hexokinase 1 (HK1) - coding DNA reference sequence

(used for variant description)

(last modified December 9, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000188.2 in the HK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012077.1, covering HK1 transcript NM_000188.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.53888
                    gaggaggagccgccgagcagccgccggaggaccacggctcg       c.-61

 .         .         .         .         .         .                g.53948
 ccagggctgcggaggaccgaccgtccccacgcctgccgccccgcgaccccgaccgccagc       c.-1

          .         .         .         .         .         .       g.54008
 ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA       c.60
 M  I  A  A  Q  L  L  A  Y  Y  F  T  E  L  K  D  D  Q  V  K         p.20

     | 02    .         .         .         .         .         .    g.78884
 AAG | ATTGACAAGTATCTCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG    c.120
 K   | I  D  K  Y  L  Y  A  M  R  L  S  D  E  T  L  I  D  I  M      p.40

          .         .         .         .         .         .       g.78944
 ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA       c.180
 T  R  F  R  K  E  M  K  N  G  L  S  R  D  F  N  P  T  A  T         p.60

          .         .         .         .       | 03 .         .    g.94911
 GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTG | AAAAGGGAGATTTC    c.240
 V  K  M  L  P  T  F  V  R  S  I  P  D  G  S  E |   K  G  D  F      p.80

          .         .         .         .         .         .       g.94971
 ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG       c.300
 I  A  L  D  L  G  G  S  S  F  R  I  L  R  V  Q  V  N  H  E         p.100

          .         .         .         .         .         .       g.95031
 AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC       c.360
 K  N  Q  N  V  H  M  E  S  E  V  Y  D  T  P  E  N  I  V  H         p.120

          .      | 04  .         .         .         .         .    g.99828
 GGCAGTGGAAGCCAG | CTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA    c.420
 G  S  G  S  Q   | L  F  D  H  V  A  E  C  L  G  D  F  M  E  K      p.140

          .         .         .         .         .         .       g.99888
 AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA       c.480
 R  K  I  K  D  K  K  L  P  V  G  F  T  F  S  F  P  C  Q  Q         p.160

          .      | 05  .         .         .         .         .    g.103581
 TCCAAAATAGATGAG | GCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG    c.540
 S  K  I  D  E   | A  I  L  I  T  W  T  K  R  F  K  A  S  G  V      p.180

          .         .         .         .         .  | 06      .    g.104246
 GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGG | GACTATGAT    c.600
 E  G  A  D  V  V  K  L  L  N  K  A  I  K  K  R  G   | D  Y  D      p.200

          .         .         .         .         .         .       g.104306
 GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC       c.660
 A  N  I  V  A  V  V  N  D  T  V  G  T  M  M  T  C  G  Y  D         p.220

          .         .         .  | 07      .         .         .    g.104470
 GACCAGCACTGTGAAGTCGGCCTGATCATCG | GCACTGGCACCAATGCTTGCTACATGGAG    c.720
 D  Q  H  C  E  V  G  L  I  I  G |   T  G  T  N  A  C  Y  M  E      p.240

          .         .         .         .         .         .       g.104530
 GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA       c.780
 E  L  R  H  I  D  L  V  E  G  D  E  G  R  M  C  I  N  T  E         p.260

          .         .         .         .         .         .       g.104590
 TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG       c.840
 W  G  A  F  G  D  D  G  S  L  E  D  I  R  T  E  F  D  R  E         p.280

          .         .         .      | 08  .         .         .    g.111959
 ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCT | GTTTGAGAAGATGGTCAGTGGCATG    c.900
 I  D  R  G  S  L  N  P  G  K  Q  L  |  F  E  K  M  V  S  G  M      p.300

          .         .         .         .         .         .       g.112019
 TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT       c.960
 Y  L  G  E  L  V  R  L  I  L  V  K  M  A  K  E  G  L  L  F         p.320

          .         .         .         .         .         .       g.112079
 GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA       c.1020
 E  G  R  I  T  P  E  L  L  T  R  G  K  F  N  T  S  D  V  S         p.340

