GTP binding protein 1 (GTPBP1) - coding DNA reference sequence

(used for variant description)

(last modified November 27, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_004286.4 in the GTPBP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering GTPBP1 transcript NM_004286.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           tgtttcttagctagaggtacgtgtcacccagtac       c.-121

 .         .         .         .         .         .                g.5094
 gcggctggagttttgcataaattattccgataaggagcggggcggggctctgtgcataga       c.-61

 .         .         .         .         .         .                g.5154
 ttagtcaaatgagcctgggagggagggaagccggctacgaattagcctaagttattaaag       c.-1

          .         .         .         .         .         .       g.5214
 ATGGCGACGGAGCGCAGTCGCTCCGCGATGGACTCGCCGGTCCCGGCCTCTATGTTCGCC       c.60
 M  A  T  E  R  S  R  S  A  M  D  S  P  V  P  A  S  M  F  A         p.20

          .         .         .         .         .         .       g.5274
 CCCGAGCCCAGCTCCCCGGGGGCGGCCAGGGCCGCGGCGGCCGCCGCCCGACTCCACGGC       c.120
 P  E  P  S  S  P  G  A  A  R  A  A  A  A  A  A  R  L  H  G         p.40

          .         .         .         .         .         .       g.5334
 GGCTTTGACTCGGACTGCAGCGAGGACGGCGAGGCGCTCAACGGCGAGCCAGAGCTGGAC       c.180
 G  F  D  S  D  C  S  E  D  G  E  A  L  N  G  E  P  E  L  D         p.60

          .   | 02     .         .         .         .         .    g.8091
 CTCACCAGCAAG | CTGGTTCTAGTGAGCCCTACATCAGAGCAGTATGACAGCCTACTTCGG    c.240
 L  T  S  K   | L  V  L  V  S  P  T  S  E  Q  Y  D  S  L  L  R      p.80

          .         .         .         .         .         .       g.8151
 CAGATGTGGGAGAGGATGGACGAGGGATGCGGAGAGACCATATATGTCATTGGGCAGGGA       c.300
 Q  M  W  E  R  M  D  E  G  C  G  E  T  I  Y  V  I  G  Q  G         p.100

      | 03   .         .         .         .         .         .    g.15161
 TCAG | ATGGGACTGAGTATGGGCTGAGTGAAGCTGACATGGAGGCCTCCTACGCCACAGTG    c.360
 S  D |   G  T  E  Y  G  L  S  E  A  D  M  E  A  S  Y  A  T  V      p.120

          .         .         .         .         .         .       g.15221
 AAGAGCATGGCGGAACAGATAGAGGCCGATGTCATCCTTCTGCGGGAACGGCAAGAAGCT       c.420
 K  S  M  A  E  Q  I  E  A  D  V  I  L  L  R  E  R  Q  E  A         p.140

          .         .         .         .         .         .       g.15281
 GGGGGCCGCGTGCGTGATTACCTGGTCCGGAAACGAGTAGGAGACAATGACTTCCTGGAG       c.480
 G  G  R  V  R  D  Y  L  V  R  K  R  V  G  D  N  D  F  L  E         p.160

       | 04  .         .         .         .         .         .    g.15905
 GTCAG | GGTAGCAGTGGTGGGCAACGTGGATGCTGGCAAAAGCACGCTTCTGGGGGTCCTG    c.540
 V  R  |  V  A  V  V  G  N  V  D  A  G  K  S  T  L  L  G  V  L      p.180

          .         .         .         .         .         .       g.15965
 ACACATGGGGAGCTGGACAATGGCCGAGGCTTTGCCCGCCAGAAACTCTTCCGCCACAAA       c.600
 T  H  G  E  L  D  N  G  R  G  F  A  R  Q  K  L  F  R  H  K         p.200

          .         .         .         .         .         .       g.16025
 CATGAAATTGAATCTGGTCGCACCAGCAGTGTGGGCAACGACATTCTGGGCTTTGACAGT       c.660
 H  E  I  E  S  G  R  T  S  S  V  G  N  D  I  L  G  F  D  S         p.220

          .         .         .         .         .         .       g.16085
 GAAGGCAATGTAGTGAACAAGCCTGACAGCCACGGCGGCAGCCTGGAGTGGACCAAGATC       c.720
 E  G  N  V  V  N  K  P  D  S  H  G  G  S  L  E  W  T  K  I         p.240

          .         .         .         .         .         .       g.16145
 TGTGAGAAGTCCACGAAAGTCATTACCTTCATCGACTTGGCTGGTCATGAGAAGTACCTG       c.780
 C  E  K  S  T  K  V  I  T  F  I  D  L  A  G  H  E  K  Y  L         p.260

