glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1) - coding DNA reference sequence

(used for variant description)

(last modified November 14, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_007327.3 in the GRIN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011507.1, covering GRIN1 transcript NM_007327.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5030
                               gtcgccgcagcgtccggaccggaaccagcg       c.-301

 .         .         .         .         .         .                g.5090
 ccgtccgcggagccgccgccgccgccgccgggccctttccaagccgggcgctcggagctg       c.-241

 .         .         .         .         .         .                g.5150
 tgcccggccccgcttcagcaccgcggacagcgccggccgcgtggggctgagccccgagcc       c.-181

 .         .         .         .         .         .                g.5210
 cccgcgcacgcttcagcgccccttccctcggccgacgtcccgggaccgccgctccggggg       c.-121

 .         .         .         .         .         .                g.5270
 agacgtggcgtccgcagcccgcggggccgggcgagcgcaggacggcccggaagccccgcg       c.-61

 .         .         .         .         .         .                g.5330
 ggggatgcgccgagggccccgcgttcgcgccgcgcagagccaggcccgcggcccgagccc       c.-1

          .         .         .         .         .         .       g.5390
 ATGAGCACCATGCGCCTGCTGACGCTCGCCCTGCTGTTCTCCTGCTCCGTCGCCCGTGCC       c.60
 M  S  T  M  R  L  L  T  L  A  L  L  F  S  C  S  V  A  R  A         p.20

          .         .         .         .         .         .       g.5450
 GCGTGCGACCCCAAGATCGTCAACATTGGCGCGGTGCTGAGCACGCGGAAGCACGAGCAG       c.120
 A  C  D  P  K  I  V  N  I  G  A  V  L  S  T  R  K  H  E  Q         p.40

          .         .         .         .         .         .       g.5510
 ATGTTCCGCGAGGCCGTGAACCAGGCCAACAAGCGGCACGGCTCCTGGAAGATTCAGCTC       c.180
 M  F  R  E  A  V  N  Q  A  N  K  R  H  G  S  W  K  I  Q  L         p.60

          .         .         .         .         .         .       g.5570
 AATGCCACCTCCGTCACGCACAAGCCCAACGCCATCCAGATGGCTCTGTCGGTGTGCGAG       c.240
 N  A  T  S  V  T  H  K  P  N  A  I  Q  M  A  L  S  V  C  E         p.80

          .         | 02         .         .         .         .    g.7898
 GACCTCATCTCCAGCCAG | GTCTACGCCATCCTAGTTAGCCATCCACCTACCCCCAACGAC    c.300
 D  L  I  S  S  Q   | V  Y  A  I  L  V  S  H  P  P  T  P  N  D      p.100

          .         .         .         .         .         .       g.7958
 CACTTCACTCCCACCCCTGTCTCCTACACAGCCGGCTTCTACCGCATACCCGTGCTGGGG       c.360
 H  F  T  P  T  P  V  S  Y  T  A  G  F  Y  R  I  P  V  L  G         p.120

          .         .         .    | 03    .         .         .    g.11596
 CTGACCACCCGCATGTCCATCTACTCGGACAAG | AGCATCCACCTGAGCTTCCTGCGCACC    c.420
 L  T  T  R  M  S  I  Y  S  D  K   | S  I  H  L  S  F  L  R  T      p.140

          .         .         .         .         .         .       g.11656
 GTGCCGCCCTACTCCCACCAGTCCAGCGTGTGGTTTGAGATGATGCGTGTCTACAGCTGG       c.480
 V  P  P  Y  S  H  Q  S  S  V  W  F  E  M  M  R  V  Y  S  W         p.160

          .         .         .         .         .         .       g.11716
 AACCACATCATCCTGCTGGTCAGCGACGACCACGAGGGCCGGGCGGCTCAGAAACGCCTG       c.540
 N  H  I  I  L  L  V  S  D  D  H  E  G  R  A  A  Q  K  R  L         p.180

