glutamate receptor, ionotropic, AMPA 3 (GRIA3) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_007325.4 in the GRIA3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009377.2, covering GRIA3 transcript NM_007325.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        agagatcctgggagcgagagggagagagagggagcaagaaaggaagagagagc       c.-241

 .         .         .         .         .         .                g.5113
 gagcgagagagagcgagcgaataagagagagagtaagagggagagagaagaagaggaaga       c.-181

 .         .         .         .         .         .                g.5173
 agaggaggcggcggcagcggaggaggaggaggactagtgtggggtggaaaggaagagtga       c.-121

 .         .         .         .         .         .                g.5233
 gcgagagcaagttaaggggagggggtgtaagagccagcgaattctttttctttttctatt       c.-61

 .         .         .         .         .         .                g.5293
 attattttgacgactcctgagttgcgcccatgctcttgtcagcttcgttttaggcgtagc       c.-1

          .         .         .         .         .         .       g.5353
 ATGGCCAGGCAGAAGAAAATGGGGCAAAGCGTGCTCCGGGCGGTCTTCTTTTTAGTCCTG       c.60
 M  A  R  Q  K  K  M  G  Q  S  V  L  R  A  V  F  F  L  V  L         p.20

          .         .         .         .          | 02        .    g.6600
 GGGCTTTTGGGTCATTCTCACGGAGGATTCCCCAACACCATCAGCATAG | GTGGACTTTTC    c.120
 G  L  L  G  H  S  H  G  G  F  P  N  T  I  S  I  G |   G  L  F      p.40

          .         .         .         .         .         .       g.6660
 ATGAGAAACACAGTGCAGGAGCACAGCGCTTTCCGCTTTGCCGTGCAGTTATACAACACC       c.180
 M  R  N  T  V  Q  E  H  S  A  F  R  F  A  V  Q  L  Y  N  T         p.60

          .         .         .         .         .         .       g.6720
 AACCAGAACACCACCGAGAAGCCCTTCCATTTGAATTACCACGTAGATCACTTGGATTCC       c.240
 N  Q  N  T  T  E  K  P  F  H  L  N  Y  H  V  D  H  L  D  S         p.80

          .         .         | 03         .         .         .    g.74092
 TCCAATAGTTTTTCCGTGACAAATGCTT | TCTGCTCCCAGTTCTCGAGAGGGGTGTATGCC    c.300
 S  N  S  F  S  V  T  N  A  F |   C  S  Q  F  S  R  G  V  Y  A      p.100

          .         .         .         .         .         .       g.74152
 ATCTTTGGATTCTATGACCAGATGTCAATGAACACCCTGACCTCCTTCTGTGGGGCCCTG       c.360
 I  F  G  F  Y  D  Q  M  S  M  N  T  L  T  S  F  C  G  A  L         p.120

          .         .         .         .         .         .       g.74212
 CACACATCCTTTGTTACGCCTAGCTTCCCCACTGACGCAGATGTGCAGTTTGTCATCCAG       c.420
 H  T  S  F  V  T  P  S  F  P  T  D  A  D  V  Q  F  V  I  Q         p.140

          .         .         .         .         .         .       g.74272
 ATGCGCCCAGCCTTGAAGGGCGCTATTCTGAGTCTTCTGGGTCATTACAAGTGGGAGAAG       c.480
 M  R  P  A  L  K  G  A  I  L  S  L  L  G  H  Y  K  W  E  K         p.160

          .         .         | 04         .         .         .    g.146815
 TTTGTGTACCTCTATGACACAGAACGAG | GATTTTCCATCCTCCAAGCGATTATGGAAGCA    c.540
 F  V  Y  L  Y  D  T  E  R  G |   F  S  I  L  Q  A  I  M  E  A      p.180

          .         .         .         .         .         .       g.146875
 GCAGTGCAAAACAACTGGCAAGTAACAGCAAGGTCTGTGGGAAACATAAAGGACGTCCAA       c.600
 A  V  Q  N  N  W  Q  V  T  A  R  S  V  G  N  I  K  D  V  Q         p.200

          .         .         .         .         .         .       g.146935
 GAATTCAGGCGCATCATTGAAGAAATGGACAGGAGGCAGGAAAAGCGATACTTGATTGAC       c.660
 E  F  R  R  I  I  E  E  M  D  R  R  Q  E  K  R  Y  L  I  D         p.220

