glycogen synthase 1 (muscle) (GYS1) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_002103.4 in the GYS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering GYS1 transcript NM_002103.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            t       c.-241

 .         .         .         .         .         .                g.5061
 cctggcggctgcgaggtttcactgcaggggcgccagtgggctcagtgacgctgcggcctc       c.-181

 .         .         .         .         .         .                g.5121
 cttctgcctaggtcccaacgcttcggggcaggggtgcggtcttgcaataggaagccgagc       c.-121

 .         .         .         .         .         .                g.5181
 gtcttgcaagcttcccgtcgggcaccagctactcggccccgcaccctacctggtgcattc       c.-61

 .         .         .         .         .         .                g.5241
 cctagacacctccggggtccctacctggagatccccggagccccccttcctgcgccagcc       c.-1

          .         .         .         .         .         .       g.5301
 ATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGAT       c.60
 M  P  L  N  R  T  L  S  M  S  S  L  P  G  L  E  D  W  E  D         p.20

          .         .         .         .         .         | 02    g.6872
 GAATTCGACCTGGAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGG | TG    c.120
 E  F  D  L  E  N  A  V  L  F  E  V  A  W  E  V  A  N  K  V |       p.40

          .         .         .         .         .         .       g.6932
 GGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAGGGGACGAATGGGGCGAC       c.180
 G  G  I  Y  T  V  L  Q  T  K  A  K  V  T  G  D  E  W  G  D         p.60

          .         .         .         .         .         .       g.6992
 AACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTG       c.240
 N  Y  F  L  V  G  P  Y  T  E  Q  G  V  R  T  Q  V  E  L  L         p.80

          .         .         .         .         .         .       g.7052
 GAGGCCCCCACCCCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAG       c.300
 E  A  P  T  P  A  L  K  R  T  L  D  S  M  N  S  K  G  C  K         p.100

  | 03       .         .         .         .         .         .    g.11028
  | GTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGGTGCTCCTGGACGTGGGT    c.360
  | V  Y  F  G  R  W  L  I  E  G  G  P  L  V  V  L  L  D  V  G      p.120

          .         .         .         .         .         .       g.11088
 GCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGA       c.420
 A  S  A  W  A  L  E  R  W  K  G  E  L  W  D  T  C  N  I  G         p.140

          .         .         .         .         .         .       g.11148
 GTGCCGTGGTACGACCGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGG       c.480
 V  P  W  Y  D  R  E  A  N  D  A  V  L  F  G  F  L  T  T  W         p.160

          .   | 04     .         .         .         .         .    g.12366
 TTCCTGGGTGAG | TTCCTGGCACAGAGTGAGGAGAAGCCACATGTGGTTGCTCACTTCCAT    c.540
 F  L  G  E   | F  L  A  Q  S  E  E  K  P  H  V  V  A  H  F  H      p.180

          .         .         .         .         .         .       g.12426
 GAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACC       c.600
 E  W  L  A  G  V  G  L  C  L  C  R  A  R  R  L  P  V  A  T         p.200

          .         .         .         .         .         .       g.12486
 ATCTTCACCACCCATGCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTC       c.660
 I  F  T  T  H  A  T  L  L  G  R  Y  L  C  A  G  A  V  D  F         p.220

          .         | 05         .         .         .         .    g.12790
 TACAACAACCTGGAGAAC | TTCAACGTGGACAAGGAAGCAGGGGAGAGGCAGATCTACCAC    c.720
 Y  N  N  L  E  N   | F  N  V  D  K  E  A  G  E  R  Q  I  Y  H      p.240

          .         .         .         .         .         .       g.12850
 CGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAG       c.780
 R  Y  C  M  E  R  A  A  A  H  C  A  H  V  F  T  T  V  S  Q         p.260

          .         .         .         .    | 06    .         .    g.15533
 ATCACCGCCATCGAGGCACAGCACTTGCTCAAGAGGAAACCAG | ATATTGTGACCCCCAAT    c.840
 I  T  A  I  E  A  Q  H  L  L  K  R  K  P  D |   I  V  T  P  N      p.280

          .         .         .         .         .         .       g.15593
 GGGCTGAATGTGAAGAAGTTTTCTGCCATGCATGAGTTCCAGAACCTCCATGCTCAGAGC       c.900
 G  L  N  V  K  K  F  S  A  M  H  E  F  Q  N  L  H  A  Q  S         p.300

          .         .         .         .  | 07      .         .    g.15997
 AAGGCTCGAATCCAGGAGTTTGTGCGGGGCCATTTTTATGG | GCATCTGGACTTCAACTTG    c.960
 K  A  R  I  Q  E  F  V  R  G  H  F  Y  G  |  H  L  D  F  N  L      p.320

