hexokinase domain containing 1 (HKDC1) - coding DNA reference sequence

(used for variant description)

(last modified September 18, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_025130.3 in the HKDC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering HKDC1 transcript NM_025130.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                atttagtccgcaa       c.-121

 .         .         .         .         .         .                g.5073
 cacctcgctccccaggaggtctgccagcctggactggaagcgtgcaacactccagagtcg       c.-61

 .         .         .         .         .         .                g.5133
 taggagtgaacactgcacaggaatctctgcccatctcaggagaaaccaaacttggggaaa       c.-1

          .         .         .         .         .         .       g.5193
 ATGTTTGCGGTCCACTTGATGGCATTTTACTTCAGCAAGCTGAAGGAGGACCAGATCAAG       c.60
 M  F  A  V  H  L  M  A  F  Y  F  S  K  L  K  E  D  Q  I  K         p.20

     | 02    .         .         .         .         .         .    g.11961
 AAG | GTGGACAGGTTCCTGTATCACATGCGGCTCTCCGATGACACCCTTTTGGACATCATG    c.120
 K   | V  D  R  F  L  Y  H  M  R  L  S  D  D  T  L  L  D  I  M      p.40

          .         .         .         .         .         .       g.12021
 AGGCGGTTCCGGGCTGAGATGGAGAAGGGCCTGGCAAAGGACACCAACCCCACGGCTGCA       c.180
 R  R  F  R  A  E  M  E  K  G  L  A  K  D  T  N  P  T  A  A         p.60

          .         .         .         .       | 03 .         .    g.17475
 GTGAAGATGTTGCCCACCTTCGTCAGGGCCATTCCCGATGGTTCCG | AAAATGGGGAGTTC    c.240
 V  K  M  L  P  T  F  V  R  A  I  P  D  G  S  E |   N  G  E  F      p.80

          .         .         .         .         .         .       g.17535
 CTTTCCCTGGATCTCGGAGGGTCCAAGTTCCGAGTGCTGAAGGTGCAAGTCGCTGAAGAG       c.300
 L  S  L  D  L  G  G  S  K  F  R  V  L  K  V  Q  V  A  E  E         p.100

          .         .         .         .         .         .       g.17595
 GGGAAGCGACACGTGCAGATGGAGAGTCAGTTCTACCCAACGCCCAATGAAATCATCCGC       c.360
 G  K  R  H  V  Q  M  E  S  Q  F  Y  P  T  P  N  E  I  I  R         p.120

          .      | 04  .         .         .         .         .    g.17756
 GGGAACGGCACAGAG | CTGTTTGAATATGTAGCTGACTGTCTGGCAGATTTCATGAAGACC    c.420
 G  N  G  T  E   | L  F  E  Y  V  A  D  C  L  A  D  F  M  K  T      p.140

          .         .         .         .         .         .       g.17816
 AAAGATTTAAAGCATAAGAAATTGCCCCTTGGCCTAACTTTTTCTTTCCCCTGTCGACAG       c.480
 K  D  L  K  H  K  K  L  P  L  G  L  T  F  S  F  P  C  R  Q         p.160

          .      | 05  .         .         .         .         .    g.23784
 ACTAAACTGGAAGAG | GGTGTCCTACTTTCGTGGACAAAAAAGTTTAAGGCACGAGGAGTT    c.540
 T  K  L  E  E   | G  V  L  L  S  W  T  K  K  F  K  A  R  G  V      p.180

          .         .         .         .         .  | 06      .    g.25358
 CAGGACACGGATGTGGTGAGCCGTCTGACCAAAGCCATGAGAAGACACAAG | GACATGGAC    c.600
 Q  D  T  D  V  V  S  R  L  T  K  A  M  R  R  H  K   | D  M  D      p.200

          .         .         .         .         .         .       g.25418
 GTGGACATCCTGGCCCTGGTCAATGACACCGTGGGGACCATGATGACCTGTGCCTATGAC       c.660
 V  D  I  L  A  L  V  N  D  T  V  G  T  M  M  T  C  A  Y  D         p.220

          .         .         .  | 07      .         .         .    g.27908
 GACCCCTACTGCGAAGTTGGTGTCATCATCG | GAACTGGCACCAATGCGTGTTACATGGAG    c.720
 D  P  Y  C  E  V  G  V  I  I  G |   T  G  T  N  A  C  Y  M  E      p.240

