GTP binding protein 2 (GTPBP2) - coding DNA reference sequence

(used for variant description)

(last modified November 27, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_019096.3 in the GTPBP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering GTPBP2 transcript NM_019096.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        ggggaggggccgggcggggggctggcggcagcggcgg       c.-1

          .         .         .         .         .         .       g.5097
 ATGGACTCGCGGGTATCGGAGCTGTTCGGCGGCTGCTGCCGGCCCGGAGGGGGCCCGGCC       c.60
 M  D  S  R  V  S  E  L  F  G  G  C  C  R  P  G  G  G  P  A         p.20

          .         .         .         .         .         .       g.5157
 GTGGGCGGAACCCTCAAGGCTAGGGGGGCCGGCAGCAGCAGCGGCTGCGGGGGGCCAAAG       c.120
 V  G  G  T  L  K  A  R  G  A  G  S  S  S  G  C  G  G  P  K         p.40

          .         .         .         .         .         .       g.5217
 GGAAAGAAGAAGAACGGAAGGAACAGAGGGGGCAAAGCCAACAACCCCCCGTATTTGCCC       c.180
 G  K  K  K  N  G  R  N  R  G  G  K  A  N  N  P  P  Y  L  P         p.60

        | 02 .         .         .    | 03    .         .         . g.7816
 CCCGAG | GCTGAAGATGGAAACATTGAATATAAA | TTGAAGCTGGTGAATCCATCCCAGTAC c.240
 P  E   | A  E  D  G  N  I  E  Y  K   | L  K  L  V  N  P  S  Q  Y   p.80

          .         .         .         .         .         .       g.7876
 CGCTTTGAGCACCTGGTGACACAAATGAAGTGGCGGCTCCAGGAGGGACGTGGTGAGGCC       c.300
 R  F  E  H  L  V  T  Q  M  K  W  R  L  Q  E  G  R  G  E  A         p.100

          .         .         .         .         .         .       g.7936
 GTCTACCAGATTGGGGTAGAGGACAATGGGCTGCTGGTGGGGCTGGCTGAGGAGGAAATG       c.360
 V  Y  Q  I  G  V  E  D  N  G  L  L  V  G  L  A  E  E  E  M         p.120

          .         .         .         | 04         .         .    g.8357
 CGAGCTTCGCTCAAGACCCTGCACCGGATGGCAGAGAA | GGTTGGGGCAGACATAACCGTT    c.420
 R  A  S  L  K  T  L  H  R  M  A  E  K  |  V  G  A  D  I  T  V      p.140

          .         .         .         .         .         .       g.8417
 CTTCGAGAGCGAGAAGTGGATTATGATAGCGACATGCCCCGGAAGATCACCGAGGTGCTA       c.480
 L  R  E  R  E  V  D  Y  D  S  D  M  P  R  K  I  T  E  V  L         p.160

          .         .        | 05.         .         .         .    g.8672
 GTACGAAAGGTCCCTGACAACCAACAG | TTCCTAGACCTCCGTGTGGCCGTCCTGGGGAAT    c.540
 V  R  K  V  P  D  N  Q  Q   | F  L  D  L  R  V  A  V  L  G  N      p.180

          .         .         .         .         .         .       g.8732
 GTGGACTCTGGGAAGTCAACTCTGCTTGGAGTCCTGACCCAGGGAGAGCTGGACAATGGG       c.600
 V  D  S  G  K  S  T  L  L  G  V  L  T  Q  G  E  L  D  N  G         p.200

          .         .         .         .         .         .       g.8792
 CGGGGCCGGGCTCGGCTCAACCTTTTCCGCCACCTGCATGAGATTCAGTCTGGCCGAACC       c.660
 R  G  R  A  R  L  N  L  F  R  H  L  H  E  I  Q  S  G  R  T         p.220

          .         .         .         .      | 06  .         .    g.9152
 TCCAGCATCAGCTTCGAGATCCTGGGCTTTAACAGCAAGGGAGAG | GTGGTGAATTACAGC    c.720
 S  S  I  S  F  E  I  L  G  F  N  S  K  G  E   | V  V  N  Y  S      p.240

          .         .         .         .         .         .       g.9212
 GACTCACGGACAGCAGAAGAGATCTGTGAGAGCAGCTCCAAGATGATCACCTTCATCGAC       c.780
 D  S  R  T  A  E  E  I  C  E  S  S  S  K  M  I  T  F  I  D         p.260

