helicase, lymphoid-specific (HELLS) - coding DNA reference sequence

(used for variant description)

(last modified May 29, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_018063.3 in the HELLS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering HELLS transcript NM_018063.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5045
                ggggatttggctagaaggctgggccggcagcggttgtgaggagtt       c.-61

 .         .         .         .         .         .                g.5105
 agctcgcggcattgcaggctctgagaggaggggacccggttcccgggtgagtgtccaggc       c.-1

          .         .         .  | 02      .         .         .    g.5589
 ATGCCAGCGGAACGGCCCGCGGGCAGCGGCG | GCTCGGAGGCTCCAGCAATGGTTGAACAA    c.60
 M  P  A  E  R  P  A  G  S  G  G |   S  E  A  P  A  M  V  E  Q      p.20

          .         .         .         .         .         .       g.5649
 CTGGACACTGCTGTGATTACCCCGGCCATGCTAGAAGAGGAAGAACAGCTTGAAGCTGCT       c.120
 L  D  T  A  V  I  T  P  A  M  L  E  E  E  E  Q  L  E  A  A         p.40

          .         .         .    | 03    .         .         .    g.13336
 GGACTAGAGAGAGAGCGGAAGATGCTGGAAAAG | GCTCGCATGTCTTGGGATAGAGAGTCG    c.180
 G  L  E  R  E  R  K  M  L  E  K   | A  R  M  S  W  D  R  E  S      p.60

          .         .         .         .         .         .       g.13396
 ACAGAAATTCGGTACCGTAGACTTCAACATTTGCTTGAAAAAAGCAATATATACTCCAAA       c.240
 T  E  I  R  Y  R  R  L  Q  H  L  L  E  K  S  N  I  Y  S  K         p.80

          .         .         .       | 04 .         .         .    g.17346
 TTTTTATTGACGAAAATGGAACAGCAACAATTAGAG | GAACAGAAGAAGAAAGAAAAATTG    c.300
 F  L  L  T  K  M  E  Q  Q  Q  L  E   | E  Q  K  K  K  E  K  L      p.100

          .         .         .    | 05    .         .         .    g.21901
 GAGAGAAAAAAGGAGTCTTTAAAAGTTAAAAAG | GGTAAAAATTCAATTGATGCAAGTGAA    c.360
 E  R  K  K  E  S  L  K  V  K  K   | G  K  N  S  I  D  A  S  E      p.120

          . | 06       .         .         .         .         .    g.22045
 GAGAAGCCAG | TTATGAGGAAAAAAAGAGGAAGAGAAGATGAATCATACAATATTTCAGAG    c.420
 E  K  P  V |   M  R  K  K  R  G  R  E  D  E  S  Y  N  I  S  E      p.140

          .      | 07  .         .         .         .        | 08. g.33146
 GTCATGTCAAAAGAG | GAAATTTTGTCTGTGGCTAAAAAAAATAAAAAGGAGAATGAG | GAT c.480
 V  M  S  K  E   | E  I  L  S  V  A  K  K  N  K  K  E  N  E   | D   p.160

          .         .         .         .         .         .       g.33206
 GAAAACTCCTCCTCTACTAATCTCTGTGTGGAAGATCTTCAGAAAAATAAAGATTCGAAT       c.540
 E  N  S  S  S  T  N  L  C  V  E  D  L  Q  K  N  K  D  S  N         p.180

          .         .         .         .         .         .       g.33266
 AGTATAATTAAAGATAGATTGTCTGAAACGGTTAGGCAGAATACTAAATTCTTTTTTGAC       c.600
 S  I  I  K  D  R  L  S  E  T  V  R  Q  N  T  K  F  F  F  D         p.200

          .         .         .         .         .         .       g.33326
 CCAGTCCGGAAGTGTAATGGTCAGCCAGTACCTTTTCAACAACCAAAGCACTTCACTGGA       c.660
 P  V  R  K  C  N  G  Q  P  V  P  F  Q  Q  P  K  H  F  T  G         p.220

          .         .         .         .      | 09  .         .    g.33752
 GGAGTGATGCGATGGTACCAAGTAGAAGGCATGGAATGGCTTAGG | ATGCTTTGGGAAAAT    c.720
 G  V  M  R  W  Y  Q  V  E  G  M  E  W  L  R   | M  L  W  E  N      p.240

          .         .         .         .         .         .       g.33812
 GGAATTAATGGCATTTTAGCAGATGAAATGGGATTGGGTAAGACAGTTCAGTGCATTGCT       c.780
 G  I  N  G  I  L  A  D  E  M  G  L  G  K  T  V  Q  C  I  A         p.260

          .         .         .         .         .         .       g.33872
 ACTATTGCATTGATGATTCAGAGAGGAGTACCAGGACCTTTTCTTGTCTGTGGCCCTTTG       c.840
 T  I  A  L  M  I  Q  R  G  V  P  G  P  F  L  V  C  G  P  L         p.280

