heparanase 2 (HPSE2) - coding DNA reference sequence

(used for variant description)

(last modified August 14, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_021828.4 in the HPSE2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering HPSE2 transcript NM_021828.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                acacactttagat       c.-61

 .         .         .         .         .         .                g.5073
 aaggacaattagtcactagcgagacccagtaggaagagaggtttaaatcagagggattga       c.-1

          .         .         .         .         .         .       g.5133
 ATGAGGGTGCTTTGTGCCTTCCCTGAAGCCATGCCCTCCAGCAACTCCCGCCCCCCCGCG       c.60
 M  R  V  L  C  A  F  P  E  A  M  P  S  S  N  S  R  P  P  A         p.20

          .         .         .         .         .         .       g.5193
 TGCCTAGCCCCGGGGGCTCTCTACTTGGCTCTGTTGCTCCATCTCTCCCTTTCCTCCCAG       c.120
 C  L  A  P  G  A  L  Y  L  A  L  L  L  H  L  S  L  S  S  Q         p.40

          .         .         .         .         .         .       g.5253
 GCTGGAGACAGGAGACCCTTGCCTGTAGACAGAGCTGCAGGTTTGAAGGAAAAGACCCTG       c.180
 A  G  D  R  R  P  L  P  V  D  R  A  A  G  L  K  E  K  T  L         p.60

          .         .         .         .         .         .       g.5313
 ATTCTACTTGATGTGAGCACCAAGAACCCAGTCAGGACAGTCAATGAGAACTTCCTCTCT       c.240
 I  L  L  D  V  S  T  K  N  P  V  R  T  V  N  E  N  F  L  S         p.80

          .         .         .         .         . | 02       .    g.8380
 CTGCAGCTGGATCCGTCCATCATTCATGATGGCTGGCTCGATTTCCTAAG | CTCCAAGCGC    c.300
 L  Q  L  D  P  S  I  I  H  D  G  W  L  D  F  L  S  |  S  K  R      p.100

          .         .         .         .         .         .       g.8440
 TTGGTGACCCTGGCCCGGGGACTTTCGCCCGCCTTTCTGCGCTTCGGGGGCAAAAGGACC       c.360
 L  V  T  L  A  R  G  L  S  P  A  F  L  R  F  G  G  K  R  T         p.120

          .         .         .         .         .         .       g.8500
 GACTTCCTGCAGTTCCAGAACCTGAGGAACCCGGCGAAAAGCCGCGGGGGCCCGGGCCCG       c.420
 D  F  L  Q  F  Q  N  L  R  N  P  A  K  S  R  G  G  P  G  P         p.140

          .         .         | 03         .         .         .    g.96508
 GATTACTATCTCAAAAACTATGAGGATG | ACATTGTTCGAAGTGATGTTGCCTTAGATAAA    c.480
 D  Y  Y  L  K  N  Y  E  D  D |   I  V  R  S  D  V  A  L  D  K      p.160

          .         .         .         .         .         .       g.96568
 CAGAAAGGCTGCAAGATTGCCCAGCACCCTGATGTTATGCTGGAGCTCCAAAGGGAGAAG       c.540
 Q  K  G  C  K  I  A  Q  H  P  D  V  M  L  E  L  Q  R  E  K         p.180

          .         .         .         .         .         .       g.96628
 GCAGCTCAGATGCATCTGGTTCTTCTAAAGGAGCAATTCTCCAATACTTACAGTAATCTC       c.600
 A  A  Q  M  H  L  V  L  L  K  E  Q  F  S  N  T  Y  S  N  L         p.200

          . | 04       .         .         .         .         .    g.496869
 ATATTAACAG | CCAGGTCTCTAGACAAACTTTATAACTTTGCTGATTGCTCTGGACTCCAC    c.660
 I  L  T  A |   R  S  L  D  K  L  Y  N  F  A  D  C  S  G  L  H      p.220

