glutamate receptor, metabotropic 6 (GRM6) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000843.3 in the GRM6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008105.1, covering GRM6 transcript NM_000843.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  cggaggcccgggcaggccggctgagctaactccccagagccgaagtggaaggcgcgccc       c.-121

 .         .         .         .         .         .                g.5119
 cgagcgccttctccccaggaccccggtgtccctccccgcgccccgagcccgcgctctcct       c.-61

 .         .         .         .         .         .                g.5179
 tcccccgccctcagagcgctccccgcccctctgtctccccgcagcccgctagacgagccg       c.-1

          .         .         .         .         .         .       g.5239
 ATGGCGCGGCCCCGGAGAGCCCGGGAGCCGCTGCTCGTGGCGCTGCTGCCGCTGGCGTGG       c.60
 M  A  R  P  R  R  A  R  E  P  L  L  V  A  L  L  P  L  A  W         p.20

          .         .         .         .         .         .       g.5299
 CTGGCGCAGGCGGGCCTGGCGCGCGCGGCGGGCTCTGTGCGCCTGGCGGGCGGCCTGACG       c.120
 L  A  Q  A  G  L  A  R  A  A  G  S  V  R  L  A  G  G  L  T         p.40

          .         .         .         .         .         .       g.5359
 CTGGGCGGCCTGTTCCCGGTGCACGCGCGGGGCGCGGCGGGCCGGGCGTGCGGGCAGCTG       c.180
 L  G  G  L  F  P  V  H  A  R  G  A  A  G  R  A  C  G  Q  L         p.60

          .         .         .         .         .         .       g.5419
 AAGAAGGAGCAGGGCGTGCACCGGCTGGAGGCCATGCTGTACGCGCTGGACCGCGTCAAC       c.240
 K  K  E  Q  G  V  H  R  L  E  A  M  L  Y  A  L  D  R  V  N         p.80

          .         .         .         .         .         .       g.5479
 GCCGACCCCGAGCTGCTGCCCGGCGTGCGCCTGGGCGCGCGGCTGCTGGACACCTGCTCG       c.300
 A  D  P  E  L  L  P  G  V  R  L  G  A  R  L  L  D  T  C  S         p.100

          .         .         .         .         .         .       g.5539
 CGGGACACCTACGCGCTGGAGCAGGCGCTGAGCTTCGTGCAGGCGCTGATCCGCGGCCGC       c.360
 R  D  T  Y  A  L  E  Q  A  L  S  F  V  Q  A  L  I  R  G  R         p.120

          .         .         .         .         .         .       g.5599
 GGCGACGGCGACGAGGTGGGCGTGCGCTGCCCGGGAGGCGTCCCTCCGCTGCGCCCCGCG       c.420
 G  D  G  D  E  V  G  V  R  C  P  G  G  V  P  P  L  R  P  A         p.140

          .         .         .         .         .         .       g.5659
 CCCCCCGAGCGCGTCGTGGCCGTCGTGGGCGCCTCGGCCAGCTCCGTCTCCATCATGGTC       c.480
 P  P  E  R  V  V  A  V  V  G  A  S  A  S  S  V  S  I  M  V         p.160

          .         .     | 02   .         .         .         .    g.8076
 GCCAACGTGCTGCGCCTGTTTGCG | ATACCCCAGATCAGCTATGCCTCCACAGCCCCGGAG    c.540
 A  N  V  L  R  L  F  A   | I  P  Q  I  S  Y  A  S  T  A  P  E      p.180

          .         .         .         .         .         .       g.8136
 CTCAGCGACTCCACACGCTATGACTTCTTCTCCCGGGTGGTGCCACCCGACTCCTACCAG       c.600
 L  S  D  S  T  R  Y  D  F  F  S  R  V  V  P  P  D  S  Y  Q         p.200

