hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (HADHB) - coding DNA reference sequence

(used for variant description)

(last modified December 6, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000183.2 in the HADHB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007294.1, covering HADHB transcript NM_000183.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4806
                                                  tcgctcctggc       c.-241

 .         .         .         .         .         .                g.4866
 taacatggccgaaaggtcgtattctccgggggaggacgggggcccggagaggagggggtg       c.-181

 .         .         .         .         .         .                g.4926
 gagtgcctggttttccagtcaggcggccggagggcagccctcaagaacggccctgaccgc       c.-121

 .         .         .         .         .         .                g.4986
 ccgcggggtgaggggccctttctgggcaggacccgccccttggtcccgcagagccttggt       c.-61

 .         .         .         .         .         .  | 02          g.14302
 acttggacctgaaccttgctccgagagggagtcctcgcggacgtcagccaag | attccaga    c.-1

          .         .         .         .         .         .       g.14362
 ATGACTATCTTGACTTACCCCTTTAAAAATCTTCCCACTGCATCAAAATGGGCCCTCAGA       c.60
 M  T  I  L  T  Y  P  F  K  N  L  P  T  A  S  K  W  A  L  R         p.20

      | 03   .         .         .         .          | 04        . g.23438
 TTTT | CCATAAGACCTCTGAGCTGTTCCTCCCAGCTACGAGCTGCCCCAG | CTGTCCAGACC c.120
 F  S |   I  R  P  L  S  C  S  S  Q  L  R  A  A  P  A |   V  Q  T   p.40

          .         .         .         .         .         .       g.23498
 AAAACGAAGAAGACGTTAGCCAAACCCAATATAAGGAATGTTGTGGTGGTGGATGGTGTT       c.180
 K  T  K  K  T  L  A  K  P  N  I  R  N  V  V  V  V  D  G  V         p.60

          .         .          | 05        .         .         .    g.30031
 CGCACTCCATTTTTGCTGTCTGGCACTTC | ATATAAAGACCTGATGCCACATGATTTGGCT    c.240
 R  T  P  F  L  L  S  G  T  S  |  Y  K  D  L  M  P  H  D  L  A      p.80

          .     | 06   .         .         .         .         .    g.33744
 AGAGCAGCGCTTAC | GGGTTTGTTGCATCGGACCAGTGTCCCTAAGGAAGTAGTTGATTAT    c.300
 R  A  A  L  T  |  G  L  L  H  R  T  S  V  P  K  E  V  V  D  Y      p.100

          .         .         .         .         .     | 07   .    g.37126
 ATCATCTTTGGTACAGTTATTCAGGAAGTGAAAACAAGCAATGTGGCTAGAGAG | GCTGCC    c.360
 I  I  F  G  T  V  I  Q  E  V  K  T  S  N  V  A  R  E   | A  A      p.120

          .         .         .         .         .         .       g.37186
 CTTGGAGCTGGCTTCTCTGACAAGACTCCTGCTCACACTGTCACCATGGCTTGTATCTCT       c.420
 L  G  A  G  F  S  D  K  T  P  A  H  T  V  T  M  A  C  I  S         p.140

          .         .   | 08     .         .         .         .    g.38699
 GCCAACCAAGCCATGACCACAG | GTGTTGGCTTGATTGCTTCTGGCCAGTGTGATGTGATC    c.480
 A  N  Q  A  M  T  T  G |   V  G  L  I  A  S  G  Q  C  D  V  I      p.160

          .         .         .         .         .         .       g.38759
 GTGGCAGGTGGTGTTGAGTTGATGTCCGATGTCCCTATTCGTCACTCAAGGAAAATGAGA       c.540
 V  A  G  G  V  E  L  M  S  D  V  P  I  R  H  S  R  K  M  R         p.180

          .         .         .         .         .         .       g.38819
 AAACTGATGCTTGATCTCAATAAGGCCAAATCTATGGGCCAGCGACTGTCTTTAATCTCT       c.600
 K  L  M  L  D  L  N  K  A  K  S  M  G  Q  R  L  S  L  I  S         p.200

          .         .         . | 09       .         .         .    g.39212
 AAATTCCGATTTAATTTCCTAGCACCTGAG | CTCCCTGCGGTTTCTGAGTTCTCCACCAGT    c.660
 K  F  R  F  N  F  L  A  P  E   | L  P  A  V  S  E  F  S  T  S      p.220

          .         .         .         .         .         .       g.39272
 GAGACCATGGGCCACTCTGCAGACCGACTGGCCGCTGCCTTTGCTGTTTCTCGGCTGGAA       c.720
 E  T  M  G  H  S  A  D  R  L  A  A  A  F  A  V  S  R  L  E         p.240

          .         .         .         .         .         .       g.39332
 CAGGATGAATATGCACTGCGCTCTCACAGTCTAGCCAAGAAGGCACAGGATGAAGGACTC       c.780
 Q  D  E  Y  A  L  R  S  H  S  L  A  K  K  A  Q  D  E  G  L         p.260