          .         .         .       | 05 .         .         .    g.175691
 TGCGAAGTCGAAAGGATTAACACAATTTTGGAACAG | GTTGTGATCCTAGGGAAACACTCA    c.720
 C  E  V  E  R  I  N  T  I  L  E  Q   | V  V  I  L  G  K  H  S      p.240

          .         .         . | 06       .         .         .    g.215755
 AGAGGTTATCACTACATGCTCGCTAACCTG | GGTTTTACTGATATTTTACTGGAAAGAGTC    c.780
 R  G  Y  H  Y  M  L  A  N  L   | G  F  T  D  I  L  L  E  R  V      p.260

          .         .         .         .         .         .       g.215815
 ATGCATGGGGGAGCCAACATTACAGGTTTCCAGATTGTCAACAATGAAAACCCTATGGTT       c.840
 M  H  G  G  A  N  I  T  G  F  Q  I  V  N  N  E  N  P  M  V         p.280

          .         .         .         .         .         .       g.215875
 CAGCAGTTCATACAGCGCTGGGTGAGGCTGGATGAAAGGGAATTCCCTGAAGCCAAGAAT       c.900
 Q  Q  F  I  Q  R  W  V  R  L  D  E  R  E  F  P  E  A  K  N         p.300

          .   | 07     .         .         .         .         .    g.219441
 GCACCACTAAAG | TATACATCTGCATTGACACACGACGCAATACTGGTCATAGCAGAAGCT    c.960
 A  P  L  K   | Y  T  S  A  L  T  H  D  A  I  L  V  I  A  E  A      p.320

          .         .         .         .         .         .       g.219501
 TTCCGCTACCTGAGGAGGCAGCGAGTAGATGTGTCCCGGAGAGGAAGTGCTGGAGACTGC       c.1020
 F  R  Y  L  R  R  Q  R  V  D  V  S  R  R  G  S  A  G  D  C         p.340

          .         .         .         .         .         .       g.219561
 TTAGCAAATCCTGCTGTGCCCTGGAGTCAAGGAATTGATATTGAGAGAGCTCTGAAAATG       c.1080
 L  A  N  P  A  V  P  W  S  Q  G  I  D  I  E  R  A  L  K  M         p.360

  | 08       .         .         .         .         .         .    g.223811
  | GTGCAAGTACAAGGAATGACTGGAAATATTCAATTTGACACTTATGGACGTAGGACAAAT    c.1140
  | V  Q  V  Q  G  M  T  G  N  I  Q  F  D  T  Y  G  R  R  T  N      p.380

          .         .         .         .      | 09  .         .    g.224184
 TATACCATCGATGTGTATGAAATGAAAGTCAGTGGCTCTCGAAAA | GCTGGCTACTGGAAT    c.1200
 Y  T  I  D  V  Y  E  M  K  V  S  G  S  R  K   | A  G  Y  W  N      p.400

          .         .         .         .         .         .       g.224244
 GAGTATGAAAGGTTTGTGCCTTTCTCAGATCAGCAAATCAGCAATGACAGTGCATCCTCA       c.1260
 E  Y  E  R  F  V  P  F  S  D  Q  Q  I  S  N  D  S  A  S  S         p.420

          .         .         .    | 10    .         .         .    g.225492
 GAGAATCGGACCATAGTAGTGACTACCATTCTG | GAATCACCATATGTAATGTACAAGAAG    c.1320
 E  N  R  T  I  V  V  T  T  I  L   | E  S  P  Y  V  M  Y  K  K      p.440

          .         .         .         .         .         .       g.225552
 AACCATGAGCAACTGGAAGGAAATGAACGATATGAAGGCTATTGTGTAGACCTAGCCTAT       c.1380
 N  H  E  Q  L  E  G  N  E  R  Y  E  G  Y  C  V  D  L  A  Y         p.460

          .         .         .         .         .         .       g.225612
 GAAATAGCCAAACATGTAAGGATCAAATACAAATTGTCCATCGTTGGTGACGGGAAATAT       c.1440
 E  I  A  K  H  V  R  I  K  Y  K  L  S  I  V  G  D  G  K  Y         p.480

