histidyl-tRNA synthetase (HARS) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_002109.3 in the HARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering HARS transcript NM_002109.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       tcgatagccggaagtcatcctt       c.-61

 .         .         .         .         .         .                g.5082
 gctgaggctggggcaaccaccgcaggtcgagacagcaggcggctcaagtggacagccggg       c.-1

          .         .         .         .         .         .       g.5142
 ATGGCAGAGCGTGCGGCGCTGGAGGAGCTGGTGAAACTTCAGGGAGAGCGCGTGCGAGGC       c.60
 M  A  E  R  A  A  L  E  E  L  V  K  L  Q  G  E  R  V  R  G         p.20

          .         .         . | 02       .         .         .    g.5472
 CTCAAGCAGCAGAAGGCCAGCGCCGAGCTG | ATCGAGGAGGAGGTGGCGAAACTCCTGAAA    c.120
 L  K  Q  Q  K  A  S  A  E  L   | I  E  E  E  V  A  K  L  L  K      p.40

          .         .         .         .         .         .       g.5532
 CTGAAGGCACAGCTGGGTCCTGATGAAAGCAAACAGAAATTTGTGCTCAAAACCCCCAAG       c.180
 L  K  A  Q  L  G  P  D  E  S  K  Q  K  F  V  L  K  T  P  K         p.60

  | 03       .         .         .         .         .         .    g.13227
  | GGCACAAGAGACTATAGTCCCCGGCAGATGGCAGTTCGCGAGAAGGTGTTTGACGTAATC    c.240
  | G  T  R  D  Y  S  P  R  Q  M  A  V  R  E  K  V  F  D  V  I      p.80

          .         .         .         .         .         .       g.13287
 ATCCGTTGCTTCAAGCGCCACGGTGCAGAAGTCATTGATACACCTGTATTTGAACTAAAG       c.300
 I  R  C  F  K  R  H  G  A  E  V  I  D  T  P  V  F  E  L  K         p.100

  | 04       .         .         .         .         .         .    g.16563
  | GAAACACTGATGGGAAAGTATGGGGAAGACTCCAAGCTTATCTATGACCTGAAGGACCAG    c.360
  | E  T  L  M  G  K  Y  G  E  D  S  K  L  I  Y  D  L  K  D  Q      p.120

          .         .         .       | 05 .         .         .    g.17283
 GGCGGGGAGCTCCTGTCCCTTCGCTATGACCTCACT | GTTCCTTTTGCTCGGTATTTGGCA    c.420
 G  G  E  L  L  S  L  R  Y  D  L  T   | V  P  F  A  R  Y  L  A      p.140

          .         .         .         .         .         .       g.17343
 ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAGGTATATCGGCGGGATAAC       c.480
 M  N  K  L  T  N  I  K  R  Y  H  I  A  K  V  Y  R  R  D  N         p.160

          .         .         .         .   | 06     .         .    g.18389
 CCAGCCATGACCCGTGGCCGATACCGGGAATTCTACCAGTGT | GATTTTGACATTGCTGGG    c.540
 P  A  M  T  R  G  R  Y  R  E  F  Y  Q  C   | D  F  D  I  A  G      p.180

          .         .         .         .         .         .       g.18449
 AACTTTGATCCCATGATCCCTGATGCAGAGTGCCTGAAGATCATGTGCGAGATCCTGAGT       c.600
 N  F  D  P  M  I  P  D  A  E  C  L  K  I  M  C  E  I  L  S         p.200

          .         .         . | 07       .         .         .    g.18663
 TCACTTCAGATAGGCGACTTCCTGGTCAAG | GTAAACGATCGACGCATTCTAGATGGGATG    c.660
 S  L  Q  I  G  D  F  L  V  K   | V  N  D  R  R  I  L  D  G  M      p.220

          .         .         .         .         .         .       g.18723
 TTTGCTATCTGTGGTGTTTCTGACAGCAAGTTCCGTACCATCTGCTCCTCAGTAGACAAG       c.720
 F  A  I  C  G  V  S  D  S  K  F  R  T  I  C  S  S  V  D  K         p.240

           | 08        .         .         .         .         .    g.19017
 CTGGACAAG | GTGTCCTGGGAAGAGGTGAAGAATGAGATGGTGGGAGAGAAGGGCCTTGCA    c.780
 L  D  K   | V  S  W  E  E  V  K  N  E  M  V  G  E  K  G  L  A      p.260

          .         .         .         .    | 09    .         .    g.19287
 CCTGAGGTGGCTGACCGCATTGGGGACTATGTCCAGCAACATG | GTGGGGTATCCCTGGTG    c.840
 P  E  V  A  D  R  I  G  D  Y  V  Q  Q  H  G |   G  V  S  L  V      p.280