          .         .         . | 04       .         .         .    g.14882
 GAGACGCTGCTGGAGGAGCGTGAGTCCAAG | GCAGAGAAGGTGCTGCAGTTTGACCCAGGG    c.600
 E  T  L  L  E  E  R  E  S  K   | A  E  K  V  L  Q  F  D  P  G      p.200

          .         .         .         .         .         .       g.14942
 ACCAAGAACGTGACGGCCCTGCTGATGGAGGCGAAAGAGCTGGAGGCCCGGGTCATCATC       c.660
 T  K  N  V  T  A  L  L  M  E  A  K  E  L  E  A  R  V  I  I         p.220

          .  | 05      .         .         .         .         .    g.22561
 CTTTCTGCCAG | CGAGGACGATGCTGCCACTGTATACCGCGCAGCCGCGATGCTGAACATG    c.720
 L  S  A  S  |  E  D  D  A  A  T  V  Y  R  A  A  A  M  L  N  M      p.240

          .         .         .         .         .         .       g.22621
 ACGGGCTCCGGGTACGTGTGGCTGGTCGGCGAGCGCGAGATCTCGGGGAACGCCCTGCGC       c.780
 T  G  S  G  Y  V  W  L  V  G  E  R  E  I  S  G  N  A  L  R         p.260

          .    | 06    .         .         .         .         .    g.22753
 TACGCCCCAGACG | GCATCCTCGGGCTGCAGCTCATCAACGGCAAGAACGAGTCGGCCCAC    c.840
 Y  A  P  D  G |   I  L  G  L  Q  L  I  N  G  K  N  E  S  A  H      p.280

          .         .         .         .         .         .       g.22813
 ATCAGCGACGCCGTGGGCGTGGTGGCCCAGGCCGTGCACGAGCTCCTCGAGAAGGAGAAC       c.900
 I  S  D  A  V  G  V  V  A  Q  A  V  H  E  L  L  E  K  E  N         p.300

          .         .         .         .         .         .       g.22873
 ATCACCGACCCGCCGCGGGGCTGCGTGGGCAACACCAACATCTGGAAGACCGGGCCGCTC       c.960
 I  T  D  P  P  R  G  C  V  G  N  T  N  I  W  K  T  G  P  L         p.320

          | 07         .         .         .         .         .    g.24274
 TTCAAGAG | AGTGCTGATGTCTTCCAAGTATGCGGATGGGGTGACTGGTCGCGTGGAGTTC    c.1020
 F  K  R  |  V  L  M  S  S  K  Y  A  D  G  V  T  G  R  V  E  F      p.340

          .         .         .         .         .         .       g.24334
 AATGAGGATGGGGACCGGAAGTTCGCCAACTACAGCATCATGAACCTGCAGAACCGCAAG       c.1080
 N  E  D  G  D  R  K  F  A  N  Y  S  I  M  N  L  Q  N  R  K         p.360

          .         .         .    | 08    .         .         .    g.24491
 CTGGTGCAAGTGGGCATCTACAATGGCACCCAC | GTCATCCCTAATGACAGGAAGATCATC    c.1140
 L  V  Q  V  G  I  Y  N  G  T  H   | V  I  P  N  D  R  K  I  I      p.380

          .         .         .         .         .        | 09.    g.26902
 TGGCCAGGCGGAGAGACAGAGAAGCCTCGAGGGTACCAGATGTCCACCAGACTGAAG | ATT    c.1200
 W  P  G  G  E  T  E  K  P  R  G  Y  Q  M  S  T  R  L  K   | I      p.400

          .         .         .         .         .         .       g.26962
 GTGACGATCCACCAGGAGCCCTTCGTGTACGTCAAGCCCACGCTGAGTGATGGGACATGC       c.1260
 V  T  I  H  Q  E  P  F  V  Y  V  K  P  T  L  S  D  G  T  C         p.420