          .         .         .         .         .         .       g.496929
 CTGATATTTGCTCTAAATGCACTGCGTCGTAATCCCAATAACTCCTGGAACAGTTCTAGT       c.720
 L  I  F  A  L  N  A  L  R  R  N  P  N  N  S  W  N  S  S  S         p.240

          .         .         .         .         .         .       g.496989
 GCCCTGAGTCTGTTGAAGTACAGCGCCAGCAAAAAGTACAACATTTCTTGGGAACTGGGT       c.780
 A  L  S  L  L  K  Y  S  A  S  K  K  Y  N  I  S  W  E  L  G         p.260

      | 05   .         .         .         .         .         .    g.519103
 AATG | AGCCAAATAACTATCGGACCATGCATGGCCGGGCAGTAAATGGCAGCCAGTTGGGA    c.840
 N  E |   P  N  N  Y  R  T  M  H  G  R  A  V  N  G  S  Q  L  G      p.280

          .         .         .         .         .         .       g.519163
 AAGGATTACATCCAGCTGAAGAGCCTGTTGCAGCCCATCCGGATTTATTCCAGAGCCAGC       c.900
 K  D  Y  I  Q  L  K  S  L  L  Q  P  I  R  I  Y  S  R  A  S         p.300

          .         .         .         .         .       | 06 .    g.546932
 TTATATGGCCCTAATATTGGGCGGCCGAGGAAGAATGTCATCGCCCTCCTAGATGG | ATTC    c.960
 L  Y  G  P  N  I  G  R  P  R  K  N  V  I  A  L  L  D  G  |  F      p.320

          .         .         .         .     | 07   .         .    g.598951
 ATGAAGGTGGCAGGAAGTACAGTAGATGCAGTTACCTGGCAACA | TTGCTACATTGATGGC    c.1020
 M  K  V  A  G  S  T  V  D  A  V  T  W  Q  H  |  C  Y  I  D  G      p.340

          .         .         .         .         .         .       g.599011
 CGGGTGGTCAAGGTGATGGACTTCCTGAAAACTCGCCTGTTAGACACACTCTCTGACCAG       c.1080
 R  V  V  K  V  M  D  F  L  K  T  R  L  L  D  T  L  S  D  Q         p.360

          .         | 08         .         .         .         .    g.620209
 ATTAGGAAAATTCAGAAA | GTGGTTAATACATACACTCCAGGAAAGAAGATTTGGCTTGAA    c.1140
 I  R  K  I  Q  K   | V  V  N  T  Y  T  P  G  K  K  I  W  L  E      p.380

          .         .         .         .         .         .       g.620269
 GGTGTGGTGACCACCTCAGCTGGAGGCACAAACAATCTATCCGATTCCTATGCTGCAGGA       c.1200
 G  V  V  T  T  S  A  G  G  T  N  N  L  S  D  S  Y  A  A  G         p.400

       | 09  .         .         .         .         .         .    g.625912
 TTCTT | ATGGTTGAACACTTTAGGAATGCTGGCCAATCAGGGCATTGATGTCGTGATACGG    c.1260
 F  L  |  W  L  N  T  L  G  M  L  A  N  Q  G  I  D  V  V  I  R      p.420

          .         .         .         .         .         .       g.625972
 CACTCATTTTTTGACCATGGATACAATCACCTCGTGGACCAGAATTTTAACCCATTACCA       c.1320
 H  S  F  F  D  H  G  Y  N  H  L  V  D  Q  N  F  N  P  L  P         p.440

  | 10       .         .         .         .         .         .    g.750739
  | GACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCAT    c.1380
  | D  Y  W  L  S  L  L  Y  K  R  L  I  G  P  K  V  L  A  V  H      p.460

          .         .         .         .         .         .       g.750799
 GTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATT       c.1440
 V  A  G  L  Q  R  K  P  R  P  G  R  V  I  R  D  K  L  R  I         p.480