          .  | 09      .         .         .         .         .    g.114911
 GCCATCGAAAA | GAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA    c.1080
 A  I  E  K  |  N  K  E  G  L  H  N  A  K  E  I  L  T  R  L  G      p.360

          .         .         .         .         .         .       g.114971
 GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT       c.1140
 V  E  P  S  D  D  D  C  V  S  V  Q  H  V  C  T  I  V  S  F         p.380

          .         .         .         .         .         .       g.115031
 CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC       c.1200
 R  S  A  N  L  V  A  A  T  L  G  A  I  L  N  R  L  R  D  N         p.400

          .         .         .         .         .         .       g.115091
 AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC       c.1260
 K  G  T  P  R  L  R  T  T  V  G  V  D  G  S  L  Y  K  T  H         p.420

       | 10  .         .         .         .         .         .    g.117542
 CCACA | GTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG    c.1320
 P  Q  |  Y  S  R  R  F  H  K  T  L  R  R  L  V  P  D  S  D  V      p.440

          .         .         .         .         .         .       g.117602
 CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC       c.1380
 R  F  L  L  S  E  S  G  S  G  K  G  A  A  M  V  T  A  V  A         p.460

          .         .         .         .         .         .       g.117662
 TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC       c.1440
 Y  R  L  A  E  Q  H  R  Q  I  E  E  T  L  A  H  F  H  L  T         p.480

          .         .         .         .         .         .       g.117722
 AAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG       c.1500
 K  D  M  L  L  E  V  K  K  R  M  R  A  E  M  E  L  G  L  R         p.500

          .         .         .         .         .         .       g.117782
 AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC       c.1560
 K  Q  T  H  N  N  A  V  V  K  M  L  P  S  F  V  R  R  T  P         p.520

          . | 11       .         .         .         .         .    g.119383
 GACGGGACCG | AGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG    c.1620
 D  G  T  E |   N  G  D  F  L  A  L  D  L  G  G  T  N  F  R  V      p.540

          .         .         .         .         .         .       g.119443
 CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC       c.1680
 L  L  V  K  I  R  S  G  K  K  R  T  V  E  M  H  N  K  I  Y         p.560

          .         .         .          | 12        .         .    g.119817
 GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAG | CTGTTTGATCACATTGTCTCC    c.1740
 A  I  P  I  E  I  M  Q  G  T  G  E  E   | L  F  D  H  I  V  S      p.580

          .         .         .         .         .         .       g.119877
 TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC       c.1800
 C  I  S  D  F  L  D  Y  M  G  I  K  G  P  R  M  P  L  G  F         p.600

          .         .         .          | 13        .         .    g.121344
 ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCG | GGAATCTTGATCACGTGGACA    c.1860
 T  F  S  F  P  C  Q  Q  T  S  L  D  A   | G  I  L  I  T  W  T      p.620

          .         .         .         .         .         .       g.121404
 AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG       c.1920
 K  G  F  K  A  T  D  C  V  G  H  D  V  V  T  L  L  R  D  A         p.640

          .      | 14  .         .         .         .         .    g.124242
 ATAAAAAGGAGAGAG | GAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC    c.1980
 I  K  R  R  E   | E  F  D  L  D  V  V  A  V  V  N  D  T  V  G      p.660

          .         .         .         .         .      | 15  .    g.127130
 ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTG | GGACC    c.2040
 T  M  M  T  C  A  Y  E  E  P  T  C  E  V  G  L  I  V  G |   T      p.680

          .         .         .         .         .         .       g.127190
 GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG       c.2100
 G  S  N  A  C  Y  M  E  E  M  K  N  V  E  M  V  E  G  D  Q         p.700

          .         .         .         .         .         .       g.127250
 GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT       c.2160
 G  Q  M  C  I  N  M  E  W  G  A  F  G  D  N  G  C  L  D  D         p.720

          .         .         .         .         .          | 16    g.129951
 ATCAGGACACACTACGACAGACTGGTGGACGAATATTCCCTAAATGCTGGGAAACAAAG | G    c.2220
 I  R  T  H  Y  D  R  L  V  D  E  Y  S  L  N  A  G  K  Q  R  |      p.740