          .         .         .         .         .     | 05   .    g.20946
 AAAACCACTGTCTTCGGCATGACAGGCCATCTGCCTGACTTCTGCATGCTCATG | GTGGGC    c.840
 K  T  T  V  F  G  M  T  G  H  L  P  D  F  C  M  L  M   | V  G      p.280

          .         .         .         .         .         .       g.21006
 AGCAATGCTGGCATCGTGGGGATGACCAAAGAACACCTGGGCTTGGCACTGGCACTCAAT       c.900
 S  N  A  G  I  V  G  M  T  K  E  H  L  G  L  A  L  A  L  N         p.300

          .         .         .         .         .         | 06    g.23497
 GTACCTGTCTTTGTGGTAGTCACCAAGATTGACATGTGTCCTGCCAACATCCTGCAAG | AA    c.960
 V  P  V  F  V  V  V  T  K  I  D  M  C  P  A  N  I  L  Q  E |       p.320

          .         .         .         .         .         .       g.23557
 ACCCTGAAGCTGTTACAGCGCCTGCTGAAGTCACCAGGCTGCCGGAAGATCCCCGTGCTG       c.1020
 T  L  K  L  L  Q  R  L  L  K  S  P  G  C  R  K  I  P  V  L         p.340

          .         .         .         .         .    | 07    .    g.25211
 GTGCAGAGCAAAGATGATGTGATTGTCACAGCCTCCAACTTCAGCTCTGAAAG | GATGTGC    c.1080
 V  Q  S  K  D  D  V  I  V  T  A  S  N  F  S  S  E  R  |  M  C      p.360

          .         .         .         .         .         .       g.25271
 CCGATATTCCAGATCTCCAACGTTACAGGCGAGAACCTAGATCTGCTGAAGATGTTCCTC       c.1140
 P  I  F  Q  I  S  N  V  T  G  E  N  L  D  L  L  K  M  F  L         p.380

          .         .         .         .         .         .       g.25331
 AACCTCCTCTCCCCCCGCACCAGCTACAGGGAGGAGGAGCCTGCTGAGTTTCAGATTGAT       c.1200
 N  L  L  S  P  R  T  S  Y  R  E  E  E  P  A  E  F  Q  I  D         p.400

          .         | 08         .         .         .         .    g.25498
 GACACCTACTCCGTCCCG | GGTGTGGGGACAGTGGTTTCGGGGACAACACTGAGAGGCCTG    c.1260
 D  T  Y  S  V  P   | G  V  G  T  V  V  S  G  T  T  L  R  G  L      p.420

          .         .         .         .         .         .       g.25558
 ATCAAGCTGAATGACACGCTGCTGCTGGGCCCAGACCCCTTGGGTAACTTCCTGTCCATT       c.1320
 I  K  L  N  D  T  L  L  L  G  P  D  P  L  G  N  F  L  S  I         p.440

          .         .         .         .         .         .       g.25618
 GCTGTCAAATCCATCCATCGCAAGCGCATGCCTGTCAAGGAGGTGCGGGGTGGCCAGACA       c.1380
 A  V  K  S  I  H  R  K  R  M  P  V  K  E  V  R  G  G  Q  T         p.460

          .         .  | 09      .         .         .         .    g.26450
 GCATCCTTTGCGCTGAAGAAG | ATCAAGCGCTCGTCCATCCGGAAGGGCATGGTGATGGTT    c.1440
 A  S  F  A  L  K  K   | I  K  R  S  S  I  R  K  G  M  V  M  V      p.480

          .         .         .         .         .         .       g.26510
 TCCCCACGTTTGAATCCCCAAGCCTCCTGGGAGTTTGAGGCCGAGATTCTCGTCCTCCAC       c.1500
 S  P  R  L  N  P  Q  A  S  W  E  F  E  A  E  I  L  V  L  H         p.500

          .         .         .        | 10.         .         .    g.27204
 CACCCCACCACAATTAGCCCGCGCTACCAGGCCATGG | TGCACTGTGGGAGCATCAGGCAG    c.1560
 H  P  T  T  I  S  P  R  Y  Q  A  M  V |   H  C  G  S  I  R  Q      p.520

          .         .         .         .         .         .       g.27264
 ACAGCCACCATTCTGAGCATGGACAAGGACTGTCTGCGCACTGGGGACAAGGCCACTGTA       c.1620
 T  A  T  I  L  S  M  D  K  D  C  L  R  T  G  D  K  A  T  V         p.540

          .         .         .         .         .         .       g.27324
 CACTTCCGCTTCATCAAGACCCCTGAGTACCTGCACATAGACCAGCGGCTGGTGTTCCGG       c.1680
 H  F  R  F  I  K  T  P  E  Y  L  H  I  D  Q  R  L  V  F  R         p.560