          .         .         .         .         .         .       g.8196
 GCGCAGGCCATGGTGGACATCGTGAGGGCACTGGGATGGAACTATGTGTCCACGCTGGCC       c.660
 A  Q  A  M  V  D  I  V  R  A  L  G  W  N  Y  V  S  T  L  A         p.220

          .         .         .         .         .         .       g.8256
 TCCGAGGGCAACTATGGCGAAAGTGGGGTTGAGGCCTTCGTTCAGATCTCCCGAGAGGCT       c.720
 S  E  G  N  Y  G  E  S  G  V  E  A  F  V  Q  I  S  R  E  A         p.240

   | 03      .         .         .         .         .         .    g.8623
 G | GGGGGGTCTGTATTGCCCAGTCTATCAAGATTCCCAGGGAACCAAAGCCAGGAGAGTTC    c.780
 G |   G  V  C  I  A  Q  S  I  K  I  P  R  E  P  K  P  G  E  F      p.260

          .         .         .         .         .         .       g.8683
 AGCAAGGTGATCAGGAGACTCATGGAGACGCCCAACGCCCGGGGCATCATCATCTTTGCC       c.840
 S  K  V  I  R  R  L  M  E  T  P  N  A  R  G  I  I  I  F  A         p.280

          .        | 04.         .         .         .         .    g.9420
 AATGAGGATGACATCAG | GCGGGTCCTGGAGGCAGCTCGCCAGGCCAACCTGACCGGCCAC    c.900
 N  E  D  D  I  R  |  R  V  L  E  A  A  R  Q  A  N  L  T  G  H      p.300

          .         .         .         .         .         .       g.9480
 TTCCTGTGGGTCGGCTCAGACAGCTGGGGAGCCAAGACCTCACCCATCTTGAGCCTGGAG       c.960
 F  L  W  V  G  S  D  S  W  G  A  K  T  S  P  I  L  S  L  E         p.320

          .         .         .         .         .   | 05     .    g.10726
 GACGTGGCCGTTGGGGCCATCACCATCCTGCCCAAAAGGGCCTCCATCGACG | GATTTGAC    c.1020
 D  V  A  V  G  A  I  T  I  L  P  K  R  A  S  I  D  G |   F  D      p.340

          .         .         .         .         .         .       g.10786
 CAGTACTTCATGACTCGATCCCTGGAGAACAACCGCAGGAACATCTGGTTCGCCGAGTTC       c.1080
 Q  Y  F  M  T  R  S  L  E  N  N  R  R  N  I  W  F  A  E  F         p.360

          .         .         .         .         .         .       g.10846
 TGGGAAGAGAATTTTAACTGCAAACTGACCAGCTCAGGTACCCAGTCAGACGATTCCACC       c.1140
 W  E  E  N  F  N  C  K  L  T  S  S  G  T  Q  S  D  D  S  T         p.380

          .    | 06    .         .         .         .         .    g.11035
 CGCAAATGCACAG | GCGAGGAACGCATCGGCCGGGACTCCACCTACGAGCAGGAGGGCAAG    c.1200
 R  K  C  T  G |   E  E  R  I  G  R  D  S  T  Y  E  Q  E  G  K      p.400

          .         .         .         .         .         .       g.11095
 GTGCAGTTTGTGATTGATGCGGTGTACGCCATTGCCCACGCCCTCCACAGCATGCACCAG       c.1260
 V  Q  F  V  I  D  A  V  Y  A  I  A  H  A  L  H  S  M  H  Q         p.420

          .         .         .         .         .         .       g.11155
 GCGCTCTGCCCTGGGCACACAGGCCTGTGCCCGGCGATGGAACCCACTGATGGGCGGATG       c.1320
 A  L  C  P  G  H  T  G  L  C  P  A  M  E  P  T  D  G  R  M         p.440

          .         .         .     | 07   .         .         .    g.13166
 CTTCTGCAGTACATTCGAGCTGTCCGCTTCAATG | GCAGCGCAGGAACCCCTGTGATGTTC    c.1380
 L  L  Q  Y  I  R  A  V  R  F  N  G |   S  A  G  T  P  V  M  F      p.460

