glutamate receptor, ionotropic, AMPA 4 (GRIA4) - coding DNA reference sequence

(used for variant description)

(last modified January 17, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000829.3 in the GRIA4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering GRIA4 transcript NM_000829.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   agtggcagaagagggctaggctgaga       c.-421

 .         .         .         .         .         .                g.5086
 gggaagccaggactgtaggagagggaggcagcccgtcctcctcacgaacctgcaaggatg       c.-361

 .         .         .         .         .         .                g.5146
 cggcaggggcctgggggcatggggaggtactaaccccccggagcccccgattggggcttg       c.-301

 .         .         .         .         .         .                g.5206
 cagacctggcccgtgggcggattttctgcctagcgcagccgagaagcagaggtgccagga       c.-241

 .         .         .         .         .         .                g.5266
 aaaccaagagaggggcgctgggggtgcccatccccagagtcggtccctctgcgaaccgag       c.-181

 .         .         .         .         .         .                g.5326
 gaagaaaagaggagggagtcagcgagtggtcagaagggaaaacctgacaccagactggct       c.-121

 .         .         .          | 02        .         .             g.5865
 ccggagcgtccgggagactggggcgctccg | cgccatcgtcttcaatgcttctctgaacag    c.-61

 .         .         .         .         .         .                g.5925
 cctttaggaagagtgcgagagaaagagagagagcgcgcgccagggagaggagaaaagaag       c.-1

          .         .         .         .         .         .       g.5985
 ATGAGGATTATTTCCAGACAGATTGTCTTGTTATTTTCTGGATTTTGGGGACTCGCCATG       c.60
 M  R  I  I  S  R  Q  I  V  L  L  F  S  G  F  W  G  L  A  M         p.20

          .         .         | 03         .         .         .    g.7235
 GGAGCCTTTCCGAGCAGCGTGCAAATAG | GTGGTCTCTTCATCCGAAACACAGATCAGGAA    c.120
 G  A  F  P  S  S  V  Q  I  G |   G  L  F  I  R  N  T  D  Q  E      p.40

          .         .         .         .         .         .       g.7295
 TACACTGCTTTTCGATTAGCAATTTTTCTTCATAACACCAGCCCCAATGCGTCGGAAGCT       c.180
 Y  T  A  F  R  L  A  I  F  L  H  N  T  S  P  N  A  S  E  A         p.60

          .         .         .         .         .         .       g.7355
 CCTTTTAATTTGGTACCTCATGTGGACAACATTGAGACAGCCAACAGTTTTGCTGTAACA       c.240
 P  F  N  L  V  P  H  V  D  N  I  E  T  A  N  S  F  A  V  T         p.80

         | 04.         .         .         .         .         .    g.147960
 AACGCCT | TCTGTTCCCAGTATTCTAGAGGAGTATTTGCCATTTTTGGACTCTATGATAAG    c.300
 N  A  F |   C  S  Q  Y  S  R  G  V  F  A  I  F  G  L  Y  D  K      p.100

          .         .         .         .         .         .       g.148020
 AGGTCGGTACATACCTTGACCTCATTCTGCAGCGCCTTACATATCTCCCTCATCACACCA       c.360
 R  S  V  H  T  L  T  S  F  C  S  A  L  H  I  S  L  I  T  P         p.120

          .         .         .         .         .         .       g.148080
 AGTTTCCCTACTGAGGGGGAGAGCCAGTTTGTGCTGCAACTAAGACCTTCGTTACGAGGA       c.420
 S  F  P  T  E  G  E  S  Q  F  V  L  Q  L  R  P  S  L  R  G         p.140

          .         .         .         .         .         .       g.148140
 GCACTCTTGAGTTTGCTGGATCACTACGAATGGAACTGTTTTGTCTTCCTGTATGACACA       c.480
 A  L  L  S  L  L  D  H  Y  E  W  N  C  F  V  F  L  Y  D  T         p.160

         | 05.         .         .         .         .         .    g.257003
 GACAGGG | GATACTCGATACTCCAAGCTATTATGGAAAAAGCAGGACAAAATGGTTGGCAT    c.540
 D  R  G |   Y  S  I  L  Q  A  I  M  E  K  A  G  Q  N  G  W  H      p.180

          .         .         .         .         .         .       g.257063
 GTCAGCGCTATATGTGTGGAAAATTTTAATGATGTCAGCTATAGGCAACTTCTAGAAGAA       c.600
 V  S  A  I  C  V  E  N  F  N  D  V  S  Y  R  Q  L  L  E  E         p.200