          .         .         .         .         .         .       g.16057
 GACAAGACCTTATACTTCTTTATCGCCGGCCGCTATGAGTTCTCCAACAAGGGTGCTGAC       c.1020
 D  K  T  L  Y  F  F  I  A  G  R  Y  E  F  S  N  K  G  A  D         p.340

          .         .         .         .   | 08     .         .    g.16735
 GTCTTCCTGGAGGCATTGGCTCGGCTCAACTATCTGCTCAGA | GTGAACGGCAGCGAGCAG    c.1080
 V  F  L  E  A  L  A  R  L  N  Y  L  L  R   | V  N  G  S  E  Q      p.360

          .         .         .         .         .         .       g.16795
 ACAGTGGTTGCCTTCTTCATCATGCCAGCGCGGACCAACAATTTCAACGTGGAAACCCTC       c.1140
 T  V  V  A  F  F  I  M  P  A  R  T  N  N  F  N  V  E  T  L         p.380

          .         .          | 09        .         .         .    g.20227
 AAAGGCCAAGCTGTGCGCAAACAGCTTTG | GGACACGGCCAACACGGTGAAGGAAAAGTTC    c.1200
 K  G  Q  A  V  R  K  Q  L  W  |  D  T  A  N  T  V  K  E  K  F      p.400

          .         .          | 10        .         .         .    g.20382
 GGGAGGAAGCTTTATGAATCCTTACTGGT | TGGGAGCCTTCCCGACATGAACAAGATGCTG    c.1260
 G  R  K  L  Y  E  S  L  L  V  |  G  S  L  P  D  M  N  K  M  L      p.420

          .         .         .         .         | 11         .    g.23632
 GATAAGGAAGACTTCACTATGATGAAGAGAGCCATCTTTGCAACGCAG | CGGCAGTCTTTC    c.1320
 D  K  E  D  F  T  M  M  K  R  A  I  F  A  T  Q   | R  Q  S  F      p.440

          .         .         .         .         .         .       g.23692
 CCCCCTGTGTGCACCCACAATATGCTGGATGACTCCTCAGACCCCATCCTGACCACCATC       c.1380
 P  P  V  C  T  H  N  M  L  D  D  S  S  D  P  I  L  T  T  I         p.460

          .         .         .         .   | 12     .         .    g.24032
 CGCCGAATCGGCCTCTTCAATAGCAGTGCCGACAGGGTGAAG | GTGATTTTCCACCCGGAG    c.1440
 R  R  I  G  L  F  N  S  S  A  D  R  V  K   | V  I  F  H  P  E      p.480

          .         .         .         .         .         .       g.24092
 TTCCTCTCCTCCACAAGCCCCCTGCTCCCTGTGGACTATGAGGAGTTTGTCCGTGGCTGT       c.1500
 F  L  S  S  T  S  P  L  L  P  V  D  Y  E  E  F  V  R  G  C         p.500

          .         .         .         .          | 13        .    g.27341
 CACCTTGGAGTCTTCCCCTCCTACTATGAGCCTTGGGGCTACACACCGG | CTGAGTGCACG    c.1560
 H  L  G  V  F  P  S  Y  Y  E  P  W  G  Y  T  P  A |   E  C  T      p.520

          .         .         .         .         .         .       g.27401
 GTTATGGGAATCCCCAGTATCTCCACCAATCTCTCCGGCTTCGGCTGCTTCATGGAGGAA       c.1620
 V  M  G  I  P  S  I  S  T  N  L  S  G  F  G  C  F  M  E  E         p.540

          .         .      | 14  .         .         .         .    g.27679
 CACATCGCAGACCCCTCAGCTTACG | GTATCTACATTCTTGACCGGCGGTTCCGCAGCCTG    c.1680
 H  I  A  D  P  S  A  Y  G |   I  Y  I  L  D  R  R  F  R  S  L      p.560

          .         .         .         .         .         .       g.27739
 GATGATTCCTGCTCGCAGCTCACCTCCTTCCTCTACAGTTTCTGTCAGCAGAGCCGGCGG       c.1740
 D  D  S  C  S  Q  L  T  S  F  L  Y  S  F  C  Q  Q  S  R  R         p.580

          .         .         .         .         .         .       g.27799
 CAGCGTATCATCCAGCGGAACCGCACGGAGCGCCTCTCCGACCTTCTGGACTGGAAATAC       c.1800
 Q  R  I  I  Q  R  N  R  T  E  R  L  S  D  L  L  D  W  K  Y         p.600

           | 15        .         .         .         .         .    g.28549
 CTAGGCCGG | TACTATATGTCTGCGCGCCACATGGCGCTGTCCAAGGCCTTTCCAGAGCAC    c.1860
 L  G  R   | Y  Y  M  S  A  R  H  M  A  L  S  K  A  F  P  E  H      p.620

