hexosaminidase B (beta polypeptide) (HEXB) - coding DNA reference sequence

(used for variant description)

(last modified October 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000521.3 in the HEXB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009770.2, covering HEXB transcript NM_000521.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.50178
    gcagtcatctgactcggtgactcacccgcggccgcgcttcctctgatccgggccggg       c.-61

 .         .         .         .         .         .                g.50238
 cgggaagtcgggtcccgaggctccggctcggcagaccgggcggaaagcagccgagcggcc       c.-1

          .         .         .         .         .         .       g.50298
 ATGGAGCTGTGCGGGCTGGGGCTGCCCCGGCCGCCCATGCTGCTGGCGCTGCTGTTGGCG       c.60
 M  E  L  C  G  L  G  L  P  R  P  P  M  L  L  A  L  L  L  A         p.20

          .         .         .         .         .         .       g.50358
 ACACTGCTGGCGGCGATGTTGGCGCTGCTGACTCAGGTGGCGCTGGTGGTGCAGGTGGCG       c.120
 T  L  L  A  A  M  L  A  L  L  T  Q  V  A  L  V  V  Q  V  A         p.40

          .         .         .         .         .         .       g.50418
 GAGGCGGCTCGGGCCCCGAGCGTCTCGGCCAAGCCGGGGCCGGCGCTGTGGCCCCTGCCG       c.180
 E  A  A  R  A  P  S  V  S  A  K  P  G  P  A  L  W  P  L  P         p.60

          .         .         .         .         .         .       g.50478
 CTCTCGGTGAAGATGACCCCGAACCTGCTGCATCTCGCCCCGGAGAACTTCTACATCAGC       c.240
 L  S  V  K  M  T  P  N  L  L  H  L  A  P  E  N  F  Y  I  S         p.80

          .         .         .         .         .          | 02    g.54306
 CACAGCCCCAATTCCACGGCGGGCCCCTCCTGCACCCTGCTGGAGGAAGCGTTTCGACG | A    c.300
 H  S  P  N  S  T  A  G  P  S  C  T  L  L  E  E  A  F  R  R  |      p.100

          .         .         .         .         .         .       g.54366
 TATCATGGCTATATTTTTGGTTTCTACAAGTGGCATCATGAACCTGCTGAATTCCAGGCT       c.360
 Y  H  G  Y  I  F  G  F  Y  K  W  H  H  E  P  A  E  F  Q  A         p.120

          .         .         .         .         .         .       g.54426
 AAAACCCAGGTTCAGCAACTTCTTGTCTCAATCACCCTTCAGTCAGAGTGTGATGCTTTC       c.420
 K  T  Q  V  Q  Q  L  L  V  S  I  T  L  Q  S  E  C  D  A  F         p.140

          .         .      | 03  .         .         .         .    g.58651
 CCCAACATATCTTCAGATGAGTCTT | ATACTTTACTTGTGAAAGAACCAGTGGCTGTCCTT    c.480
 P  N  I  S  S  D  E  S  Y |   T  L  L  V  K  E  P  V  A  V  L      p.160

          .         .         .  | 04      .         .         .    g.61699
 AAGGCCAACAGAGTTTGGGGAGCATTACGAG | GTTTAGAGACCTTTAGCCAGTTAGTTTAT    c.540
 K  A  N  R  V  W  G  A  L  R  G |   L  E  T  F  S  Q  L  V  Y      p.180

          .         | 05         .         .         .         .    g.62015
 CAAGATTCTTATGGAACT | TTCACCATCAATGAATCCACCATTATTGATTCTCCAAGGTTT    c.600
 Q  D  S  Y  G  T   | F  T  I  N  E  S  T  I  I  D  S  P  R  F      p.200

          .         .         .         .         .         .       g.62075
 TCTCACAGAGGAATTTTGATTGATACATCCAGACATTATCTGCCAGTTAAGATTATTCTT       c.660
 S  H  R  G  I  L  I  D  T  S  R  H  Y  L  P  V  K  I  I  L         p.220

           | 06        .         .         .         .         .    g.70247
 AAAACTCTG | GATGCCATGGCTTTTAATAAGTTTAATGTTCTTCACTGGCACATAGTTGAT    c.720
 K  T  L   | D  A  M  A  F  N  K  F  N  V  L  H  W  H  I  V  D      p.240

          .         .         .         .         .  | 07      .    g.78492
 GACCAGTCTTTCCCATATCAGAGCATCACTTTTCCTGAGTTAAGCAATAAA | GGAAGCTAT    c.780
 D  Q  S  F  P  Y  Q  S  I  T  F  P  E  L  S  N  K   | G  S  Y      p.260

          .         .         .         .         .         .       g.78552
 TCTTTGTCTCATGTTTATACACCAAATGATGTCCGTATGGTGATTGAATATGCCAGATTA       c.840
 S  L  S  H  V  Y  T  P  N  D  V  R  M  V  I  E  Y  A  R  L         p.280