          .         .       | 11 .         .         .         .    g.758127
 TATGCTCACTGCACAAACCACCACAA | CCACAACTACGTTCGTGGGTCCATTACACTTTTT    c.1500
 Y  A  H  C  T  N  H  H  N  |  H  N  Y  V  R  G  S  I  T  L  F      p.500

          .         .         .         .         .         .       g.758187
 ATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAG       c.1560
 I  I  N  L  H  R  S  R  K  K  I  K  L  A  G  T  L  R  D  K         p.520

          .         .         .         .         .    | 12    .    g.781143
 CTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAA | GTCAGTG    c.1620
 L  V  H  Q  Y  L  L  Q  P  Y  G  Q  E  G  L  K  S  K  |  S  V      p.540

          .         .         .         .         .         .       g.781203
 CAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCC       c.1680
 Q  L  N  G  Q  P  L  V  M  V  D  D  G  T  L  P  E  L  K  P         p.560

          .         .         .         .         .         .       g.781263
 CGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTG       c.1740
 R  P  L  R  A  G  R  T  L  V  I  P  P  V  T  M  G  F  Y  V         p.580

          .         .         .                                     g.781302
 GTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAA                            c.1779
 V  K  N  V  N  A  L  A  C  R  Y  R  X                              p.592

          .         .         .         .         .         .       g.781362
 gctatcctcacactcacggctaccagtgggcctgctgggctgcttccactcctccactcc       c.*60

          .         .         .         .         .         .       g.781422
 agtagtatcctctgttttcagacatcctagcaaccagcccctgctgccccatcctgctgg       c.*120

          .         .         .         .         .         .       g.781482
 aatcaacacagacttgctctccaaagagactaaatgtcatagcgtgatcttagcctaggt       c.*180

          .         .         .         .         .         .       g.781542
 aggccacatccatcccaaaggaaaatgtagacatcacctgtacctatataaggataaagg       c.*240

          .         .         .         .         .         .       g.781602
 catgtgtatagagcagaatgtttcccttcatgtgcactatgaaaacgagctgacagcaca       c.*300

          .         .         .         .         .         .       g.781662
 ctcccaggagaaatgtttccagacaactccccatgatcctgtcacacagcattataacca       c.*360

          .         .         .         .         .         .       g.781722
 caaatccaaaccttagcctgctgctgctgctgccctcagaggaagatgaggaaggaaaaa       c.*420

          .         .         .         .         .         .       g.781782
 aactgggtggacctacaaaaacccatcctctcccaactccttcttctctgcctctttctt       c.*480

          .         .         .         .         .         .       g.781842
 gctgctgccctgagttttttgacacatctctttccataggggagtaatgggtgtgtcagc       c.*540

          .         .         .         .         .         .       g.781902
 cctggcctgctgggagagctgtttgtatgatttcccggctgatgtatgagcgtgcgcatc       c.*600

          .         .         .         .         .         .       g.781962
 tgggttcctgacagtggcatccatcactggcagttcttctgggaagcgggtgcttcaaaa       c.*660

          .         .         .         .         .         .       g.782022
 gtaaaattacaatcacactccagatttggtaagaaggttctattcctctgtgaatccaga       c.*720

          .         .         .         .         .         .       g.782082
 ttcccccagagttgtaatgggagtcaagtaacaatattcattgagtggagagcagtttat       c.*780

          .         .         .         .         .         .       g.782142
 taggcacaacaaaaagtagtcatcattcttcatgttgctatgagggagagtttgagtaca       c.*840

          .         .         .         .         .         .       g.782202
 aagagaaagcatactgaaacatcaggtacacacacacaccccaactggacaaagcaaatt       c.*900

          .         .         .         .         .         .       g.782262
 agacctctccaaaattaagagaatattaggggctctatagggtaagcccttaattgtttg       c.*960