          .         .         .         .         .         .       g.13226
 AACGAGAACGGAGATGCGCCCGGGCGGTACGACATCTTCCAGTACCAGGCGACCAATGGC       c.1440
 N  E  N  G  D  A  P  G  R  Y  D  I  F  Q  Y  Q  A  T  N  G         p.480

          .         .         .         .         .         .       g.13286
 AGTGCCAGCAGTGGCGGGTACCAGGCAGTGGGCCAGTGGGCAGAGACCCTCAGACTGGAT       c.1500
 S  A  S  S  G  G  Y  Q  A  V  G  Q  W  A  E  T  L  R  L  D         p.500

  | 08       .         .         .         .         .         .    g.13430
  | GTGGAGGCCCTGCAGTGGTCTGGCGACCCCCACGAGGTGCCCTCGTCTCTGTGCAGCCTG    c.1560
  | V  E  A  L  Q  W  S  G  D  P  H  E  V  P  S  S  L  C  S  L      p.520

          .         .         .         .         .         .       g.13490
 CCCTGCGGGCCGGGGGAGCGGAAGAAGATGGTGAAGGGCGTCCCCTGCTGTTGGCACTGC       c.1620
 P  C  G  P  G  E  R  K  K  M  V  K  G  V  P  C  C  W  H  C         p.540

          .         .         .         .         .         .       g.13550
 GAGGCCTGTGACGGGTACCGCTTCCAGGTGGACGAGTTCACATGCGAGGCCTGTCCTGGG       c.1680
 E  A  C  D  G  Y  R  F  Q  V  D  E  F  T  C  E  A  C  P  G         p.560

          .         .         .         .         .         .       g.13610
 GACATGAGGCCCACGCCCAACCACACGGGCTGCCGCCCCACACCTGTGGTGCGCCTGAGC       c.1740
 D  M  R  P  T  P  N  H  T  G  C  R  P  T  P  V  V  R  L  S         p.580

          .         .         .         .         .         .       g.13670
 TGGTCCTCCCCCTGGGCAGCCCCGCCGCTCCTCCTGGCCGTGCTGGGCATCGTGGCCACT       c.1800
 W  S  S  P  W  A  A  P  P  L  L  L  A  V  L  G  I  V  A  T         p.600

          .         .         .         .         .         .       g.13730
 ACCACGGTGGTGGCCACCTTCGTGCGGTACAACAACACGCCCATCGTCCGGGCCTCGGGC       c.1860
 T  T  V  V  A  T  F  V  R  Y  N  N  T  P  I  V  R  A  S  G         p.620

          .         .         .         .         .         .       g.13790
 CGAGAGCTCAGCTACGTCCTCCTCACCGGCATCTTCCTCATCTACGCCATCACCTTCCTC       c.1920
 R  E  L  S  Y  V  L  L  T  G  I  F  L  I  Y  A  I  T  F  L         p.640

          .         .         .         .         .         .       g.13850
 ATGGTGGCTGAGCCTGGGGCCGCGGTCTGTGCCGCCCGCAGGCTCTTCCTGGGCCTGGGC       c.1980
 M  V  A  E  P  G  A  A  V  C  A  A  R  R  L  F  L  G  L  G         p.660

          .         .         .         .         .         .       g.13910
 ACGACCCTCAGCTACTCTGCCCTGCTCACCAAGACCAACCGTATCTACCGCATCTTTGAG       c.2040
 T  T  L  S  Y  S  A  L  L  T  K  T  N  R  I  Y  R  I  F  E         p.680

          .         .         .         .         .         .       g.13970
 CAGGGCAAGCGCTCGGTCACACCCCCTCCCTTCATCAGCCCCACCTCACAGCTGGTCATC       c.2100
 Q  G  K  R  S  V  T  P  P  P  F  I  S  P  T  S  Q  L  V  I         p.700

