hepatocyte nuclear factor 4, alpha (HNF4A) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_175914.4 in the HNF4A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009818.1, covering HNF4A transcript NM_175914.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         ggcc       c.-1

          .         .         .         .          | 02        .    g.55268
 ATGGTCAGCGTGAACGCGCCCCTCGGGGCTCCAGTGGAGAGTTCTTACG | ACACGTCCCCA    c.60
 M  V  S  V  N  A  P  L  G  A  P  V  E  S  S  Y  D |   T  S  P      p.20

          .         .         .         .         .         .       g.55328
 TCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCCCTGTGTGCCATC       c.120
 S  E  G  T  N  L  N  A  P  N  S  L  G  V  S  A  L  C  A  I         p.40

          .         .         .         .         .         .       g.55388
 TGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGC       c.180
 C  G  D  R  A  T  G  K  H  Y  G  A  S  S  C  D  G  C  K  G         p.60

          .         .         .         .     | 03   .         .    g.56596
 TTCTTCCGGAGGAGCGTGCGGAAGAACCACATGTACTCCTGCAG | ATTTAGCCGGCAGTGC    c.240
 F  F  R  R  S  V  R  K  N  H  M  Y  S  C  R  |  F  S  R  Q  C      p.80

          .         .         .         .         .         .       g.56656
 GTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAGAAATGCTTCCGG       c.300
 V  V  D  K  D  K  R  N  Q  C  R  Y  C  R  L  K  K  C  F  R         p.100

          .          | 04        .         .         .         .    g.62934
 GCTGGCATGAAGAAGGAAG | CCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCA    c.360
 A  G  M  K  K  E  A |   V  Q  N  E  R  D  R  I  S  T  R  R  S      p.120

          .         .         .         .         .         .       g.62994
 AGCTATGAGGACAGCAGCCTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCC       c.420
 S  Y  E  D  S  S  L  P  S  I  N  A  L  L  Q  A  E  V  L  S         p.140

        | 05 .         .         .         .         .         .    g.63760
 CGACAG | ATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCGAAGAAGATTGCC    c.480
 R  Q   | I  T  S  P  V  S  G  I  N  G  D  I  R  A  K  K  I  A      p.160

          .         .         .         .         .         .       g.63820
 AGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCC       c.540
 S  I  A  D  V  C  E  S  M  K  E  Q  L  L  V  L  V  E  W  A         p.180

          .         .         .         .   | 06     .         .    g.67642
 AAGTACATCCCAGCTTTCTGCGAGCTCCCCCTGGACGACCAG | GTGGCCCTGCTCAGAGCC    c.600
 K  Y  I  P  A  F  C  E  L  P  L  D  D  Q   | V  A  L  L  R  A      p.200

          .         .         .         .         .         .       g.67702
 CATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTGTTCAAGGACGTG       c.660
 H  A  G  E  H  L  L  L  G  A  T  K  R  S  M  V  F  K  D  V         p.220

          . | 07       .         .         .         .         .    g.68970
 CTGCTCCTAG | GCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGC    c.720
 L  L  L  G |   N  D  Y  I  V  P  R  H  C  P  E  L  A  E  M  S      p.240

          .         .         .         .         .         .       g.69030
 CGGGTGTCCATACGCATCCTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGAT       c.780
 R  V  S  I  R  I  L  D  E  L  V  L  P  F  Q  E  L  Q  I  D         p.260

          .         .         .         .       | 08 .         .    g.73231
 GACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAG | ATGCCAAGGGGCTG    c.840
 D  N  E  Y  A  Y  L  K  A  I  I  F  F  D  P  D |   A  K  G  L      p.280

          .         .         .         .         .         .       g.73291
 AGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTAC       c.900
 S  D  P  G  K  I  K  R  L  R  S  Q  V  Q  V  S  L  E  D  Y         p.300

          .         .         .         .         .         .       g.73351
 ATCAACGACCGCCAGTATGACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCC       c.960
 I  N  D  R  Q  Y  D  S  R  G  R  F  G  E  L  L  L  L  L  P         p.320

          .         .         .         .         .         .       g.73411
 ACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATCAAGCTCTTCGGC       c.1020
 T  L  Q  S  I  T  W  Q  M  I  E  Q  I  Q  F  I  K  L  F  G         p.340

          .         .         .         .    | 09    .         .    g.77551
 ATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAG | GGTCCCCCAGCGATGCA    c.1080
 M  A  K  I  D  N  L  L  Q  E  M  L  L  G  G |   S  P  S  D  A      p.360

          .         .         .         .         .         .       g.77611
 CCCCATGCCCACCACCCCCTGCACCCTCACCTGATGCAGGAACATATGGGAACCAACGTC       c.1140
 P  H  A  H  H  P  L  H  P  H  L  M  Q  E  H  M  G  T  N  V         p.380