          .         .         .         .         .         .       g.257123
 CTTGACAGAAGACAAGAGAAGAAGTTTGTAATAGACTGTGAGATAGAGAGACTTCAAAAC       c.660
 L  D  R  R  Q  E  K  K  F  V  I  D  C  E  I  E  R  L  Q  N         p.220

          .   | 06     .         .         .         .         .    g.282493
 ATATTAGAACAG | ATTGTAAGTGTTGGAAAGCATGTTAAAGGCTACCATTATATCATTGCA    c.720
 I  L  E  Q   | I  V  S  V  G  K  H  V  K  G  Y  H  Y  I  I  A      p.240

        | 07 .         .         .         .         .         .    g.293249
 AACTTG | GGATTCAAGGATATTTCTCTTGAGAGGTTTATACATGGTGGAGCCAATGTTACT    c.780
 N  L   | G  F  K  D  I  S  L  E  R  F  I  H  G  G  A  N  V  T      p.260

          .         .         .         .         .         .       g.293309
 GGATTCCAGTTGGTGGATTTTAATACACCTATGGTAATCAAACTAATGGATCGCTGGAAG       c.840
 G  F  Q  L  V  D  F  N  T  P  M  V  I  K  L  M  D  R  W  K         p.280

          .         .         .         .      | 08  .         .    g.298755
 AAACTAGATCAGAGAGAGTATCCAGGATCTGAGACTCCTCCAAAG | TACACCTCTGCTCTG    c.900
 K  L  D  Q  R  E  Y  P  G  S  E  T  P  P  K   | Y  T  S  A  L      p.300

          .         .         .         .         .         .       g.298815
 ACTTATGATGGAGTCCTTGTGATGGCTGAAACTTTCCGAAGTCTTAGGAGGCAGAAAATT       c.960
 T  Y  D  G  V  L  V  M  A  E  T  F  R  S  L  R  R  Q  K  I         p.320

          .         .         .         .         .         .       g.298875
 GATATCTCAAGGAGAGGAAATGCTGGGGATTGTCTGGCAAATCCTGCTGCTCCATGGGGC       c.1020
 D  I  S  R  R  G  N  A  G  D  C  L  A  N  P  A  A  P  W  G         p.340

          .         .         .    | 09    .         .         .    g.300150
 CAGGGAATTGACATGGAGAGGACACTCAAACAG | GTTCGAATTCAAGGGCTGACAGGGAAT    c.1080
 Q  G  I  D  M  E  R  T  L  K  Q   | V  R  I  Q  G  L  T  G  N      p.360

          .         .         .         .         .         .       g.300210
 GTTCAGTTTGACCACTATGGACGTAGAGTCAATTACACAATGGATGTGTTTGAGCTGAAA       c.1140
 V  Q  F  D  H  Y  G  R  R  V  N  Y  T  M  D  V  F  E  L  K         p.380

          .         | 10         .         .         .         .    g.305403
 AGCACAGGACCTAGAAAG | GTTGGTTACTGGAATGATATGGATAAGTTAGTCTTGATTCAA    c.1200
 S  T  G  P  R  K   | V  G  Y  W  N  D  M  D  K  L  V  L  I  Q      p.400

          .         .         .         .         .         .       g.305463
 GATGTACCAACTCTTGGCAATGACACAGCTGCTATTGAGAACAGAACAGTGGTTGTAACC       c.1260
 D  V  P  T  L  G  N  D  T  A  A  I  E  N  R  T  V  V  V  T         p.420

           | 11        .         .         .         .         .    g.313689
 ACAATTATG | GAATCCCCATATGTTATGTACAAGAAAAATCATGAAATGTTTGAAGGAAAT    c.1320
 T  I  M   | E  S  P  Y  V  M  Y  K  K  N  H  E  M  F  E  G  N      p.440

          .         .         .         .         .         .       g.313749
 GACAAGTATGAAGGATACTGTGTAGATTTGGCATCTGAAATTGCAAAACATATTGGTATC       c.1380
 D  K  Y  E  G  Y  C  V  D  L  A  S  E  I  A  K  H  I  G  I         p.460

          .         .         .         .         .         .       g.313809
 AAGTATAAAATTGCCATTGTCCCTGATGGAAAATATGGAGCAAGGGATGCAGACACAAAA       c.1440
 K  Y  K  I  A  I  V  P  D  G  K  Y  G  A  R  D  A  D  T  K         p.480