          .         .         .       | 11 .         .         .    g.28684
 GAAGGCCGCACCAAGGCTGTCGGCACCATCACCAAG | CTCCTCCAGACCACCAACAACTCC    c.1740
 E  G  R  T  K  A  V  G  T  I  T  K   | L  L  Q  T  T  N  N  S      p.580

          .         .         .         .         .         .       g.28744
 CCAATGAACTCCAAGCCGCAGCAGATTAAAATGCAGTCGACGAAAAAGGGCCCCCTGACG       c.1800
 P  M  N  S  K  P  Q  Q  I  K  M  Q  S  T  K  K  G  P  L  T         p.600

          .         .         .         .         .         .       g.28804
 AAACGAGACGAGGGGGGCCCGTCTGGTGGGCCAGCAGTAGGAGCACCCCCACCTGGAGAT       c.1860
 K  R  D  E  G  G  P  S  G  G  P  A  V  G  A  P  P  P  G  D         p.620

          .         .         .         .         .        | 12.    g.29813
 GAAGCCTCCTCTGTAGGGGCAGGGCAACCAGCTGCGTCCAGCAATCTCCAGCCTCAG | CCT    c.1920
 E  A  S  S  V  G  A  G  Q  P  A  A  S  S  N  L  Q  P  Q   | P      p.640

          .         .         .         .         .         .       g.29873
 AAGCCCAGCAGTGGAGGCCGGCGACGAGGGGGCCAGCGCCACAAGGTGAAGTCCCAGGGG       c.1980
 K  P  S  S  G  G  R  R  R  G  G  Q  R  H  K  V  K  S  Q  G         p.660

          .         .         .                                     g.29903
 GCCTGTGTGACTCCTGCCAGCGGCTGCTGA                                     c.2010
 A  C  V  T  P  A  S  G  C  X                                       p.669

          .         .         .         .         .         .       g.29963
 accttcccctggcccaccctcaccacccaaggggtcatcatctctggccaccactccacc       c.*60

          .         .         .         .         .         .       g.30023
 agatgggcagagcagctatgaccgccacccagccctcccgctcaggccacagccggagcc       c.*120

          .         .         .         .         .         .       g.30083
 tccgcattgcccccacccccattttccaggggggttgtaatttataagctgacgaaggta       c.*180

          .         .         .         .         .         .       g.30143
 gccagacttccggaggactgaccatctctcactgtcctccccaccttcttcctcactcac       c.*240

          .         .         .         .         .         .       g.30203
 acattttttgtacatctgggcccttagtttttattctgtttattatatgtctctgtctct       c.*300

          .         .         .         .         .         .       g.30263
 ctctattgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtggtgcaggagtgcca       c.*360

          .         .         .         .         .         .       g.30323
 cccccagggccctgtcaacctctcttttctcctccatggctgtctgcctgcgtatctgtc       c.*420

          .         .         .         .         .         .       g.30383
 tctgagaatcctcggggcggtcaggggatgtcaggaggggaaggagccgccctccctatc       c.*480

          .         .         .         .         .         .       g.30443
 ttgctgctcctcttggcactcaggggcaccttccatggagccagaccgggtggaggggct       c.*540

          .         .         .         .         .         .       g.30503
 tctgggatttggtgtctgctgctgccagagcaggaacccccagtctaggacttgggcatt       c.*600

          .         .         .         .         .         .       g.30563
 ttaacagggagaaagtagtggcttcccttttctctctctcctcctttttccctttaagcc       c.*660

          .         .         .         .         .         .       g.30623
 cacagattcaggtcatgccaaaagctctctggttgtaacctggagacatgtggaggggaa       c.*720

          .         .         .         .         .         .       g.30683
 tggcgatgggattataggactctccccatctcgggccctgaccctgacccttgccaccaa       c.*780

          .         .         .         .         .         .       g.30743
 cccaaagacagctggtgggtttccccttggagacaatcctgcgtttgcctgggccggccc       c.*840

          .         .         .         .         .         .       g.30803
 tggctgccctcagctttcgctgatctgcccggcctggagcctcccatcaccccgcttctt       c.*900

          .         .         .         .         .         .       g.30863
 gttgggcctcaggcactggttaccagaagggggtctgggtctgctcaggatcatgttttg       c.*960

          .         .         .         .         .         .       g.30923
 tagcacctcctgttggaggggtggagggatgttcccctgagccaggctgagactagaacc       c.*1020

          .         .         .         .         .         .       g.30983
 ccatcttccctgagccaggctgagactagaaccccatcttccccaccacgccacccctgt       c.*1080

          .         .         .         .         .         .       g.31043
 ggctgctacaggagcacagtagtgaaggcctgagctccaggtttgaaagacccaactgga       c.*1140