          .         .         .         .         .         .       g.27022
 AAGGAGGAGTTCACAGTCAACGGCGACCCAGTCAAGAAGGTGATCTGCACCGGGCCCAAC       c.1320
 K  E  E  F  T  V  N  G  D  P  V  K  K  V  I  C  T  G  P  N         p.440

          .          | 10        .         .         .         .    g.27173
 GACACGTCGCCGGGCAGCC | CCCGCCACACGGTGCCTCAGTGTTGCTACGGCTTTTGCATC    c.1380
 D  T  S  P  G  S  P |   R  H  T  V  P  Q  C  C  Y  G  F  C  I      p.460

          .         .         .         .         .         .       g.27233
 GACCTGCTCATCAAGCTGGCACGGACCATGAACTTCACCTACGAGGTGCACCTGGTGGCA       c.1440
 D  L  L  I  K  L  A  R  T  M  N  F  T  Y  E  V  H  L  V  A         p.480

          .         .        | 11.         .         .         .    g.27800
 GATGGCAAGTTCGGCACACAGGAGCGG | GTGAACAACAGCAACAAGAAGGAGTGGAATGGG    c.1500
 D  G  K  F  G  T  Q  E  R   | V  N  N  S  N  K  K  E  W  N  G      p.500

          .         .         .         .         .         .       g.27860
 ATGATGGGCGAGCTGCTCAGCGGGCAGGCAGACATGATCGTGGCGCCGCTAACCATAAAC       c.1560
 M  M  G  E  L  L  S  G  Q  A  D  M  I  V  A  P  L  T  I  N         p.520

          .         .         .         .         .         .       g.27920
 AACGAGCGCGCGCAGTACATCGAGTTTTCCAAGCCCTTCAAGTACCAGGGCCTGACTATT       c.1620
 N  E  R  A  Q  Y  I  E  F  S  K  P  F  K  Y  Q  G  L  T  I         p.540

          .   | 12     .         .         .         .         .    g.28063
 CTGGTCAAGAAG | GAGATTCCCCGGAGCACGCTGGACTCGTTCATGCAGCCGTTCCAGAGC    c.1680
 L  V  K  K   | E  I  P  R  S  T  L  D  S  F  M  Q  P  F  Q  S      p.560

          .         .         .         .         .         .       g.28123
 ACACTGTGGCTGCTGGTGGGGCTGTCGGTGCACGTGGTGGCCGTGATGCTGTACCTGCTG       c.1740
 T  L  W  L  L  V  G  L  S  V  H  V  V  A  V  M  L  Y  L  L         p.580

          .  | 13      .         .         .         .         .    g.28296
 GACCGCTTCAG | CCCCTTCGGCCGGTTCAAGGTGAACAGCGAGGAGGAGGAGGAGGACGCA    c.1800
 D  R  F  S  |  P  F  G  R  F  K  V  N  S  E  E  E  E  E  D  A      p.600

          .         .         .         .         .         .       g.28356
 CTGACCCTGTCCTCGGCCATGTGGTTCTCCTGGGGCGTCCTGCTCAACTCCGGCATCGGG       c.1860
 L  T  L  S  S  A  M  W  F  S  W  G  V  L  L  N  S  G  I  G         p.620

      | 14   .         .         .         .         .         .    g.28490
 GAAG | GCGCCCCCAGAAGCTTCTCAGCGCGCATCCTGGGCATGGTGTGGGCCGGCTTTGCC    c.1920
 E  G |   A  P  R  S  F  S  A  R  I  L  G  M  V  W  A  G  F  A      p.640

          .         .         .         .         .         .       g.28550
 ATGATCATCGTGGCCTCCTACACCGCCAACCTGGCGGCCTTCCTGGTGCTGGACCGGCCG       c.1980
 M  I  I  V  A  S  Y  T  A  N  L  A  A  F  L  V  L  D  R  P         p.660