          .         .         .         .         .         .       g.225672
 GGTGCAAGGGATCCAGAGACTAAAATATGGAACGGCATGGTTGGGGAACTTGTCTATGGG       c.1500
 G  A  R  D  P  E  T  K  I  W  N  G  M  V  G  E  L  V  Y  G         p.500

  | 11       .         .         .         .         .         .    g.238219
  | AGAGCTGATATAGCTGTTGCTCCACTCACTATAACATTGGTCCGTGAAGAAGTCATAGAT    c.1560
  | R  A  D  I  A  V  A  P  L  T  I  T  L  V  R  E  E  V  I  D      p.520

          .         .         .         .         .         .       g.238279
 TTTTCAAAGCCATTCATGAGCCTGGGCATCTCCATCATGATAAAGAAGCCTCAGAAATCA       c.1620
 F  S  K  P  F  M  S  L  G  I  S  I  M  I  K  K  P  Q  K  S         p.540

          .         .         .         .         .         .       g.238339
 AAACCAGGCGTATTCTCATTTCTGGATCCCCTGGCTTATGAAATCTGGATGTGCATTGTC       c.1680
 K  P  G  V  F  S  F  L  D  P  L  A  Y  E  I  W  M  C  I  V         p.560

          .         .         .         .         .         .       g.238399
 TTTGCTTACATTGGAGTCAGCGTAGTTCTTTTCCTAGTCAGCAGGTTCAGTCCTTATGAA       c.1740
 F  A  Y  I  G  V  S  V  V  L  F  L  V  S  R  F  S  P  Y  E         p.580

          .         .         .         .         .         .       g.238459
 TGGCACTTGGAAGACAACAATGAAGAACCTCGTGACCCACAAAGTCCTCCTGATCCTCCA       c.1800
 W  H  L  E  D  N  N  E  E  P  R  D  P  Q  S  P  P  D  P  P         p.600

          .         .         .         .         .         .       g.238519
 AATGAATTTGGAATATTTAACAGTCTTTGGTTTTCCTTGGGTGCCTTTATGCAGCAAGGA       c.1860
 N  E  F  G  I  F  N  S  L  W  F  S  L  G  A  F  M  Q  Q  G         p.620

          .        | 12.         .         .         .         .    g.248741
 TGTGATATTTCTCCAAG | ATCACTCTCCGGGCGCATTGTTGGAGGGGTTTGGTGGTTCTTC    c.1920
 C  D  I  S  P  R  |  S  L  S  G  R  I  V  G  G  V  W  W  F  F      p.640

          .         .         .         .         .         .       g.248801
 ACCCTGATCATAATTTCTTCCTATACTGCCAATCTCGCTGCTTTCCTGACTGTGGAGAGG       c.1980
 T  L  I  I  I  S  S  Y  T  A  N  L  A  A  F  L  T  V  E  R         p.660

          .         .         .         .         .         .       g.248861
 ATGGTTTCTCCCATAGAGAGTGCTGAAGACTTAGCTAAACAGACTGAAATTGCATATGGG       c.2040
 M  V  S  P  I  E  S  A  E  D  L  A  K  Q  T  E  I  A  Y  G         p.680

          .         .         .       | 13 .         .         .    g.285646
 ACCCTGGACTCCGGTTCAACAAAAGAATTTTTCAGA | AGATCCAAAATTGCTGTGTACGAG    c.2100
 T  L  D  S  G  S  T  K  E  F  F  R   | R  S  K  I  A  V  Y  E      p.700

          .         .         .         .         .         .       g.285706
 AAAATGTGGTCTTACATGAAATCAGCGGAGCCATCTGTGTTTACCAAAACAACAGCAGAC       c.2160
 K  M  W  S  Y  M  K  S  A  E  P  S  V  F  T  K  T  T  A  D         p.720

          .         .         .         .         .         .       g.285766
 GGAGTGGCCCGAGTGCGAAAGTCCAAGGGAAAGTTCGCCTTCCTGCTGGAGTCAACCATG       c.2220
 G  V  A  R  V  R  K  S  K  G  K  F  A  F  L  L  E  S  T  M         p.740