          .         .         .         .         .         .       g.77671
 ATCGTTGCCAACACAATGCCCACTCACCTCAGCAACGGACAGATGTGTGAGTGGCCCCGA       c.1200
 I  V  A  N  T  M  P  T  H  L  S  N  G  Q  M  C  E  W  P  R         p.400

          .       | 10 .         .         .         .         .    g.78766
 CCCAGGGGACAGGCAG | CCACCCCTGAGACCCCACAGCCCTCACCGCCAGGTGGCTCAGGG    c.1260
 P  R  G  Q  A  A |   T  P  E  T  P  Q  P  S  P  P  G  G  S  G      p.420

          .         .         .         .         .         .       g.78826
 TCTGAGCCCTATAAGCTCCTGCCGGGAGCCGTCGCCACAATCGTCAAGCCCCTCTCTGCC       c.1320
 S  E  P  Y  K  L  L  P  G  A  V  A  T  I  V  K  P  L  S  A         p.440

          .         .         .                                     g.78865
 ATCCCCCAGCCGACCATCACCAAGCAGGAAGTTATCTAG                            c.1359
 I  P  Q  P  T  I  T  K  Q  E  V  I  X                              p.452

          .         .         .         .         .         .       g.78925
 caagccgctggggcttgggggctccactggctccccccagccccctaagagagcacctgg       c.*60

          .         .         .         .         .         .       g.78985
 tgatcacgtggtcacggcaaaggaagacgtgatgccaggaccagtcccagagcaggaatg       c.*120

          .         .         .         .         .         .       g.79045
 ggaaggatgaagggcccgagaacatggcctaagggccacatcccactgccacccttgacg       c.*180

          .         .         .         .         .         .       g.79105
 ccctgctctggataacaagactttgacttggggagacctctactgccttggacaactttt       c.*240

          .         .         .         .         .         .       g.79165
 ctcatgttgaagccactgccttcaccttcaccttcatccatgtccaacccccgacttcat       c.*300

          .         .         .         .         .         .       g.79225
 cccaaaggacagccgcctggagatgacttgaggccttacttaaacccagctcccttcttc       c.*360

          .         .         .         .         .         .       g.79285
 cctagcctggtgcttctcctctcctagcccctgtcatggtgtccagacagagccctgtga       c.*420

          .         .         .         .         .         .       g.79345
 ggctgggtccaattgtggcacttggggcaccttgctcctccttctgctgctgcccccacc       c.*480

          .         .         .         .         .         .       g.79405
 tctgctgcctccctctgctgtcaccttgctcagccatcccgtcttctccaacaccacctc       c.*540

          .         .         .         .         .         .       g.79465
 tccagaggccaaggaggccttggaaacgattcccccagtcattctgggaacatgttgtaa       c.*600

          .         .         .         .         .         .       g.79525
 gcactgactgggaccaggcaccaggcagggtctagaaggctgtggtgagggaagacgcct       c.*660

          .         .         .         .         .         .       g.79585
 ttctcctccaacccaacctcatcctccttcttcagggacttgggtgggtacttgggtgag       c.*720

          .         .         .         .         .         .       g.79645
 gatccctgaaggccttcaacccgagaaaacaaacccaggttggcgactgcaacaggaact       c.*780

          .         .         .         .         .         .       g.79705
 tggagtggagaggaaaagcatcagaaagaggcagaccatccaccaggcctttgagaaagg       c.*840

          .         .         .         .         .         .       g.79765
 gtagaattctggctggtagagcaggtgagatgggacattccaaagaacagcctgagccaa       c.*900

          .         .         .         .         .         .       g.79825
 ggcctagtggtagtaagaatctagcaagaattgaggaagaatggtgtgggagagggatga       c.*960

          .         .         .         .         .         .       g.79885
 tgaagagagagagggcctgctggagagcatagggtctggaacaccaggctgaggtcctga       c.*1020

          .         .         .         .         .         .       g.79945
 tcagcttcaaggagtatgcagggagctgggcttccagaaaatgaacacagcagttctgca       c.*1080

          .         .         .         .         .         .       g.80005
 gaggacgggaggctggaagctgggaggtcaggtggggtggatgatataatgcgggtgaga       c.*1140

          .         .         .         .         .         .       g.80065
 gtaatgaggcttggggctggagaggacaagatgggtaaaccctcacatcagagtgacatc       c.*1200

          .         .         .         .         .         .       g.80125
 caggaggaataagctcccagggcctgtctcaagctcttccttactcccaggcactgtctt       c.*1260

          .         .         .         .         .         .       g.80185
 aaggcatctgacatgcatcatctcatttaatcctcccttcctccctattaacctagagat       c.*1320

          .         .         .         .         .         .       g.80245
 tgtttttgttttttattctcctcctccctccccgccctcacccgccccactccctcctaa       c.*1380