          .         .         .    | 15    .         .         .    g.28716
 GAGGAGCGCATCACGGGCATCAACGACCCTCGG | CTGAGGAACCCCTCGGACAAGTTTATC    c.2040
 E  E  R  I  T  G  I  N  D  P  R   | L  R  N  P  S  D  K  F  I      p.680

          .         .         .         .         .         .       g.28776
 TACGCCACGGTGAAGCAGAGCTCCGTGGATATCTACTTCCGGCGCCAGGTGGAGCTGAGC       c.2100
 Y  A  T  V  K  Q  S  S  V  D  I  Y  F  R  R  Q  V  E  L  S         p.700

          .         .         .         .         .         .       g.28836
 ACCATGTACCGGCATATGGAGAAGCACAACTACGAGAGTGCGGCGGAGGCCATCCAGGCC       c.2160
 T  M  Y  R  H  M  E  K  H  N  Y  E  S  A  A  E  A  I  Q  A         p.720

          .  | 16      .         .         .         .         .    g.29061
 GTGAGAGACAA | CAAGCTGCATGCCTTCATCTGGGACTCGGCGGTGCTGGAGTTCGAGGCC    c.2220
 V  R  D  N  |  K  L  H  A  F  I  W  D  S  A  V  L  E  F  E  A      p.740

          .         .         .         .         .         .       g.29121
 TCGCAGAAGTGCGACCTGGTGACGACTGGAGAGCTGTTTTTCCGCTCGGGCTTCGGCATA       c.2280
 S  Q  K  C  D  L  V  T  T  G  E  L  F  F  R  S  G  F  G  I         p.760

          .         .         .         .         .    | 17    .    g.29409
 GGCATGCGCAAAGACAGCCCCTGGAAGCAGAACGTCTCCCTGTCCATCCTCAA | GTCCCAC    c.2340
 G  M  R  K  D  S  P  W  K  Q  N  V  S  L  S  I  L  K  |  S  H      p.780

          .         .         .         .         .         .       g.29469
 GAGAATGGCTTCATGGAAGACCTGGACAAGACGTGGGTTCGGTATCAGGAATGTGACTCG       c.2400
 E  N  G  F  M  E  D  L  D  K  T  W  V  R  Y  Q  E  C  D  S         p.800

          .         .         .         .    | 18    .         .    g.29619
 CGCAGCAACGCCCCTGCGACCCTTACTTTTGAGAACATGGCCG | GGGTCTTCATGCTGGTA    c.2460
 R  S  N  A  P  A  T  L  T  F  E  N  M  A  G |   V  F  M  L  V      p.820

          .         .         .         .         .         .       g.29679
 GCTGGGGGCATCGTGGCCGGGATCTTCCTGATTTTCATCGAGATTGCCTACAAGCGGCAC       c.2520
 A  G  G  I  V  A  G  I  F  L  I  F  I  E  I  A  Y  K  R  H         p.840

          .         .         .         .         .         .       g.29739
 AAGGATGCTCGCCGGAAGCAGATGCAGCTGGCCTTTGCCGCCGTTAACGTGTGGCGGAAG       c.2580
 K  D  A  R  R  K  Q  M  Q  L  A  F  A  A  V  N  V  W  R  K         p.860

           | 19        .         .         .         .         .    g.31080
 AACCTGCAG | GATAGAAAGAGTGGTAGAGCAGAGCCTGACCCTAAAAAGAAAGCCACATTT    c.2640
 N  L  Q   | D  R  K  S  G  R  A  E  P  D  P  K  K  K  A  T  F      p.880

          .         .         .         .         .         .       g.31140
 AGGGCTATCACCTCCACCCTGGCTTCCAGCTTCAAGAGGCGTAGGTCCTCCAAAGACACG       c.2700
 R  A  I  T  S  T  L  A  S  S  F  K  R  R  R  S  S  K  D  T         p.900

  | 20       .         .         .         .         .         .    g.33314
  | AGCACCGGGGGTGGACGCGGCGCTTTGCAAAACCAAAAAGACACAGTGCTGCCGCGACGC    c.2760
  | S  T  G  G  G  R  G  A  L  Q  N  Q  K  D  T  V  L  P  R  R      p.920

