heterogeneous nuclear ribonucleoprotein K (HNRNPK) - coding DNA reference sequence

(used for variant description)

(last modified April 2, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002140.3 in the HNRNPK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029577.1, covering HNRNPK transcript NM_002140.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          ccctagccgcccctccccc       c.-241

 .         .         .         .         .         .                g.5079
 cagctagtgagtgcgcgaacgagaaaggaggagggcgctccaggcgacagcactgcagac       c.-181

 .         .         .         .         .         .                g.5139
 gccattatcctctgtttctctgctgcaccgacctcgacgtcttgcctgtgtcccacttgt       c.-121

 .         .   | 02     .         .         .         .             g.7249
 tcgcggcctatag | gctactgcagcactggggtgtcagttgttggtccgacccagaacgct    c.-61

 .         .         .         .   | 03     .         .             g.7402
 tcagttctgctctgcaaggatatataataactg | attggtgtgcccgtttaataaaagaat    c.-1

          .         .         .         .         .         | 04    g.7870
 ATGGAAACTGAACAGCCAGAAGAAACCTTCCCTAACACTGAAACCAATGGTGAATTTG | GT    c.60
 M  E  T  E  Q  P  E  E  T  F  P  N  T  E  T  N  G  E  F  G |       p.20

          .         .         .         .         .         .       g.7930
 AAACGCCCTGCAGAAGATATGGAAGAGGAACAAGCATTTAAAAGATCTAGAAACACTGAT       c.120
 K  R  P  A  E  D  M  E  E  E  Q  A  F  K  R  S  R  N  T  D         p.40

          .         .         .       | 05 .         .         .    g.8627
 GAGATGGTTGAATTACGCATTCTGCTTCAGAGCAAG | AATGCTGGGGCAGTGATTGGAAAA    c.180
 E  M  V  E  L  R  I  L  L  Q  S  K   | N  A  G  A  V  I  G  K      p.60

          .         .         .    | 06    .         .         .    g.10176
 GGAGGCAAGAATATTAAGGCTCTCCGTACAGAC | TACAATGCCAGTGTTTCAGTCCCAGAC    c.240
 G  G  K  N  I  K  A  L  R  T  D   | Y  N  A  S  V  S  V  P  D      p.80

          .        | 07.         .         .         .         .    g.11108
 AGCAGTGGCCCCGAGCG | CATATTGAGTATCAGTGCTGATATTGAAACAATTGGAGAAATT    c.300
 S  S  G  P  E  R  |  I  L  S  I  S  A  D  I  E  T  I  G  E  I      p.100

          .         .         . | 08       .         .         .    g.11711
 CTGAAGAAAATCATCCCTACCTTGGAAGAG | GGCCTGCAGTTGCCATCACCCACTGCAACC    c.360
 L  K  K  I  I  P  T  L  E  E   | G  L  Q  L  P  S  P  T  A  T      p.120

          .         .         .         .   | 09     .         .    g.12273
 AGCCAGCTCCCGCTCGAATCTGATGCTGTGGAATGCTTAAAT | TACCAACACTATAAAGGA    c.420
 S  Q  L  P  L  E  S  D  A  V  E  C  L  N   | Y  Q  H  Y  K  G      p.140

          .         .         .         .         .         .       g.12333
 AGTGACTTTGACTGCGAGTTGAGGCTGTTGATTCATCAGAGTCTAGCAGGAGGAATTATT       c.480
 S  D  F  D  C  E  L  R  L  L  I  H  Q  S  L  A  G  G  I  I         p.160

          .         .         .       | 10 .         .         .    g.12706
 GGGGTCAAAGGTGCTAAAATCAAAGAACTTCGAGAG | AACACTCAAACCACCATCAAGCTT    c.540
 G  V  K  G  A  K  I  K  E  L  R  E   | N  T  Q  T  T  I  K  L      p.180

          .         .         .         .         .         .       g.12766
 TTCCAGGAATGCTGTCCTCATTCCACTGACAGAGTTGTTCTTATTGGAGGAAAACCCGAT       c.600
 F  Q  E  C  C  P  H  S  T  D  R  V  V  L  I  G  G  K  P  D         p.200