          .         .         .         .         .         .       g.9272
 CTGGCAGGCCACCATAAGTACCTACACACCACCATCTTTGGCCTCACATCATACTGCCCC       c.840
 L  A  G  H  H  K  Y  L  H  T  T  I  F  G  L  T  S  Y  C  P         p.280

          .         .         .         . | 07       .         .    g.9490
 GACTGCGCCCTGCTCCTCGTCAGTGCCAACACTGGGATTG | CTGGCACCACAAGGGAACAT    c.900
 D  C  A  L  L  L  V  S  A  N  T  G  I  A |   G  T  T  R  E  H      p.300

          .         .         .         .         .         .       g.9550
 CTGGGGCTGGCCCTGGCCCTGAAAGTGCCCTTCTTCATCGTGGTCAGCAAGATCGACCTA       c.960
 L  G  L  A  L  A  L  K  V  P  F  F  I  V  V  S  K  I  D  L         p.320

          .         .         .         .         .         .       g.9610
 TGTGCCAAGACCACAGTGGAGAGGACAGTACGCCAGCTGGAGCGGGTCCTCAAGCAGCCT       c.1020
 C  A  K  T  T  V  E  R  T  V  R  Q  L  E  R  V  L  K  Q  P         p.340

          .         .         .         .         .         .       g.9670
 GGCTGCCACAAGGTCCCCATGCTGGTCACCTCTGAGGATGATGCCGTCACTGCTGCCCAG       c.1080
 G  C  H  K  V  P  M  L  V  T  S  E  D  D  A  V  T  A  A  Q         p.360

          .         . | 08       .         .         .         .    g.10171
 CAGTTTGCTCAGTCACCCAA | TGTCACCCCCATCTTCACATTGTCCAGTGTGTCTGGAGAG    c.1140
 Q  F  A  Q  S  P  N  |  V  T  P  I  F  T  L  S  S  V  S  G  E      p.380

          .         .         .         .         .         .       g.10231
 AGTCTGGACCTCCTCAAAGTCTTTCTGAATATTCTGCCGCCACTCACCAACAGCAAAGAG       c.1200
 S  L  D  L  L  K  V  F  L  N  I  L  P  P  L  T  N  S  K  E         p.400

          .         .         .       | 09 .         .         .    g.10428
 CAGGAGGAACTCATGCAGCAGCTGACGGAGTTCCAG | GTGGATGAAATCTACACAGTACCA    c.1260
 Q  E  E  L  M  Q  Q  L  T  E  F  Q   | V  D  E  I  Y  T  V  P      p.420

          .         .         .      | 10  .         .         .    g.11420
 GAGGTGGGGACTGTTGTTGGAGGAACACTTTCCAG | TGGGATTTGCCGTGAGGGGGACCAG    c.1320
 E  V  G  T  V  V  G  G  T  L  S  S  |  G  I  C  R  E  G  D  Q      p.440

          .         .         .         .         .         .       g.11480
 CTGGTGGTGGGCCCCACGGATGATGGCTGCTTCCTGGAGCTGAGAGTATGCAGCATCCAG       c.1380
 L  V  V  G  P  T  D  D  G  C  F  L  E  L  R  V  C  S  I  Q         p.460

          .         .         .         .         .         .       g.11540
 CGCAACCGCTCTGCCTGTCGTGTGCTGCGAGCTGGTCAGGCTGCTACACTGGCGCTTGGG       c.1440
 R  N  R  S  A  C  R  V  L  R  A  G  Q  A  A  T  L  A  L  G         p.480

          .         .        | 11.         .         .         .    g.12065
 GACTTTGACCGTGCACTGCTTCGCAAG | GGCATGGTGATGGTGAGCCCGGAGATGAATCCT    c.1500
 D  F  D  R  A  L  L  R  K   | G  M  V  M  V  S  P  E  M  N  P      p.500

          .         .         .         .         .         .       g.12125
 ACCATCTGCTCGGTGTTTGAGGCAGAGATAGTCTTACTGTTCCATGCCACCACCTTCCGA       c.1560
 T  I  C  S  V  F  E  A  E  I  V  L  L  F  H  A  T  T  F  R         p.520

