heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) - coding DNA reference sequence

(used for variant description)

(last modified August 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_152419.2 in the HGSNAT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009552.1, covering HGSNAT transcript NM_152419.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             agggcggggcgcagcgggcaggcaagggcggccgagcgggcggcgggc       c.-1

          .         .         .         .         .         .       g.5108
 ATGAGCGGGGCGGGCAGGGCGCTGGCCGCGCTGCTGCTGGCCGCGTCCGTGCTGAGCGCC       c.60
 M  S  G  A  G  R  A  L  A  A  L  L  L  A  A  S  V  L  S  A         p.20

          .         .         .         .         .         | 02    g.11501
 GCGCTGCTGGCCCCCGGCGGCTCTTCGGGGCGCGATGCCCAGGCCGCGCCGCCACGAG | AC    c.120
 A  L  L  A  P  G  G  S  S  G  R  D  A  Q  A  A  P  P  R  D |       p.40

          .         .         .         .         .         .       g.11561
 TTAGACAAAAAAAGACATGCAGAGCTGAAGATGGATCAGGCTTTGCTACTCATCCATAAT       c.180
 L  D  K  K  R  H  A  E  L  K  M  D  Q  A  L  L  L  I  H  N         p.60

          .         .         .         .         .     | 03   .    g.23132
 GAACTTCTCTGGACCAACTTGACCGTCTACTGGAAATCTGAATGCTGTTATCAC | TGCTTG    c.240
 E  L  L  W  T  N  L  T  V  Y  W  K  S  E  C  C  Y  H   | C  L      p.80

          .         .         .         .         .         .       g.23192
 TTTCAGGTTCTGGTAAACGTTCCTCAGAGTCCAAAAGCAGGGAAGCCTAGTGCTGCAGCT       c.300
 F  Q  V  L  V  N  V  P  Q  S  P  K  A  G  K  P  S  A  A  A         p.100

          .         .         .         .         .         .       g.23252
 GCCTCTGTCAGCACCCAGCACGGATCTATCCTGCAGCTGAACGACACCTTGGAAGAGAAA       c.360
 A  S  V  S  T  Q  H  G  S  I  L  Q  L  N  D  T  L  E  E  K         p.120

          .  | 04      .         .         .         .         .    g.23523
 GAAGTTTGTAG | GTTGGAATACAGATTTGGAGAATTTGGAAACTATTCTCTCTTGGTAAAG    c.420
 E  V  C  R  |  L  E  Y  R  F  G  E  F  G  N  Y  S  L  L  V  K      p.140

          .         .         .         .         .         .       g.23583
 AACATCCATAATGGAGTTAGTGAAATTGCCTGTGACCTGGCTGTGAACGAGGATCCAGTT       c.480
 N  I  H  N  G  V  S  E  I  A  C  D  L  A  V  N  E  D  P  V         p.160

          .    | 05    .         .         .         .         .    g.26036
 GATAGTAACCTTC | CTGTGAGCATTGCATTCCTTATTGGTCTTGCTGTCATCATTGTGATA    c.540
 D  S  N  L  P |   V  S  I  A  F  L  I  G  L  A  V  I  I  V  I      p.180

          .         .    | 06    .         .         .         .    g.33761
 TCCTTTCTGAGGCTCTTGTTGAG | TTTGGATGACTTTAACAATTGGATTTCTAAAGCCATA    c.600
 S  F  L  R  L  L  L  S  |  L  D  D  F  N  N  W  I  S  K  A  I      p.200

          .         .         .    | 07    .         .         .    g.35163
 AGTTCTCGAGAAACTGATCGCCTCATCAATTCT | GAGCTGGGATCTCCCAGCAGGACAGAC    c.660
 S  S  R  E  T  D  R  L  I  N  S   | E  L  G  S  P  S  R  T  D      p.220

          .         .         .         .         .         .       g.35223
 CCTCTCGATGGTGATGTTCAGCCAGCAACGTGGCGTCTATCTGCCCTGCCGCCCCGCCTC       c.720
 P  L  D  G  D  V  Q  P  A  T  W  R  L  S  A  L  P  P  R  L         p.240

          .         .    | 08    .         .         .         .    g.36898
 CGCAGCGTGGACACCTTCAGGGG | GATTGCTCTTATACTCATGGTCTTTGTCAATTATGGA    c.780
 R  S  V  D  T  F  R  G  |  I  A  L  I  L  M  V  F  V  N  Y  G      p.260

          .         .         .         . | 09       .         .    g.38284
 GGAGGAAAATATTGGTACTTCAAACATGCAAGTTGGAATG | GGCTGACAGTGGCTGACCTC    c.840
 G  G  K  Y  W  Y  F  K  H  A  S  W  N  G |   L  T  V  A  D  L      p.280