          .         .         .         .         .         .       g.130011
 TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC       c.2280
 Y  E  K  M  I  S  G  M  Y  L  G  E  I  V  R  N  I  L  I  D         p.760

          .         .         .         .         .         .       g.130071
 TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGCTGAAGACCCGGGGC       c.2340
 F  T  K  K  G  F  L  F  R  G  Q  I  S  E  T  L  K  T  R  G         p.780

          .         .         .      | 17  .         .         .    g.133620
 ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAG | TGACCGATTAGCACTGCTCCAGGTC    c.2400
 I  F  E  T  K  F  L  S  Q  I  E  S  |  D  R  L  A  L  L  Q  V      p.800

          .         .         .         .         .         .       g.133680
 CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG       c.2460
 R  A  I  L  Q  Q  L  G  L  N  S  T  C  D  D  S  I  L  V  K         p.820

          .         .         .         .         .         .       g.133740
 ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG       c.2520
 T  V  C  G  V  V  S  R  R  A  A  Q  L  C  G  A  G  M  A  A         p.840

          .         .         .         .         .         .       g.133800
 GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG       c.2580
 V  V  D  K  I  R  E  N  R  G  L  D  R  L  N  V  T  V  G  V         p.860

          .         .          | 18        .         .         .    g.136022
 GACGGGACACTCTACAAGCTTCATCCACA | CTTCTCCAGAATCATGCACCAGACGGTGAAG    c.2640
 D  G  T  L  Y  K  L  H  P  H  |  F  S  R  I  M  H  Q  T  V  K      p.880

          .         .         .         .         .         .       g.136082
 GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG       c.2700
 E  L  S  P  K  C  N  V  S  F  L  L  S  E  D  G  S  G  K  G         p.900

          .         .         .         .         .                 g.136136
 GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA             c.2754
 A  A  L  I  T  A  V  G  V  R  L  R  T  E  A  S  S  X               p.917

          .         .         .         .         .         .       g.136196
 gagtccgggatccccagcctactgcctctccagcacttctctcttcaagcggcgaccccc       c.*60

          .         .         .         .         .         .       g.136256
 taccctcccagcgagttgcgctgggagacgctggcgccagggcctgccggcgcggggagg       c.*120

          .         .         .         .         .         .       g.136316
 aaagcaaaatccaactaatggtatatattgtagggtacagaatagagcgtgtgctgttga       c.*180

          .         .         .         .         .         .       g.136376
 taatatctctcacccggatccctcctcacttgccctgccactttgcatggtttgattttg       c.*240

          .         .         .         .         .         .       g.136436
 acctggtcccccacgtgtgaagtgtagtggcatccatttctaatgtatgcattcatccaa       c.*300

          .         .         .         .         .         .       g.136496
 cagagttatttattggctggagatggaaaatcacaccacctgacaggccttctgggcctc       c.*360

          .         .         .         .         .         .       g.136556
 caaagcccatccttggggttccccctccctgtgtgaaatgtattatcaccagcagacact       c.*420

          .         .         .         .         .         .       g.136616
 gccgggcctccctcccgggggcactgcctgaaggcgagtgtgggcatagcattagctgct       c.*480

          .         .         .         .         .         .       g.136676
 tcctcccctcctggcacccactgtggcctggcatcgcatcgtggtgtgtcaatgccacaa       c.*540

          .         .         .         .         .         .       g.136736
 aatcgtgtgtccgtggaaccagtcctagccgcgtgtgacagtcttgcattctgtttgtct       c.*600

          .         .         .         .         .         .       g.136796
 cgtggggggaggtggacagtcctgcggaaatgtgtcttgtctccatttggataaaaggaa       c.*660

          .         .         .         .         .         .       g.136856
 ccaaccaacaaacaatgccatcactggaatttcccaccgctttgtgagccgtgtcgtatg       c.*720

          .         .                                               g.136883
 acctagtaaactttgtaccaattcaaa                                        c.*747

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hexokinase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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