          .         .         .         .         .         .       g.285826
 AATGAGTACATTGAGCAGAGAAAACCATGTGATACGATGAAAGTTGGTGGAAATCTGGAT       c.2280
 N  E  Y  I  E  Q  R  K  P  C  D  T  M  K  V  G  G  N  L  D         p.760

          .         .         .         .     | 14   .         .    g.300836
 TCCAAAGGCTATGGTGTGGCAACCCCTAAAGGCTCAGCATTAGG | AACGCCTGTAAACCTT    c.2340
 S  K  G  Y  G  V  A  T  P  K  G  S  A  L  G  |  T  P  V  N  L      p.780

          .         .         .         .         .         .       g.300896
 GCAGTATTGAAACTCAGTGAACAAGGCATCTTAGACAAGCTGAAAAACAAATGGTGGTAC       c.2400
 A  V  L  K  L  S  E  Q  G  I  L  D  K  L  K  N  K  W  W  Y         p.800

          .         .         .          | 15        .         .    g.303577
 GATAAGGGGGAATGTGGAGCCAAGGACTCCGGGAGTAAG | GACAAGACCAGCGCTCTGAGC    c.2460
 D  K  G  E  C  G  A  K  D  S  G  S  K   | D  K  T  S  A  L  S      p.820

          .         .         .         .         .         .       g.303637
 CTGAGCAATGTGGCAGGCGTTTTCTATATACTTGTCGGAGGTCTGGGGCTGGCCATGATG       c.2520
 L  S  N  V  A  G  V  F  Y  I  L  V  G  G  L  G  L  A  M  M         p.840

          .         .         .         .         .         .       g.303697
 GTGGCTTTGATAGAATTCTGTTACAAATCACGGGCAGAGTCCAAACGCATGAAACTCACA       c.2580
 V  A  L  I  E  F  C  Y  K  S  R  A  E  S  K  R  M  K  L  T         p.860

          .         .         .         .         .         .       g.303757
 AAGAACACCCAAAACTTTAAGCCTGCTCCTGCCACCAACACTCAGAATTATGCTACATAC       c.2640
 K  N  T  Q  N  F  K  P  A  P  A  T  N  T  Q  N  Y  A  T  Y         p.880

          .         .         .         .                       g.303802
 AGAGAAGGCTACAACGTGTATGGAACAGAGAGTGTTAAGATCTAG |                   c.2686
 R  E  G  Y  N  V  Y  G  T  E  S  V  K  I  X                     p.894

    | 16     .         .         .         .         .         .    g.309528
 gg | atcccttcccactggaggcatgtgatgagaggaaatcaccgaaaacgtggctgcttca    c.*60

          .         .         .         .         .         .       g.309588
 aggatcctgagccagatttcactctccttggtgtcgggcatgacacgaatattgctgatg       c.*120

          .         .         .         .         .         .       g.309648
 gtgcaatgacctttcaataggaaaaactgatttttttttccttcagtgccttatggaaca       c.*180

          .         .         .         .         .         .       g.309708
 ctctgagactcgcgacaatgcaaaccatcattgaaatctttttgctttgcttgaaaaaaa       c.*240

          .         .         .         .         .         .       g.309768
 ataattaaaataaaaaccaacaaaaatggacatgcaagattccagtatgcgaaaaaaaat       c.*300

          .         .         .         .         .         .       g.309828
 cttattaagtcaattcaacaaaagccattctttgataccactgcagagtatataaacacc       c.*360

          .         .         .         .         .         .       g.309888
 atgttctttaatacacacacacacacacacacacacacacacacacatttaaattccaat       c.*420

          .         .         .         .         .         .       g.309948
 tcagcaaagaggcccatctaagctaaaaaaattaattcttcctgattaaaaagaaaaaat       c.*480

          .         .         .         .         .         .       g.310008
 ctgtctcccagtgtttgggaagacggactggcatttcttctaggatctgctgaccagatg       c.*540

          .         .         .         .         .         .       g.310068
 tttttggtatttcctgttggtggtgatgttctgtgcactctatttcctttcaatgttgct       c.*600

          .         .         .         .         .         .       g.310128
 gaaatgtgtatatctttagaatgtaaatgcaacacttaagaaaattcaaacactttggaa       c.*660

