GUF1 GTPase homolog (S. cerevisiae) (GUF1) - coding DNA reference sequence

(used for variant description)

(last modified March 6, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_021927.2 in the GUF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering GUF1 transcript NM_021927.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  gtgcagacgtcggcaagctgcgccgcc       c.-181

 .         .         .         .         .         .                g.5087
 gcttcgggttgcttccggatctggtacttgggcagagctccccggggttcattgtcttcg       c.-121

 .         .         .         .         .         .                g.5147
 cttcacaggatctgtttgagtcctgtccaccggatcctacggggggtaccttcgaaaaaa       c.-61

 .         .         .         .         .         .                g.5207
 aacgggctatgctgctgttgcgtgtgggtaccctctcctgacgcctccgccgcccgggtc       c.-1

          .         .         .         .         .         .       g.5267
 ATGTGGACCCTCGTGGGTCGGGGCTGGGGGTGCGCACGCGCTCTCGCGCCACGAGCCACT       c.60
 M  W  T  L  V  G  R  G  W  G  C  A  R  A  L  A  P  R  A  T         p.20

          .         .         .         .         .         .       g.5327
 GGGGCCGCGCTTCTGGTGGCCCCGGGGCCCCGGTCCGCGCCGACCCTTGGGGCTGCTCCA       c.120
 G  A  A  L  L  V  A  P  G  P  R  S  A  P  T  L  G  A  A  P         p.40

          .         .         .         .      | 02  .         .    g.7040
 GAGTCCTGGGCTACCGACAGGCTCTACAGCTCCGCAGAATTCAAG | GAAAAACTTGACATG    c.180
 E  S  W  A  T  D  R  L  Y  S  S  A  E  F  K   | E  K  L  D  M      p.60

          .         .         .         .         .         .       g.7100
 TCTAGGTTTCCTGTTGAAAATATTAGAAATTTCAGTATTGTTGCACACGTGGATCATGGC       c.240
 S  R  F  P  V  E  N  I  R  N  F  S  I  V  A  H  V  D  H  G         p.80

          .         .         .        | 03.         .         .    g.7301
 AAAAGTACTTTAGCTGACAGGCTCCTAGAACTTACAG | GGACAATTGATAAAACAAAGAAT    c.300
 K  S  T  L  A  D  R  L  L  E  L  T  G |   T  I  D  K  T  K  N      p.100

          .         .         .         .         .         .       g.7361
 AATAAGCAGGTTCTTGATAAATTGCAAGTGGAACGAGAAAGAGGAATCACTGTTAAAGCA       c.360
 N  K  Q  V  L  D  K  L  Q  V  E  R  E  R  G  I  T  V  K  A         p.120

          .         .         .         .         .         .       g.7421
 CAGACAGCATCTCTCTTTTACAATTGTGAAGGAAAGCAGTACCTTTTAAATCTCATTGAT       c.420
 Q  T  A  S  L  F  Y  N  C  E  G  K  Q  Y  L  L  N  L  I  D         p.140

        | 04 .         .         .         .         .         .    g.7761
 ACACCG | GGCCATGTTGATTTTAGTTATGAAGTATCCAGGTCACTTTCTGCTTGCCAGGGT    c.480
 T  P   | G  H  V  D  F  S  Y  E  V  S  R  S  L  S  A  C  Q  G      p.160

          .         .        | 05.         .         .         .    g.8951
 GTTTTACTTGTGGTTGATGCAAATGAG | GGAATTCAAGCCCAAACTGTAGCAAACTTCTTT    c.540
 V  L  L  V  V  D  A  N  E   | G  I  Q  A  Q  T  V  A  N  F  F      p.180

          .         .         .         .      | 06  .         .    g.9834
 CTTGCCTTCGAAGCACAGCTATCGGTAATTCCAGTTATAAATAAG | ATAGATCTGAAGAAT    c.600
 L  A  F  E  A  Q  L  S  V  I  P  V  I  N  K   | I  D  L  K  N      p.200

