glutamate receptor, ionotropic, kainate 2 (GRIK2) - coding DNA reference sequence

(used for variant description)

(last modified August 13, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_021956.4 in the GRIK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering GRIK2 transcript NM_021956.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        gctcgcgcggccggacattgtgggtgtgcgtgctggatttctcccggatgctc       c.-241

 .         .         .         .         .         .                g.5113
 tccgactaacatggatgtcccaccattccttgcagtggaaggttgttccttggcgcagtg       c.-181

 .         .         .         .         .         .                g.5173
 agtgaagaacatgcagcgattgctaatgggtttgggaagcggagactccttcctctctct       c.-121

 .         .         .         .         .         .                g.5233
 atgaccatgccgtgatcgtgtctgcggtcaccactcgacgcatcctcatttctacccgaa       c.-61

 .         .         .         .         .         .                g.5293
 cccaggagccgaacgctagatcggggaagtgggtgccgtgcgtgtgggcacagaaacacc       c.-1

          .         .         .         .         .         .       g.5353
 ATGAAGATTATTTTCCCGATTCTAAGTAATCCAGTCTTCAGGCGCACCGTTAAACTCCTG       c.60
 M  K  I  I  F  P  I  L  S  N  P  V  F  R  R  T  V  K  L  L         p.20

          .         .         .         .         .      | 02  .    g.227968
 CTCTGTTTACTGTGGATTGGATATTCTCAAGGAACCACACATGTATTAAGATTTG | GTGGT    c.120
 L  C  L  L  W  I  G  Y  S  Q  G  T  T  H  V  L  R  F  G |   G      p.40

          .         .         .         .         .         .       g.228028
 ATTTTTGAATATGTGGAATCTGGCCCAATGGGAGCTGAGGAACTTGCATTCAGATTTGCT       c.180
 I  F  E  Y  V  E  S  G  P  M  G  A  E  E  L  A  F  R  F  A         p.60

          .         .         .         .         .         .       g.228088
 GTGAACACAATTAACAGAAACAGAACATTGCTACCCAATACTACCCTTACCTATGATACC       c.240
 V  N  T  I  N  R  N  R  T  L  L  P  N  T  T  L  T  Y  D  T         p.80

          .         .         .         .    | 03    .         .    g.232411
 CAGAAGATAAACCTTTATGATAGTTTTGAAGCATCCAAGAAAG | CCTGTGATCAGCTGTCT    c.300
 Q  K  I  N  L  Y  D  S  F  E  A  S  K  K  A |   C  D  Q  L  S      p.100

          .         .         .         .         .         .       g.232471
 CTTGGGGTGGCTGCCATCTTCGGGCCTTCACACAGCTCATCAGCAAACGCAGTGCAGTCC       c.360
 L  G  V  A  A  I  F  G  P  S  H  S  S  S  A  N  A  V  Q  S         p.120

          .         .         .         .         .         .       g.232531
 ATCTGCAATGCTCTGGGAGTTCCCCACATACAGACCCGCTGGAAGCACCAGGTGTCAGAC       c.420
 I  C  N  A  L  G  V  P  H  I  Q  T  R  W  K  H  Q  V  S  D         p.140

          .         .         .         .         .         .       g.232591
 AACAAAGATTCCTTCTATGTCAGTCTCTACCCAGACTTCTCTTCACTCAGCCGTGCCATT       c.480
 N  K  D  S  F  Y  V  S  L  Y  P  D  F  S  S  L  S  R  A  I         p.160

          .         .         .         .         .         .       g.232651
 TTAGACCTGGTGCAGTTTTTCAAGTGGAAAACCGTCACGGTTGTGTATGATGACAGCACT       c.540
 L  D  L  V  Q  F  F  K  W  K  T  V  T  V  V  Y  D  D  S  T         p.180

   | 04      .         .         .         .         .         .    g.282696
 G | GTCTCATTCGTTTGCAAGAGCTCATCAAAGCTCCATCAAGGTATAATCTTCGACTCAAA    c.600
 G |   L  I  R  L  Q  E  L  I  K  A  P  S  R  Y  N  L  R  L  K      p.200