          .  | 10      .         .         .         .         .    g.42674
 GTGTTCCCGTG | GTTTGTATTTATTATGGGATCTTCCATTTTTCTATCGATGACTTCTATA    c.900
 V  F  P  W  |  F  V  F  I  M  G  S  S  I  F  L  S  M  T  S  I      p.300

          .         .         .         .         .         .       g.42734
 CTGCAACGGGGGTGTTCAAAATTCAGATTGCTGGGGAAGATTGCATGGAGGAGTTTCCTG       c.960
 L  Q  R  G  C  S  K  F  R  L  L  G  K  I  A  W  R  S  F  L         p.320

          .         .         .         .         .   | 11     .    g.46704
 TTAATCTGCATAGGAATTATCATTGTGAATCCCAATTATTGCCTTGGTCCAT | TGTCTTGG    c.1020
 L  I  C  I  G  I  I  I  V  N  P  N  Y  C  L  G  P  L |   S  W      p.340

          .         .         .         .         .         .       g.46764
 GACAAGGTGCGCATTCCTGGTGTGCTGCAGCGATTGGGAGTGACATACTTTGTGGTTGCT       c.1080
 D  K  V  R  I  P  G  V  L  Q  R  L  G  V  T  Y  F  V  V  A         p.360

          .         .         .         .         | 12         .    g.56037
 GTGTTGGAGCTCCTCTTTGCTAAACCTGTGCCTGAACATTGTGCCTCG | GAGAGGAGCTGC    c.1140
 V  L  E  L  L  F  A  K  P  V  P  E  H  C  A  S   | E  R  S  C      p.380

          .         .         .         .         .         .       g.56097
 CTTTCTCTTCGAGACATCACGTCCAGCTGGCCCCAGTGGCTGCTCATCCTGGTGCTGGAA       c.1200
 L  S  L  R  D  I  T  S  S  W  P  Q  W  L  L  I  L  V  L  E         p.400

          .         .         .         .         . | 13       .    g.56865
 GGCCTGTGGCTGGGCTTGACATTCCTCCTGCCAGTCCCTGGGTGCCCTAC | TGGTTATCTT    c.1260
 G  L  W  L  G  L  T  F  L  L  P  V  P  G  C  P  T  |  G  Y  L      p.420

          .         .         .         .         .         .       g.56925
 GGTCCTGGGGGCATTGGAGATTTTGGCAAGTATCCAAATTGCACTGGAGGAGCTGCAGGC       c.1320
 G  P  G  G  I  G  D  F  G  K  Y  P  N  C  T  G  G  A  A  G         p.440

          .         .         .         .         .        | 14.    g.58311
 TACATCGACCGCCTGCTGCTGGGAGACGATCACCTTTACCAGCACCCATCTTCTGCT | GTA    c.1380
 Y  I  D  R  L  L  L  G  D  D  H  L  Y  Q  H  P  S  S  A   | V      p.460

          .         .         .         .         .         .       g.58371
 CTTTACCACACCGAGGTGGCCTATGACCCCGAGGGCATCCTGGGCACCATCAACTCCATC       c.1440
 L  Y  H  T  E  V  A  Y  D  P  E  G  I  L  G  T  I  N  S  I         p.480

          .         .     | 15   .         .         .         .    g.61535
 GTGATGGCCTTTTTAGGAGTTCAG | GCAGGAAAAATACTATTGTATTACAAGGCTCGGACC    c.1500
 V  M  A  F  L  G  V  Q   | A  G  K  I  L  L  Y  Y  K  A  R  T      p.500

          .         .         .         .   | 16     .         .    g.62241
 AAAGACATCCTGATTCGATTCACTGCTTGGTGTTGTATTCTT | GGGCTCATTTCTGTTGCT    c.1560
 K  D  I  L  I  R  F  T  A  W  C  C  I  L   | G  L  I  S  V  A      p.520

          .         .         .         .         .    | 17    .    g.62398
 CTGACGAAGGTTTCTGAAAATGAAGGCTTTATTCCAGTAAACAAAAATCTCTG | GTCCCTT    c.1620
 L  T  K  V  S  E  N  E  G  F  I  P  V  N  K  N  L  W  |  S  L      p.540

          .         .         .         .         .         .       g.62458
 TCGTATGTCACTACGCTCAGTTCTTTTGCCTTCTTCATCCTGCTGGTCCTGTACCCAGTT       c.1680
 S  Y  V  T  T  L  S  S  F  A  F  F  I  L  L  V  L  Y  P  V         p.560

          .         .         .         .       | 18 .         .    g.63953
 GTGGATGTGAAGGGGCTGTGGACAGGAACCCCATTCTTTTATCCAG | GAATGAATTCCATT    c.1740
 V  D  V  K  G  L  W  T  G  T  P  F  F  Y  P  G |   M  N  S  I      p.580