          .         .         .         .         .         .       g.80305
 cctagagattgttacagaagctgaaattgcgttctaagaggtgaagtgattttttttctg       c.*1440

          .         .         .         .         .         .       g.80365
 aaactcacacaactaggaagtggctgagtcaggacttgaacccaggtctccctggatcag       c.*1500

          .         .         .         .         .         .       g.80425
 aacaggagctcttaactacagtggctgaatagcttctccaaaggctccctgtgttctcac       c.*1560

          .         .         .         .         .         .       g.80485
 cgtgatcaagttgaggggcttccggctcccttctacagcctcagaaaccagactcgttct       c.*1620

          .         .         .         .         .         .       g.80545
 tctgggaaccctgcccactcccaggaccaagattggcctgaggctgcactaaaattcact       c.*1680

          .         .         .         .         .         .       g.80605
 tagggtcgagcatcctgtttgctgataaatattaaggagaattcatgactcttgacagct       c.*1740

          .         .         .         .         .         .       g.80665
 tttctctcttcactccccaagtcaaggggaggggtggcaggggtctgtttcctggaagtc       c.*1800

          .         .         .         .         .         .       g.80725
 aggctcatctggcctgttggcatgggggtgggacagtgtgcacagtgtgggggcagggga       c.*1860

          .         .         .         .         .         .       g.80785
 gggctaagcaggcctgggtttgagggctgctccggagaccgtcactccaggtgcattctg       c.*1920

          .         .         .         .         .         .       g.80845
 gaagcattagaccccaggatggagcgaccagcatgtcatccatgtggaatcttggtggct       c.*1980

          .         .         .         .         .         .       g.80905
 ttgaggacattctggaaaatgccactgaccagtgtgaacaaaagggatgtgttatggggc       c.*2040

          .         .         .         .         .         .       g.80965
 tggaggtgtgattaggtaggagggaaactgttggaccgactcctgccccctgctcaacac       c.*2100

          .         .         .         .         .         .       g.81025
 tgacccctctgagtggttggaggcagtgccccagtgcccagaaatcccaccattagtgat       c.*2160

          .         .         .         .         .         .       g.81085
 tgttttttatgagaaagaggcgtggagaagtattggggcaatgtgtcagggaggaatcac       c.*2220

          .         .         .         .         .         .       g.81145
 cacatccctacggcagtcccagccaagcccccaatcccagcggagactgtgccctgctca       c.*2280

          .         .         .         .         .         .       g.81205
 gagctcccaagccttcccccaccacctcactcaagtgcccctgaaatccctgccagacgg       c.*2340

          .         .         .         .         .         .       g.81265
 ctcagcctggtctgcggtaaggcagggaggctggaaccatttctgggcattgtggtcatt       c.*2400

          .         .         .         .         .         .       g.81325
 cccactgtgttcctccacctcctccctccagcgttgctcagacctctgtcttgggagaaa       c.*2460

          .         .         .         .         .         .       g.81385
 ggttgagataagaatgtcccatggagtgccgtgggcaacagtggcccttcatgggaacaa       c.*2520

          .         .         .         .         .         .       g.81445
 tctgttggagcagggggtcagttctctgctgggaatctacccctttctggaggagaaacc       c.*2580

          .         .         .         .         .         .       g.81505
 cattccaccttaataactttattgtaatgtgagaaacacaaaacaaagtttacttttttg       c.*2640

          .         .         .         .         .         .       g.81565
 actctaagctgacatgatattagaaaatctctcgctctcttttttttttttttttttttt       c.*2700

          .         .         .         .         .         .       g.81625
 tttggctacttgagttgtggtcctaaaacataaaatctgatggacaaacagagggttgct       c.*2760

          .         .         .         .         .         .       g.81685
 ggggggacaagcgtgggcacaatttccccaccaagacaccctgatcttcaggcgggtctc       c.*2820

          .         .         .         .         .         .       g.81745
 aggagcttctaaaaatccgcatggctctcctgagagtggacagaggagaggagagggtca       c.*2880

          .         .         .         .         .         .       g.81805
 gaaatgaacgctcttctatttcttgtcattaccaagccaattacttttgccaaatttttc       c.*2940

          .         .         .         .         .         .       g.81865
 tgtgatctgccctgattaagatgaattgtgaaatttacatcaagcaattatcaaagcggg       c.*3000

          .         .         .         .         .         .       g.81925
 ctgggtcccatcagaacgacccacatctttctgtgggtgtgaatgtcattaggtcttgcg       c.*3060

          .         .         .         .         .         .       g.81985
 ctgacccctgagcccccatcactgccgcctgatggggcaaagaaacaaaaaacatttctt       c.*3120

          .         .         .         .         .         .       g.82045
 actcttctgtgttttaacaaaagtttataaaacaaaataaatggcgcatatgttttctaa       c.*3180

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hepatocyte nuclear factor 4, alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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