          .         .         .         .         .         .       g.282756
 ATTCGTCAGTTACCTGCTGATACAAAGGATGCAAAACCCTTACTAAAAGAAATGAAAAGA       c.660
 I  R  Q  L  P  A  D  T  K  D  A  K  P  L  L  K  E  M  K  R         p.220

          .         .         .         .         .         .       g.282816
 GGCAAGGAGTTTCATGTAATCTTTGATTGTAGCCATGAAATGGCAGCAGGCATTTTAAAA       c.720
 G  K  E  F  H  V  I  F  D  C  S  H  E  M  A  A  G  I  L  K         p.240

     | 05    .         .         .         .         .        | 06. g.292197
 CAG | GCATTAGCTATGGGAATGATGACAGAATACTATCATTATATCTTTACCACTCTG | GAC c.780
 Q   | A  L  A  M  G  M  M  T  E  Y  Y  H  Y  I  F  T  T  L   | D   p.260

          .         .         .         .         .         .       g.292257
 CTCTTTGCTCTTGATGTTGAGCCCTACCGATACAGTGGTGTTAACATGACAGGGTTCAGA       c.840
 L  F  A  L  D  V  E  P  Y  R  Y  S  G  V  N  M  T  G  F  R         p.280

          .         .         .         .         .         .       g.292317
 ATATTAAATACAGAAAATACCCAAGTCTCCTCCATCATTGAAAAGTGGTCGATGGAACGA       c.900
 I  L  N  T  E  N  T  Q  V  S  S  I  I  E  K  W  S  M  E  R         p.300

          .         .         .         .         .  | 07      .    g.405671
 TTGCAGGCACCTCCGAAACCCGATTCAGGTTTGCTGGATGGATTTATGACG | ACTGATGCT    c.960
 L  Q  A  P  P  K  P  D  S  G  L  L  D  G  F  M  T   | T  D  A      p.320

          .         .         .         .         .         .       g.405731
 GCTCTAATGTATGATGCTGTGCATGTGGTGTCTGTGGCCGTTCAACAGTTTCCCCAGATG       c.1020
 A  L  M  Y  D  A  V  H  V  V  S  V  A  V  Q  Q  F  P  Q  M         p.340

          .         .         .         .         .         .       g.405791
 ACAGTCAGTTCCTTGCAGTGTAATCGACATAAACCCTGGCGCTTCGGGACCCGCTTTATG       c.1080
 T  V  S  S  L  Q  C  N  R  H  K  P  W  R  F  G  T  R  F  M         p.360

          .      | 08  .         .         .         .         .    g.408390
 AGTCTAATTAAAGAG | GCACATTGGGAAGGCCTCACAGGCAGAATAACTTTCAACAAAACC    c.1140
 S  L  I  K  E   | A  H  W  E  G  L  T  G  R  I  T  F  N  K  T      p.380

          .         .         .         .         .         .       g.408450
 AATGGCTTGAGAACAGATTTTGATTTGGATGTGATCAGTCTGAAGGAAGAAGGTCTAGAA       c.1200
 N  G  L  R  T  D  F  D  L  D  V  I  S  L  K  E  E  G  L  E         p.400

     | 09    .         .         .         .         .         .    g.424441
 AAG | ATTGGAACGTGGGATCCAGCCAGTGGCCTGAATATGACAGAAAGTCAAAAGGGAAAG    c.1260
 K   | I  G  T  W  D  P  A  S  G  L  N  M  T  E  S  Q  K  G  K      p.420

          .         .         .         .         .        | 10.    g.465304
 CCAGCGAACATCACAGATTCCTTATCCAATCGTTCTTTGATTGTTACCACCATTTTG | GAA    c.1320
 P  A  N  I  T  D  S  L  S  N  R  S  L  I  V  T  T  I  L   | E      p.440