          .         .         .         .         .         .       g.9894
 GCTGATCCTGAAAGGGTTGAAAACCAAATTGAGAAAGTGTTTGATATTCCAAGTGATGAA       c.660
 A  D  P  E  R  V  E  N  Q  I  E  K  V  F  D  I  P  S  D  E         p.220

           | 07        .         .         .         .         .    g.12594
 TGTATTAAG | ATTTCTGCTAAACTTGGAACAAATGTTGAGAGTGTTCTTCAGGCAATTATT    c.720
 C  I  K   | I  S  A  K  L  G  T  N  V  E  S  V  L  Q  A  I  I      p.240

          .     | 08   .         .         .         .         .    g.13140
 GAAAGAATCCCCCC | TCCTAAAGTGCATCGCAAAAATCCTCTGAGAGCTTTGGTATTTGAC    c.780
 E  R  I  P  P  |  P  K  V  H  R  K  N  P  L  R  A  L  V  F  D      p.260

          .         .         .         .         .         .       g.13200
 TCCACCTTTGACCAGTATAGAGGTGTGATAGCCAATGTAGCATTATTTGACGGAGTGGTT       c.840
 S  T  F  D  Q  Y  R  G  V  I  A  N  V  A  L  F  D  G  V  V         p.280

          .         .         .         .         .         .       g.13260
 TCCAAAGGAGATAAAATTGTATCTGCACATACTCAAAAGACATACGAAGTTAATGAAGTA       c.900
 S  K  G  D  K  I  V  S  A  H  T  Q  K  T  Y  E  V  N  E  V         p.300

          .         .         .         | 09         .         .    g.14613
 GGAGTCTTGAATCCTAATGAGCAGCCAACTCATAAATT | ATATGCAGGACAGGTGGGCTAT    c.960
 G  V  L  N  P  N  E  Q  P  T  H  K  L  |  Y  A  G  Q  V  G  Y      p.320

          .         .         .         .         .         .       g.14673
 CTGATTGCTGGGATGAAAGATGTCACTGAAGCGCAAATAGGAGATACATTATGTTTACAT       c.1020
 L  I  A  G  M  K  D  V  T  E  A  Q  I  G  D  T  L  C  L  H         p.340

          .         .         .         .         .         | 10    g.15872
 AAGCAACCAGTGGAGCCCTTGCCTGGGTTTAAATCAGCGAAACCAATGGTATTTGCAG | GA    c.1080
 K  Q  P  V  E  P  L  P  G  F  K  S  A  K  P  M  V  F  A  G |       p.360

          .         .         .         .         .         .       g.15932
 ATGTATCCTCTAGACCAATCTGAATATAACAATCTGAAGAGTGCTATAGAAAAACTGACT       c.1140
 M  Y  P  L  D  Q  S  E  Y  N  N  L  K  S  A  I  E  K  L  T         p.380

          .         .         .         .         .         .       g.15992
 TTAAATGATTCCAGTGTGACCGTTCATCGGGATAGTAGCCTTGCTCTGGGTGCTGGCTGG       c.1200
 L  N  D  S  S  V  T  V  H  R  D  S  S  L  A  L  G  A  G  W         p.400

    | 11     .         .         .         .         .         .    g.16485
 AG | GCTAGGATTTCTTGGACTTTTGCACATGGAAGTTTTCAACCAGCGACTGGAGCAAGAA    c.1260
 R  |  L  G  F  L  G  L  L  H  M  E  V  F  N  Q  R  L  E  Q  E      p.420

          .         .         .         .         .         .       g.16545
 TATAATGCTTCTGTTATTTTAACAACCCCTACTGTTCCATATAAAGCTGTACTGTCATCA       c.1320
 Y  N  A  S  V  I  L  T  T  P  T  V  P  Y  K  A  V  L  S  S         p.440

          .      | 12  .         .         .         .         .    g.17346
 TCAAAATTGATAAAG | GAACATAGAGAAAAAGAAATTACAATTATCAATCCTGCACAATTC    c.1380
 S  K  L  I  K   | E  H  R  E  K  E  I  T  I  I  N  P  A  Q  F      p.460

          .         .         .         .         .         .       g.17406
 CCCGATAAATCAAAAGTAACAGAATATTTGGAGCCAGTTGTTTTGGGCACTATTATCACA       c.1440
 P  D  K  S  K  V  T  E  Y  L  E  P  V  V  L  G  T  I  I  T         p.480