          .         .         . | 16       .         .         .    g.28772
 TTCACCTACGAGCCCAACGAGGCGGATGCG | GCCCAGGGGTACCGCTACCCACGGCCAGCC    c.1920
 F  T  Y  E  P  N  E  A  D  A   | A  Q  G  Y  R  Y  P  R  P  A      p.640

          .         .         .         .         .         .       g.28832
 TCGGTGCCACCGTCGCCCTCGCTGTCACGACACTCCAGCCCGCACCAGAGTGAGGACGAG       c.1980
 S  V  P  P  S  P  S  L  S  R  H  S  S  P  H  Q  S  E  D  E         p.660

          .         .         .         .         .         .       g.28892
 GAGGATCCCCGGAACGGGCCGCTGGAGGAAGACGGCGAGCGCTACGATGAGGACGAGGAG       c.2040
 E  D  P  R  N  G  P  L  E  E  D  G  E  R  Y  D  E  D  E  E         p.680

          .         .         .         .         .         .       g.28952
 GCCGCCAAGGACCGGCGCAACATCCGTGCACCAGAGTGGCCGCGCCGAGCGTCCTGCACC       c.2100
 A  A  K  D  R  R  N  I  R  A  P  E  W  P  R  R  A  S  C  T         p.700

          .         .         .         .         .         .       g.29012
 TCCTCCACCAGCGGCAGCAAGCGCAACTCTGTGGACACGGCCACCTCCAGCTCACTCAGC       c.2160
 S  S  T  S  G  S  K  R  N  S  V  D  T  A  T  S  S  S  L  S         p.720

          .         .         .         .         .                 g.29066
 ACCCCGAGCGAGCCCCTCAGCCCCACCAGCTCCCTGGGCGAGGAGCGTAACTAA             c.2214
 T  P  S  E  P  L  S  P  T  S  S  L  G  E  E  R  N  X               p.737

          .         .         .         .         .         .       g.29126
 gtccgccccaccacactccccgcctgtcctgcctctctgctccagagagaggatgcagag       c.*60

          .         .         .         .         .         .       g.29186
 gggtgctgctcctaaacccccgctccagatctgcactgggtgtggccccgcagtgccccc       c.*120

          .         .         .         .         .         .       g.29246
 acccagtccgccaaacactccaccccctccagctccagtttccaagttcctgcactccag       c.*180

          .         .         .         .         .         .       g.29306
 aatccacaaagccgtgcctttctctggctccagaatatgcataatcagcgccctggagtc       c.*240

          .         .         .         .         .         .       g.29366
 ccctgggcctggaccgcttcccagaggccaggaatctgccattactctgcggtggtgcca       c.*300

          .         .         .         .         .         .       g.29426
 gaggttttaggaaacctggcatggtgctttcaggtctggggcttttagagccccccgtgt       c.*360

          .         .         .         .         .         .       g.29486
 ggcttacaaattctacagcatacagagcaggccacgctcaggcccggcatgcgggccacc       c.*420

          .         .         .         .         .         .       g.29546
 aagttctggaaaccacgtggtgtccctgcgaatggggcgatcaagtccagagccggggca       c.*480

          .         .         .         .         .         .       g.29606
 ctttcagagtttgaaggtaactgagagcagatggtcctccatttcaactccagaagtggg       c.*540

          .         .         .         .         .         .       g.29666
 gctctgggagggatgttctagccctccctggcatgtcagagccaggctctgcctggagga       c.*600

          .         .         .         .         .         .       g.29726
 tccctccatccggctcctgtcatcccctacactttggccaagcaagaggtggtagaacca       c.*660

          .         .         .         .         .         .       g.29786
 cttggctgctcattccttctggaggacacacagtctcagtccagatgccttcctgtcttt       c.*720

          .         .         .         .         .         .       g.29846
 ctggccctttctggaccagatcctactcttcctttctaaatctgagatctccctccaggg       c.*780

          .         .         .         .         .         .       g.29906
 aatccgcctgcagaggacagagctggctgtcttcccccacccctaacctggcttattccc       c.*840

          .         .         .         .         .         .       g.29966
 aactgctctgcccactgtgaaaccactaggttctaggtcctggcttctagatctggaacc       c.*900

          .         .         .         .         .         .       g.30026
 ttaccacgttactgcatactgatccctttcccatgatccagaactgaggtcactgggttc       c.*960

          .         .         .         .         .         .       g.30086
 tagaacccccacatttacctcgaggctcttccatccccaaactgtgccctgccttcagct       c.*1020

          .         .         .         .         .         .       g.30146
 ttggtgaaagggagggcccctcatgtgtgctgtgctgtgtctgcaccgcttggtttgcag       c.*1080

          .         .         .         .         .         .       g.30206
 ttgagaggggagggcaggaggggtgtgattggagtgtgtccggagatgagatgaaaaaaa       c.*1140

          .         .                                               g.30229
 tacatctatatttaagaatccca                                            c.*1163

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glycogen synthase 1 (muscle) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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