          .         .         .         .         .         .       g.27968
 GACATGAGCAACATTGACCTGGTGGAGGGCGACGAGGGCAGGATGTGCATCAACACAGAG       c.780
 D  M  S  N  I  D  L  V  E  G  D  E  G  R  M  C  I  N  T  E         p.260

          .         .         .         .         .         .       g.28028
 TGGGGGGCCTTCGGGGACGACGGGGCCCTGGAGGACATTCGCACTGAGTTCGACAGGGAG       c.840
 W  G  A  F  G  D  D  G  A  L  E  D  I  R  T  E  F  D  R  E         p.280

          .         .         .      | 08  .         .         .    g.30801
 CTGGACCTCGGCTCTCTCAACCCAGGAAAGCAACT | GTTCGAGAAGATGATCAGTGGCCTG    c.900
 L  D  L  G  S  L  N  P  G  K  Q  L  |  F  E  K  M  I  S  G  L      p.300

          .         .         .         .         .         .       g.30861
 TACCTGGGGGAGCTTGTCAGGCTTATCTTGCTGAAGATGGCCAAGGCTGGCCTCCTGTTT       c.960
 Y  L  G  E  L  V  R  L  I  L  L  K  M  A  K  A  G  L  L  F         p.320

          .         .         .         .         .         .       g.30921
 GGTGGTGAGAAATCTTCTGCTCTCCACACTAAGGGCAAGATCGAAACACGGCACGTGGCT       c.1020
 G  G  E  K  S  S  A  L  H  T  K  G  K  I  E  T  R  H  V  A         p.340

          .  | 09      .         .         .         .         .    g.32106
 GCCATGGAGAA | GTATAAAGAAGGCCTTGCTAATACAAGAGAGATCCTGGTGGACCTGGGT    c.1080
 A  M  E  K  |  Y  K  E  G  L  A  N  T  R  E  I  L  V  D  L  G      p.360

          .         .         .         .         .         .       g.32166
 CTGGAACCGTCTGAGGCTGACTGCATTGCCGTCCAGCATGTCTGTACCATCGTCTCCTTC       c.1140
 L  E  P  S  E  A  D  C  I  A  V  Q  H  V  C  T  I  V  S  F         p.380

          .         .         .         .         .         .       g.32226
 CGCTCGGCCAATCTCTGTGCAGCAGCTCTGGCGGCCATCCTGACACGCCTCCGGGAGAAC       c.1200
 R  S  A  N  L  C  A  A  A  L  A  A  I  L  T  R  L  R  E  N         p.400

          .         .         .         .         .         .       g.32286
 AAGAAGGTGGAACGGCTCCGGACCACAGTGGGCATGGACGGCACCCTCTACAAGATACAC       c.1260
 K  K  V  E  R  L  R  T  T  V  G  M  D  G  T  L  Y  K  I  H         p.420

       | 10  .         .         .         .         .         .    g.33176
 CCTCA | GTACCCAAAACGCCTGCACAAGGTGGTGAGGAAACTGGTCCCAAGCTGTGATGTC    c.1320
 P  Q  |  Y  P  K  R  L  H  K  V  V  R  K  L  V  P  S  C  D  V      p.440

          .         .         .         .         .         .       g.33236
 CGCTTCCTCCTGTCAGAGAGTGGCAGCACCAAGGGGGCCGCCATGGTGACCGCGGTGGCC       c.1380
 R  F  L  L  S  E  S  G  S  T  K  G  A  A  M  V  T  A  V  A         p.460

          .         .         .         .         .         .       g.33296
 TCCCGCGTGCAGGCCCAGCGGAAGCAGATCGACAGGGTGCTGGCTTTGTTCCAGCTGACC       c.1440
 S  R  V  Q  A  Q  R  K  Q  I  D  R  V  L  A  L  F  Q  L  T         p.480

          .         .         .         .         .         .       g.33356
 CGAGAGCAGCTCGTGGACGTGCAGGCCAAGATGCGGGCTGAGCTGGAGTATGGGCTGAAG       c.1500
 R  E  Q  L  V  D  V  Q  A  K  M  R  A  E  L  E  Y  G  L  K         p.500

          .         .         .         .         .         .       g.33416
 AAGAAGAGCCACGGGCTGGCCACGGTCAGGATGCTGCCCACCTACGTCTGCGGGCTGCCG       c.1560
 K  K  S  H  G  L  A  T  V  R  M  L  P  T  Y  V  C  G  L  P         p.520

