G protein-coupled receptor kinase 1 (GRK1) - coding DNA reference sequence

(used for variant description)

(last modified January 27, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002929.2 in the GRK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.11, covering GRK1 transcript NM_002929.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             acgggccacaggccaagggcagcagtcaggcctgctctgtctgtgaac       c.-61

 .         .         .         .         .         .                g.5108
 gctcccggcttggcctcggctgatgggccctcacgcctgaagcgggcaggaagctccggg       c.-1

          .         .         .         .         .         .       g.5168
 ATGGATTTCGGGTCTTTGGAGACCGTGGTGGCCAACTCTGCCTTCATCGCCGCCCGAGGC       c.60
 M  D  F  G  S  L  E  T  V  V  A  N  S  A  F  I  A  A  R  G         p.20

          .         .         .         .         .         .       g.5228
 AGCTTTGACGGCAGCAGCTCCCAACCCTCCCGGGACAAGAAGTACCTGGCCAAGCTCAAG       c.120
 S  F  D  G  S  S  S  Q  P  S  R  D  K  K  Y  L  A  K  L  K         p.40

          .         .         .         .         .         .       g.5288
 CTGCCCCCGCTGTCCAAGTGTGAGTCCCTCCGCGACAGCCTCAGCCTGGAGTTTGAGAGT       c.180
 L  P  P  L  S  K  C  E  S  L  R  D  S  L  S  L  E  F  E  S         p.60

          .         .         .         .         .         .       g.5348
 GTGTGCTTGGAGCAGCCCATCGGCAAGAAGCTCTTTCAGCAGTTCCTACAATCGGCAGAG       c.240
 V  C  L  E  Q  P  I  G  K  K  L  F  Q  Q  F  L  Q  S  A  E         p.80

          .         .         .         .         .         .       g.5408
 AAGCACCTGCCGGCCCTGGAGCTCTGGAAAGACATCGAGGACTATGACACGGCAGACAAT       c.300
 K  H  L  P  A  L  E  L  W  K  D  I  E  D  Y  D  T  A  D  N         p.100

          .         .         .         .         .         .       g.5468
 GACCTCCAGCCACAGAAGGCCCAGACCATCCTGGCCCAGTACCTGGACCCCCAGGCCAAA       c.360
 D  L  Q  P  Q  K  A  Q  T  I  L  A  Q  Y  L  D  P  Q  A  K         p.120

          .         .         .         .         .         .       g.5528
 CTCTTCTGCAGCTTCCTGGATGAGGGGATAGTGGCGAAGTTTAAGGAGGGGCCTGTGGAG       c.420
 L  F  C  S  F  L  D  E  G  I  V  A  K  F  K  E  G  P  V  E         p.140

          .         .         .         .         .         .       g.5588
 ATCCAGGACGGGCTCTTCCAGCCCCTGCTGCAGGCCACCCTGGCACACCTGGGCCAAGCC       c.480
 I  Q  D  G  L  F  Q  P  L  L  Q  A  T  L  A  H  L  G  Q  A         p.160

          .         .         .         .         .         .       g.5648
 CCCTTCCAGGAGTACCTGGGCAGCCTGTACTTCCTGAGGTTCCTGCAGTGGAAGTGGCTG       c.540
 P  F  Q  E  Y  L  G  S  L  Y  F  L  R  F  L  Q  W  K  W  L         p.180

          .         .         .         .         .         .       g.5708
 GAAGCCCAGCCCATGGGGGAGGACTGGTTCCTGGACTTCAGGGTCCTAGGGAAAGGGGGC       c.600
 E  A  Q  P  M  G  E  D  W  F  L  D  F  R  V  L  G  K  G  G         p.200

          .         .         .         .         .         .       g.5768
 TTCGGGGAGGTGTCGGCCTGCCAGATGAAGGCGACCGGCAAGCTGTATGCCTGCAAGAAG       c.660
 F  G  E  V  S  A  C  Q  M  K  A  T  G  K  L  Y  A  C  K  K         p.220

          .         .         .          | 02        .         .    g.7429
 CTGAACAAGAAGCGGCTGAAGAAGAGGAAGGGCTACCAG | GGTGCTATGGTGGAGAAGAAG    c.720
 L  N  K  K  R  L  K  K  R  K  G  Y  Q   | G  A  M  V  E  K  K      p.240

          .         .         .         .         .         .       g.7489
 ATTCTGATGAAAGTACACAGCAGGTTCATCGTGTCTCTGGCCTATGCGTTTGAAACCAAA       c.780
 I  L  M  K  V  H  S  R  F  I  V  S  L  A  Y  A  F  E  T  K         p.260

          .         .         .         .        | 03.         .    g.9233
 GCCGACCTCTGTCTGGTGATGACCATCATGAACGGAGGTGACATCAG | GTACCACATCTAC    c.840
 A  D  L  C  L  V  M  T  I  M  N  G  G  D  I  R  |  Y  H  I  Y      p.280

          .         .         .         .         .         .       g.9293
 AACGTGAATGAGGAGAACCCTGGCTTCCCGGAGCCGCGCGCCCTCTTCTACACGGCGCAG       c.900
 N  V  N  E  E  N  P  G  F  P  E  P  R  A  L  F  Y  T  A  Q         p.300

