hepatocyte growth factor (hepapoietin A; scatter factor) (HGF) - coding DNA reference sequence

(used for variant description)

(last modified December 31, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000601.4 in the HGF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering HGF transcript NM_000601.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5045
                gggagttcagacctagatctttccagttaatcacacaacaaactt       c.-121

 .         .         .         .         .         .                g.5105
 agctcatcgcaataaaaagcagctcagagccgactggctcttttaggcactgactccgaa       c.-61

 .         .         .         .         .         .                g.5165
 caggattctttcacccaggcatctcctccagagggatccgccagcccgtccagcagcacc       c.-1

          .         .         .         .         .         .       g.5225
 ATGTGGGTGACCAAACTCCTGCCAGCCCTGCTGCTGCAGCATGTCCTCCTGCATCTCCTC       c.60
 M  W  V  T  K  L  L  P  A  L  L  L  Q  H  V  L  L  H  L  L         p.20

          .         .         | 02         .         .         .    g.12296
 CTGCTCCCCATCGCCATCCCCTATGCAG | AGGGACAAAGGAAAAGAAGAAATACAATTCAT    c.120
 L  L  P  I  A  I  P  Y  A  E |   G  Q  R  K  R  R  N  T  I  H      p.40

          .         .         .         .         .         .       g.12356
 GAATTCAAAAAATCAGCAAAGACTACCCTAATCAAAATAGATCCAGCACTGAAGATAAAA       c.180
 E  F  K  K  S  A  K  T  T  L  I  K  I  D  P  A  L  K  I  K         p.60

          .         .         .         .         .         .       g.12416
 ACCAAAAAAGTGAATACTGCAGACCAATGTGCTAATAGATGTACTAGGAATAAAGGACTT       c.240
 T  K  K  V  N  T  A  D  Q  C  A  N  R  C  T  R  N  K  G  L         p.80

          .     | 03   .         .         .         .         .    g.16378
 CCATTCACTTGCAA | GGCTTTTGTTTTTGATAAAGCAAGAAAACAATGCCTCTGGTTCCCC    c.300
 P  F  T  C  K  |  A  F  V  F  D  K  A  R  K  Q  C  L  W  F  P      p.100

          .         .         .         .         .         .       g.16438
 TTCAATAGCATGTCAAGTGGAGTGAAAAAAGAATTTGGCCATGAATTTGACCTCTATGAA       c.360
 F  N  S  M  S  S  G  V  K  K  E  F  G  H  E  F  D  L  Y  E         p.120

         | 04.         .         .         .         .         .    g.17886
 AACAAAG | ACTACATTAGAAACTGCATCATTGGTAAAGGACGCAGCTACAAGGGAACAGTA    c.420
 N  K  D |   Y  I  R  N  C  I  I  G  K  G  R  S  Y  K  G  T  V      p.140

          .         .         .         .         .         .       g.17946
 TCTATCACTAAGAGTGGCATCAAATGTCAGCCCTGGAGTTCCATGATACCACACGAACAC       c.480
 S  I  T  K  S  G  I  K  C  Q  P  W  S  S  M  I  P  H  E  H         p.160

    | 05     .         .         .         .         .         .    g.22932
 AG | CTTTTTGCCTTCGAGCTATCGGGGTAAAGACCTACAGGAAAACTACTGTCGAAATCCT    c.540
 S  |  F  L  P  S  S  Y  R  G  K  D  L  Q  E  N  Y  C  R  N  P      p.180

          .         .         .         .         .         .       g.22992
 CGAGGGGAAGAAGGGGGACCCTGGTGTTTCACAAGCAATCCAGAGGTACGCTACGAAGTC       c.600
 R  G  E  E  G  G  P  W  C  F  T  S  N  P  E  V  R  Y  E  V         p.200

          .         .      | 06  .         .         .         .    g.30051
 TGTGACATTCCTCAGTGTTCAGAAG | TTGAATGCATGACCTGCAATGGGGAGAGTTATCGA    c.660
 C  D  I  P  Q  C  S  E  V |   E  C  M  T  C  N  G  E  S  Y  R      p.220

          .         .         .         .         .         .       g.30111
 GGTCTCATGGATCATACAGAATCAGGCAAGATTTGTCAGCGCTGGGATCATCAGACACCA       c.720
 G  L  M  D  H  T  E  S  G  K  I  C  Q  R  W  D  H  Q  T  P         p.240