          .         .         .         .         .         .       g.465364
 GAGCCTTATGTCCTTTTTAAGAAGTCTGACAAACCTCTCTATGGTAATGATCGATTTGAA       c.1380
 E  P  Y  V  L  F  K  K  S  D  K  P  L  Y  G  N  D  R  F  E         p.460

          .         .         .         .         .         .       g.465424
 GGCTATTGCATTGATCTCCTCAGAGAGTTATCTACAATCCTTGGCTTTACATATGAAATT       c.1440
 G  Y  C  I  D  L  L  R  E  L  S  T  I  L  G  F  T  Y  E  I         p.480

          .         .         .         .         .         .       g.465484
 AGACTTGTGGAAGATGGGAAATATGGAGCCCAGGATGATGCCAATGGACAATGGAATGGA       c.1500
 R  L  V  E  D  G  K  Y  G  A  Q  D  D  A  N  G  Q  W  N  G         p.500

          .         .     | 11   .         .         .         .    g.495690
 ATGGTTCGTGAACTAATTGATCAT | AAAGCTGACCTTGCAGTTGCTCCACTGGCTATTACC    c.1560
 M  V  R  E  L  I  D  H   | K  A  D  L  A  V  A  P  L  A  I  T      p.520

          .         .         .         .         .         .       g.495750
 TATGTTCGAGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACACTTGGAATAAGTATT       c.1620
 Y  V  R  E  K  V  I  D  F  S  K  P  F  M  T  L  G  I  S  I         p.540

          .         .         .         .         .         .       g.495810
 TTGTACCGCAAGCCCAATGGTACAAACCCAGGCGTCTTCTCCTTCCTGAATCCTCTCTCC       c.1680
 L  Y  R  K  P  N  G  T  N  P  G  V  F  S  F  L  N  P  L  S         p.560

          .         .         .         .         .         .       g.495870
 CCTGATATCTGGATGTATATTCTGCTGGCTTACTTGGGTGTCAGTTGTGTGCTCTTTGTC       c.1740
 P  D  I  W  M  Y  I  L  L  A  Y  L  G  V  S  C  V  L  F  V         p.580

          | 12         .         .         .         .         .    g.530667
 ATAGCCAG | GTTTAGTCCTTATGAGTGGTATAATCCACACCCTTGCAACCCTGACTCAGAC    c.1800
 I  A  R  |  F  S  P  Y  E  W  Y  N  P  H  P  C  N  P  D  S  D      p.600

          .         .         .         .         .         .       g.530727
 GTGGTGGAAAACAATTTTACCTTGCTAAATAGTTTCTGGTTTGGAGTTGGAGCTCTCATG       c.1860
 V  V  E  N  N  F  T  L  L  N  S  F  W  F  G  V  G  A  L  M         p.620

         | 13.         .         .         .         .         .    g.534482
 CAGCAAG | GTTCTGAGCTCATGCCCAAAGCACTGTCCACCAGGATAGTGGGAGGCATTTGG    c.1920
 Q  Q  G |   S  E  L  M  P  K  A  L  S  T  R  I  V  G  G  I  W      p.640

          .         .         .         .         .         .       g.534542
 TGGTTTTTCACACTTATCATCATTTCTTCGTATACTGCTAACTTAGCCGCCTTTCTGACA       c.1980
 W  F  F  T  L  I  I  I  S  S  Y  T  A  N  L  A  A  F  L  T         p.660

          .         .         .         .         .         .       g.534602
 GTGGAACGCATGGAATCCCCTATTGACTCTGCTGATGATTTAGCTAAACAAACCAAGATA       c.2040
 V  E  R  M  E  S  P  I  D  S  A  D  D  L  A  K  Q  T  K  I         p.680