          .         .         .         .         .         .       g.19347
 GAACAGCTGCTCCAGGATCCTAAACTATCCCAAAACAAGCAGGCCTTGGAGGGCCTGGGA       c.900
 E  Q  L  L  Q  D  P  K  L  S  Q  N  K  Q  A  L  E  G  L  G         p.300

          .         .         .         .         .  | 10      .    g.19499
 GACCTGAAGTTGCTCTTTGAGTACCTGACCCTATTTGGCATTGATGACAAA | ATCTCCTTT    c.960
 D  L  K  L  L  F  E  Y  L  T  L  F  G  I  D  D  K   | I  S  F      p.320

          .         .         .         .         .         .       g.19559
 GACCTGAGCCTTGCTCGAGGGCTGGATTACTACACTGGGGTGATCTATGAGGCAGTGCTG       c.1020
 D  L  S  L  A  R  G  L  D  Y  Y  T  G  V  I  Y  E  A  V  L         p.340

          .         .         .         .         .         .       g.19619
 CTACAGACCCCAGCCCAGGCAGGGGAAGAGCCCCTGGGTGTGGGCAGTGTGGCTGCTGGA       c.1080
 L  Q  T  P  A  Q  A  G  E  E  P  L  G  V  G  S  V  A  A  G         p.360

          .         .         .         .         .         .       g.19679
 GGACGCTATGATGGGCTAGTGGGCATGTTCGACCCCAAAGGGCGCAAGGTGCCATGTGTG       c.1140
 G  R  Y  D  G  L  V  G  M  F  D  P  K  G  R  K  V  P  C  V         p.380

          .         .         .         .         .     | 11   .    g.21259
 GGGCTCAGCATTGGGGTGGAGCGGATTTTCTCCATCGTGGAACAGAGACTAGAG | GCTTTG    c.1200
 G  L  S  I  G  V  E  R  I  F  S  I  V  E  Q  R  L  E   | A  L      p.400

          .         .         .         .         .         .       g.21319
 GAGGAGAAGATACGGACCACGGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG       c.1260
 E  E  K  I  R  T  T  E  T  Q  V  L  V  A  S  A  Q  K  K  L         p.420

          .         .         .         .         .  | 12      .    g.21570
 CTAGAGGAAAGACTAAAGCTTGTCTCAGAACTGTGGGATGCTGGGATCAAG | GCTGAGCTG    c.1320
 L  E  E  R  L  K  L  V  S  E  L  W  D  A  G  I  K   | A  E  L      p.440

          .         .         .         .         .         .       g.21630
 CTGTACAAGAAGAACCCAAAGCTACTGAACCAGTTACAGTACTGTGAGGAGGCAGGCATC       c.1380
 L  Y  K  K  N  P  K  L  L  N  Q  L  Q  Y  C  E  E  A  G  I         p.460

          .         .         .         .         .         .       g.21690
 CCACTGGTGGCTATCATCGGCGAGCAGGAACTCAAGGATGGGGTCATCAAGCTCCGTTCA       c.1440
 P  L  V  A  I  I  G  E  Q  E  L  K  D  G  V  I  K  L  R  S         p.480

          .         | 13         .         .         .         .    g.22100
 GTGACGAGCAGGGAAGAG | GTGGATGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG    c.1500
 V  T  S  R  E  E   | V  D  V  R  R  E  D  L  V  E  E  I  K  R      p.500

          .         .         .                                     g.22130
 AGAACAGGCCAGCCCCTCTGCATCTGCTGA                                     c.1530
 R  T  G  Q  P  L  C  I  C  X                                       p.509

          .         .         .         .         .         .       g.22190
 actgaacaaactatcagaggaaaggaagtgggactggcactatttgaggttaagacaaac       c.*60

          .         .         .         .         .         .       g.22250
 tgcatatgtacttcaattgctttgcacttttccgtttcagcggaagacctgaagagtggt       c.*120

          .         .         .         .         .         .       g.22310
 cagaacagagcctttgatttttattatggttattttattgattattactggcaaaaacgg       c.*180

          .         .         .         .         .         .       g.22370
 ccaggtacaacacctttttcatacaaggcccaggaggcttagtccagtctgtgctcctgg       c.*240

          .         .         .         .         .         .       g.22430
 gctacaaggacccagcctgagatggtcccatctgcagggccccgcaccagttggagcaga       c.*300

          .         .         .         .         .                 g.22482
 tgcctccccaccaccaattgccaaaggtccaataaaatgcctcaaccacgga               c.*352

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Histidyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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