          .         .         .         .         .         .       g.9353
 ATCATCTGCGGCCTGGAGCACCTGCACCAGAGGCGGATCGTCTACCGCGACCTCAAGCCC       c.960
 I  I  C  G  L  E  H  L  H  Q  R  R  I  V  Y  R  D  L  K  P         p.320

          .         .      | 04  .         .         .         .    g.109488
 GAGAACGTGCTGCTGGACAATGACG | GCAATGTCCGGATCTCTGACCTTGGGCTGGCCGTG    c.1020
 E  N  V  L  L  D  N  D  G |   N  V  R  I  S  D  L  G  L  A  V      p.340

          .         .         .         .          | 05        .    g.117609
 GAGCTGCTGGACGGACAGAGCAAGACCAAGGGCTACGCAGGGACCCCAG | GTTTCATGGCC    c.1080
 E  L  L  D  G  Q  S  K  T  K  G  Y  A  G  T  P  G |   F  M  A      p.360

          .         .         .         .         .         .       g.117669
 CCCGAGCTCCTGCAGGGCGAGGAGTACGACTTCTCCGTGGACTACTTTGCCCTGGGGGTC       c.1140
 P  E  L  L  Q  G  E  E  Y  D  F  S  V  D  Y  F  A  L  G  V         p.380

          .         .         .         .         .     | 06   .    g.119269
 ACCCTGTATGAGATGATTGCGGCCAGAGGACCCTTCCGAGCCCGTGGAGAGAAG | GTGGAG    c.1200
 T  L  Y  E  M  I  A  A  R  G  P  F  R  A  R  G  E  K   | V  E      p.400

          .         .         .         .         .         .       g.119329
 AACAAGGAGCTGAAGCACCGGATCATCTCAGAGCCCGTGAAGTACCCTGATAAGTTCAGC       c.1260
 N  K  E  L  K  H  R  I  I  S  E  P  V  K  Y  P  D  K  F  S         p.420

          .         .         .         .         .         .       g.119389
 CAGGCCAGCAAGGACTTCTGCGAGGCGCTGCTGGAGAAGGACCCGGAGAAGCGCCTGGGG       c.1320
 Q  A  S  K  D  F  C  E  A  L  L  E  K  D  P  E  K  R  L  G         p.440

          .         .         .         .         .         .       g.119449
 TTCAGAGATGAGACCTGCGACAAGCTCCGTGCCCACCCCCTCTTCAAGGACCTTAACTGG       c.1380
 F  R  D  E  T  C  D  K  L  R  A  H  P  L  F  K  D  L  N  W         p.460

          .       | 07 .         .         .         .         .    g.121491
 AGGCAGCTGGAGGCTG | GGATGCTGATGCCCCCTTTCATCCCAGACTCCAAAACTGTCTAC    c.1440
 R  Q  L  E  A  G |   M  L  M  P  P  F  I  P  D  S  K  T  V  Y      p.480

          .         .         .         .         .         .       g.121551
 GCAAAGGATATTCAGGACGTGGGTGCCTTTTCCACCGTCAAAGGTGTGGCCTTTGACAAA       c.1500
 A  K  D  I  Q  D  V  G  A  F  S  T  V  K  G  V  A  F  D  K         p.500

          .         .         .         .         .         .       g.121611
 ACAGACACAGAATTCTTTCAGGAATTTGCCACTGGCAACTGCCCCATCCCCTGGCAGGAG       c.1560
 T  D  T  E  F  F  Q  E  F  A  T  G  N  C  P  I  P  W  Q  E         p.520

          .         .         .         .         .         .       g.121671
 GAGATGATCGAGACGGGCATCTTTGGCGAGCTGAACGTGTGGCGCTCGGACGGTCAGATG       c.1620
 E  M  I  E  T  G  I  F  G  E  L  N  V  W  R  S  D  G  Q  M         p.540

          .         .         .         .         .         .       g.121731
 CCGGACGACATGAAGGGCATCTCCGGGGGCTCCAGCTCCTCGTCCAAGTCAGGGATGTGT       c.1680
 P  D  D  M  K  G  I  S  G  G  S  S  S  S  S  K  S  G  M  C         p.560

          .                                                         g.121743
 CTGGTTTCCTAG                                                       c.1692
 L  V  S  X                                                         p.563

          .         .         .         .         .         .       g.121803
 gtgacgccccagagtccacgtggaggaaaaggacccatacggctcgatgggggccgcctg       c.*60

          .         .         .         .         .         .       g.121863
 cctccgtggtgccagcctggggtctgctagcaaggggacacgtggttccctccacccagg       c.*120

          .         .         .         .         .         .       g.121923
 tccccatcacgccatctccttgcggcccaaggaggagaaagcccacatcggcctgagccg       c.*180

          .         .         .         .         .         .       g.121983
 ccagacgcacatgctggtgccgtgagcccccgactgcatatttcacgtcttttgctccat       c.*240

          .         .         .         .         .         .       g.122043
 ctcactgagaagacataagatgctctccagagggagtaagccaaaaatctacaaactctt       c.*300

                                                                    g.122044
 a                                                                  c.*301

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The G protein-coupled receptor kinase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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