major histocompatibility complex, class I, B (HLA-B) - coding DNA reference sequence

(used for variant description)

(last modified July 16, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_005514.6 in the HLA-B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023187.1, covering HLA-B transcript NM_005514.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       agttctaaagtccccacgcacccacccggactcagagtctcctcagacgccgag       c.-1

          .         .         .         .         .         .       g.5114
 ATGCTGGTCATGGCGCCCCGAACCGTCCTCCTGCTGCTCTCGGCGGCCCTGGCCCTGACC       c.60
 M  L  V  M  A  P  R  T  V  L  L  L  L  S  A  A  L  A  L  T         p.20

          .    | 02    .         .         .         .         .    g.5302
 GAGACCTGGGCCG | GCTCCCACTCCATGAGGTATTTCTACACCTCCGTGTCCCGGCCCGGC    c.120
 E  T  W  A  G |   S  H  S  M  R  Y  F  Y  T  S  V  S  R  P  G      p.40

          .         .         .         .         .         .       g.5362
 CGCGGGGAGCCCCGCTTCATCTCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTC       c.180
 R  G  E  P  R  F  I  S  V  G  Y  V  D  D  T  Q  F  V  R  F         p.60

          .         .         .         .         .         .       g.5422
 GACAGCGACGCCGCGAGTCCGAGAGAGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGG       c.240
 D  S  D  A  A  S  P  R  E  E  P  R  A  P  W  I  E  Q  E  G         p.80

          .         .         .         .         .         .       g.5482
 CCGGAGTATTGGGACCGGAACACACAGATCTACAAGGCCCAGGCACAGACTGACCGAGAG       c.300
 P  E  Y  W  D  R  N  T  Q  I  Y  K  A  Q  A  Q  T  D  R  E         p.100

          .         .         .         .    | 03    .         .    g.5787
 AGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG | GGTCTCACACCCTCCAG    c.360
 S  L  R  N  L  R  G  Y  Y  N  Q  S  E  A  G |   S  H  T  L  Q      p.120

          .         .         .         .         .         .       g.5847
 AGCATGTACGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTAC       c.420
 S  M  Y  G  C  D  V  G  P  D  G  R  L  L  R  G  H  D  Q  Y         p.140

          .         .         .         .         .         .       g.5907
 GCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCCTGGACCGCCGCG       c.480
 A  Y  D  G  K  D  Y  I  A  L  N  E  D  L  R  S  W  T  A  A         p.160

          .         .         .         .         .         .       g.5967
 GACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCGG       c.540
 D  T  A  A  Q  I  T  Q  R  K  W  E  A  A  R  E  A  E  Q  R         p.180

          .         .         .         .         .         .       g.6027
 AGAGCCTACCTGGAGGGCGAGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAG       c.600
 R  A  Y  L  E  G  E  C  V  E  W  L  R  R  Y  L  E  N  G  K         p.200

          .          | 04        .         .         .         .    g.6661
 GACAAGCTGGAGCGCGCTG | ACCCCCCAAAGACACACGTGACCCACCACCCCATCTCTGAC    c.660
 D  K  L  E  R  A  D |   P  P  K  T  H  V  T  H  H  P  I  S  D      p.220

          .         .         .         .         .         .       g.6721
 CATGAGGCCACCCTGAGGTGCTGGGCCCTGGGTTTCTACCCTGCGGAGATCACACTGACC       c.720
 H  E  A  T  L  R  C  W  A  L  G  F  Y  P  A  E  I  T  L  T         p.240

          .         .         .         .         .         .       g.6781
 TGGCAGCGGGATGGCGAGGACCAAACTCAGGACACTGAGCTTGTGGAGACCAGACCAGCA       c.780
 W  Q  R  D  G  E  D  Q  T  Q  D  T  E  L  V  E  T  R  P  A         p.260

          .         .         .         .         .         .       g.6841
 GGAGATAGAACCTTCCAGAAGTGGGCAGCTGTGGTGGTGCCTTCTGGAGAAGAGCAGAGA       c.840
 G  D  R  T  F  Q  K  W  A  A  V  V  V  P  S  G  E  E  Q  R         p.280

          .         .         .         .         .      | 05  .    g.6994
 TACACATGCCATGTACAGCATGAGGGGCTGCCGAAGCCCCTCACCCTGAGATGGG | AGCCG    c.900
 Y  T  C  H  V  Q  H  E  G  L  P  K  P  L  T  L  R  W  E |   P      p.300

          .         .         .         .         .         .       g.7054
 TCTTCCCAGTCCACCGTCCCCATCGTGGGCATTGTTGCTGGCCTGGCTGTCCTAGCAGTT       c.960
 S  S  Q  S  T  V  P  I  V  G  I  V  A  G  L  A  V  L  A  V         p.320

          .         .         .         .         .   | 06     .    g.7555
 GTGGTCATCGGAGCTGTGGTCGCTGCTGTGATGTGTAGGAGGAAGAGTTCAG | GTGGAAAA    c.1020
 V  V  I  G  A  V  V  A  A  V  M  C  R  R  K  S  S  G |   G  K      p.340

          .         .      | 07  .         .         .         .    g.7721
 GGAGGGAGCTACTCTCAGGCTGCGT | GCAGCGACAGTGCCCAGGGCTCTGATGTGTCTCTC    c.1080
 G  G  S  Y  S  Q  A  A  C |   S  D  S  A  Q  G  S  D  V  S  L      p.360

                                                                g.7730
 ACAGCTTGA |                                                       c.1090
 T  A  X                                                         p.362

      | 08   .         .         .         .         .         .    g.7972
 aaag | cctgagacagctgtcttgtgagggactgagatgcaggatttcttcacgcctcccct    c.*60

          .         .         .         .         .         .       g.8032
 ttgtgacttcaagagcctctggcatctctttctgcaaaggcacctgaatgtgtctgcgtc       c.*120

          .         .         .         .         .         .       g.8092
 cctgttagcataatgtgaggaggtggagagacagcccacccttgtgtccactgtgacccc       c.*180

          .         .         .         .         .         .       g.8152
 tgttcccatgctgacctgtgtttcctccccagtcatctttcttgttccagagaggtgggg       c.*240

          .         .         .         .         .         .       g.8212
 ctggatgtctccatctctgtctcaactttacgtgcactgagctgcaacttcttacttccc       c.*300

          .         .         .         .         .         .       g.8272
 tactgaaaataagaatctgaatataaatttgttttctcaaatatttgctatgagaggttg       c.*360

          .         .         .         .         .         .       g.8332
 atggattaattaaataagtcaattcctggaatttgagagagcaaataaagacctgagaac       c.*420

                                                                    g.8341
 cttccagaa                                                          c.*429

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Major histocompatibility complex, class I, B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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