          .         .     | 09   .         .         .         .    g.16938
 ACCTTCAGCCTCACCTCCCTGCAG | GTGGTGGGGATGATAGCATGGCTGGGGGCCCGGCCC    c.2160
 T  F  S  L  T  S  L  Q   | V  V  G  M  I  A  W  L  G  A  R  P      p.720

          .         .         .         .         .         .       g.16998
 CCACACAGCGTGATTGACTATGAGGAACAGCGGACGGTGGACCCCGAGCAGGCCAGAGGG       c.2220
 P  H  S  V  I  D  Y  E  E  Q  R  T  V  D  P  E  Q  A  R  G         p.740

          .         .         .         .         .         .       g.17058
 GTGCTCAAGTGCGACATGTCGGATCTGTCTCTCATCGGCTGCCTGGGCTACAGCCTCCTG       c.2280
 V  L  K  C  D  M  S  D  L  S  L  I  G  C  L  G  Y  S  L  L         p.760

          .         .         .         .         .         .       g.17118
 CTCATGGTCACGTGCACAGTGTACGCCATCAAGGCCCGTGGCGTGCCCGAGACCTTCAAC       c.2340
 L  M  V  T  C  T  V  Y  A  I  K  A  R  G  V  P  E  T  F  N         p.780

          .         .         .         .         .         .       g.17178
 GAGGCCAAGCCCATCGGCTTCACCATGTACACCACCTGCATCATCTGGCTGGCATTCGTG       c.2400
 E  A  K  P  I  G  F  T  M  Y  T  T  C  I  I  W  L  A  F  V         p.800

          .         .         .       | 10 .         .         .    g.18293
 CCCATCTTCTTTGGCACTGCCCAGTCAGCTGAAAAG | ATCTACATCCAGACAACCACGCTA    c.2460
 P  I  F  F  G  T  A  Q  S  A  E  K   | I  Y  I  Q  T  T  T  L      p.820

          .         .         .         .         .         .       g.18353
 ACCGTGTCCTTGAGCCTGAGTGCCTCGGTGTCCCTCGGCATGCTCTACGTACCCAAAACC       c.2520
 T  V  S  L  S  L  S  A  S  V  S  L  G  M  L  Y  V  P  K  T         p.840

          .         .         .         .         .         .       g.18413
 TACGTCATCCTCTTCCATCCAGAGCAGAATGTGCAGAAGCGAAAGCGGAGCCTCAAGGCC       c.2580
 Y  V  I  L  F  H  P  E  Q  N  V  Q  K  R  K  R  S  L  K  A         p.860

          .         .         .         .         .                 g.18467
 ACCTCCACGGTGGCAGCCCCACCCAAGGGCGAGGATGCAGAGGCCCACAAGTAG             c.2634
 T  S  T  V  A  A  P  P  K  G  E  D  A  E  A  H  K  X               p.877

          .         .         .         .         .         .       g.18527
 cagggcaggtgggaacgggactgcttgctgcctctcctttcttcctcttgcctcgaggtg       c.*60

          .         .         .         .         .         .       g.18587
 gaagctgtatagagcccgggtccacggtgaacagtcagtggcagggagtttgccaagacc       c.*120

          .         .         .         .         .         .       g.18647
 atgctccgcgtcggtggggctggccttgagaaggaactggacccagctctaccccgattc       c.*180

          .         .         .         .         .         .       g.18707
 cagcatgtgagcttcatgcttcctcaccacagaccagactcgcttcccatggtgggaaac       c.*240

          .         .         .         .         .         .       g.18767
 agccaccgagaaggttctagctctagaaagggactaaacttattctctcatccgaagtcc       c.*300

          .         .         .         .         .         .       g.18827
 aaagaggatgatgaagccctgggctttgcctggtttgcgggagatttcctcccctcagtc       c.*360

          .         .         .         .         .         .       g.18887
 aacccccataacctggggattgggcagtgtggaagaacgtgtagaccccagaatgaaaca       c.*420