          .         .         .         .         .         .       g.64013
 CTGGTATATGTCGGCCACGAGGTGTTTGAGAACTACTTCCCCTTTCAGTGGAAGCTGAAG       c.1800
 L  V  Y  V  G  H  E  V  F  E  N  Y  F  P  F  Q  W  K  L  K         p.600

          .         .         .         .         .         .       g.64073
 GACAACCAGTCCCACAAGGAGCACCTGACTCAGAACATCGTCGCCACTGCCCTCTGGGTG       c.1860
 D  N  Q  S  H  K  E  H  L  T  Q  N  I  V  A  T  A  L  W  V         p.620

          .         .         .         .                           g.64121
 CTCATTGCCTACATCCTCTATAGAAAGAAGATTTTTTGGAAAATCTGA                   c.1908
 L  I  A  Y  I  L  Y  R  K  K  I  F  W  K  I  X                     p.635

          .         .         .         .         .         .       g.64181
 tggctcccactgagatgtgctgctggaagactctagtaggcctgcagggaggactgaagc       c.*60

          .         .         .         .         .         .       g.64241
 agcctttgttaaagggaagcattcattaggaaattgactggctgcgtgtttacagactct       c.*120

          .         .         .         .         .         .       g.64301
 gggggaagacactgatgtcctcaaactggttaactgtgacacggctcgccagaactctgc       c.*180

          .         .         .         .         .         .       g.64361
 ctgtctatttgtgacttacagatttgaaatgtaattgtcttttttcctccatcttctgtg       c.*240

          .         .         .         .         .         .       g.64421
 gaaatggatgtctttggaacttcattccgaggagataagctttaactttccaaaagggaa       c.*300

          .         .         .         .         .         .       g.64481
 ttgccatgggtgtttttcttctgtggtgagtgaaacaatctgaggtctggttcttgctga       c.*360

          .         .         .         .         .         .       g.64541
 ccttgttgccctgcaaacttcctttccacgtgtacgcgcacaccaacacgaaatgccatc       c.*420

          .         .         .         .         .         .       g.64601
 actcctactgcggctgctatgaagcttactggttgtgatgtgttataatttagtctgttt       c.*480

          .         .         .         .         .         .       g.64661
 ttttgattgaatgcagtttaatgtttccagaaagccaaagtaattttcttttcagatatg       c.*540

          .         .         .         .         .         .       g.64721
 caaggctttggtgggtccaaaaaatgtctatcacaagccattttttccttttcctctctc       c.*600

          .         .         .         .         .         .       g.64781
 gaaaagttaaaatatctatgtgttattcccaaaccctcttacctatgtatctgcctgtct       c.*660

          .         .         .         .         .         .       g.64841
 gtccatcatcttccttcctccctatctctgtgtatctggatggcagccgctgcccagggg       c.*720

          .         .         .         .         .         .       g.64901
 agtggctgtggggagggcaggtactgtctttgcctgtgggtccagctgagccatccctgc       c.*780

          .         .         .         .         .         .       g.64961
 tgggtgatgctgggcaagacccttggcccgtctgggccttggcttcctcacttgtgaaat       c.*840

          .         .         .         .         .         .       g.65021
 gagcgggaagatgactctcagttccttccacctcttagacatggtgaggtaacagacatc       c.*900

          .         .         .         .         .         .       g.65081
 aaaagcttttctgaaatcttcagaagaaatagttccattacagaaaactcttcaaaataa       c.*960

          .         .         .         .         .         .       g.65141
 atagtagtgaaaacttttaaaaactctcattggagtaagtcttttcaagatgatcctcca       c.*1020

          .         .         .         .         .         .       g.65201
 caatggaggcagcgttcctacttgtcatcacacagctgaagacattgtttcttaggtgtg       c.*1080

          .         .         .         .         .         .       g.65261
 aaatcggggacaaaggacaaacagagacacacggcattgttcatgggaggcatcgtcacc       c.*1140

          .         .         .         .         .         .       g.65321
 ctcctgggtgttctgtgggaatttcctgtgtgaggaaaacgtggccacagggttgtgctg       c.*1200

          .         .         .         .         .         .       g.65381
 tacccacccttccccggcgagatggccctcggcctgtgccgctgcttccaccctcgccac       c.*1260

          .         .         .         .         .         .       g.65441
 tccatggcagcttttggtctgtttccggctctgccctctgccctgaactctcatccggct       c.*1320

          .         .         .         .         .         .       g.65501
 tgtacctgcctgctggacccctccacctggaggccagcccatgtctcaggcccagcccta       c.*1380

          .         .         .         .         .         .       g.65561
 gcctcttctcctcaaattctaagtgttttctctttaggtttccctggctttgtgaatgga       c.*1440

          .         .         .         .         .         .       g.65621
 tcatgtgtctctaggtataaacctgacatcatctttccacccggcttacctccaccagat       c.*1500

