .    g.325561
  | GGTTTTTGTTTGATCCCACAGCAATCCATCAACGAAGCCATACGGACATCGACCCTCCCC    c.2580
  | G  F  C  L  I  P  Q  Q  S  I  N  E  A  I  R  T  S  T  L  P      p.860

          .         .         .         .         .         .       g.325621
 CGCAACAGCGGGGCAGGAGCCAGCAGCGGCGGCAGTGGAGAGAATGGTCGGGTGGTCAGC       c.2640
 R  N  S  G  A  G  A  S  S  G  G  S  G  E  N  G  R  V  V  S         p.880

          .         .         .         .         .         .       g.325681
 CATGACTTCCCCAAGTCCATGCAATCGATTCCTTGCATGAGCCACAGTTCAGGGATGCCC       c.2700
 H  D  F  P  K  S  M  Q  S  I  P  C  M  S  H  S  S  G  M  P         p.900

          .         .                                               g.325702
 TTGGGAGCCACGGGATTGTAA                                              c.2721
 L  G  A  T  G  L  X                                                p.906

          .         .         .         .         .         .       g.325762
 ctggagcagatggagaccccttggggagcaggctcgggctccccagccccatcccaaacc       c.*60

          .         .         .         .         .         .       g.325822
 cttcagtgccaaaaacaacaacaaaatgaaacgcaaccaccaccaaccactgcgaccaca       c.*120

          .         .         .         .         .         .       g.325882
 agaaggatgattcaacaggttttcctgaagaattgaaaaaccattttgctgtcccttttc       c.*180

          .         .         .         .         .         .       g.325942
 cttttttgatgttctttcacccttttctgtttgctaagtgaggatgaaaaaataacactg       c.*240

          .         .         .         .         .         .       g.326002
 tactgcaataaggggagagtaaccctgtctaatgaaacctgtgtctctgagagtagagtc       c.*300

          .         .         .         .         .         .       g.326062
 actggaacactaatgaggaaactgcactgttttattttaattcagttgttagtgtgtctt       c.*360

          .         .         .         .         .         .       g.326122
 agtgtgtgcaattttttttcttactaatatccatggtttgcaggttctgttaggcccttt       c.*420

          .         .         .         .         .         .       g.326182
 ccttctccttacttcttatccccaactccctacccacccctcttcagttttcagattgga       c.*480

          .         .         .         .         .         .       g.326242
 gattcaagatttgttccactttacaagcaagaggaaaaaaaagcaaccttcaaactaatt       c.*540

          .         .         .         .         .         .       g.326302
 ctccatgggggctctccatgttaccctccactccttggcccaaacctctgatggagatag       c.*600

          .         .         .         .         .         .       g.326362
 acattgttggagaagtgggctgccttccccaagtggggcactgcttaagcacttattcag       c.*660

          .         .         .         .         .         .       g.326422
 tggagaacacaggtgaaaagcaactcaggatgagggtggtggagagggcaggggcagatg       c.*720

          .         .         .         .         .         .       g.326482
 tgcagtcagagaaggactcctgaagttactgctgctcagaaaaacagttcctttaatgtg       c.*780

          .         .         .         .         .         .       g.326542
 gaagagccatttcataggtcataggtggtatggtatatttcttcagagtcaaccttggcc       c.*840

          .         .         .         .         .         .       g.326602
 ctgagaagtatgtcctcctggtgtgctcaggctcaacggcagtctggtggctgaaggcac       c.*900

          .         .         .         .         .         .       g.326662
 ttggcctcctaaaccaagcagaattttgggaagagataacagccagggagatattgccca       c.*960

          .         .         .         .         .         .       g.326722
 tgattctcactttttctttgcctggcatctaagcaggaacccattgtggagtagactctc       c.*1020

          .         .         .         .         .         .       g.326782
 ttcttctatggagcctctgacatggggagcaatgctaagcaagctaagtgtaaaagaaaa       c.*1080

          .         .         .         .         .         .       g.326842
 gtgacagaataattttggaagaggaagcctcatcaaaagctcacacaaaatagagcttcc       c.*1140

