glycophorin A (MNS blood group) (GYPA) - coding DNA reference sequence

(used for variant description)

(last modified December 15, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_002099.6 in the GYPA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering GYPA transcript NM_002099.6.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5056
     gcaggaaggtgggcctggaagataacagctagcaggctaaggtcagacactgacac       c.-61

 .         .         .         .         .         .                g.5116
 ttgcagttgtctttggtagtttttttgcactaacttcaggaaccagctcatgatctcagg       c.-1

          .         .         .        | 02.         .         .    g.25186
 ATGTATGGAAAAATAATCTTTGTATTACTATTGTCAG | AAATTGTGAGCATATCAGCATTA    c.60
 M  Y  G  K  I  I  F  V  L  L  L  S  E |   I  V  S  I  S  A  L      p.20

          .         .         .         .         .         .       g.25246
 AGTACCACTGAGGTGGCAATGCACACTTCAACTTCTTCTTCAGTCACAAAGAGTTACATC       c.120
 S  T  T  E  V  A  M  H  T  S  T  S  S  S  V  T  K  S  Y  I         p.40

          .       | 03 .         .         .         .         .    g.26014
 TCATCACAGACAAATG | ATACGCACAAACGGGACACATATGCAGCCACTCCTAGAGCTCAT    c.180
 S  S  Q  T  N  D |   T  H  K  R  D  T  Y  A  A  T  P  R  A  H      p.60

          .         .         .         .         .   | 04     .    g.27007
 GAAGTTTCAGAAATTTCTGTTAGAACTGTTTACCCTCCAGAAGAGGAAACCG | GAGAAAGG    c.240
 E  V  S  E  I  S  V  R  T  V  Y  P  P  E  E  E  T  G |   E  R      p.80

          .         .         .  | 05      .         .         .    g.28841
 GTACAACTTGCCCATCATTTCTCTGAACCAG | AGATAACACTCATTATTTTTGGGGTGATG    c.300
 V  Q  L  A  H  H  F  S  E  P  E |   I  T  L  I  I  F  G  V  M      p.100

          .         .         .         .         .        | 06.    g.30987
 GCTGGTGTTATTGGAACGATCCTCTTAATTTCTTACGGTATTCGCCGACTGATAAAG | AAA    c.360
 A  G  V  I  G  T  I  L  L  I  S  Y  G  I  R  R  L  I  K   | K      p.120

          .         .         .         .         .         .       g.31047
 AGCCCATCTGATGTAAAACCTCTCCCCTCACCTGACACAGACGTGCCTTTAAGTTCTGTT       c.420
 S  P  S  D  V  K  P  L  P  S  P  D  T  D  V  P  L  S  S  V         p.140

          .       | 07 .         .                                  g.34385
 GAAATAGAAAATCCAG | AGACAAGTGATCAATGA                               c.453
 E  I  E  N  P  E |   T  S  D  Q  X                                 p.150

          .         .         .         .         .         .       g.34445
 gaatctgttcaccaaaccaaatgtggaaagaacacaaagaagacataagacttcagtcaa       c.*60

          .         .         .         .         .         .       g.34505
 gtgaaaaattaacatgtggactggacactccaataaattatatacctgcctaagttgtac       c.*120

          .         .         .         .         .         .       g.34565
 aatttcagaatgcaattttcattataatgagttccagtgactcaatgatggggaaaaaaa       c.*180

          .         .         .         .         .         .       g.34625
 tctctgctcattaatatttcaagataaagaacaaatgtttccttgaatgcttgcttttgt       c.*240

          .         .         .         .         .         .       g.34685
 gtgttagcataatttttagaattgtttgagaattctgatccaaaactttagttgaattca       c.*300

          .         .         .         .         .         .       g.34745
 tctacgtttgtttaatattaacttaacctattctattgtattataatgatgattctgtca       c.*360

          .         .         .         .         .         .       g.34805
 aatgaaaggcttgaaatacctagatgaagtttagattttcttcctattgtaaacttttga       c.*420

          .         .         .         .         .         .       g.34865
 gtctggtttcattgttttaaataaattaaggggacactaaagtcctatcattcatttcct       c.*480

          .         .         .         .         .         .       g.34925
 tcattgctgaacaggcaagatataatattacatgaatgattactatattttgttcacact       c.*540