          .         .       | 07 .         .         .         .    g.31699
 CACCGGCACAAATTCTTGCCTGAAAG | ATATCCCGACAAGGGCTTTGATGATAATTATTGC    c.780
 H  R  H  K  F  L  P  E  R  |  Y  P  D  K  G  F  D  D  N  Y  C      p.260

          .         .         .         .         .         .       g.31759
 CGCAATCCCGATGGCCAGCCGAGGCCATGGTGCTATACTCTTGACCCTCACACCCGCTGG       c.840
 R  N  P  D  G  Q  P  R  P  W  C  Y  T  L  D  P  H  T  R  W         p.280

          .         .      | 08  .         .         .         .    g.45392
 GAGTACTGTGCAATTAAAACATGCG | CTGACAATACTATGAATGACACTGATGTTCCTTTG    c.900
 E  Y  C  A  I  K  T  C  A |   D  N  T  M  N  D  T  D  V  P  L      p.300

          .         .         .         .         .         .       g.45452
 GAAACAACTGAATGCATCCAAGGTCAAGGAGAAGGCTACAGGGGCACTGTCAATACCATT       c.960
 E  T  T  E  C  I  Q  G  Q  G  E  G  Y  R  G  T  V  N  T  I         p.320

          .         .         .         .         .         .       g.45512
 TGGAATGGAATTCCATGTCAGCGTTGGGATTCTCAGTATCCTCACGAGCATGACATGACT       c.1020
 W  N  G  I  P  C  Q  R  W  D  S  Q  Y  P  H  E  H  D  M  T         p.340

          .         . | 09       .         .         .         .    g.49159
 CCTGAAAATTTCAAGTGCAA | GGACCTACGAGAAAATTACTGCCGAAATCCAGATGGGTCT    c.1080
 P  E  N  F  K  C  K  |  D  L  R  E  N  Y  C  R  N  P  D  G  S      p.360

          .         .         .         .         .         .       g.49219
 GAATCACCCTGGTGTTTTACCACTGATCCAAACATCCGAGTTGGCTACTGCTCCCAAATT       c.1140
 E  S  P  W  C  F  T  T  D  P  N  I  R  V  G  Y  C  S  Q  I         p.380

          .         .         | 10         .         .         .    g.54321
 CCAAACTGTGATATGTCACATGGACAAG | ATTGTTATCGTGGGAATGGCAAAAATTATATG    c.1200
 P  N  C  D  M  S  H  G  Q  D |   C  Y  R  G  N  G  K  N  Y  M      p.400

          .         .         .         .         .         .       g.54381
 GGCAACTTATCCCAAACAAGATCTGGACTAACATGTTCAATGTGGGACAAGAACATGGAA       c.1260
 G  N  L  S  Q  T  R  S  G  L  T  C  S  M  W  D  K  N  M  E         p.420

          .  | 11      .         .         .         .         .    g.57820
 GACTTACATCG | TCATATCTTCTGGGAACCAGATGCAAGTAAGCTGAATGAGAATTACTGC    c.1320
 D  L  H  R  |  H  I  F  W  E  P  D  A  S  K  L  N  E  N  Y  C      p.440

          .         .         .         .         .         .       g.57880
 CGAAATCCAGATGATGATGCTCATGGACCCTGGTGCTACACGGGAAATCCACTCATTCCT       c.1380
 R  N  P  D  D  D  A  H  G  P  W  C  Y  T  G  N  P  L  I  P         p.460

          .         .      | 12  .         .         .         .    g.63652
 TGGGATTATTGCCCTATTTCTCGTT | GTGAAGGTGATACCACACCTACAATAGTCAATTTA    c.1440
 W  D  Y  C  P  I  S  R  C |   E  G  D  T  T  P  T  I  V  N  L      p.480

      | 13   .         .         .         .         .         .    g.64949
 GACC | ATCCCGTAATATCTTGTGCCAAAACGAAACAATTGCGAGTTGTAAATGGGATTCCA    c.1500
 D  H |   P  V  I  S  C  A  K  T  K  Q  L  R  V  V  N  G  I  P      p.500

          .         .         .         .  | 14      .         .    g.67791
 ACACGAACAAACATAGGATGGATGGTTAGTTTGAGATACAG | AAATAAACATATCTGCGGA    c.1560
 T  R  T  N  I  G  W  M  V  S  L  R  Y  R  |  N  K  H  I  C  G      p.520