          .         .         .         .         .         .       g.12185
 CGAGGATTCCAGGTGACAGTACACGTGGGCAACGTACGTCAGACGGCAGTGGTGGAAAAG       c.1620
 R  G  F  Q  V  T  V  H  V  G  N  V  R  Q  T  A  V  V  E  K         p.540

          .   | 12     .         .         .         .         .    g.12457
 ATCCATGCCAAG | GACAAACTGCGGACAGGCGAGAAGGCAGTGGTACGTTTCCGCTTCCTG    c.1680
 I  H  A  K   | D  K  L  R  T  G  E  K  A  V  V  R  F  R  F  L      p.560

          .         .         .         .         .         .       g.12517
 AAACACCCAGAGTACCTGAAGGTGGGCGCCAAACTGCTGTTCCGGGAGGGTGTCACCAAG       c.1740
 K  H  P  E  Y  L  K  V  G  A  K  L  L  F  R  E  G  V  T  K         p.580

          .         .         .         .         .         .       g.12577
 GGCATCGGCCATGTCACTGATGTACAAGCCATTACAGCAGGAGAAGCCCAGGCCAACATG       c.1800
 G  I  G  H  V  T  D  V  Q  A  I  T  A  G  E  A  Q  A  N  M         p.600

                                                                    g.12586
 GGCTTCTGA                                                          c.1809
 G  F  X                                                            p.602

          .         .         .         .         .         .       g.12646
 acccttcaggcagggacagttctattgctgtccctacaatatataaggtgacttctggcc       c.*60

          .         .         .         .         .         .       g.12706
 atgctgccctgccattggcggctctgtgtgttaataggctagggagagaggggtgctgtc       c.*120

          .         .         .         .         .         .       g.12766
 tgccacttgctccctgccaactttctggagaggtgccaaacttggtgtggccaggaaagg       c.*180

          .         .         .         .         .         .       g.12826
 gcagtcctgagggagaagacaggattcagggcagtgctccgaagctgtgtgctcacctgg       c.*240

          .         .         .         .         .         .       g.12886
 ttggctcatcaaacctggcaaccctgtggcctgtctgccggagctgactggatccactca       c.*300

          .         .         .         .         .         .       g.12946
 tcaattcttcgtccccactactaagactgggcatgttttgctggtgtggtctctgcactt       c.*360

          .         .         .         .         .         .       g.13006
 caggaatggtcacaacagggggtagccctcaaaagcactcctttttctatacctcttctc       c.*420

          .         .         .         .         .         .       g.13066
 aaggccatgtaagttgcccatctctacctggctgtggacaaaaggttatctgctcttggc       c.*480

          .         .         .         .         .         .       g.13126
 catctggtggtggtggcggcccagagtctgaagaaatggcacagggacagtgaatggtag       c.*540

          .         .         .         .         .         .       g.13186
 tgttgccaccctgtgctgaggcctgaggcctcttcctcagctttatctccctttccttca       c.*600

          .         .         .         .         .         .       g.13246
 ctcaagggccatttccccagtccctatctcccccatcccctcccggcttataggccccac       c.*660

          .         .         .         .         .         .       g.13306
 aggtgctatttgttgtgctggcccaggcgtggggctaccaagcaaaggcttggcatatac       c.*720

          .         .         .         .         .         .       g.13366
 caaaggccagctgcatgcccatcagtctggtctttttcctctgcggtcatgttggctttc       c.*780

          .         .         .         .         .         .       g.13426
 atgctggatcaaatgttttactttcccagactggtggcatctgagttccccatcctacca       c.*840

          .         .         .         .         .         .       g.13486
 ctctcaccccactttcctgccccacctaaaccctcgttttagtaatttgtagtgactgtt       c.*900

          .         .         .         .         .         .       g.13546
 cccttccctctgttgcagggaaccaggaggaaagggaaagatgttgccatatttcctact       c.*960

          .         .         .         .         .         .       g.13606
 ctttaggcatggactctcctttccctttgttagtgtcctgggttcccatggactcaggga       c.*1020

          .         .         .         .         .         .       g.13666
 tttgttggctaaggtttctctgtgcatatatatatatatacatatgtatatatatttaaa       c.*1080

          .         .         .         .         .                 g.13719
 tacacatatatattgtacagaataaaaatgttttattgaatacactgtgctta              c.*1133

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GTP binding protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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