          .         .         .         .         .         .       g.65681
 ctccccagttctgtctccatcttctacctgcagctgctctgttctcatggtcactgctgc       c.*1560

          .         .         .         .         .         .       g.65741
 atcactgagtctggacccttgttatcattttcaaactggcctccttccctcgttccccac       c.*1620

          .         .         .         .         .         .       g.65801
 ttcttaaagtcacctgtccattgccaccagattaagctttctccagccagatcacctctc       c.*1680

          .         .         .         .         .         .       g.65861
 tctgagaaacctccattgacatggaaacaccattgtctggcacacatactcacatactca       c.*1740

          .         .         .         .         .         .       g.65921
 ccttcccgtcttgatccccacacatctttccagcctcccctcccactccactccctgctc       c.*1800

          .         .         .         .         .         .       g.65981
 tctcctccacctccccatcctcttgtctcccctcccctctgaatccagcccagcggggct       c.*1860

          .         .         .         .         .         .       g.66041
 tctcctgcctccatcacatcacagaagtacctcctgcttctggttttaattagagccttc       c.*1920

          .         .         .         .         .         .       g.66101
 cccgattacattttcctctgaattttttcctatctacatttgatctgtcatgtttaaacc       c.*1980

          .         .         .         .         .         .       g.66161
 ccctacttctaagggaacttctctaatctcttatcctcatccccaaatagtgttttcttc       c.*2040

          .         .         .         .         .         .       g.66221
 ctctgggttcttataatgttggtatcaatctcacagcatttagtgcttcctgcctggtgt       c.*2100

          .         .         .         .         .         .       g.66281
 gacagttacctgtgtgcatgtgcaatttctaatttcccacgctagactgtgagcttccta       c.*2160

          .         .         .         .         .         .       g.66341
 aggcaagaatcatgccttgttggtttctgtattcctcatggtgccaaacacagtgccttc       c.*2220

          .         .         .         .         .         .       g.66401
 tacattgcaggcgctgaataaacatttttaaagcaaaatgatgtggatttttaaaataaa       c.*2280

          .         .         .         .         .         .       g.66461
 tatttaagtgctggtaagatgagcatgtatccggggtgcccatgaaatgttcttggggcc       c.*2340

          .         .         .         .         .         .       g.66521
 gtgtggggacagtcgtcattcctcctcctgccacccttttctttcagtgagtcactgtgg       c.*2400

          .         .         .         .         .         .       g.66581
 atggtcccagctgtgtcatcccaaagttcagcagggaaagctgagctgggcctctccagg       c.*2460

          .         .         .         .         .         .       g.66641
 tgagttttctagaagcatttctcaaactgtgggttacatcaacttgggtgtcttgagctg       c.*2520

          .         .         .         .         .         .       g.66701
 taaggaaggaactccggagtcagctgggctacaggggagcttctctaagtcctgcgggag       c.*2580

          .         .         .         .         .         .       g.66761
 gccagacccagcctgagcttgctgttagctagcggaggcagctgctggtggcccaggtgc       c.*2640

          .         .         .         .         .         .       g.66821
 tcgacaccaggcatcccctctcctcccacgaagggtgtgccataatccccttcaacagga       c.*2700

          .         .         .         .         .         .       g.66881
 aatgcttcccagaagcctctcagcagcctcccctcctgtcctatcagctagaagcgcctc       c.*2760

          .         .         .         .         .         .       g.66941
 gcttgtcccaagaccagcagggacagggaactgtccgagcccgtggctgtgtggaggaag       c.*2820

          .         .         .         .         .         .       g.67001
 gcgacccccagcacaagattggtttcctttgggaagggaagagggagtgtgttggggtaa       c.*2880

          .         .         .         .         .         .       g.67061
 ggggtagagcagaggaatggtcagggggcaacaaccgctgacagctgcaacaggtgcatg       c.*2940

          .         .         .         .         .         .       g.67121
 gcatctcacagggaggcagggaggtgcgagctcctaagtaatggagcaaaaaaattctat       c.*3000

          .         .         .         .         .         .       g.67181
 tctgtagaatggggagagaaaatgtgacattttaatttttttttgcatttatattcctaa       c.*3060

          .         .         .         .         .         .       g.67241
 ttcctacttaaagtgaatatactgccgctgtagatcataaaatgtatcttttccatggcc       c.*3120

          .         .         .         .         .         .       g.67301
 aacaaggggcatcttttataaatgcataataacccagtttgtatcaaagggtatcgactt       c.*3180

          .         .         .         .         .         .       g.67361
 aagtgaaatttcaacatgctgttactttttccttttaatgtaattctgttttccaaataa       c.*3240

          .                                                         g.67379
 atgggggagacaaatgga                                                 c.*3258

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Heparan-alpha-glucosaminide N-acetyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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