          .         .         .         .         .                 g.33371
 GCTATTGAGAGGGAGGAGGGCCAGCTGCAGCTGTGTTCCCGTCATAGGGAGAGCTGA          c.2817
 A  I  E  R  E  E  G  Q  L  Q  L  C  S  R  H  R  E  S  X            p.938

          .         .         .         .         .         .       g.33431
 gactccccgcccgccctcctctgccccctcccccgcagacagacagacagacggacggga       c.*60

          .         .         .         .         .         .       g.33491
 cagcggcccggcccacgcagagccccggagcaccacggggtcgggggaggagcaccccca       c.*120

          .         .         .         .         .         .       g.33551
 gcctcccccaggctgcgcctgcccgcccgccggttggccggctggccggtccaccccgtc       c.*180

          .         .         .         .         .         .       g.33611
 ccggccccgcgcgtgcccccagcgtggggctaacgggcgccttgtctgtgtatttctatt       c.*240

          .         .         .         .         .         .       g.33671
 ttgcagcagtaccatcccactgatatcacgggcccgctcaacctctcagatccctcggtc       c.*300

          .         .         .         .         .         .       g.33731
 agcaccgtggtgtgaggcccccggaggcgcccacctgcccagttagcccggccaaggaca       c.*360

          .         .         .         .         .         .       g.33791
 ctgatgggtcctgctgctcgggaaggcctgagggaagcccacccgccccagagactgccc       c.*420

          .         .         .         .         .         .       g.33851
 accctgggcctcccgtccgtccgcccgcccaccccgctgcctggcgggcagcccctgctg       c.*480

          .         .         .         .         .         .       g.33911
 gaccaaggtgcggaccggagcggctgaggacggggcagagctgagtcggctgggcagggc       c.*540

          .         .         .         .         .         .       g.33971
 cgcagggcgctccggcagaggcagggccctggggtctctgagcagtggggagcgggggct       c.*600

          .         .         .         .         .         .       g.34031
 aactggccccaggcggaggggcttggagcagagacggcagccccatccttcccgcagcac       c.*660

          .         .         .         .         .         .       g.34091
 cagcctgagccacagtggggcccatggccccagctggctgggtcgcccctcctcgggcgc       c.*720

          .         .         .         .         .         .       g.34151
 ctgcgctcctctgcagcctgagctccaccctcccctcttcttgcggcaccgcccacccac       c.*780

          .         .         .         .         .         .       g.34211
 accccgtctgccccttgaccccacacgccggggctggccctgccctcccccacggccgtc       c.*840

          .         .         .         .         .         .       g.34271
 cctgacttcccagctggcagcgcctcccgccgcctcgggccgcctcctccagactcgaga       c.*900

          .         .         .         .         .         .       g.34331
 gggctgagcccctcctctcctcgtccggcctgcagcccagaacgggcctccccgggggtc       c.*960

          .         .         .         .         .         .       g.34391
 cccggacgctggctcgggactgtcttcaaccctgccctgcaccttgggcacgggagagcg       c.*1020

          .         .         .         .         .         .       g.34451
 ccacccgcccgcccccgccctcgctccgggtgcgtgaccggcccgccaccttgtacagaa       c.*1080

          .         .         .         .         .         .       g.34511
 ccagcactcccagggcccgagcgcgtgccttccccgtgcggcccgtgcgcagccgcgctc       c.*1140

          .         .         .         .         .         .       g.34571
 tgcccctccgtccccagggtgcaggcgcgcaccgcccaacccccacctcccggtgtatgc       c.*1200

          .         .         .                                     g.34606
 agtggtgatgcctaaaggaatgtcacgcagttttc                                c.*1235

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, ionotropic, N-methyl D-aspartate 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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