          .         .         .       | 12 .         .         .    g.319349
 ATCTGGAATGGGATGGTAGGAGAACTTGTTTATGGG | AAAGCAGAGATTGCTATTGCCCCT    c.1500
 I  W  N  G  M  V  G  E  L  V  Y  G   | K  A  E  I  A  I  A  P      p.500

          .         .         .         .         .         .       g.319409
 CTGACAATCACTTTGGTACGAGAGGAGGTCATTGACTTTTCTAAGCCCTTCATGAGTTTG       c.1560
 L  T  I  T  L  V  R  E  E  V  I  D  F  S  K  P  F  M  S  L         p.520

          .         .         .         .         .         .       g.319469
 GGCATATCTATCATGATCAAAAAGCCTCAGAAATCCAAACCAGGAGTGTTTTCCTTCTTG       c.1620
 G  I  S  I  M  I  K  K  P  Q  K  S  K  P  G  V  F  S  F  L         p.540

          .         .         .         .         .         .       g.319529
 GATCCTCTGGCCTATGAGATTTGGATGTGCATAGTCTTTGCCTACATTGGTGTCAGCGTG       c.1680
 D  P  L  A  Y  E  I  W  M  C  I  V  F  A  Y  I  G  V  S  V         p.560

          .         .         .         .         .         .       g.319589
 GTCTTATTCCTAGTTAGTAGATTTAGTCCATATGAGTGGCACACAGAAGAGCCAGAGGAC       c.1740
 V  L  F  L  V  S  R  F  S  P  Y  E  W  H  T  E  E  P  E  D         p.580

          .         .         .         .         .         .       g.319649
 GGAAAGGAAGGACCCAGCGACCAGCCTCCCAATGAGTTTGGCATCTTTAACAGCCTCTGG       c.1800
 G  K  E  G  P  S  D  Q  P  P  N  E  F  G  I  F  N  S  L  W         p.600

          .         .         .         .        | 13.         .    g.321680
 TTTTCCCTGGGTGCTTTTATGCAGCAAGGATGTGACATTTCACCCAG | ATCCCTCTCAGGT    c.1860
 F  S  L  G  A  F  M  Q  Q  G  C  D  I  S  P  R  |  S  L  S  G      p.620

          .         .         .         .         .         .       g.321740
 CGAATTGTTGGAGGTGTTTGGTGGTTCTTTACACTCATCATTATATCATCTTATACTGCT       c.1920
 R  I  V  G  G  V  W  W  F  F  T  L  I  I  I  S  S  Y  T  A         p.640

          .         .         .         .         .         .       g.321800
 AACCTCGCTGCTTTCCTGACGGTTGAGCGAATGGTCTCTCCCATAGAAAGTGCAGAAGAC       c.1980
 N  L  A  A  F  L  T  V  E  R  M  V  S  P  I  E  S  A  E  D         p.660

          .         .         .         .         .         .       g.321860
 CTGGCCAAACAAACAGAAATTGCCTATGGAACACTGGATTCAGGATCAACAAAAGAATTC       c.2040
 L  A  K  Q  T  E  I  A  Y  G  T  L  D  S  G  S  T  K  E  F         p.680

        | 14 .         .         .         .         .         .    g.328702
 TTCAGA | AGATCAAAAATAGCAGTGTATGAAAAGATGTGGACCTACATGCGATCAGCAGAG    c.2100
 F  R   | R  S  K  I  A  V  Y  E  K  M  W  T  Y  M  R  S  A  E      p.700

          .         .         .         .         .         .       g.328762
 CCATCAGTATTCACTAGGACTACAGCTGAGGGAGTAGCTCGTGTCCGCAAATCCAAGGGC       c.2160
 P  S  V  F  T  R  T  T  A  E  G  V  A  R  V  R  K  S  K  G         p.720

          .         .         .         .         .         .       g.328822
 AAATTTGCCTTTCTCCTGGAGTCCACTATGAATGAATACATTGAGCAGCGAAAGCCATGT       c.2220
 K  F  A  F  L  L  E  S  T  M  N  E  Y  I  E  Q  R  K  P  C         p.740

          .         .         .         .         .         .       g.328882
 GACACGATGAAAGTGGGAGGAAATCTGGATTCCAAAGGCTATGGAGTAGCAACGCCCAAG       c.2280
 D  T  M  K  V  G  G  N  L  D  S  K  G  Y  G  V  A  T  P  K         p.760