          .         .         .          | 13        .         .    g.18271
 CCAGATGAATACACTGGAAAAATAATGATGCTTTGCGAG | GCTCGAAGAGCAGTTCAGAAG    c.1500
 P  D  E  Y  T  G  K  I  M  M  L  C  E   | A  R  R  A  V  Q  K      p.500

          .         .         .         .         .         .       g.18331
 AATATGATATTTATTGATCAAAATAGAGTTATGCTTAAATATCTCTTTCCTTTGAATGAA       c.1560
 N  M  I  F  I  D  Q  N  R  V  M  L  K  Y  L  F  P  L  N  E         p.520

          .         .         .         .         .    | 14    .    g.21003
 ATTGTGGTAGATTTTTATGACTCTTTGAAATCCCTATCTTCTGGATATGCTAG | TTTTGAT    c.1620
 I  V  V  D  F  Y  D  S  L  K  S  L  S  S  G  Y  A  S  |  F  D      p.540

          .         .         .         .         .         .       g.21063
 TACGAAGATGCAGGCTACCAGACTGCAGAACTTGTAAAAATGGATATTCTACTGAATGGA       c.1680
 Y  E  D  A  G  Y  Q  T  A  E  L  V  K  M  D  I  L  L  N  G         p.560

          .         .         .      | 15  .         .         .    g.22224
 AATACTGTAGAGGAGCTAGTAACTGTTGTACACAA | AGACAAAGCTCATTCAATTGGCAAA    c.1740
 N  T  V  E  E  L  V  T  V  V  H  K  |  D  K  A  H  S  I  G  K      p.580

          .         .         .         .         .         .       g.22284
 GCCATATGTGAACGGCTGAAGGATTCTCTTCCTAGGCAACTGTTTGAGATAGCAATTCAA       c.1800
 A  I  C  E  R  L  K  D  S  L  P  R  Q  L  F  E  I  A  I  Q         p.600

          .         .         .      | 16  .         .         .    g.24017
 GCTGCTATTGGAAGTAAAATCATTGCAAGAGAAAC | TGTGAAAGCCTATAGGAAAAACGTT    c.1860
 A  A  I  G  S  K  I  I  A  R  E  T  |  V  K  A  Y  R  K  N  V      p.620

          .   | 17     .         .         .         .         .    g.25176
 TTGGCAAAATGT | TATGGTGGTGATATTACCCGAAAAATGAAGCTTTTGAAGAGACAAGCA    c.1920
 L  A  K  C   | Y  G  G  D  I  T  R  K  M  K  L  L  K  R  Q  A      p.640

          .         .         .         .         .         .       g.25236
 GAAGGGAAAAAAAAGCTGAGGAAAATTGGCAACGTTGAAGTTCCAAAAGATGCTTTTATA       c.1980
 E  G  K  K  K  L  R  K  I  G  N  V  E  V  P  K  D  A  F  I         p.660

          .         .         .                                     g.25266
 AAAGTTCTGAAAACACAATCTTCTAAATAA                                     c.2010
 K  V  L  K  T  Q  S  S  K  X                                       p.669

          .         .         .         .         .         .       g.25326
 ttggtgggaaaacaaagaattttcattgcaatttgtaatatgctgacaacagaaagaaaa       c.*60

          .         .         .         .         .         .       g.25386
 ttataaaatttgcttgttactttcagggtattcaggttcaaataacctactagtctttcg       c.*120

          .         .         .         .         .         .       g.25446
 ttgaaagggagtagttagtgggtaggcaagagcttagattttgaagccatgttgcctgtt       c.*180

          .         .         .         .         .         .       g.25506
 ctcaaatatctgttccaaccactcactagtaaggtgaccgtggccagattaacctttgtt       c.*240

          .         .         .         .         .         .       g.25566
 tcctcttcagtaaaatcgagattatactactacctacataagttgttgttgtgaagatta       c.*300

          .         .         .         .         .         .       g.25626
 aatgaggtaatacgttaaatattcagaggtgcaagacacatagtaagcactcaattgtaa       c.*360

          .         .         .         .         .         .       g.25686
 ctacagttaagtccttaaatgccatcgaaaggttcttagaaactgactttaagcaaaatg       c.*420