          .         .         .         .         .         .       g.18947
 tggggttggagtggaggaggagctgtctcagcaagaggagacctggggctgtgcatctgg       c.*480

          .         .         .         .         .         .       g.19007
 atggaggcactcaggcctgggtaggattcctctggcacggagggagagaccctgggtgag       c.*540

          .         .         .         .         .         .       g.19067
 acccctgtgagcatgggaagggcctgcagtgggcgcgggagtgagctgaggaactggggt       c.*600

          .         .         .         .         .         .       g.19127
 gcgcccccatgagattcccaatgccatgggctttcccccatccccccgggattgggcaag       c.*660

          .         .         .         .         .         .       g.19187
 gtcagacttagagtacagctgttttcctcccctctgtgtactcccttaaatcaccccaac       c.*720

          .         .         .         .         .         .       g.19247
 cttggccaggcatggtggctcacacctgtaatcccagcactttgggaggccgaggcaggt       c.*780

          .         .         .         .         .         .       g.19307
 ggatcacctgaggtccggagttcgagaccagcctggccaatgtggtgaaaccctgtctct       c.*840

          .         .         .         .         .         .       g.19367
 actaaaaatacaaaaattagccaggtgtgatggtgggtgcctgtaatcccagttacttgg       c.*900

          .         .         .         .         .         .       g.19427
 gaggctgaggcaggagaatcgcttgaacctgggaggtggaggttgcagtgagctgtgatt       c.*960

          .         .         .         .         .         .       g.19487
 gtgccactgtactccagcctgggtgacagagcgagactctgtctcaaaaaaacaaaacaa       c.*1020

          .         .         .         .         .         .       g.19547
 aaaaacaccaaaaaaacccccaaacctgaagaaattcagatacacgtgtgtaatgttagt       c.*1080

          .         .         .         .         .         .       g.19607
 gatgtgagaacaaggagcaggggtgcatttgtgttgtgttcgggttggggatgggtttag       c.*1140

          .         .         .         .         .         .       g.19667
 gagctccaggttgggagcagtgacagagagtcatggccgtggtgagggtgaatcccaagt       c.*1200

          .         .         .         .         .         .       g.19727
 ggatggctcaggacgggtatggaaacccttcattcctcataggtactgggaagtccattt       c.*1260

          .         .         .         .         .         .       g.19787
 gcaagctgagcgccaggcctggggaggaagaggcttgggctgcagatgcacgcacatttg       c.*1320

          .         .         .         .         .         .       g.19847
 tttttcactgatagtttttacaaaaagcttggtttaagttatggagttttatgtccctgg       c.*1380

          .         .         .         .         .         .       g.19907
 gagtagaatttacatttgttaaattgaccactgtttaagatcagtatacattctctagtc       c.*1440

          .         .         .         .         .         .       g.19967
 tgtgatgtctggagctagttttgagggtgaaccacactttatccaacatacaaactttcc       c.*1500

          .         .         .         .         .         .       g.20027
 catgcagcttctctggtgcgcagttggttttgaccgtgggactaggtgcttctgcaggtt       c.*1560

          .         .         .         .         .         .       g.20087
 ttaagtaattaacttaaaagcttctcctctgagaaacatttctgttgcgctactgactct       c.*1620

          .         .         .         .         .         .       g.20147
 ccttctccacatttgttgtgttcctagggcttctctatagtgcacattaggacgtttcat       c.*1680

          .         .         .         .         .         .       g.20207
 ttgttgctgaatgctttccagaattatttattccatagggtttctctcctgtgcagctct       c.*1740

          .         .         .         .         .         .       g.20267
 ctcatgggtaatggggcgtgttttcttgccaaaggcggttccaccctcgtgattgtatag       c.*1800

          .         .         .         .         .         .       g.20327
 ggctcttctcctgtatgaactctgagatcagtgagctctgatctccaagggaaagttttc       c.*1860