          .     | 15   .         .         .         .         .    g.366887
 GGTTCCTCATTAAG | AACTCCTGTAAACCTTGCCGTTTTGAAACTCAGTGAGGCAGGCGTC    c.2340
 G  S  S  L  R  |  T  P  V  N  L  A  V  L  K  L  S  E  A  G  V      p.780

          .         .         .         .         .         .       g.366947
 TTAGACAAGCTGAAAAACAAATGGTGGTACGATAAAGGTGAATGTGGACCCAAGGACTCT       c.2400
 L  D  K  L  K  N  K  W  W  Y  D  K  G  E  C  G  P  K  D  S         p.800

           | 16        .         .         .         .         .    g.369288
 GGAAGCAAG | GACAAGACGAGTGCCTTGAGCCTGAGCAATGTAGCAGGCGTCTTCTACATT    c.2460
 G  S  K   | D  K  T  S  A  L  S  L  S  N  V  A  G  V  F  Y  I      p.820

          .         .         .         .         .         .       g.369348
 CTGGTTGGCGGCTTGGGCTTGGCAATGCTGGTGGCTTTGATAGAGTTCTGTTACAAGTCC       c.2520
 L  V  G  G  L  G  L  A  M  L  V  A  L  I  E  F  C  Y  K  S         p.840

          .         .     | 17   .         .         .         .    g.374538
 AGGGCAGAAGCGAAGAGAATGAAG | CTGACCTTTTCTGAAGCCATAAGAAACAAAGCCAGA    c.2580
 R  A  E  A  K  R  M  K   | L  T  F  S  E  A  I  R  N  K  A  R      p.860

          .         .         .         .         .         .       g.374598
 TTATCCATCACTGGGAGTGTGGGAGAGAATGGCCGCGTCTTGACGCCTGACTGCCCAAAG       c.2640
 L  S  I  T  G  S  V  G  E  N  G  R  V  L  T  P  D  C  P  K         p.880

          .         .         .         .         .         .       g.374658
 GCTGTACACACTGGAACTGCAATCAGACAAAGTTCAGGATTGGCTGTCATTGCATCGGAC       c.2700
 A  V  H  T  G  T  A  I  R  Q  S  S  G  L  A  V  I  A  S  D         p.900

                                                                    g.374667
 CTACCATAA                                                          c.2709
 L  P  X                                                            p.902

          .         .         .         .         .         .       g.374727
 aaaccaaaaaaataattgagtgccttaattaaactgttggtgactggtggaaacgcagcc       c.*60

          .         .         .         .         .         .       g.374787
 ctgagggacacgccacgcgcgggtctttgctaaaccaatcctttggctgagagcgggaag       c.*120

          .         .         .         .         .         .       g.374847
 tccgtcctaacgcgctggccggacatcagcagcagcaacgtgtgcatgagctcagctcgg       c.*180

          .         .         .         .         .         .       g.374907
 aaacccaaactcagattttatatcaggaaaactcacaattgaggtttttttcggggagtg       c.*240

          .         .         .         .         .         .       g.374967
 ggtgggggagggatctgggatgggtgtattaacagcaacaaatttcattcgagtggactc       c.*300

          .         .         .         .         .         .       g.375027
 aaaaactaatcagacttatgagttagcgcattaaactgtgaagttcttgctcagaaaggc       c.*360

          .         .         .         .         .         .       g.375087
 ctttgtcttcaccggaaaggataaaatagttgtagaagtccgtgaacatgctaacctgtg       c.*420

          .         .         .         .         .         .       g.375147
 tctccagaacatccatatagtccatggaagaaaatccagctgagaaaacaaatcactaaa       c.*480

          .         .         .         .         .         .       g.375207
 ctgtgataagaaaataatgaacaaacatgtaaaacctgtgggaaaaaaaaataaaggaag       c.*540

          .         .         .         .         .         .       g.375267
 tatgtacacttactttggagaaaacaaatactgaaacatgcttgctttttaactgacgta       c.*600

          .         .         .         .         .         .       g.375327
 aattcagtagaggacaacacaattcttttttctaaccatcttagggaacaatacattgca       c.*660

          .         .         .         .         .         .       g.375387
 ataattgatataaatgccatcactgtaataaactttagagacttttttttataaaagttg       c.*720