          .         .         .         .         .         .       g.25746
 acacgtagcacaatgttcttgaatgatgtcatttccttaagtggtttgtaacatcgatga       c.*480

          .         .         .         .         .         .       g.25806
 ggaaaaaaaattggtttatgcgtcatttcattttatttttatttattttttgagacagag       c.*540

          .         .         .         .         .         .       g.25866
 tcttgccctgtcgcccaggctggagtgcaatggcacaatctcgactcactgcaacctctg       c.*600

          .         .         .         .         .         .       g.25926
 cctcctgggttcaagagattctcctgcctcagcctccattacaggcgtgcaccaccatgc       c.*660

          .         .         .         .         .         .       g.25986
 tcggctaattttttgtatctttagtagagtcggggtttcaccatgttggccaggctggtc       c.*720

          .         .         .         .         .         .       g.26046
 ttgaactcctgacctcgtgatccacccaccgtggcctcccaaagtgctgattacaggtgt       c.*780

          .         .         .         .         .         .       g.26106
 gagccaccatgcccagccatgtcatttcatttaaagtcacaatttccatgaatctcaaca       c.*840

          .         .         .         .         .         .       g.26166
 agtgaggacctgctatattttgttgcatgcagtttttctttacggacactaaaaggcccc       c.*900

          .         .         .         .         .         .       g.26226
 atacttaagattccatctactttaagtttaaaggattttcagaatcaccttaagtgtcaa       c.*960

          .         .         .         .         .         .       g.26286
 atttgttagcaggattaattgatatgaattcacttattaaacagtaaactcaaataacat       c.*1020

          .         .         .         .         .         .       g.26346
 agacatcaaataacagacatctgctctagttaatgataaaatgtttatagattttatcag       c.*1080

          .         .         .         .         .         .       g.26406
 gtggttagtttgaaactaaatggtttacatctaaattaagggcaggagctgtctttcaga       c.*1140

          .         .         .         .         .         .       g.26466
 cattcaaaacgcatttgtgtaaaatgacaggtgtttggtattaccaggaactcataatga       c.*1200

          .         .         .         .         .         .       g.26526
 cattttaataattattgtctaaatttcataatcgaagcgattttagagtagttaacttga       c.*1260

          .         .         .         .         .         .       g.26586
 gatttcacagccagtaaatggctgtatttctccagagctctcagctcccatgtttattca       c.*1320

          .         .         .         .         .         .       g.26646
 gccaacgaacaaaccagactgcagactgtattagagcaagacaacatcatttagccattg       c.*1380

          .         .         .         .         .         .       g.26706
 atttttatcttctaccttgaatgaattgaatgaagaaaatgtcttttagggataaacact       c.*1440

          .         .         .         .         .         .       g.26766
 atcaaggatgaattttatactaaggttatatgaaagaaaaatctcaaaaccactaagcca       c.*1500

          .         .         .         .         .         .       g.26826
 aagggaagtcaagctgggaactgattgaggcaaacctgcctcccattttattcctaaata       c.*1560

          .         .         .         .         .         .       g.26886
 agacagccacaaagataaaatttgctcacaagggaattccttatggacaaagaactcaaa       c.*1620

          .         .         .         .         .         .       g.26946
 gtcttcacatgaaacaaatgcataaatgattgctttctctgtttcatgtttcactaagcc       c.*1680

          .         .         .         .         .         .       g.27006
 agattaaggtataactgactattcctctactctcctctcacatgtaaattgtatattcag       c.*1740

          .         .         .         .         .         .       g.27066
 tgaaaggctaatcagaaactcaaaaaaatgcaaccctttctctcttacctgcctatgctt       c.*1800

          .         .         .         .         .         .       g.27126
 gaagcccccgcccctcttcaagttgtcctgcctttcaagaccaatgtacaccttacacat       c.*1860

          .         .         .         .         .         .       g.27186
 actgattgatgtctcatgtctctctaaaatgtgtaaaaccaagctgtgccccaaccacct       c.*1920

          .         .         .         .         .         .       g.27246
 tgggcacatgtggtgaggacctcctgaggctgtgtcatgggcacaccttaaccctgggaa       c.*1980

          .                                                         g.27265
 aataaactttctaaactga                                                c.*1999

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GUF1 GTPase homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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