Hermansky-Pudlak syndrome 6 (HPS6) - coding DNA reference sequence

(used for variant description)

(last modified July 25, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_024747.5 in the HPS6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012029.1, covering HPS6 transcript NM_024747.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5025
             cgggagacggaagtcttggccctgctccgctcccccgagaatcgggcc       c.-61

 .         .         .         .         .         .                g.5085
 tcgccctgctgggcggctggacctgggcaaagcctgggcgcgctcccgcgcagcggcgcc       c.-1

          .         .         .         .         .         .       g.5145
 ATGAAGCGCTCGGGGACTCTGCGGCTGCTCTCGGACCTGAGCGCCTTCGGCGGCGCGGCG       c.60
 M  K  R  S  G  T  L  R  L  L  S  D  L  S  A  F  G  G  A  A         p.20

          .         .         .         .         .         .       g.5205
 CGGCTCCGGGAGCTGGTGGCCGGGGACTCAGCGGTCCGAGTCCGTGGCAGTCCGGACGGC       c.120
 R  L  R  E  L  V  A  G  D  S  A  V  R  V  R  G  S  P  D  G         p.40

          .         .         .         .         .         .       g.5265
 CGCCACTTGCTGCTCCTGCGACCCCCTGGGGCGGTAGCCCCACAGCTGCTAGTCGCGTCG       c.180
 R  H  L  L  L  L  R  P  P  G  A  V  A  P  Q  L  L  V  A  S         p.60

          .         .         .         .         .         .       g.5325
 CGAGGGCCCGGCGCGGAGCTAGAGCGGGCCTGGCCGGCCGGCCAGCCCTCCCCGCTGGAC       c.240
 R  G  P  G  A  E  L  E  R  A  W  P  A  G  Q  P  S  P  L  D         p.80

          .         .         .         .         .         .       g.5385
 GCCTTCTTCCTGCCGTGGCCAGCGCGGCCGGCGCTGGTGCTGGTGTGGGAGAGTGGCCTG       c.300
 A  F  F  L  P  W  P  A  R  P  A  L  V  L  V  W  E  S  G  L         p.100

          .         .         .         .         .         .       g.5445
 GCCGAGGTGTGGGGCGCGGGCGTGGGGCCTGGCTGGCGGCCGCTGCAGAGCACCGAGCTG       c.360
 A  E  V  W  G  A  G  V  G  P  G  W  R  P  L  Q  S  T  E  L         p.120

          .         .         .         .         .         .       g.5505
 TGTCCGGGCGGGGGAGCCCGCGTTGTGGCAGTGGCGGCGCTCCGAGGCCGCCTGGTGTGG       c.420
 C  P  G  G  G  A  R  V  V  A  V  A  A  L  R  G  R  L  V  W         p.140

          .         .         .         .         .         .       g.5565
 TGCGAGGAGCGGCAGGCCCGGGCCGAGGGCCCGTCAGGGTCGCCAGCAGCCGCTTTCAGC       c.480
 C  E  E  R  Q  A  R  A  E  G  P  S  G  S  P  A  A  A  F  S         p.160

          .         .         .         .         .         .       g.5625
 CACTGTGTGTGCGTCCGGACTCTGGAGCCCAGCGGGGAAGCTAGCACCAGCCTGGGCCGC       c.540
 H  C  V  C  V  R  T  L  E  P  S  G  E  A  S  T  S  L  G  R         p.180

          .         .         .         .         .         .       g.5685
 ACACACGTCCTGCTGCACCACTGCCCTGCCTTCGGGCTGCTGGCCTCCTGCAGACAACTC       c.600
 T  H  V  L  L  H  H  C  P  A  F  G  L  L  A  S  C  R  Q  L         p.200

          .         .         .         .         .         .       g.5745
 TTCCTGGTGCCCACTGCCACCACCTGGCCTGGCGTGGCCCACGTTCTACTCATCTGGAGC       c.660
 F  L  V  P  T  A  T  T  W  P  G  V  A  H  V  L  L  I  W  S         p.220

          .         .         .         .         .         .       g.5805
 CCAGGCAAGGGCAAAGTGATGGTGGCTGCCCCACGGCTTGGTCTCTCCTACAGTAAGAGT       c.720
 P  G  K  G  K  V  M  V  A  A  P  R  L  G  L  S  Y  S  K  S         p.240

          .         .         .         .         .         .       g.5865
 CTGAATCCTGGACGAGGGGACACATGGGACTTCCGGACCCTGCTCCGAGGCCTTCCTGGG       c.780
 L  N  P  G  R  G  D  T  W  D  F  R  T  L  L  R  G  L  P  G         p.260