          .         .         .         .      | 14  .         .    g.641370
 GAATATGGAGCAGTAGAGGATGGTGCAACCATGACTTTTTTCAAG | AAATCAAAAATCTCC    c.2100
 E  Y  G  A  V  E  D  G  A  T  M  T  F  F  K   | K  S  K  I  S      p.700

          .         .         .         .         .         .       g.641430
 ACGTATGACAAAATGTGGGCCTTTATGAGTAGCAGAAGGCAGTCAGTGCTGGTCAAAAGT       c.2160
 T  Y  D  K  M  W  A  F  M  S  S  R  R  Q  S  V  L  V  K  S         p.720

          .         .         .         .         .         .       g.641490
 AATGAAGAAGGAATCCAGCGAGTCCTCACCTCTGATTATGCTTTCCTAATGGAGTCAACA       c.2220
 N  E  E  G  I  Q  R  V  L  T  S  D  Y  A  F  L  M  E  S  T         p.740

          .         .         .         .         .         .       g.641550
 ACCATCGAGTTTGTTACCCAGCGGAACTGTAACCTGACACAGATTGGCGGCCTTATAGAC       c.2280
 T  I  E  F  V  T  Q  R  N  C  N  L  T  Q  I  G  G  L  I  D         p.760

          .         .         .  | 15      .         .         .    g.661373
 TCTAAAGGTTATGGCGTTGGCACTCCCATGG | GTTCTCCATATCGAGACAAAATTACCATA    c.2340
 S  K  G  Y  G  V  G  T  P  M  G |   S  P  Y  R  D  K  I  T  I      p.780

          .         .         .         .         .         .       g.661433
 GCAATTCTTCAGCTGCAAGAGGAAGGCAAACTGCATATGATGAAGGAGAAATGGTGGAGG       c.2400
 A  I  L  Q  L  Q  E  E  G  K  L  H  M  M  K  E  K  W  W  R         p.800

          .         .         .         .         .         .       g.661493
 GGCAATGGTTGCCCAGAAGAGGAGAGCAAAGAGGCCAGTGCCCTGGGGGTTCAGAATATT       c.2460
 G  N  G  C  P  E  E  E  S  K  E  A  S  A  L  G  V  Q  N  I         p.820

          .         .         .         .         .         .       g.661553
 GGTGGCATCTTCATTGTTCTGGCAGCCGGCTTGGTGCTTTCAGTTTTTGTGGCAGTGGGA       c.2520
 G  G  I  F  I  V  L  A  A  G  L  V  L  S  V  F  V  A  V  G         p.840

          .         .         .         .   | 16     .         .    g.674379
 GAATTTTTATACAAATCCAAAAAAAACGCTCAATTGGAAAAG | AGGTCCTTCTGTAGTGCC    c.2580
 E  F  L  Y  K  S  K  K  N  A  Q  L  E  K   | R  S  F  C  S  A      p.860

          .         .         .         .         .         .       g.674439
 ATGGTAGAAGAATTGAGGATGTCCCTGAAGTGCCAGCGTCGGTTAAAACATAAGCCACAG       c.2640
 M  V  E  E  L  R  M  S  L  K  C  Q  R  R  L  K  H  K  P  Q         p.880

          .         .         .         .         .         .       g.674499
 GCCCCAGTTATTGTGAAAACAGAAGAAGTTATCAACATGCACACATTTAACGACAGAAGG       c.2700
 A  P  V  I  V  K  T  E  E  V  I  N  M  H  T  F  N  D  R  R         p.900

          .         .                                               g.674526
 TTGCCAGGTAAAGAAACCATGGCATAA                                        c.2727
 L  P  G  K  E  T  M  A  X                                          p.908

          .         .         .         .         .         .       g.674586
 agctgggaggccaaacacccaagcacaaactgtcgtctttttccaaacaatttagccaga       c.*60

          .         .         .         .         .         .       g.674646
 atgtttcctgtggaaatatgcaacctgtgcaaaataaaatgagttacctcatgccgctgt       c.*120