          .         .         .         .         .         .       g.34985
 aataaagcttatgctcagaaatgccatacacacacacacacacacacacaaacacacaca       c.*600

          .         .         .         .         .         .       g.35045
 tttatcatttaatgcataaatcaacacaaaaggttttcccattaatatgaaatattacat       c.*660

          .         .         .         .         .         .       g.35105
 atatataagtgccatatttaaaataatttgtctaacagtagaactgtgtcggagcactca       c.*720

          .         .         .         .         .         .       g.35165
 ctgaagcttgcattccactgaaagagttatttgtgtaagtagagtatccggagaaggaaa       c.*780

          .         .         .         .         .         .       g.35225
 agaacttacgacctttctttataacagaaactcaactctaaattcaacaagatgtgcaaa       c.*840

          .         .         .         .         .         .       g.35285
 ccggacatgcaggtgaatattttaataggttactataaggttctcaattaaattctttaa       c.*900

          .         .         .         .         .         .       g.35345
 tctgtccagtcccagtttctcttattaataaaactttggaaattgctttaaaccatttaa       c.*960

          .         .         .         .         .         .       g.35405
 aggaaatttctagatatagaaactaaggactgtgactatacagctgtcactcatttgtag       c.*1020

          .         .         .         .         .         .       g.35465
 taaaacttaaaaagcaaaaacaaaaaacaaaaaagaccttcctgtgatactttatttccg       c.*1080

          .         .         .         .         .         .       g.35525
 aactaataaaaatctatatgactttttattattgtgtgataaccaagtaaatgttttcta       c.*1140

          .         .         .         .         .         .       g.35585
 ttttgcatattttcaggcatggtaacagaaatttaccttttaataaattaaaaaatctaa       c.*1200

          .         .         .         .         .         .       g.35645
 attttaacctacttgtatgttcggagagtgtttttgtactatattgactacttaaaatag       c.*1260

          .         .         .         .         .         .       g.35705
 agaatgagactaagaagggaacatttctgttgatacatgttttttaaaagtaattttaag       c.*1320

          .         .         .         .         .         .       g.35765
 agcattattaggttaattaatccaattaatgacccaaatgccaaggtaattttaaattta       c.*1380

          .         .         .         .         .         .       g.35825
 catttttaataaaagcaacatgttgaaacaagagagggtgagattaacctttttgctaaa       c.*1440

          .         .         .         .         .         .       g.35885
 gtaatttacaagtcaaagacaggaagagatcagagtgaatgtgccttcttaaccagagct       c.*1500

          .         .         .         .         .         .       g.35945
 acagaatttagtgaataattaaagtacaaactgctttgacctccttgaacttttccaagc       c.*1560

          .         .         .         .         .         .       g.36005
 aatttctctgtacttctatatatgaatgtcttagccaattttctgctactataacagaat       c.*1620

          .         .         .         .         .         .       g.36065
 acgacagactgggtaatttaaaaagaaaagaaatttattttcttcctagttctggaggct       c.*1680

          .         .         .         .         .         .       g.36125
 gggaaggcgaagggcatggcactgacatctgccttgtaactgatgagaaccttcttactg       c.*1740

          .         .         .         .         .         .       g.36185
 catgataacaaagcagcaaggcaagcaaaagcgtaagatgaagagagaggaaatgaagcc       c.*1800

          .         .         .         .         .         .       g.36245
 aaacacatcctttcatcagaagcccattccctctataaggcgttattacatttatgagaa       c.*1860

          .         .         .         .         .         .       g.36305
 tggagtcctcatgacctaatcgtgaccttaaaggcccctcccaacactgttacaatggca       c.*1920

          .         .         .         .         .         .       g.36365
 attaaatttcaacaaaggttccagaggtgacattcgaatcagcaatgaaattttcatagt       c.*1980

          .         .         .         .         .         .       g.36425
 taaatttggtattcgtgggggaagaaatgaccatttcccttgtatttttataattaaatc       c.*2040

          .         .         .         .         .                 g.36476
 agcaaaatattgtaataaagaaatctttcctgtgaagataccatgacccca                c.*2091

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Glycophorin A (MNS blood group) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.