major histocompatibility complex, class I, A (HLA-A) - coding DNA reference sequence

(used for variant description)

(last modified November 1, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_002116.7 in the HLA-A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering HLA-A transcript NM_002116.7.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     gagaagccaatcagtgtcgtcgcg       c.-61

 .         .         .         .         .         .                g.5084
 gtcgctgttctaaagcccgcacgcacccaccgggactcagattctccccagacgccgagg       c.-1

          .         .         .         .         .         .       g.5144
 ATGGCCGTCATGGCGCCCCGAACCCTCCTCCTGCTACTCTCGGGGGCCCTGGCCCTGACC       c.60
 M  A  V  M  A  P  R  T  L  L  L  L  L  S  G  A  L  A  L  T         p.20

          .    | 02    .         .         .         .         .    g.5334
 CAGACCTGGGCGG | GCTCCCACTCCATGAGGTATTTCTTCACATCCGTGTCCCGGCCCGGC    c.120
 Q  T  W  A  G |   S  H  S  M  R  Y  F  F  T  S  V  S  R  P  G      p.40

          .         .         .         .         .         .       g.5394
 CGCGGGGAGCCCCGCTTCATCGCCGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTC       c.180
 R  G  E  P  R  F  I  A  V  G  Y  V  D  D  T  Q  F  V  R  F         p.60

          .         .         .         .         .         .       g.5454
 GACAGCGACGCCGCGAGCCAGAGGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGG       c.240
 D  S  D  A  A  S  Q  R  M  E  P  R  A  P  W  I  E  Q  E  G         p.80

          .         .         .         .         .         .       g.5514
 CCGGAGTATTGGGACCAGGAGACACGGAATGTGAAGGCCCAGTCACAGACTGACCGAGTG       c.300
 P  E  Y  W  D  Q  E  T  R  N  V  K  A  Q  S  Q  T  D  R  V         p.100

          .         .         .         .    | 03    .         .    g.5815
 GACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGCCG | GTTCTCACACCATCCAG    c.360
 D  L  G  T  L  R  G  Y  Y  N  Q  S  E  A  G |   S  H  T  I  Q      p.120

          .         .         .         .         .         .       g.5875
 ATAATGTATGGCTGCGACGTGGGGTCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGAC       c.420
 I  M  Y  G  C  D  V  G  S  D  G  R  F  L  R  G  Y  R  Q  D         p.140

          .         .         .         .         .         .       g.5935
 GCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCG       c.480
 A  Y  D  G  K  D  Y  I  A  L  N  E  D  L  R  S  W  T  A  A         p.160

          .         .         .         .         .         .       g.5995
 GACATGGCGGCTCAGATCACCAAGCGCAAGTGGGAGGCGGCCCATGAGGCGGAGCAGTTG       c.540
 D  M  A  A  Q  I  T  K  R  K  W  E  A  A  H  E  A  E  Q  L         p.180

          .         .         .         .         .         .       g.6055
 AGAGCCTACCTGGATGGCACGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAG       c.600
 R  A  Y  L  D  G  T  C  V  E  W  L  R  R  Y  L  E  N  G  K         p.200

          .          | 04        .         .         .         .    g.6693
 GAGACGCTGCAGCGCACGG | ACCCCCCCAAGACACATATGACCCACCACCCCATCTCTGAC    c.660
 E  T  L  Q  R  T  D |   P  P  K  T  H  M  T  H  H  P  I  S  D      p.220

          .         .         .         .         .         .       g.6753
 CATGAGGCCACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCACACTGACC       c.720
 H  E  A  T  L  R  C  W  A  L  G  F  Y  P  A  E  I  T  L  T         p.240

          .         .         .         .         .         .       g.6813
 TGGCAGCGGGATGGGGAGGACCAGACCCAGGACACGGAGCTCGTGGAGACCAGGCCTGCA       c.780
 W  Q  R  D  G  E  D  Q  T  Q  D  T  E  L  V  E  T  R  P  A         p.260

          .         .         .         .         .         .       g.6873
 GGGGATGGAACCTTCCAGAAGTGGGCGGCTGTGGTGGTGCCTTCTGGAGAGGAGCAGAGA       c.840
 G  D  G  T  F  Q  K  W  A  A  V  V  V  P  S  G  E  E  Q  R         p.280

          .         .         .         .         .      | 05  .    g.7035
 TACACCTGCCATGTGCAGCATGAGGGTCTGCCCAAGCCCCTCACCCTGAGATGGG | AGCTG    c.900
 Y  T  C  H  V  Q  H  E  G  L  P  K  P  L  T  L  R  W  E |   L      p.300

          .         .         .         .         .         .       g.7095
 TCTTCCCAGCCCACCATCCCCATCGTGGGCATCATTGCTGGCCTGGTTCTCCTTGGAGCT       c.960
 S  S  Q  P  T  I  P  I  V  G  I  I  A  G  L  V  L  L  G  A         p.320

          .         .         .         .         .   | 06     .    g.7597
 GTGATCACTGGAGCTGTGGTCGCTGCCGTGATGTGGAGGAGGAAGAGCTCAG | ATAGAAAA    c.1020
 V  I  T  G  A  V  V  A  A  V  M  W  R  R  K  S  S  D |   R  K      p.340

          .         .      | 07  .         .         .         .    g.7799
 GGAGGGAGTTACACTCAGGCTGCAA | GCAGTGACAGTGCCCAGGGCTCTGATGTGTCCCTC    c.1080
 G  G  S  Y  T  Q  A  A  S |   S  D  S  A  Q  G  S  D  V  S  L      p.360

          .    | 08                                                 g.8028
 ACAGCTTGTAAAG | TGTGA                                              c.1098
 T  A  C  K  V |   X                                                p.365

          .         .         .         .         .         .       g.8088
 gacagctgccttgtgtgggactgagaggcaagagttgttcctgcccttccctttgtgact       c.*60

          .         .         .         .         .         .       g.8148
 tgaagaaccctgactttgtttctgcaaaggcacctgcatgtgtctgtgttcgtgtaggca       c.*120

          .         .         .         .         .         .       g.8208
 taatgtgaggaggtggggagaccaccccacccccatgtccaccatgaccctcttcccacg       c.*180

          .         .         .         .         .         .       g.8268
 ctgacctgtgctccctccccaatcatctttcctgttccagagaggtggggctgaggtgtc       c.*240

          .         .         .         .         .         .       g.8328
 tccatctctgtctcaacttcatggtgcactgagctgtaacttcttccttccctattaaaa       c.*300

          .         .         .         .         .         .       g.8388
 ttagaaccttagtataaatttactttctcaaattcttgccatgagaggttgatgagttaa       c.*360

          .         .         .         .         .         .       g.8448
 ttaaaggagaagattcctaaaatttgagagacaaaataaatggaagacatgagaaccttc       c.*420

                                                                    g.8457
 cagagtcca                                                          c.*429

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Major histocompatibility complex, class I, A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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