          .         .         .         .         .         .       g.326902
 catggtgtgccctatcctaggtttaagaaaacacgtatgaagtttatgctgatgcaaaga       c.*1200

          .         .         .         .         .         .       g.326962
 acttgggtttttatgttaatataaagtgttgttttagcatgtggccagatgatgctctgt       c.*1260

          .         .         .         .         .         .       g.327022
 catctttagaaagtgagataaccaaggaaataattgaaggagtatagggagatggattaa       c.*1320

          .         .         .         .         .         .       g.327082
 gttgataatgacatttagggcaacttaagacctttgatcccaggttctaactcaaagagg       c.*1380

          .         .         .         .         .         .       g.327142
 ctgaccttcccccagctaagatagcatgaggacgttgtattccaatatacgtatgattgg       c.*1440

          .         .         .         .         .         .       g.327202
 ggctacaaagctgaactaaagcaagattggtgaagtggcagggtttatagagagaagccc       c.*1500

          .         .         .         .         .         .       g.327262
 aggctgagttcagcttttgttggaagtgagaatccctgacatatagctttcttggagatc       c.*1560

          .         .         .         .         .         .       g.327322
 ccaactctcattcttggtgcaactggcttccagctctccagcagtcactctcctaggtgc       c.*1620

          .         .         .         .         .         .       g.327382
 atgattcagtgcgtgccatgtgtcattagcttttactgataaccatattctggcttgttc       c.*1680

          .         .         .         .         .         .       g.327442
 ccttaccccctacttctatccaattttctctgctaggggttatcattagcaattgacatg       c.*1740

          .         .         .         .         .         .       g.327502
 ctaaaggttttggagcccacctaggggtaggtgcagctttattggcttttctgtggattc       c.*1800

          .         .         .         .         .         .       g.327562
 tctcagtggacccacaccatctctatgtctctccactctcctgccttcagccatagcaaa       c.*1860

          .         .         .         .         .         .       g.327622
 gaatccttccaaaatcaaactcttcacttttttgactcaagtgttgttgttcagtctctc       c.*1920

          .         .         .         .         .         .       g.327682
 gcgtgtcaatgtggtcatggttcatgaaaccggaccctcaagatggatgattgcttttaa       c.*1980

          .         .         .         .         .         .       g.327742
 ctactgccagctgatgtctctcagcccctgccctcatacaagatttttctcagccttcag       c.*2040

          .         .         .         .         .         .       g.327802
 cctaccactgcagaatccgatgtgacccaccattagggagtctgcatcttggaagagttg       c.*2100

          .         .         .         .         .         .       g.327862
 gaaataaccctttaacatcaacatgcttcaaagactttttgcctttggcctagtaagatg       c.*2160

          .         .         .         .         .         .       g.327922
 cctctccagctactgagcccacaagtaacatgagcggataaaaagagacttgtttgtgct       c.*2220

          .         .         .         .         .         .       g.327982
 agaaatgagggtctatgctatgagggggtccaagactctggcgaaatgtgctttttcatc       c.*2280

          .         .         .         .         .         .       g.328042
 aatggagaaatgaaaggaaaacacaagcaagaaaaaagttaacttgtattatgtattttt       c.*2340

          .         .         .         .         .         .       g.328102
 actacacttttcttaaaaatagagcattgggaaaactctgaaagagactgacatttttct       c.*2400

          .         .         .         .         .         .       g.328162
 caacaggaatccatacttaacagttctggctttcattaaattttgctctttggtacctgg       c.*2460

          .         .         .         .         .         .       g.328222
 gccttttatttaacatctatatttgttttaactctcttggcagatgtgtgaaaggattct       c.*2520

          .         .         .         .         .         .       g.328282
 tgcttgatcaaacactaagtatttttttggttcttgtttttctttcaaatagccaggttt       c.*2580

          .         .         .         .         .         .       g.328342
 ttttcttttggtatttgcataaaatgaaaatatcaccgaatattaaatcactgtggatcc       c.*2640

                                                                    g.328346
 atta                                                               c.*2644

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, ionotropic, AMPA 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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