          .         .         .         .         | 10         .    g.35857
 TCTACACTTCCTAACTGGATGGCTGAATTCAAAAGATTTACACCAGAT | ATCCCTACAATG    c.900
 S  T  L  P  N  W  M  A  E  F  K  R  F  T  P  D   | I  P  T  M      p.300

          .         .         .         .         .         .       g.35917
 TTATATCATGGAACCCAGGAGGAACGTCAAAAATTGGTAAGAAATATTTACAAACGGAAA       c.960
 L  Y  H  G  T  Q  E  E  R  Q  K  L  V  R  N  I  Y  K  R  K         p.320

          .         .         .         .         .         .       g.35977
 GGGACTTTGCAGATTCATCCTGTGGTAATCACGTCATTTGAAATAGCCATGAGAGACCGA       c.1020
 G  T  L  Q  I  H  P  V  V  I  T  S  F  E  I  A  M  R  D  R         p.340

          .   | 11     .         .         .         .         .    g.40557
 AATGCGTTACAG | CATTGCTATTGGAAATACTTAATAGTAGATGAAGGACACAGGATTAAG    c.1080
 N  A  L  Q   | H  C  Y  W  K  Y  L  I  V  D  E  G  H  R  I  K      p.360

          .         .         .         .         .         .       g.40617
 AATATGAAGTGCCGTCTAATCAGGGAGTTAAAACGATTCAATGCTGATAACAAACTTCTT       c.1140
 N  M  K  C  R  L  I  R  E  L  K  R  F  N  A  D  N  K  L  L         p.380

          .         .         .         .         .         .       g.40677
 TTGACTGGTACTCCCTTGCAAAACAATTTATCAGAACTTTGGTCATTGCTAAACTTTTTG       c.1200
 L  T  G  T  P  L  Q  N  N  L  S  E  L  W  S  L  L  N  F  L         p.400

          .         .          | 12        .         .         .    g.42177
 TTGCCAGATGTATTTGATGACTTGAAAAG | CTTTGAGTCTTGGTTTGACATCACTAGTCTT    c.1260
 L  P  D  V  F  D  D  L  K  S  |  F  E  S  W  F  D  I  T  S  L      p.420

          .         .         .         .         .         .       g.42237
 TCTGAAACTGCTGAAGATATTATTGCTAAAGAAAGAGAACAGAATGTATTGCATATGCTG       c.1320
 S  E  T  A  E  D  I  I  A  K  E  R  E  Q  N  V  L  H  M  L         p.440

        | 13 .         .         .         .         .         .    g.47466
 CACCAG | ATTTTAACACCTTTCTTATTGAGAAGACTGAAGTCTGATGTTGCTCTTGAAGTT    c.1380
 H  Q   | I  L  T  P  F  L  L  R  R  L  K  S  D  V  A  L  E  V      p.460

          .         .         .         .         .         .       g.47526
 CCTCCTAAACGAGAAGTAGTCGTTTATGCTCCACTTTCAAAGAAGCAGGAGATCTTTTAT       c.1440
 P  P  K  R  E  V  V  V  Y  A  P  L  S  K  K  Q  E  I  F  Y         p.480

          .         .         .         .         | 14         .    g.49608
 ACAGCCATTGTGAACCGTACAATTGCAAACATGTTTGGATCCAGTGAG | AAAGAAACAATT    c.1500
 T  A  I  V  N  R  T  I  A  N  M  F  G  S  S  E   | K  E  T  I      p.500

          .         .         .         .         .         .       g.49668
 GAGTTAAGTCCTACTGGTCGACCAAAACGACGAACTAGAAAATCAATAAATTACAGCAAA       c.1560
 E  L  S  P  T  G  R  P  K  R  R  T  R  K  S  I  N  Y  S  K         p.520

          .         .         .         .         .         .       g.49728
 ATAGATGATTTCCCTAATGAATTGGAAAAACTGATCAGTCAAATACAGCCAGAGGTGGAC       c.1620
 I  D  D  F  P  N  E  L  E  K  L  I  S  Q  I  Q  P  E  V  D         p.540

          | 15         .         .         .         .         .    g.49873
 CGAGAAAG | AGCTGTTGTGGAAGTGAATATCCCTGTAGAATCTGAAGTTAATCTGAAGCTG    c.1680
 R  E  R  |  A  V  V  E  V  N  I  P  V  E  S  E  V  N  L  K  L      p.560

          .         .         .         .         .         .       g.49933
 CAGAATATAATGATGCTACTTCGTAAATGTTGTAATCATCCATATTTGATTGAATATCCT       c.1740
 Q  N  I  M  M  L  L  R  K  C  C  N  H  P  Y  L  I  E  Y  P         p.580

          .         .        | 16.         .         .         .    g.51445
 ATAGACCCTGTTACACAAGAATTTAAG | ATCGATGAAGAATTGGTAACAAATTCTGGGAAG    c.1800
 I  D  P  V  T  Q  E  F  K   | I  D  E  E  L  V  T  N  S  G  K      p.600