          .         .         .         .         .         .       g.310188
 aagggactaaacagtgatttctctgtgttcttgaaatggttttgtgaaaatgctttgata       c.*720

          .         .         .         .         .         .       g.310248
 acttcccactcaaagaagagatttacagagctttcgaaattgactttgtgtgtagcaagg       c.*780

          .         .         .         .         .         .       g.310308
 gacggggcactatcaggatacctcttggtgctttcctaaaatggatcccggggctttcca       c.*840

          .         .         .         .         .         .       g.310368
 aggagcctggaatttcagctcacagatctgtttttcttgcttcagtgtgcattttaagtc       c.*900

          .         .         .         .         .         .       g.310428
 aatagagctgagtatctagcattgaggtgagggaaatgctgcctatactcccagatgtgt       c.*960

          .         .         .         .         .         .       g.310488
 ttagaatatctcagaaacaacactgtgtttagctcggctttctctgctaagtatgccttt       c.*1020

          .         .         .         .         .         .       g.310548
 caagtgtacaccacggagacaggaccgcgttgcaaggcgggacagcaggttcagaccaca       c.*1080

          .         .         .         .         .         .       g.310608
 gttctcagtctgactttactcttgctaggtctgtcctactagctgttgcctgctaccgcc       c.*1140

          .         .         .         .         .         .       g.310668
 catggctctccatcggactgcatgtgtccttttctagtttgcaaagactaaaatgcattc       c.*1200

          .         .         .         .         .         .       g.310728
 ccaaacctactgctaatctgagggcctcagcatcacttccagatccttgcttggagcagt       c.*1260

          .         .         .         .         .         .       g.310788
 ctctctattgactctctcagatcgctccactgctccatgggctatcaagtaactaactgc       c.*1320

          .         .         .         .         .         .       g.310848
 atacctgccgttggcatcatcagaacagtccgaagaaatagtctccactcactaattacc       c.*1380

          .         .         .         .         .         .       g.310908
 tcctatataacgacgtatgcttcctgtagttcagtagtttgctctcatcgataacgtgca       c.*1440

          .         .         .         .         .         .       g.310968
 ttgggaagtttccagactgcaaaaactaggagctcgcattcatttcccaagtgtgaccct       c.*1500

          .         .         .         .         .         .       g.311028
 tagatgcttagttgactcgctgcatatttgctcttgtcttcagaaaagaaaggaagaagt       c.*1560

          .         .         .         .         .         .       g.311088
 atcgttccaacgaaatgtttccagaaaagtgtactataaactttcattccaaaaatggtg       c.*1620

          .         .         .         .         .         .       g.311148
 tcataagcaaacaactcacttgtcaaatttcaaatggtattgaacaaaaaaagaaagctg       c.*1680

          .         .         .         .         .         .       g.311208
 ttgtgtttttgttttgttttgttttcatgaaactgtgattttcaacttatgaatgctata       c.*1740

          .         .         .         .         .         .       g.311268
 atgtcccagcgcgggaagctcacgctgtgtgaacatgaagttgtataaaacaaaccaacc       c.*1800

          .         .         .         .         .         .       g.311328
 aacctacacacaaatgttttcataggcactgtataaagaaaaatgtatgtttattaactc       c.*1860

          .         .         .         .         .         .       g.311388
 aaatcagtttttcagagaggaaacgtcactgagatgaagaggcgggtaaattggtttgtt       c.*1920

          .         .         .         .         .         .       g.311448
 attttttaaaaaaaacttgcatgtttaaaaaaaagttgattgcttcaaatttctgctact       c.*1980

          .         .         .         .         .         .       g.311508
 aacttcaagctatgggagtttggcagtagtcacttgaggattttttttccaattcttttc       c.*2040

          .         .         .         .         .         .       g.311568
 tttttgttgttaaagctgtacttcagtgaacagaaaaattgccaagcaaactaatggcta       c.*2100

          .         .         .         .         .         .       g.311628
 taaaagcgtaatttgcatgtgtgggcataaactacagagcctcattgccatgaggtattg       c.*2160

          .         .         .         .                           g.311673
 tacaaagttttaatacattttgtaaataaaattgtaaagaaagaa                      c.*2205

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, ionotropic, AMPA 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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