          .         .         .         .         .       | 15 .    g.68713
 GGATCATTGATAAAGGAGAGTTGGGTTCTTACTGCACGACAGTGTTTCCCTTCTCG | AGAC    c.1620
 G  S  L  I  K  E  S  W  V  L  T  A  R  Q  C  F  P  S  R  |  D      p.540

          .         .         .         .         .         .       g.68773
 TTGAAAGATTATGAAGCTTGGCTTGGAATTCATGATGTCCACGGAAGAGGAGATGAGAAA       c.1680
 L  K  D  Y  E  A  W  L  G  I  H  D  V  H  G  R  G  D  E  K         p.560

          .         .         .         .         .         .       g.68833
 TGCAAACAGGTTCTCAATGTTTCCCAGCTGGTATATGGCCCTGAAGGATCAGATCTGGTT       c.1740
 C  K  Q  V  L  N  V  S  Q  L  V  Y  G  P  E  G  S  D  L  V         p.580

          .        | 16.         .         .         .         .    g.69426
 TTAATGAAGCTTGCCAG | GCCTGCTGTCCTGGATGATTTTGTTAGTACGATTGATTTACCT    c.1800
 L  M  K  L  A  R  |  P  A  V  L  D  D  F  V  S  T  I  D  L  P      p.600

          .         .         .         .         .         .       g.69486
 AATTATGGATGCACAATTCCTGAAAAGACCAGTTGCAGTGTTTATGGCTGGGGCTACACT       c.1860
 N  Y  G  C  T  I  P  E  K  T  S  C  S  V  Y  G  W  G  Y  T         p.620

      | 17   .         .         .         .         .         .    g.69657
 GGAT | TGATCAACTATGATGGCCTATTACGAGTGGCACATCTCTATATAATGGGAAATGAG    c.1920
 G  L |   I  N  Y  D  G  L  L  R  V  A  H  L  Y  I  M  G  N  E      p.640

          .         .         .         .         .         .       g.69717
 AAATGCAGCCAGCATCATCGAGGGAAGGTGACTCTGAATGAGTCTGAAATATGTGCTGGG       c.1980
 K  C  S  Q  H  H  R  G  K  V  T  L  N  E  S  E  I  C  A  G         p.660

          .         .         . | 18       .         .         .    g.72409
 GCTGAAAAGATTGGATCAGGACCATGTGAG | GGGGATTATGGTGGCCCACTTGTTTGTGAG    c.2040
 A  E  K  I  G  S  G  P  C  E   | G  D  Y  G  G  P  L  V  C  E      p.680

          .         .         .         .         .         .       g.72469
 CAACATAAAATGAGAATGGTTCTTGGTGTCATTGTTCCTGGTCGTGGATGTGCCATTCCA       c.2100
 Q  H  K  M  R  M  V  L  G  V  I  V  P  G  R  G  C  A  I  P         p.700

          .         .         .         .         .         .       g.72529
 AATCGTCCTGGTATTTTTGTCCGAGTAGCATATTATGCAAAATGGATACACAAAATTATT       c.2160
 N  R  P  G  I  F  V  R  V  A  Y  Y  A  K  W  I  H  K  I  I         p.720

          .         .                                               g.72556
 TTAACATATAAGGTACCACAGTCATAG                                        c.2187
 L  T  Y  K  V  P  Q  S  X                                          p.728

          .         .         .         .         .         .       g.72616
 ctgaagtaagtgtgtctgaagcacccaccaatacaactgtcttttacatgaagatttcag       c.*60

          .         .         .         .         .         .       g.72676
 agaatgtggaatttaaaatgtcacttacaacaatcctaagacaactactggagagtcatg       c.*120

          .         .         .         .         .         .       g.72736
 tttgttgaaattctcattaatgtttatgggtgttttctgttgttttgtttgtcagtgtta       c.*180

          .         .         .         .         .         .       g.72796
 ttttgtcaatgttgaagtgaattaaggtacatgcaagtgtaataacatatctcctgaaga       c.*240

          .         .         .         .         .         .       g.72856
 tacttgaatggattaaaaaaacacacaggtatatttgctggatgataaagatttcatggg       c.*300

          .         .         .         .         .         .       g.72916
 aaaaaaaatcaattaatctgtctaagctgctttctgatgttggtttcttaataatgagta       c.*360

          .         .         .         .         .         .       g.72976
 aaccacaaattaaatgttattttaacctcaccaaaacaatttataccttgtgtccctaaa       c.*420

          .         .         .                                     g.73009
 ttgtagccctatattaaattatattacatttca                                  c.*453

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hepatocyte growth factor (hepapoietin A; scatter factor) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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