          .         .         .         .         .  | 17      .    g.51587
 TTCTTGATTTTGGATCGAATGCTGCCAGAACTAAAAAAAAGAGGTCACAAG | GTGCTGCTT    c.1860
 F  L  I  L  D  R  M  L  P  E  L  K  K  R  G  H  K   | V  L  L      p.620

          .         .         .         .         .         .       g.51647
 TTTTCACAAATGACAAGCATGTTGGACATTTTGATGGATTACTGCCATCTCAGAGATTTC       c.1920
 F  S  Q  M  T  S  M  L  D  I  L  M  D  Y  C  H  L  R  D  F         p.640

          .         .         .         .         .  | 18      .    g.52691
 AACTTCAGCAGGCTTGATGGGTCCATGTCTTACTCAGAGAGAGAAAAAAAC | ATGCACAGC    c.1980
 N  F  S  R  L  D  G  S  M  S  Y  S  E  R  E  K  N   | M  H  S      p.660

          .         .         .         .         .         .       g.52751
 TTCAACACGGATCCAGAGGTGTTTATCTTCTTAGTGAGTACACGAGCTGGTGGCCTGGGC       c.2040
 F  N  T  D  P  E  V  F  I  F  L  V  S  T  R  A  G  G  L  G         p.680

          .         .         .         .         | 19         .    g.53890
 ATTAATCTGACTGCAGCAGATACAGTTATCATTTATGATAGTGATTGG | AACCCCCAGTCG    c.2100
 I  N  L  T  A  A  D  T  V  I  I  Y  D  S  D  W   | N  P  Q  S      p.700

          .         .         .         .         .         .       g.53950
 GATCTTCAGGCCCAGGATAGATGTCATAGAATTGGTCAGACAAAGCCAGTTGTTGTTTAT       c.2160
 D  L  Q  A  Q  D  R  C  H  R  I  G  Q  T  K  P  V  V  V  Y         p.720

          .         .         .         .         .         .       g.54010
 CGCCTTGTTACAGCAAATACTATCGATCAGAAAATTGTGGAAAGAGCAGCTGCTAAAAGG       c.2220
 R  L  V  T  A  N  T  I  D  Q  K  I  V  E  R  A  A  A  K  R         p.740

          .         .         | 20         .         .         .    g.56075
 AAACTGGAAAAGTTGATCATCCATAAAA | ATCATTTCAAAGGTGGTCAGTCTGGATTAAAT    c.2280
 K  L  E  K  L  I  I  H  K  N |   H  F  K  G  G  Q  S  G  L  N      p.760

          .         .         .         .         .         .       g.56135
 CTGTCTAAGAATTTCTTAGATCCTAAGGAATTAATGGAATTATTAAAATCTAGAGATTAT       c.2340
 L  S  K  N  F  L  D  P  K  E  L  M  E  L  L  K  S  R  D  Y         p.780

       | 21  .         .         .         .         .         .    g.56273
 GAAAG | GGAAATAAAAGGATCAAGAGAGAAGGTCATTAGTGATAAAGATCTAGAGTTGTTG    c.2400
 E  R  |  E  I  K  G  S  R  E  K  V  I  S  D  K  D  L  E  L  L      p.800

          .         .   | 22     .         .         .         .    g.60749
 TTAGATCGAAGTGATCTTATTG | ATCAAATGAATGCTTCAGGACCAATTAAAGAGAAGATG    c.2460
 L  D  R  S  D  L  I  D |   Q  M  N  A  S  G  P  I  K  E  K  M      p.820

          .         .         .         .         .                 g.60806
 GGGATATTCAAGATATTAGAAAATTCTGAAGATTCCAGTCCTGAATGTTTGTTTTAA          c.2517
 G  I  F  K  I  L  E  N  S  E  D  S  S  P  E  C  L  F  X            p.838

          .         .         .         .         .         .       g.60866
 agtggagctcaagaatagcttttaaaagttcttatttacatctagtgatttccctgtatt       c.*60

          .         .         .         .         .         .       g.60926
 gggtttgaaatactgattgtccacttcaccttttttattatatcagttgacatgtaacta       c.*120

          .         .         .         .         .         .       g.60986
 gtaccatgcgtacttaaatagatggtaattttctgagccttaccaagaacaaagaagtat       c.*180

          .         .         .         .         .         .       g.61046
 ccatattaagtttagattttcagttaatttttgagactgagtagtattcttggatacagg       c.*240

          .         .         .         .         .         .       g.61106
 ctgatgtgtacttaaccacttccagatttatacagtcttcctgtggaagtttagtaaatg       c.*300

          .         .         .         .         .         .       g.61166
 tctttttccctcctttcttctagtaatgcagttcatgggctttaggtacttcagttatga       c.*360

          .         .         .         .         .         .       g.61226
 agtaggcttttcatggggagagattgggattatgctctctgttgtttaagaaactgtttg       c.*420

          .         .         .         .         .                 g.61283
 attttagagtctatttctatgagatagtttaccaaataaatgttccttataagatga          c.*477

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Helicase, lymphoid-specific protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 13
©2004-2015 Leiden University Medical Center