GTP binding protein 3 (mitochondrial) (GTPBP3) - coding DNA reference sequence

(used for variant description)

(last modified May 25, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_032620.3 in the GTPBP3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering GTPBP3 transcript NM_032620.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.7570
                          actttactagtcaagccgcggagtgggcggggccc       c.-61

 .         .         .         .         .         .                g.7630
 cctgcccagacttgaagccacacaggcaggtcgggcaggcgggtcgcaggttgtaaatcc       c.-1

          .         .         .         .         .    | 02    .    g.8033
 ATGTGGCGGGGGCTTTGGACCCTGGCGGCCCAAGCGGCACGTGGGCCTCGCAG | ATTGTGC    c.60
 M  W  R  G  L  W  T  L  A  A  Q  A  A  R  G  P  R  R  |  L  C      p.20

          .         .         .         .         .         .       g.8093
 ACGCGCCGGAGCAGCGGCGCACCAGCCCCCGGCTCCGGCGCCACCATCTTCGCGCTAAGC       c.120
 T  R  R  S  S  G  A  P  A  P  G  S  G  A  T  I  F  A  L  S         p.40

          .         .         .         .         .         .       g.8153
 TCTGGCCAAGGCCGCTGCGGCATCGCAGTGATCCGGACCAGCGGCCCCGCCAGCGGCCAC       c.180
 S  G  Q  G  R  C  G  I  A  V  I  R  T  S  G  P  A  S  G  H         p.60

          .         .         .         .         .         .       g.8213
 GCCCTCCGAATTCTCACAGCACCCCGAGACCTGCCCCTTGCTCGCCACGCCAGCCTGCGC       c.240
 A  L  R  I  L  T  A  P  R  D  L  P  L  A  R  H  A  S  L  R         p.80

          .         .         .         .         .         .       g.8273
 CTGCTCAGCGATCCCCGCTCCGGGGAGCCTCTGGACCGCGCACTGGTGCTCTGGTTCCCA       c.300
 L  L  S  D  P  R  S  G  E  P  L  D  R  A  L  V  L  W  F  P         p.100

   | 03      .         .         .         .         .         .    g.8442
 G | GTCCCCAGAGTTTCACCGGTGAGGACTGCGTGGAGTTCCACGTGCATGGAGGCCCGGCA    c.360
 G |   P  Q  S  F  T  G  E  D  C  V  E  F  H  V  H  G  G  P  A      p.120

          .         .         | 04         .         .         .    g.8589
 GTGGTGAGCGGCGTCCTGCAGGCCTTGG | GCAGCGTGCCAGGGCTTCGACCGGCGGAGGCA    c.420
 V  V  S  G  V  L  Q  A  L  G |   S  V  P  G  L  R  P  A  E  A      p.140

          .         .         .         .         .         .       g.8649
 GGCGAGTTCACCAGACGGGCGTTCGCCAATGGGAAGCTGAACCTGACCGAAGTGGAGGGG       c.480
 G  E  F  T  R  R  A  F  A  N  G  K  L  N  L  T  E  V  E  G         p.160

          .         .         .         .         .         .       g.8709
 CTGGCGGACCTTATCCACGCGGAAACAGAGGCGCAGCGGCGGCAGGCCCTCAGGCAGCTG       c.540
 L  A  D  L  I  H  A  E  T  E  A  Q  R  R  Q  A  L  R  Q  L         p.180

          .         .         .         .         .  | 05      .    g.8981
 GACGGAGAGCTGGGCCACCTCTGCCGTGGCTGGGCCGAGACCCTCACCAAA | GCTCTGGCC    c.600
 D  G  E  L  G  H  L  C  R  G  W  A  E  T  L  T  K   | A  L  A      p.200

          .         .         .         .         .         .       g.9041
 CACGTGGAGGCCTATATCGATTTCGGCGAGGATGACAACCTGGAGGAGGGGGTCCTGGAG       c.660
 H  V  E  A  Y  I  D  F  G  E  D  D  N  L  E  E  G  V  L  E         p.220

      | 06   .         .         .         .         .         .    g.9197
 CAAG | CCGACATCGAAGTACGGGCACTGCAGGTGGCCCTGGGTGCACATCTACGAGATGCC    c.720
 Q  A |   D  I  E  V  R  A  L  Q  V  A  L  G  A  H  L  R  D  A      p.240

          .         .         .         .         .         .       g.9257
 AGGCGCGGGCAGAGGCTCCGCTCAGGGGTGCACGTAGTGGTCACTGGACCCCCCAATGCG       c.780
 R  R  G  Q  R  L  R  S  G  V  H  V  V  V  T  G  P  P  N  A         p.260

          .         .         | 07         .         .         .    g.9484
 GGCAAGAGCAGCCTAGTGAACCTGCTCA | GTCGGAAGCCTGTGTCCATCGTGTCCCCGGAG    c.840
 G  K  S  S  L  V  N  L  L  S |   R  K  P  V  S  I  V  S  P  E      p.280

          .         .         .         .         .         .       g.9544
 CCAGGGACCACCCGTGACGTGCTGGAGACCCCAGTCGACCTGGCCGGATTTCCTGTGCTG       c.900
 P  G  T  T  R  D  V  L  E  T  P  V  D  L  A  G  F  P  V  L         p.300

          .         .         .         .         .         .       g.9604
 CTGAGCGACACGGCTGGGTTGCGGGAGGGCGTGGGGCCCGTGGAGCAGGAGGGCGTGCGG       c.960
 L  S  D  T  A  G  L  R  E  G  V  G  P  V  E  Q  E  G  V  R         p.320