          .         .         .         .         .         .       g.5925
 TTGCTGTCCCCCAGGGAGCCACTGGCTGTACACACCTGGGCCCCAACTCCCCAGGGCCTG       c.840
 L  L  S  P  R  E  P  L  A  V  H  T  W  A  P  T  P  Q  G  L         p.280

          .         .         .         .         .         .       g.5985
 CTGTTGCTTGACTTCGGGGGCACTGTGAGCCTATTGCAGTCCCACGGTGGTACGCGGGCT       c.900
 L  L  L  D  F  G  G  T  V  S  L  L  Q  S  H  G  G  T  R  A         p.300

          .         .         .         .         .         .       g.6045
 GTGGGCACCCTGCAGGAGGCACCTGTAGGCCCGTGGGGGTCTGCAGCCCTAGGCACATTT       c.960
 V  G  T  L  Q  E  A  P  V  G  P  W  G  S  A  A  L  G  T  F         p.320

          .         .         .         .         .         .       g.6105
 CAGGGCACTCTGGCCTGTGTGCTGGGCTCCACATTGGAACTGCTGGACATGGGCAGTGGG       c.1020
 Q  G  T  L  A  C  V  L  G  S  T  L  E  L  L  D  M  G  S  G         p.340

          .         .         .         .         .         .       g.6165
 CAGCTGCTGGAGAGGAAGGTCCTAAGTACAGACAGGGTACATCTGCTAGAACCGCCAGCC       c.1080
 Q  L  L  E  R  K  V  L  S  T  D  R  V  H  L  L  E  P  P  A         p.360

          .         .         .         .         .         .       g.6225
 CCCGGCATGGAGGATGAGGAAGAGCTGGAGACCCGAGGGAATCTTCGTCTGCTTTCAGCC       c.1140
 P  G  M  E  D  E  E  E  L  E  T  R  G  N  L  R  L  L  S  A         p.380

          .         .         .         .         .         .       g.6285
 TTGGGTCTGTTTTGTGTGGGCTGGGAAGCCCCACAGGGTGTTGAGTTGCCTTCAGCCAAG       c.1200
 L  G  L  F  C  V  G  W  E  A  P  Q  G  V  E  L  P  S  A  K         p.400

          .         .         .         .         .         .       g.6345
 GATCTGGTGTTTGAGGAGGCCTGCGGGTACTACCAGCGGCGGAGCCTGCGGGGTGCCCAG       c.1260
 D  L  V  F  E  E  A  C  G  Y  Y  Q  R  R  S  L  R  G  A  Q         p.420

          .         .         .         .         .         .       g.6405
 CTCACTCCAGAAGAACTGAGACACAGCAGCACATTCCGGGCACCTCAGGCTCTGGCCTCC       c.1320
 L  T  P  E  E  L  R  H  S  S  T  F  R  A  P  Q  A  L  A  S         p.440

          .         .         .         .         .         .       g.6465
 ATCCTCCAGGGCCACCTGCCCCCATCTGCACTGCTGACCATGTTGAGGACCGAGCTTCGG       c.1380
 I  L  Q  G  H  L  P  P  S  A  L  L  T  M  L  R  T  E  L  R         p.460

          .         .         .         .         .         .       g.6525
 GATTACCGAGGCTTAGAACAGCTGAAGGCCCAGCTGGTGGCTGGGGATGATGAGGAGGCT       c.1440
 D  Y  R  G  L  E  Q  L  K  A  Q  L  V  A  G  D  D  E  E  A         p.480

          .         .         .         .         .         .       g.6585
 GGTTGGACTGAGCTGGCGGAGCAGGAAGTGGCACGCCTGCTGAGGACTGAGTTGATAGGA       c.1500
 G  W  T  E  L  A  E  Q  E  V  A  R  L  L  R  T  E  L  I  G         p.500

          .         .         .         .         .         .       g.6645
 GACCAGCTAGCCCAGCTCAACACCGTTTTCCAAGCCCTTCCTACAGCAGCCTGGGGTGCC       c.1560
 D  Q  L  A  Q  L  N  T  V  F  Q  A  L  P  T  A  A  W  G  A         p.520

          .         .         .         .         .         .       g.6705
 ACCCTCAGGGCCCTGCAGCTCCAGCTAGATGGGAATGGCAAGCTGAGGTCCCAAGCACCC       c.1620
 T  L  R  A  L  Q  L  Q  L  D  G  N  G  K  L  R  S  Q  A  P         p.540