          .         .         .         .         .         .       g.78612
 CGAGGAATTCGAGTCCTGCCAGAATTTGATACCCCTGGGCATACACTATCTTGGGGAAAA       c.900
 R  G  I  R  V  L  P  E  F  D  T  P  G  H  T  L  S  W  G  K         p.300

   | 08      .         .         .         .         .         .    g.80546
 G | GTCAGAAAGACCTCCTGACTCCATGTTACAGTAGACAAAACAAGTTGGACTCTTTTGGA    c.960
 G |   Q  K  D  L  L  T  P  C  Y  S  R  Q  N  K  L  D  S  F  G      p.320

          .         .         .         .         .         .       g.80606
 CCTATAAACCCTACTCTGAATACAACATACAGCTTCCTTACTACATTTTTCAAAGAAATT       c.1020
 P  I  N  P  T  L  N  T  T  Y  S  F  L  T  T  F  F  K  E  I         p.340

          .         .         .         .         .         .       g.80666
 AGTGAGGTGTTTCCAGATCAATTCATTCATTTGGGAGGAGATGAAGTGGAATTTAAATGT       c.1080
 S  E  V  F  P  D  Q  F  I  H  L  G  G  D  E  V  E  F  K  C         p.360

    | 09     .         .         .         .         .         .    g.81622
 TG | GGAATCAAATCCAAAAATTCAAGATTTCATGAGGCAAAAAGGCTTTGGCACAGATTTT    c.1140
 W  |  E  S  N  P  K  I  Q  D  F  M  R  Q  K  G  F  G  T  D  F      p.380

          .         .          | 10        .         .         .    g.83299
 AAGAAACTAGAATCTTTCTACATTCAAAA | GGTTTTGGATATTATTGCAACCATAAACAAG    c.1200
 K  K  L  E  S  F  Y  I  Q  K  |  V  L  D  I  I  A  T  I  N  K      p.400

          .         .         .         .   | 11     .         .    g.83792
 GGATCCATTGTCTGGCAGGAGGTTTTTGATGATAAAGCAAAG | CTTGCGCCGGGCACAATA    c.1260
 G  S  I  V  W  Q  E  V  F  D  D  K  A  K   | L  A  P  G  T  I      p.420

          .         .         .         .         .         .       g.83852
 GTTGAAGTATGGAAAGACAGCGCATATCCTGAGGAACTCAGTAGAGTCACAGCATCTGGC       c.1320
 V  E  V  W  K  D  S  A  Y  P  E  E  L  S  R  V  T  A  S  G         p.440

          .         .         .         .         .         .       g.83912
 TTCCCTGTAATCCTTTCTGCTCCTTGGTACTTAGATTTGATTAGCTATGGACAAGATTGG       c.1380
 F  P  V  I  L  S  A  P  W  Y  L  D  L  I  S  Y  G  Q  D  W         p.460

          .         .         .        | 12.         .         .    g.85428
 AGGAAATACTATAAAGTGGAACCTCTTGATTTTGGCG | GTACTCAGAAACAGAAACAACTT    c.1440
 R  K  Y  Y  K  V  E  P  L  D  F  G  G |   T  Q  K  Q  K  Q  L      p.480

          .         .         .         .         .         .       g.85488
 TTCATTGGTGGAGAAGCTTGTCTATGGGGAGAATATGTGGATGCAACTAACCTCACTCCA       c.1500
 F  I  G  G  E  A  C  L  W  G  E  Y  V  D  A  T  N  L  T  P         p.500

          | 13         .         .         .         .         .    g.85672
 AGATTATG | GCCTCGGGCAAGTGCTGTTGGTGAGAGACTCTGGAGTTCCAAAGATGTCAGA    c.1560
 R  L  W  |  P  R  A  S  A  V  G  E  R  L  W  S  S  K  D  V  R      p.520

          .         .         .         .         .    | 14    .    g.86102
 GATATGGATGACGCCTATGACAGACTGACAAGGCACCGCTGCAGGATGGTCGA | ACGTGGA    c.1620
 D  M  D  D  A  Y  D  R  L  T  R  H  R  C  R  M  V  E  |  R  G      p.540

          .         .         .         .         .                 g.86153
 ATAGCTGCACAACCTCTTTATGCTGGATATTGTAACCATGAGAACATGTAA                c.1671
 I  A  A  Q  P  L  Y  A  G  Y  C  N  H  E  N  M  X                  p.556

          .         .         .         .         .         .       g.86213
 aaaatggaggggaaaaaggccacagcaatctgtactacaatcaactttattttgaaatca       c.*60

          .         .         .         .         .                 g.86266
 tgtaaaataagatattagactgttttttgaataaaatatttttattgattgaa              c.*113

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hexosaminidase B (beta polypeptide) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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