          .     | 08   .         .         .         .         .    g.11108
 CGCGCCCGGGAGAG | GCTAGAGCAGGCTGACCTCATTCTGGCCATGCTGGATGCTTCTGAC    c.1020
 R  A  R  E  R  |  L  E  Q  A  D  L  I  L  A  M  L  D  A  S  D      p.340

          .         .         .         .         .         .       g.11168
 CTGGCCTCTCCCTCCAGTTGCAACTTCCTGGCCACCGTCGTAGCCTCTGTGGGAGCCCAG       c.1080
 L  A  S  P  S  S  C  N  F  L  A  T  V  V  A  S  V  G  A  Q         p.360

          .         .         .         .         .         .       g.11228
 AGCCCCAGTGACAGCAGCCAGCGCCTCCTCCTGGTGCTGAACAAGTCGGACCTGCTGTCC       c.1140
 S  P  S  D  S  S  Q  R  L  L  L  V  L  N  K  S  D  L  L  S         p.380

          .         .         .         .         .         .       g.11288
 CCGGAGGGCCCAGGTCCCGGTCCTGACCTGCCCCCGCACCTGCTGCTGTCCTGTCTGACG       c.1200
 P  E  G  P  G  P  G  P  D  L  P  P  H  L  L  L  S  C  L  T         p.400

          .         .         .         .         .    | 09    .    g.11503
 GGAGAGGGGCTGGACGGCCTCCTGGAGGCGCTGAGGAAGGAGCTAGCTGCAGT | GTGTGGG    c.1260
 G  E  G  L  D  G  L  L  E  A  L  R  K  E  L  A  A  V  |  C  G      p.420

          .         .         .         .         .         .       g.11563
 GACCCGTCCACAGATCCCCCGCTGCTGACCCGAGCAAGGCACCAGCACCACCTCCAGGGT       c.1320
 D  P  S  T  D  P  P  L  L  T  R  A  R  H  Q  H  H  L  Q  G         p.440

          .         .         .         .         .         .       g.11623
 TGCCTGGATGCCCTCGGCCACTACAAGCAGTCAAAAGACCTGGCCCTGGCGGCAGAGGCG       c.1380
 C  L  D  A  L  G  H  Y  K  Q  S  K  D  L  A  L  A  A  E  A         p.460

          .         .         .         .         .         .       g.11683
 CTGCGGGTGGCCCGGGGTCACCTGACCCGGCTCACAGGTGGAGGGGGTACCGAGGAGATC       c.1440
 L  R  V  A  R  G  H  L  T  R  L  T  G  G  G  G  T  E  E  I         p.480

          .         .         .                                     g.11722
 CTGGACATCATCTTCCAGGACTTCTGTGTGGGCAAGTGA                            c.1479
 L  D  I  I  F  Q  D  F  C  V  G  K  X                              p.492

          .         .         .         .         .         .       g.11782
 cgggatccagggaagtcgcacccaagctgcgtggagacccaggagcctcgggggatctgg       c.*60

          .         .         .         .         .         .       g.11842
 aaacagtttaggccaattgggattctcattcgcctgggaaagaacttgattctcaaatag       c.*120

          .         .         .         .         .         .       g.11902
 tgaagcaacacagctgagaggtagtgagatccctgcagggactccctggagattcaggcc       c.*180

          .         .         .         .         .         .       g.11962
 ctggaatggggctgaatggaggtcccgttcgacccttgatgctggggcatccgggttggg       c.*240

          .         .         .         .         .         .       g.12022
 atggagataggaggatctcagtatatttgtttcgtagttttttatttattttgcaaatac       c.*300

          .         .         .         .         .         .       g.12082
 caaaggaatgtaaaaaaaactcaggtgatctagaagtgtttattttcttcccttcccttc       c.*360

          .         .         .         .         .         .       g.12142
 ccttccctttccttttccctttccctttccccttccccttccccttccccttcccctacc       c.*420

          .         .         .         .         .         .       g.12202
 cttccctcctctgtctattgcccaggctggagtgcagtggtgcgaccttggctcactgca       c.*480

          .         .         .         .         .         .       g.12262
 acctccatctccggggctcaagcgcttctcctgcctcagcctcctgagtagctgggatta       c.*540

          .         .         .         .         .         .       g.12322
 caggcatgtgccagcatgcccggctaatttttttctttttttgagacagagtctcgctct       c.*600

          .         .         .         .         .         .       g.12382
 gtcacccaggctggagttcagtggtgcgacctcggcttactgcaacctccacctcccggg       c.*660

          .         .         .         .         .         .       g.12442
 ttcaagtgattctcctgcctcagcctcttgagtagctgggactacaggcgcacaccacca       c.*720

          .         .         .         .         .         .       g.12502
 cgccaggctaatttttgtatttttagtagagacaaggtttcaccatgttgaccaggctgg       c.*780

          .         .         .         .         .         .       g.12562
 tcttgaactccttgacctcaggtaatctgcctaccttggcctcccaaagtgctgggatca       c.*840

          .         .         .         .         .         .       g.12622
 caggcgtgagctatcacacctggccccagaagtgtttcaacatggaaattttccttagcc       c.*900

          .         .         .         .         .         .       g.12682
 cttctgtggttgtcatggcttaatgtgtgtctttccagaactttgaatgtttgcatactt       c.*960

          .         .         .         .         .         .       g.12742
 gtggatgtacctttcaaatatgtttgtcttgtgtatcatatataaatggtattgtgttca       c.*1020

                                                                    g.12750
 ttgctcta                                                           c.*1028

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GTP binding protein 3 (mitochondrial) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2022 Leiden University Medical Center