          .         .         .         .         .         .       g.20387
 ctgcatttgctgttttctcatgtctctcccagtgtgaattctttggtgtgcagtgcgctc       c.*1920

          .         .         .         .         .         .       g.20447
 tggcttctagctgaaaacttttccacagttttacattcatgtggttttctccactgtgaa       c.*1980

          .         .         .         .         .         .       g.20507
 ctctgtgattcagaatcagaagcagttcttagtagaggcatttctacactgattgcactg       c.*2040

          .         .         .         .         .         .       g.20567
 aggatttctccccagtgtgaagtttctggcatagagtcctggcttcccgcagacgacttt       c.*2100

          .         .         .         .         .         .       g.20627
 cacactctgccatgttcatgcctgtgggcctctctggcaggaactctgatgcaccgcgag       c.*2160

          .         .         .         .         .         .       g.20687
 gcccatgtactcctgtggctttctcacattcggtctacttgcagggtatctccacagcat       c.*2220

          .         .         .         .         .         .       g.20747
 gcaccattctgggtacagggggacatcctctgttactgaagatgttgtcatatttagtac       c.*2280

          .         .         .         .         .         .       g.20807
 cttcacaaggtttctctccttccagaattttctgatgtacacaaataactgacttccaca       c.*2340

          .         .         .         .         .         .       g.20867
 agagggcttttccacactcggtgtgtgcatacagtttctgcctgtgatcatttctttatg       c.*2400

          .         .         .         .         .         .       g.20927
 ttattattttattttttcgagatagggtcttgctcaatttcttaggctggagtgcagtgg       c.*2460

          .         .         .         .         .         .       g.20987
 cacgatcatagctcactgaagtttcgacctgggctcaagcaatcctcccgcttcagcctc       c.*2520

          .         .         .         .         .         .       g.21047
 ctgagtagctggtgcgcacgaccatacccagctaatgttttattttttgtagagacgagg       c.*2580

          .         .         .         .         .         .       g.21107
 tctcactatgttgcccaggctggtctcgaacttctgagctcgagcgatcctcctgcctcc       c.*2640

          .         .         .         .         .         .       g.21167
 acctcccaaagtgttcggattacaaacgtgagccatcgcacctagcctctttgatcattt       c.*2700

          .         .         .         .         .         .       g.21227
 ctgtggtgttcagtggaggttgacagctccctaaagattttcctgtttttttgcatgcat       c.*2760

          .         .         .         .         .         .       g.21287
 gggtttgaattctttgaggtccaatttatttggacccctgaataaagttttgtgggtttt       c.*2820

          .         .         .         .         .         .       g.21347
 cttctatgtgtggaatttataaggcattcttccagtgtggtttctcttatgtcgagtgag       c.*2880

          .         .         .         .         .         .       g.21407
 agctgacctgcaccgaaggttttgtcccatttgttgcccttgaattatttgtatgaatta       c.*2940

          .         .         .         .         .         .       g.21467
 tatgttccagtgaaaatggagttctgggttggaggcttattccatgtttacacaattaaa       c.*3000

          .         .         .         .         .         .       g.21527
 attgcagtgttcctctctgggatgagagctctaaagcagagtaagattacgttctgatgt       c.*3060

          .         .         .         .         .         .       g.21587
 aagctttaaccacctatttataaggtctcacctgtggtccactgtgttgagacttctaca       c.*3120

          .         .         .         .         .         .       g.21647
 gaagagcttctgtatagtaaccattttcttaggctgtctcacttgtgtgaatcttctgac       c.*3180

          .         .         .         .         .         .       g.21707
 acatttattatagctttgtcccatttcttatcctttttgctctttagaaatttcccttta       c.*3240

          .         .         .         .         .         .       g.21767
 atttattacattcattgcttactgtaaagagtccaggtaactgactttattcagttactt       c.*3300

          .         .         .                                     g.21797
 cctgttcaataaatttaacttttcccaaaa                                     c.*3330

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate receptor, metabotropic 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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