          . | 11       .         .         .         .         .    g.35037
 GACGGCACAG | AGAAAGGAAAGTTTCTCGCCCTGGATCTTGGGGGAACCAACTTCCGGGTC    c.1620
 D  G  T  E |   K  G  K  F  L  A  L  D  L  G  G  T  N  F  R  V      p.540

          .         .         .         .         .         .       g.35097
 CTCCTGGTGAAGATCAGAAGTGGACGGAGGTCAGTGCGAATGTACAACAAGATCTTCGCC       c.1680
 L  L  V  K  I  R  S  G  R  R  S  V  R  M  Y  N  K  I  F  A         p.560

          .         .         .       | 12 .         .         .    g.35254
 ATCCCCCTGGAGATCATGCAGGGCACTGGTGAGGAG | CTCTTTGATCACATTGTGCAGTGC    c.1740
 I  P  L  E  I  M  Q  G  T  G  E  E   | L  F  D  H  I  V  Q  C      p.580

          .         .         .         .         .         .       g.35314
 ATCGCCGACTTCCTGGACTACATGGGCCTCAAGGGAGCCTCCCTACCTTTGGGCTTCACA       c.1800
 I  A  D  F  L  D  Y  M  G  L  K  G  A  S  L  P  L  G  F  T         p.600

          .         .         .       | 13 .         .         .    g.41757
 TTCTCATTTCCCTGCAGGCAGATGAGCATTGACAAG | GGAACACTCATAGGGTGGACCAAA    c.1860
 F  S  F  P  C  R  Q  M  S  I  D  K   | G  T  L  I  G  W  T  K      p.620

          .         .         .         .         .         .       g.41817
 GGTTTCAAGGCCACTGACTGTGAAGGGGAGGACGTGGTGGACATGCTCAGGGAAGCCATC       c.1920
 G  F  K  A  T  D  C  E  G  E  D  V  V  D  M  L  R  E  A  I         p.640

          .   | 14     .         .         .         .         .    g.42072
 AAGAGGAGAAAC | GAGTTTGACCTGGACATTGTTGCAGTCGTGAATGATACAGTGGGGACC    c.1980
 K  R  R  N   | E  F  D  L  D  I  V  A  V  V  N  D  T  V  G  T      p.660

          .         .         .         .         .   | 15     .    g.43481
 ATGATGACCTGTGGCTATGAAGATCCTAATTGTGAGATTGGCCTGATTGCAG | GAACAGGC    c.2040
 M  M  T  C  G  Y  E  D  P  N  C  E  I  G  L  I  A  G |   T  G      p.680

          .         .         .         .         .         .       g.43541
 AGCAACATGTGCTACATGGAGGACATGAGGAACATCGAGATGGTGGAGGGGGGTGAAGGG       c.2100
 S  N  M  C  Y  M  E  D  M  R  N  I  E  M  V  E  G  G  E  G         p.700

          .         .         .         .         .         .       g.43601
 AAGATGTGCATCAATACAGAGTGGGGAGGATTTGGAGACAATGGCTGCATAGATGACATC       c.2160
 K  M  C  I  N  T  E  W  G  G  F  G  D  N  G  C  I  D  D  I         p.720

          .         .         .         .         .       | 16 .    g.45840
 TGGACCCGATACGACACGGAGGTGGATGAGGGGTCCTTGAATCCTGGCAAGCAGAG | ATAC    c.2220
 W  T  R  Y  D  T  E  V  D  E  G  S  L  N  P  G  K  Q  R  |  Y      p.740

          .         .         .         .         .         .       g.45900
 GAGAAAATGACCAGTGGGATGTACTTGGGGGAGATTGTGCGGCAGATCCTGATCGACCTG       c.2280
 E  K  M  T  S  G  M  Y  L  G  E  I  V  R  Q  I  L  I  D  L         p.760

          .         .         .         .         .         .       g.45960
 ACCAAGCAGGGTCTCCTCTTCCGAGGGCAGATTTCAGAGCGTCTCCGGACCAGGGGCATC       c.2340
 T  K  Q  G  L  L  F  R  G  Q  I  S  E  R  L  R  T  R  G  I         p.780