          .         .         .         .         .         .       g.674706
 gtctatgaactagagactctgtgatctaagcagttgcaatgatcagacttgatttacaag       c.*180

          .         .         .         .         .         .       g.674766
 catcatggatcaaccaagttacacggggttacactgttaatcatgggttcctcccttctt       c.*240

          .         .         .         .         .         .       g.674826
 ctgagtgaatgttaacatgcgcattttgtggctgatttcaaatgcagtccagtgagaaat       c.*300

          .         .         .         .         .         .       g.674886
 tacaggttccttttgaagctcaactgttgccaggagatggaatatcaatgcccaacaggg       c.*360

          .         .         .         .         .         .       g.674946
 caaccaataaaagtgtcactaagaatataaatatttggaatcagcaaaaactgtagtgtt       c.*420

          .         .         .         .         .         .       g.675006
 acaggaaacagtacagtcttctgaacacccagatcatagaggtgatgatgttactagccc       c.*480

          .         .         .         .         .         .       g.675066
 ccaactactcagtataattattgtctgaatgcaaagtatgtgtttataggatgtgaaaaa       c.*540

          .         .         .         .         .         .       g.675126
 atgtaatgcaaaacaaatttgaatcccatggcagttggaatataaagcagatgttcatca       c.*600

          .         .         .         .         .         .       g.675186
 cttattttccttttttcttttcttatttttttttttgacagtctgtgtcactgattgaga       c.*660

          .         .         .         .         .         .       g.675246
 tagaaatgccaattatcaaggaaataatgttttcttaagttccctaaggcagaagattta       c.*720

          .         .         .         .         .         .       g.675306
 acatgcaattctaccagatcccttcctattcccccaacaccttttctctaacccccatat       c.*780

          .         .         .         .         .         .       g.675366
 cccaaataataataataataataataataataataataataataataaaagcagttggtt       c.*840

          .         .         .         .         .         .       g.675426
 cagtgattctgaattaaaaggataatgttttgcaatgttcaagttgtaaaaactggccga       c.*900

          .         .         .         .         .         .       g.675486
 gtattggctgtgtggaagactaaagctttcattctaacattcagacatagcaatccaaac       c.*960

          .         .         .         .         .         .       g.675546
 ccttgttcctgctgtaaatgaacttgatggagcatgggcagatttcagtgatacgagaaa       c.*1020

          .         .         .         .         .         .       g.675606
 ggggactggtcatctatagaaaaatctgtgagagaacttggaagtggactgcgtttatca       c.*1080

          .         .         .         .         .         .       g.675666
 atacagtcacaatgttaaatgaacaaaattcttgaacagttttttttcaaaaaatgttca       c.*1140

          .         .         .         .         .         .       g.675726
 ggtttatttgtggaaatgcaagatttctatgaaaatagtttttgtatggaaatttttgta       c.*1200

          .         .         .         .         .         .       g.675786
 atactttttatcaacaaaacaagaacatgtgttcctgtcaggggtgtgatgtcaagcatg       c.*1260

          .         .         .         .         .         .       g.675846
 aatggtagtgcgtgtgcaccaccaacgtttggtgaaaactatttttatcaagaaaaaagg       c.*1320

          .         .         .         .         .         .       g.675906
 aatcatagaagagaaatattttcaagttagataatataaaagctaggtgcactaccacca       c.*1380

          .         .         .         .         .         .       g.675966
 ctgcttaccatgccacacccctggtttccacgaggctgacaacatactgtaatgaacaat       c.*1440

          .         .         .         .         .         .       g.676026
 tgtgtgtaaaatggtaaaagacacagacctcttgacaacattgtgataacagttgagtgc       c.*1500

          .         .         .         .         .         .       g.676086
 acacagtttgctgtttgaatccaatgcacaaaattaaaaaaaatcattaaaactatgttc       c.*1560

          .                                                         g.676098
 attttactttca                                                       c.*1572

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, ionotropic, kainate 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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