          .         .         .         .         .         .       g.31103
 gcgtggggcgggcaggcaggggttagtgaaaggacacttccagggttaggacagagcatt       c.*1200

          .         .         .         .         .         .       g.31163
 tagccttctggaagaacccctgcctggggtgggactgtgcaggccagagaaggtggcatg       c.*1260

          .         .         .         .         .         .       g.31223
 ggcctgaacccacctggactgacttctgcactgaagccacagatggagggtaggctggtg       c.*1320

          .         .         .         .         .         .       g.31283
 ggtgggggtggttcgttctctagccggggcagacacccagctggctgggtccttcctcag       c.*1380

          .         .         .         .         .         .       g.31343
 ccttgcctcctcctgtccccaaccctttcctttcctcctgcttgcggactgctggtcccc       c.*1440

          .         .         .         .         .         .       g.31403
 tctccttccctccttccagctgtttctagttaccacctacccctggccgtggactgatca       c.*1500

          .         .         .         .         .         .       g.31463
 gaccagcattcaaaataaaagtttgttccaagttgacagtgtggtgctccctgcccagcc       c.*1560

          .         .         .         .         .         .       g.31523
 cctccaggtggaggtgctgccacgggaacgcagttgctctgcctgccctggggcccctgg       c.*1620

          .         .         .         .         .         .       g.31583
 cgacagctgggagcagggcagtgctgtgaggagcccagctttcccagtcaggcaggcatg       c.*1680

          .         .         .         .         .         .       g.31643
 gcttccgtgttcaggctccctcaccagctggtgacacgggacaagcttacaaaccttctc       c.*1740

          .         .         .         .         .         .       g.31703
 tgaacctcagttttctcatttacaagaggcaaagccatccatcaccttgtgtggattcag       c.*1800

          .         .         .         .         .         .       g.31763
 agaatgtgaggccctggggtgtcctacacaagggaaaggcttgctcagtgagcggtctgc       c.*1860

          .         .         .         .         .         .       g.31823
 acaccgttagccaccctgccacctctgtgccctgggcaggctccaaaggaaagctctggc       c.*1920

          .         .         .         .         .         .       g.31883
 tgggactgccaggagtctcacacgctcctgttgacattcccagcagccgcccctgaggtc       c.*1980

          .         .         .         .         .         .       g.31943
 gatgtttgttctgtttttctttttcttttttgagacggagtctcgctgtgttgccaggct       c.*2040

          .         .         .         .         .         .       g.32003
 ggagtgcagtggtgtgatctctgctcactgcaacctccgcctgccagtttcaagtgattc       c.*2100

          .         .         .         .         .         .       g.32063
 tctgcctcagccttctgagtagctgggactacaggtgcacgccaccacgcccagctaact       c.*2160

          .         .         .         .         .         .       g.32123
 ttttgtattttagtagagacagggtttcgccatgtcggccagggtggtcttgatctcctg       c.*2220

          .         .         .         .         .         .       g.32183
 acctcatgatccacccgcctcagcctcccaaagtgctgggattacaggtatgagccaccg       c.*2280

          .         .         .         .         .         .       g.32243
 caccgggcctgttctatttttctagttaagggaactgaagctcagagaggtgtcaccagc       c.*2340

          .         .         .         .         .         .       g.32303
 aggtgttcattcccatgccagccttgccccccggcttttcccaggcaggctcctgcgtgc       c.*2400

          .         .         .         .         .         .       g.32363
 ccactggctccagcctggtcctctgtctcttggctgcttcactcctgctctttgtcccga       c.*2460

          .         .         .         .         .         .       g.32423
 ctctggccctgcttacaggggccactacctgctggtgcctccataacaagcgtctggcgt       c.*2520

          .         .         .         .         .         .       g.32483
 tgagacccctggcatggcaggggctttggggtctggtttccacaaggcttagccatggca       c.*2580

          .         .         .         .         .         .       g.32543
 gaacctcgttttattttaactctttgcccctacaaacaaacagcagtacttgccagaacc       c.*2640

          .         .         .         .         .         .       g.32603
 attcttgggattcaggagctcgggcgactgccttggcctctggccgcacccaggagggtg       c.*2700

          .         .         .         .         .         .       g.32663
 gggttggatctgtgtagttgccaggcccacacctgccagcagggggctgactggatccat       c.*2760

          .         .         .         .         .         .       g.32723
 gctttactgtgtttaatgggggtaacaggggtccctacagccctcccagctaaacatttg       c.*2820

          .         .         .         .         .         .       g.32783
 gaacaaaacaccagcccttttgtagtggatgcagaataaaattgttaatccaatcacctc       c.*2880

                                                                    g.32786
 caa                                                                c.*2883

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GTP binding protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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