          .         .         .   | 17     .         .         .    g.50310
 TTCGAAACCAAGTTCCTGTCCCAGATCGAAAG | CGATCGGCTGGCCCTTCTCCAGGTCAGG    c.2400
 F  E  T  K  F  L  S  Q  I  E  S  |  D  R  L  A  L  L  Q  V  R      p.800

          .         .         .         .         .         .       g.50370
 AGGATTCTGCAGCAGCTGGGCCTGGACAGCACGTGTGAGGACAGCATCGTGGTGAAGGAG       c.2460
 R  I  L  Q  Q  L  G  L  D  S  T  C  E  D  S  I  V  V  K  E         p.820

          .         .         .         .         .         .       g.50430
 GTGTGCGGAGCCGTGTCCCGGCGGGCGGCCCAGCTCTGCGGTGCTGGCCTGGCCGCTATA       c.2520
 V  C  G  A  V  S  R  R  A  A  Q  L  C  G  A  G  L  A  A  I         p.840

          .         .         .         .         .         .       g.50490
 GTGGAAAAAAGGAGAGAAGACCAGGGGCTAGAGCACCTGAGGATCACTGTGGGTGTGGAC       c.2580
 V  E  K  R  R  E  D  Q  G  L  E  H  L  R  I  T  V  G  V  D         p.860

          .         .       | 18 .         .         .         .    g.51341
 GGCACCCTGTACAAGCTGCACCCTCA | CTTTTCTAGAATATTGCAGGAAACTGTGAAGGAA    c.2640
 G  T  L  Y  K  L  H  P  H  |  F  S  R  I  L  Q  E  T  V  K  E      p.880

          .         .         .         .         .         .       g.51401
 CTAGCCCCTCGATGTGATGTGACATTCATGCTGTCAGAAGATGGCAGTGGAAAAGGGGCA       c.2700
 L  A  P  R  C  D  V  T  F  M  L  S  E  D  G  S  G  K  G  A         p.900

          .         .         .         .         .                 g.51455
 GCACTGATCACTGCTGTGGCCAAGAGGTTACAGCAGGCACAGAAGGAGAACTAG             c.2754
 A  L  I  T  A  V  A  K  R  L  Q  Q  A  Q  K  E  N  X               p.917

          .         .         .         .         .         .       g.51515
 gaacccctgggattggacctgatgcatcttggatactgaacagcttttcctctggcagat       c.*60

          .         .         .         .         .         .       g.51575
 cagttggtcagagaccaatgggcaccctcctggctgacctcaccttctggatggccgaaa       c.*120

          .         .         .         .         .         .       g.51635
 gagaaccccaggttctcgggtactcttagtatcttgtactggatttgcagtgacattaca       c.*180

          .         .         .         .         .         .       g.51695
 tgacatctctatttggtatatttgggccaaaatgggccaacttatgaaatcaaagtgtct       c.*240

          .         .         .         .         .         .       g.51755
 gtcctgagagatcccctttcaacacattgttcaggtgaggcttgagctgtcaattctcta       c.*300

          .         .         .         .         .         .       g.51815
 tggctttcagtcttgtggctgcgggacttggaaatatatagaatctgcccatgtggctgg       c.*360

          .         .         .         .         .         .       g.51875
 caggctgtttccccattgggatgcttaagccatctcttataggggattggaccctgtact       c.*420

          .         .         .         .         .         .       g.51935
 tgtggatgaacattggagagcaagaggaactcacgttatgaactagggggatctcatcta       c.*480

          .         .         .         .         .         .       g.51995
 acttgtccttaacttgccatgttgacttcaaacctattaagagaacaaagactttgaagt       c.*540

          .         .         .         .         .         .       g.52055
 atccagccccagggtgcagagaggttgattgccagggagcactgcaggaatcattgcatg       c.*600

          .         .         .         .         .         .       g.52115
 cttaaagcgagttatgtcagcaccctgtaggattttgttccttattaagtgtgtgccatg       c.*660

          .         .         .         .         .         .       g.52175
 tggtggggtgctgtctggggcatctgtttttcattttgcctgtggtttgtgttgcaggtg       c.*720

          .         .         .         .         .         .       g.52235
 ttgatagttgttttaaggattgttaggtataggaaatccagtaaattaataaaaaaattt       c.*780

          .         .                                               g.52257
 tgattttccaataaactttgca                                             c.*802

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hexokinase domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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