          .         .         .         .      | 11  .         .    g.13480
 AGGGTTGTAGAGTGCATAAAGATCATCCTTGATCTTATATCTGAG | TCTCCCATCAAAGGA    c.660
 R  V  V  E  C  I  K  I  I  L  D  L  I  S  E   | S  P  I  K  G      p.220

          .         .         .         .         .         .       g.13540
 CGTGCACAGCCTTATGATCCCAATTTTTACGATGAAACCTATGATTATGGTGGTTTTACA       c.720
 R  A  Q  P  Y  D  P  N  F  Y  D  E  T  Y  D  Y  G  G  F  T         p.240

          .         .         .         .         .         .       g.13600
 ATGATGTTTGATGACCGTCGCGGACGCCCAGTGGGATTTCCCATGCGGGGAAGAGGTGGT       c.780
 M  M  F  D  D  R  R  G  R  P  V  G  F  P  M  R  G  R  G  G         p.260

          .         .         .         .         .         .       g.13660
 TTTGACAGAATGCCTCCTGGTCGGGGTGGGCGTCCCATGCCTCCATCTAGAAGAGATTAT       c.840
 F  D  R  M  P  P  G  R  G  G  R  P  M  P  P  S  R  R  D  Y         p.280

          .         .         .         .         .         .       g.13720
 GATGATATGAGCCCTCGTCGAGGACCACCTCCCCCTCCTCCCGGACGAGGCGGCCGGGGT       c.900
 D  D  M  S  P  R  R  G  P  P  P  P  P  P  G  R  G  G  R  G         p.300

          .         .         .         .         .    | 12    .    g.13935
 GGTAGCAGAGCTCGGAATCTTCCTCTTCCTCCACCACCACCACCTAGAGGGGG | AGACCTC    c.960
 G  S  R  A  R  N  L  P  L  P  P  P  P  P  P  R  G  G  |  D  L      p.320

          .         .         .         .         | 13         .    g.14310
 ATGGCCTATGACAGAAGAGGGAGACCTGGAGACCGTTACGACGGCATG | GTTGGTTTCAGT    c.1020
 M  A  Y  D  R  R  G  R  P  G  D  R  Y  D  G  M   | V  G  F  S      p.340

          .         .         .         .         .         .       g.14370
 GCTGATGAAACTTGGGACTCTGCAATAGATACATGGAGCCCATCAGAATGGCAGATGGCT       c.1080
 A  D  E  T  W  D  S  A  I  D  T  W  S  P  S  E  W  Q  M  A         p.360

          .   | 14     .         | 15         .         .         . g.14867
 TATGAACCACAG | GGTGGCTCCGGATATG | ATTATTCCTATGCAGGGGGTCGTGGCTCATAT c.1140
 Y  E  P  Q   | G  G  S  G  Y  D |   Y  S  Y  A  G  G  R  G  S  Y   p.380

          .         .         .         .         .  | 16      .    g.15332
 GGTGATCTTGGTGGACCTATTATTACTACACAAGTAACTATTCCCAAAGAT | TTGGCTGGA    c.1200
 G  D  L  G  G  P  I  I  T  T  Q  V  T  I  P  K  D   | L  A  G      p.400

          .         .         .         .         .         .       g.15392
 TCTATTATTGGCAAAGGTGGTCAGCGGATTAAACAAATCCGTCATGAGTCGGGAGCTTCG       c.1260
 S  I  I  G  K  G  G  Q  R  I  K  Q  I  R  H  E  S  G  A  S         p.420

          .         .         .         .         .         .       g.15452
 ATCAAAATTGATGAGCCTTTAGAAGGATCCGAAGATCGGATCATTACCATTACAGGAACA       c.1320
 I  K  I  D  E  P  L  E  G  S  E  D  R  I  I  T  I  T  G  T         p.440

