histone deacetylase 3 (HDAC3) - coding DNA reference sequence

(used for variant description)

(last modified September 10, 2024)

This file was created to facilitate the description of sequence variants on transcript NM_003883.3 in the HDAC3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering HDAC3 transcript NM_003883.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5006
                                                       gggagg       c.-61

 .         .         .         .         .         .                g.5066
 ggctggcggcggccgcgggcggcgggcggcggaggtgcggggcctgctcccgccggcacc       c.-1

          .         .         .         .         .      | 02  .    g.5231
 ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACG | GAGCT    c.60
 M  A  K  T  V  A  Y  F  Y  D  P  D  V  G  N  F  H  Y  G |   A      p.20

          .         .         .         .         .         .       g.5291
 GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT       c.120
 G  H  P  M  K  P  H  R  L  A  L  T  H  S  L  V  L  H  Y  G         p.40

          .         | 03         .         .         .         .    g.6945
 CTCTATAAGAAGATGATC | GTCTTCAAGCCATACCAGGCCTCCCAACATGACATGTGCCGC    c.180
 L  Y  K  K  M  I   | V  F  K  P  Y  Q  A  S  Q  H  D  M  C  R      p.60

          .         .         .         .         .         .       g.7005
 TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC       c.240
 F  H  S  E  D  Y  I  D  F  L  Q  R  V  S  P  T  N  M  Q  G         p.80

          .         .         .         .  | 04      .         .    g.11750
 TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTG | CCCAGTGTTTCCCGGGCTC    c.300
 F  T  K  S  L  N  A  F  N  V  G  D  D  C  |  P  V  F  P  G  L      p.100

          .         .         .         .         .         .       g.11810
 TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC       c.360
 F  E  F  C  S  R  Y  T  G  A  S  L  Q  G  A  T  Q  L  N  N         p.120

     | 05    .         .         .         .         .         .    g.11997
 AAG | ATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG    c.420
 K   | I  C  D  I  A  I  N  W  A  G  G  L  H  H  A  K  K  F  E      p.140

  | 06       .         .         .         .         .       | 07 . g.12554
  | GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAA | GTAC c.480
  | A  S  G  F  C  Y  V  N  D  I  V  I  G  I  L  E  L  L  K  |  Y   p.160

          .         .         .         .         .         .       g.12614
 CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT       c.540
 H  P  R  V  L  Y  I  D  I  D  I  H  H  G  D  G  V  Q  E  A         p.180

          .         .         .         .         .         .       g.12674
 TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC       c.600
 F  Y  L  T  D  R  V  M  T  V  S  F  H  K  Y  G  N  Y  F  F         p.200

          . | 08       .         .         .         .         .    g.13267
 CCTGGCACAG | GTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC    c.660
 P  G  T  G |   D  M  Y  E  V  G  A  E  S  G  R  Y  Y  C  L  N      p.220

          .         .         .  | 09      .         .         .    g.13698
 GTGCCCCTGCGGGATGGCATTGATGACCAGA | GTTACAAGCACCTTTTCCAGCCGGTTATC    c.720
 V  P  L  R  D  G  I  D  D  Q  S |   Y  K  H  L  F  Q  P  V  I      p.240

          .         .         .         .      | 10  .         .    g.13914
 AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAG | TGTGGAGCTGACTCT    c.780
 N  Q  V  V  D  F  Y  Q  P  T  C  I  V  L  Q   | C  G  A  D  S      p.260

          .         .         .         .         . | 11       .    g.15583
 CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGG | GGAATGCGTT    c.840
 L  G  C  D  R  L  G  C  F  N  L  S  I  R  G  H  G  |  E  C  V      p.280

          .         .         .         .         .         .       g.15643
 GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC       c.900
 E  Y  V  K  S  F  N  I  P  L  L  V  L  G  G  G  G  Y  T  V         p.300

          .         . | 12       .         .         .         .    g.15825
 CGAAATGTTGCCCGCTGCTG | GACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT    c.960
 R  N  V  A  R  C  W  |  T  Y  E  T  S  L  L  V  E  E  A  I  S      p.320

          .          | 13        .         .         .         .    g.16133
 GAGGAGCTTCCCTATAGTG | AATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA    c.1020
 E  E  L  P  Y  S  E |   Y  F  E  Y  F  A  P  D  F  T  L  H  P      p.340

          .         .         .          | 14        .         .    g.16512
 GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAG | TATCTGGACCAGATCCGCCAG    c.1080
 D  V  S  T  R  I  E  N  Q  N  S  R  Q   | Y  L  D  Q  I  R  Q      p.360

          .         .         .         .         .         .       g.16572
 ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG       c.1140
 T  I  F  E  N  L  K  M  L  N  H  A  P  S  V  Q  I  H  D  V         p.380

          .         .         .         .         .         .       g.16632
 CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT       c.1200
 P  A  D  L  L  T  Y  D  R  T  D  E  A  D  A  E  E  R  G  P         p.400

          .        | 15.         .         .         .         .    g.20362
 GAGGAGAACTATAGCAG | GCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT    c.1260
 E  E  N  Y  S  R  |  P  E  A  P  N  E  F  Y  D  G  D  H  D  N      p.420

          .         .                                               g.20389
 GACAAGGAAAGCGATGTGGAGATTTAA                                        c.1287
 D  K  E  S  D  V  E  I  X                                          p.428

          .         .         .         .         .         .       g.20449
 gagtggcttgggatgctgtgtcccaaggaatttcttttcacctcttggttgggctggagg       c.*60

          .         .         .         .         .         .       g.20509
 gaaaaggagtggctcctagagtcctgggggtcaccccagggcttttgctgactctgggaa       c.*120

          .         .         .         .         .         .       g.20569
 agagtctggagaccacatttggttctcgaaccatctacctgcttttcctctctctcccaa       c.*180

          .         .         .         .         .         .       g.20629
 ggcctgacaatggtacctattagggatgagatacagacaaggatagctatctgggacatt       c.*240

          .         .         .         .         .         .       g.20689
 attggcagtgggccctggaggccagtccctagccccccttgccccttatttcttccctgc       c.*300

          .         .         .         .         .         .       g.20749
 ttccctcgaacccagagatttttgagggatgaacgggtagacaaggactgagattgcctc       c.*360

          .         .         .         .         .         .       g.20809
 tgacttcctcctcccctgggttctgacttcttcctccccttgcttccagggaagatgaag       c.*420

          .         .         .         .         .         .       g.20869
 agagagagatttggaaggggctctggctccctaacacctgaatcccagatgatgggaagt       c.*480

          .         .         .         .         .         .       g.20929
 atgttttcaagtgtggggaggatatgaaaatgttctgttctcacttttggctttatgtcc       c.*540

          .         .         .         .         .                 g.20981
 attttaccactgtttttatccaataaactaagtcggtattttttgtaccttt               c.*592

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Histone deacetylase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.