          .         .         .         .         .         .       g.375447
 ttggtcatcttcttgtttgctgtaaccttcactatgtcacatgagtcgattcaccgattg       c.*780

          .         .         .         .         .         .       g.375507
 catttgtctcacaaccaggaagaaaagcaaaaggaagaaaacgtttaggttcaatcatca       c.*840

          .         .         .         .         .         .       g.375567
 gtctgcggtgtagactcgaaagagatgacaggtcactcatgttaatggtattatttataa       c.*900

          .         .         .         .         .         .       g.375627
 tctcattctgtgtacaacattgtggtttttgtacccaccaaaaagaataaaacagcagat       c.*960

          .         .         .         .         .         .       g.375687
 gttcttacaatatctacagagcttaaaagttttttcttatcgttataaaagttatttgag       c.*1020

          .         .         .         .         .         .       g.375747
 aaattataagactataagagagattgtattagtggtgggccatagtggaaaatgtagcta       c.*1080

          .         .         .         .         .         .       g.375807
 gccctcattattttttgcatactaagctacccctccttttcagatctttgactcattaac       c.*1140

          .         .         .         .         .         .       g.375867
 agattaaactgtcaaagatggagtctttgagttggggaatgaatcactgtcctaacaaca       c.*1200

          .         .         .         .         .         .       g.375927
 acataccttgtaattgtgtgttgaaattttacttgactgtattttgctgcataaaattat       c.*1260

          .         .         .         .         .         .       g.375987
 gtgtctcttgggcttcttcccttattcctattgttccctttaaatcatatgaaggcattc       c.*1320

          .         .         .         .         .         .       g.376047
 ataatagcttggggtagataacaaatgaagaattagtctttgttttcaactggaaattgt       c.*1380

          .         .         .         .         .         .       g.376107
 aaagaaaattatactcatgtttatttataaaaatcaccttatgtatgaattaaactaaca       c.*1440

          .         .         .         .         .         .       g.376167
 tggttcaaaagaaggtttggttcatttgaaataataaataagtactctaatacagataaa       c.*1500

          .         .         .         .         .         .       g.376227
 aatcatgtacttagggtattggcagaaagcacaagttaggatgatttcagaagtctggcc       c.*1560

          .         .         .         .         .         .       g.376287
 ttgaaggatgagttgagttttaacaggaggagaaggtgttaagagccatatgagtgagca       c.*1620

          .         .         .         .         .         .       g.376347
 gtggcccaaagccatgcacatcagtggctcatttaaggaatgaatgccattagatgggct       c.*1680

          .         .         .         .         .         .       g.376407
 actgagagtacagggatattatggaagataaagttggaaaagctgaaggattgattttct       c.*1740

          .         .         .         .         .         .       g.376467
 tccatcaactctcaagatcccattcgccattcaatctctgtgctgcagtaagagcaatct       c.*1800

          .         .         .         .         .         .       g.376527
 taaacagtataaatcacacacacacacacacacacacacacacacacacacaagtccctc       c.*1860

          .         .         .         .         .         .       g.376587
 aggaaaaattccaagctcttgagaagatcacatgagccccttcatgacctggcgcttgct       c.*1920

          .         .         .         .         .         .       g.376647
 tatttcttccaggacttctctcacttctatccagctattcccgtcagcaaatgaacctcc       c.*1980

          .         .         .         .         .         .       g.376707
 aaagcagcacatggagcactgcatagactatttcctcagtgcgtaactcctccctgtctc       c.*2040

          .         .         .         .         .         .       g.376767
 ctctttacctgagtaacttgtactcatccttcaatactccaactgaattttacttaccct       c.*2100

          .         .         .         .         .         .       g.376827
 gaaaagatttccatggctatccaccacccccctgcctgtgagactgagttaggtgccctt       c.*2160

          .         .         .         .         .         .       g.376887
 tttcatgtctttcccccatcacggcacttaccatactgcgttgtaattgcctgtgtactc       c.*2220

          .         .         .         .         .         .       g.376947
 gtctgtataactactagactgtaagctccttgagggcagggactgtgtctatcttgttca       c.*2280

          .         .         .         .         .         .       g.377007
 cagttgtatccccagcacccagcacagtgcctggcatattgtaggtgcttaataaatatt       c.*2340

          .                                                         g.377020
 tgttgaatgaatg                                                      c.*2353

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, ionotropic, AMPA 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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