          .         .         .         .  | 17      .         .    g.16233
 CAGGACCAGATACAGAATGCACAGTATTTGCTGCAGAACAG | TGTGAAGCAGTATGCAGAT    c.1380
 Q  D  Q  I  Q  N  A  Q  Y  L  L  Q  N  S  |  V  K  Q  Y  A  D      p.460

          .                                                         g.16248
 GTTGAAGGATTCTAA                                                    c.1395
 V  E  G  F  X                                                      p.464

          .         .         .         .         .         .       g.16308
 tgcaagatattttttcttttttatagtgtgaagcagtattctggaaagtttttctaagac       c.*60

          .         .         .         .         .         .       g.16368
 tagtgaagaactgaaggagtcctgcatctttttttttttatctgcttctgtttaaaaagc       c.*120

          .         .         .         .         .         .       g.16428
 caacattcctctgcttcataggtgttctgcatttgaggtgtagtgaaatctttgctgttc       c.*180

          .         .         .         .         .         .       g.16488
 accagatgtaatgttttagttccttacaaacagggttgggggggggaagggcgtgcaaaa       c.*240

          .         .         .         .         .         .       g.16548
 actaacattgaaattttgaaacagcagcagagtgagtggattttatttttcgttattgtt       c.*300

          .         .         .         .         .         .       g.16608
 ggtggtttaaaaaattccccccatgtaattattgtgaacaccttgctttgtggtcactgt       c.*360

          .         .         .         .         .         .       g.16668
 aacatttggggggtgggacagggaggaaaagtaacaatagtccacatgtccctggcatct       c.*420

          .         .         .         .         .         .       g.16728
 gttcagagcagtgtgcagaatgtaatgctcttttgtaagaaacgttttatgatttttaaa       c.*480

          .         .         .         .         .         .       g.16788
 ataaatttagtgaacctatttttggtggtcattttttttttaagacagtcattttaaaat       c.*540

          .         .         .         .         .         .       g.16848
 ggtggctgaatttcccaacccacccccaaactaaacactaagtttaattttcagctcctc       c.*600

          .         .         .         .         .         .       g.16908
 tgttggacatataagtgcatctcttgttggacataggcaaaataacttggcaaacttagt       c.*660

          .         .         .         .         .         .       g.16968
 tctggtgatttcttgatggtttggaagtctattgctgggaagaaattccatcatacatat       c.*720

          .         .         .         .         .         .       g.17028
 tcatgcttataataagctggggattttttgtttgtttttgcaaatgcttgcccctacttt       c.*780

          .         .         .         .         .         .       g.17088
 tcaacaattttctatgttagttgtgaagaactaaggtggggagcagtactacaagttgag       c.*840

          .         .         .         .         .         .       g.17148
 taatggtatgagtatataccagaattctgattggcagcaagttttattaatcagaataac       c.*900

          .         .         .         .         .         .       g.17208
 acttggttatggaagtgactaatgctgaaaaaattgattatttttattagataatttctc       c.*960

          .         .         .         .         .         .       g.17268
 acctatagacttaaactgtcaatttgctctagtgtcttattagttaaactttgtaaaata       c.*1020

          .         .         .         .         .         .       g.17328
 tatatatacttgtttttccattgtatgcaaattgaaagaaaaagatgtaccatttctctg       c.*1080

          .         .         .         .         .         .       g.17388
 ttgtatgttggattatgtaggaaatgtttgtgtacaattcaaaaaaaaaaaagatgaaaa       c.*1140

          .         .         .         .         .         .       g.17448
 aagttcctgtggatgttttgtgtagtatcttggcatttgtattgatagttaaaattcact       c.*1200

          .         .         .         .         .         .       g.17508
 tccaaataaataaaacacccatgatgctagatttgatgtgtgcccgatttgaacaagggt       c.*1260

          .         .         .         .         .         .       g.17568
 tgattgacacctgtaaaatttgttgaaacgttcctcttaaaaggaaatatagtaatctta       c.*1320

                                                                    g.17572
 tgta                                                               c.*1324

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Heterogeneous nuclear ribonucleoprotein K protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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