general transcription factor IIIA (GTF3A) - coding DNA reference sequence

(used for variant description)

(last modified May 30, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_002097.2 in the GTF3A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.10, covering GTF3A transcript NM_002097.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               atgcgcgatctccc       c.-181

 .         .         .         .         .         .                g.5074
 ggagcatgcgcagcagcggcgccgacgcggggcggtgcctggtgaccgcgcgcgctcccg       c.-121

 .         .         .         .         .         .                g.5134
 gaagtgtgccggcgtcgcgcgaaggttcagcagggagccgtgggccgggcgcgccggttc       c.-61

 .         .         .         .         .         .                g.5194
 ccggcacgtgtctcggcacgtggcagcgcgcctggccctgggcttggaggcgccggcgcc       c.-1

          .         .         .         .         .         .       g.5254
 CTGGATCCGCCGGCCGTGGTCGCCGAGTCGGTGTCGTCCTTGACCATCGCCGACGCGTTC       c.60
 L  D  P  P  A  V  V  A  E  S  V  S  S  L  T  I  A  D  A  F         p.20

          .         .         .         .         .         .       g.5314
 ATTGCAGCCGGCGAGAGCTCAGCTCCGACCCCGCCGCGCCCCGCGCTTCCCAGGAGGTTC       c.120
 I  A  A  G  E  S  S  A  P  T  P  P  R  P  A  L  P  R  R  F         p.40

          .         .         .         .         .         .       g.5374
 ATCTGCTCCTTCCCTGACTGCAGCGCCAATTACAGCAAAGCCTGGAAGCTTGACGCGCAC       c.180
 I  C  S  F  P  D  C  S  A  N  Y  S  K  A  W  K  L  D  A  H         p.60

          .         .  | 02      .         .         .         .    g.7587
 CTGTGCAAGCACACGGGGGAG | AGACCATTTGTTTGTGACTATGAAGGGTGTGGCAAGGCC    c.240
 L  C  K  H  T  G  E   | R  P  F  V  C  D  Y  E  G  C  G  K  A      p.80

          .         .         .         .         .         .       g.7647
 TTCATCAGGGACTACCATCTGAGCCGCCACATTCTGACTCACACAGGAGAAAAGCCGTTT       c.300
 F  I  R  D  Y  H  L  S  R  H  I  L  T  H  T  G  E  K  P  F         p.100

    | 03     .         .         .         .         .         .    g.10384
 GT | TTGTGCAGCCAATGGCTGTGATCAAAAATTCAACACAAAATCAAACTTGAAGAAACAT    c.360
 V  |  C  A  A  N  G  C  D  Q  K  F  N  T  K  S  N  L  K  K  H      p.120

          .         .         .          | 04        .         .    g.11010
 TTTGAACGCAAACATGAAAATCAACAAAAACAATATATA | TGCAGTTTTGAAGACTGTAAG    c.420
 F  E  R  K  H  E  N  Q  Q  K  Q  Y  I   | C  S  F  E  D  C  K      p.140

          .         .         .         .         .         .       g.11070
 AAGACCTTTAAGAAACATCAGCAGCTGAAAATCCATCAGTGCCAGCATACCAATGAACCT       c.480
 K  T  F  K  K  H  Q  Q  L  K  I  H  Q  C  Q  H  T  N  E  P         p.160

          | 05         .         .         .         .         .    g.13239
 CTATTCAA | GTGTACCCAGGAAGGATGTGGGAAACACTTTGCATCACCCAGCAAGCTGAAA    c.540
 L  F  K  |  C  T  Q  E  G  C  G  K  H  F  A  S  P  S  K  L  K      p.180

          .         .   | 06     .         .         .         .    g.14633
 CGACATGCCAAGGCCCACGAGG | GCTATGTATGTCAAAAAGGATGTTCCTTTGTGGCAAAA    c.600
 R  H  A  K  A  H  E  G |   Y  V  C  Q  K  G  C  S  F  V  A  K      p.200

          .         .         .         .    | 07    .         .    g.15278
 ACATGGACGGAACTTCTGAAACATGTGAGAGAAACCCATAAAG | AGGAAATACTATGTGAA    c.660
 T  W  T  E  L  L  K  H  V  R  E  T  H  K  E |   E  I  L  C  E      p.220

          .         .         .         .         .         .       g.15338
 GTATGCCGGAAAACATTTAAACGCAAAGATTACCTTAAGCAACACATGAAAACTCATGCC       c.720
 V  C  R  K  T  F  K  R  K  D  Y  L  K  Q  H  M  K  T  H  A         p.240

          .         .         .         .         .         .       g.15398
 CCAGAAAGGGATGTATGTCGCTGTCCAAGAGAAGGCTGTGGAAGAACCTATACAACTGTG       c.780
 P  E  R  D  V  C  R  C  P  R  E  G  C  G  R  T  Y  T  T  V         p.260

          .         .         .         .         .         .       g.15458
 TTTAATCTCCAAAGCCATATCCTCTCCTTCCATGAGGAAAGCCGCCCTTTTGTGTGTGAA       c.840
 F  N  L  Q  S  H  I  L  S  F  H  E  E  S  R  P  F  V  C  E         p.280

          .         .         .    | 08    .         .         .    g.15616
 CATGCTGGCTGTGGCAAAACATTTGCAATGAAA | CAAAGTCTCACTAGGCATGCTGTTGTA    c.900
 H  A  G  C  G  K  T  F  A  M  K   | Q  S  L  T  R  H  A  V  V      p.300

          .         .         .    | 09    .         .         .    g.15916
 CATGATCCTGACAAGAAGAAAATGAAGCTCAAA | GTCAAAAAATCTCGTGAAAAACGGAGT    c.960
 H  D  P  D  K  K  K  M  K  L  K   | V  K  K  S  R  E  K  R  S      p.320

          .         .         .         .         .         .       g.15976
 TTGGCCTCTCATCTCAGTGGATATATCCCTCCCAAAAGGAAACAAGGGCAAGGCTTATCT       c.1020
 L  A  S  H  L  S  G  Y  I  P  P  K  R  K  Q  G  Q  G  L  S         p.340

          .         .         .         .         .         .       g.16036
 TTGTGTCAAAACGGAGAGTCACCCAACTGTGTGGAAGACAAGATGCTCTCGACAGTTGCA       c.1080
 L  C  Q  N  G  E  S  P  N  C  V  E  D  K  M  L  S  T  V  A         p.360

          .                                                         g.16054
 GTACTTACCCTTGGCTAA                                                 c.1098
 V  L  T  L  G  X                                                   p.365

          .         .         .         .         .         .       g.16114
 gaactgcactgctttgtttaaaggactgcagaccaaggagcgagctttctctcagagcat       c.*60

          .         .         .         .         .                 g.16166
 gcttttctttattaaaattactgatgcagaacatttgattccttatcatttc               c.*112

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The General transcription factor IIIA protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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