          .         .         .  | 10      .         .         .    g.40070
 CTTTCTGATGTGGTACCCTTCAAAGTACCAG | GAAAAGATACAGTTACCAAAGATAATGGC    c.840
 L  S  D  V  V  P  F  K  V  P  G |   K  D  T  V  T  K  D  N  G      p.280

          .         .         .         .         .         .       g.40130
 ATCCGTCCTTCCTCACTGGAGCAGATGGCCAAACTAAAACCTGCATTCATCAAGCCCTAC       c.900
 I  R  P  S  S  L  E  Q  M  A  K  L  K  P  A  F  I  K  P  Y         p.300

          .         .         .    | 11    .         .         .    g.42919
 GGCACAGTGACAGCTGCAAATTCTTCTTTCTTG | ACTGATGGTGCATCTGCAATGTTAATC    c.960
 G  T  V  T  A  A  N  S  S  F  L   | T  D  G  A  S  A  M  L  I      p.320

          .         .         .         .         .    | 12    .    g.43058
 ATGGCGGAGGAAAAGGCTCTGGCCATGGGTTATAAGCCGAAGGCATATTTGAG | GGATTTT    c.1020
 M  A  E  E  K  A  L  A  M  G  Y  K  P  K  A  Y  L  R  |  D  F      p.340

          .         .         .         .  | 13      .         .    g.44183
 ATGTATGTGTCTCAGGATCCAAAAGATCAACTATTACTTGG | ACCAACATATGCTACTCCA    c.1080
 M  Y  V  S  Q  D  P  K  D  Q  L  L  L  G  |  P  T  Y  A  T  P      p.360

          .         .         .         .         .         .       g.44243
 AAAGTTCTAGAAAAGGCAGGATTGACCATGAATGATATTGATGCTTTTGAATTTCATGAA       c.1140
 K  V  L  E  K  A  G  L  T  M  N  D  I  D  A  F  E  F  H  E         p.380

           | 14        .         .         .         .         .    g.44981
 GCTTTCTCG | GGTCAGATTTTGGCAAATTTTAAAGCCATGGATTCTGATTGGTTTGCAGAA    c.1200
 A  F  S   | G  Q  I  L  A  N  F  K  A  M  D  S  D  W  F  A  E      p.400

          .         .     | 15   .         .         .         .    g.45490
 AACTACATGGGTAGAAAAACCAAG | GTTGGATTGCCTCCTTTGGAGAAGTTTAATAACTGG    c.1260
 N  Y  M  G  R  K  T  K   | V  G  L  P  P  L  E  K  F  N  N  W      p.420

          .         .         .         .         .         .       g.45550
 GGTGGATCTCTGTCCCTGGGACACCCATTTGGAGCCACTGGCTGCAGGTTGGTCATGGCT       c.1320
 G  G  S  L  S  L  G  H  P  F  G  A  T  G  C  R  L  V  M  A         p.440

          .         .         .         .         .         .       g.45610
 GCTGCCAACAGATTACGGAAAGAAGGAGGCCAGTATGGCTTAGTGGCTGCGTGTGCAGCT       c.1380
 A  A  N  R  L  R  K  E  G  G  Q  Y  G  L  V  A  A  C  A  A         p.460

           | 16        .         .         .                        g.50016
 GGAGGGCAG | GGCCATGCTATGATAGTGGAAGCTTATCCAAAATAA                   c.1425
 G  G  Q   | G  H  A  M  I  V  E  A  Y  P  K  X                     p.474

          .         .         .         .         .         .       g.50076
 tagatccagaagaagtgacctgaagtttctgtgcaacactcacactaggcaatgccattt       c.*60

          .         .         .         .         .         .       g.50136
 caatgcattactaaatgacatttgtagttcctagctcctcttaggaaaacagttcttgtg       c.*120

          .         .         .         .         .         .       g.50196
 gccttctattaaatagtttgcacttaagccttgccagtgttctgagcttttcaataatca       c.*180

          .         .         .         .         .         .       g.50256
 gtttactgctctttcagggatttctaagccaccagaatctcacatgagatgtgtgggtgg       c.*240

          .         .         .         .         .         .       g.50316
 ttgtttttggtctctgttgtcactaaagactaaatgagggtttgcagttgggaaagaggt       c.*300

          .         .         .         .         .         .       g.50376
 caactgagatttggaaatcatctttgtaatatttgcaaattatacttgttcttatctgtg       c.*360

          .         .         .         .         .         .       g.50436
 tcctaaagatgtgttctctataaaatacaaaccaacgtgcctaattaattatggaaaaat       c.*420

          .         .         .         .         .         .       g.50496
 aattcagaatctaaacaccactgaaaacttataaaaaatgtttagatacataaatatggt       c.*480

          .         .         .                                     g.50528
 ggtcagcgttaataaagtggagaaatattgga                                   c.*512

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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