          .         .         .         .         .         .       g.6765
 CCTGATGTGTGGAAGAAAGTGTTAGGGGGAATAACCGCTGGAAAGGAACCCCCCAATGGA       c.1680
 P  D  V  W  K  K  V  L  G  G  I  T  A  G  K  E  P  P  N  G         p.560

          .         .         .         .         .         .       g.6825
 ATACTGCCCCCCTTTGAACTCCTGTGCCAGTGTCTGTGCCAGCTGGAGCCTCGATGGCTG       c.1740
 I  L  P  P  F  E  L  L  C  Q  C  L  C  Q  L  E  P  R  W  L         p.580

          .         .         .         .         .         .       g.6885
 CCACCCTTTGTGGAGCTGGCACAGCAGCAGGGCGGGCCGGGCTGGGGGGCAGGGGGCCCA       c.1800
 P  P  F  V  E  L  A  Q  Q  Q  G  G  P  G  W  G  A  G  G  P         p.600

          .         .         .         .         .         .       g.6945
 GGACTGCCCCTGTATCGCCGAGCTCTGGCAGTGCTAGGTGAGGAGGGGACCAGGCCTGAG       c.1860
 G  L  P  L  Y  R  R  A  L  A  V  L  G  E  E  G  T  R  P  E         p.620

          .         .         .         .         .         .       g.7005
 GCTCTGGAGCTAGAGCTGCTCTTGAGCAGTGGGCGGCCTAAAGCTGTGCTCCAAGCTGTC       c.1920
 A  L  E  L  E  L  L  L  S  S  G  R  P  K  A  V  L  Q  A  V         p.640

          .         .         .         .         .         .       g.7065
 GGGCAGCTGGTGCAAAAGGAACAATGGGATCGGGCTCTGGATGCTGGCCTGGCCCTCGGC       c.1980
 G  Q  L  V  Q  K  E  Q  W  D  R  A  L  D  A  G  L  A  L  G         p.660

          .         .         .         .         .         .       g.7125
 CCCTCCAGTCCCCTGCTTCGAAGTGAAATCTTCAAACTGCTGCTGGCCGAGTTTGCCCAG       c.2040
 P  S  S  P  L  L  R  S  E  I  F  K  L  L  L  A  E  F  A  Q         p.680

          .         .         .         .         .         .       g.7185
 CACCGCCGGCTTGATGCTCACCTCCCCCTCCTTTGCCGCCTGTGCCCACCAGAACTGGCT       c.2100
 H  R  R  L  D  A  H  L  P  L  L  C  R  L  C  P  P  E  L  A         p.700

          .         .         .         .         .         .       g.7245
 CCAGCTGAGCTCCTGCTTCTACTGAGGACATACCTCCCAGATGAGGTGGGGCCCCCAACC       c.2160
 P  A  E  L  L  L  L  L  R  T  Y  L  P  D  E  V  G  P  P  T         p.720

          .         .         .         .         .         .       g.7305
 CCATTCCCTGAGCCTGGAGCAGAGCCCCCTCTCACTGTGGGCTTGCTCAAAGCCCTGCTG       c.2220
 P  F  P  E  P  G  A  E  P  P  L  T  V  G  L  L  K  A  L  L         p.740

          .         .         .         .         .         .       g.7365
 GAGCAGACTGGGGCTCAAGGATGGCTGTCGGGCCCAGTTCTAAGCCCATATGAGGACATC       c.2280
 E  Q  T  G  A  Q  G  W  L  S  G  P  V  L  S  P  Y  E  D  I         p.760

          .         .         .         .                           g.7413
 CTATGGGACCCCAGCACTCCACCCCCGACTCCACCTCGGGACCTATGA                   c.2328
 L  W  D  P  S  T  P  P  P  T  P  P  R  D  L  X                     p.775

          .         .         .         .         .         .       g.7473
 ctacccttcaggcatcagaacactcagggcctggaggcttgcttgggactggaggcttgc       c.*60

          .         .         .         .         .         .       g.7533
 ttggacagttcctctgtgtcactgacacaggaaatcatttctaggacacagtgatcaggg       c.*120

          .         .         .         .         .         .       g.7593
 aagggtgcctgggacttggagggtcccatgtatggacctgtgtatgcaatactgttctgt       c.*180

          .         .         .         .         .                 g.7649
 catctggagctatttttaagatgtgtgtgttaaatatatacatagtttaatatata           c.*236

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Hermansky-Pudlak syndrome 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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