          .         .         .         .         .         .       g.782322
 gttaactcaaatcattatttttaaaaaagaagaaaaaagtgtgaatcaaggtcatcactg       c.*1020

          .         .         .         .         .         .       g.782382
 gaagacacaactgaatctaacctttttgcctcttcccaagtagcctatttgagctagaac       c.*1080

          .         .         .         .         .         .       g.782442
 aaaactttgttagccattttgggagagaatagggaatctagagaatgaagatctggccaa       c.*1140

          .         .         .         .         .         .       g.782502
 aactatggaatggtaggtaggaagcttctgagttgggcaggtgtgaagtgggggatgagg       c.*1200

          .         .         .         .         .         .       g.782562
 acgttctatatgattcaaggggcatgagggtctttgccaatgagctacagctgaaatgac       c.*1260

          .         .         .         .         .         .       g.782622
 tttcttttctgtggatgtgattttctttctcaggataaatgacaggaatgatgcttttgt       c.*1320

          .         .         .         .         .         .       g.782682
 tagaaggaggagagatttgacactgttccaagtgagacggtgatacaatttctgctgttt       c.*1380

          .         .         .         .         .         .       g.782742
 gtgaaaggacaggaatggggcgggggcaaggcagggttgcctagggcagagactagggag       c.*1440

          .         .         .         .         .         .       g.782802
 gctgcctaagacgcacacggagttaaggatttgggccaagtctgcaaagtgagagatgga       c.*1500

          .         .         .         .         .         .       g.782862
 agggagattagaccaaagaggagggagagaattctgagcttggagaacggtggatttggg       c.*1560

          .         .         .         .         .         .       g.782922
 agagggaagctgactacctaattccaggaagcgaggggaccgggttttgacatgcttatc       c.*1620

          .         .         .         .         .         .       g.782982
 attaagcacaggaggaacagcatacagcagatgtactacagcgagcaagaaagggagagc       c.*1680

          .         .         .         .         .         .       g.783042
 ccgaggaccaggctgcaccaggtcagtggctgtgctcagcatggaagcaactggagagag       c.*1740

          .         .         .         .         .         .       g.783102
 aggggcagaccctgagaccgccctgcaaggctgcccagaagggacccgtttctctgggac       c.*1800

          .         .         .         .         .         .       g.783162
 caggcacctcccactgaggcttcagctctgagagggcaggaaagtgaagtaccaagatgg       c.*1860

          .         .         .         .         .         .       g.783222
 gggcggggcggggggtaggaaataagagaaagaagaaacagattgacaggccaaagtgag       c.*1920

          .         .         .         .         .         .       g.783282
 gaaaagagaggaaaagagaaatgagactaaaaggtcgttcccccaactgttaaaaatgtg       c.*1980

          .         .         .         .         .         .       g.783342
 tgcagatatcaacgtctcttctacatactggtacaggtgcgactgcagggccccctgata       c.*2040

          .         .         .         .         .         .       g.783402
 taacaagagtaaccaaaggtccctaagagcctggccctggggacctatggtttgctttgc       c.*2100

          .         .         .         .         .         .       g.783462
 gtccttagtaaccccatgataaaggggtactactgttatccccatttttcctacgaggca       c.*2160

          .         .         .         .         .         .       g.783522
 tggagaggatccatggctcgcccaggggcacccggggaaatgggttgccgagcgcgaaat       c.*2220

          .         .         .         .         .         .       g.783582
 aatccagagcctgcccactcagccacaaggctcagcggctccacaggtccagacacctcc       c.*2280

          .         .         .         .         .         .       g.783642
 ttcacatctttgtaggttctgctcattcagaacagccagaactccactcaaacacacttt       c.*2340

          .         .         .         .         .         .       g.783702
 ctgtaaataagtgttgatttttttttactaaaccttgcagaatatgggtaattcctgctt       c.*2400

          .         .         .         .         .         .       g.783762
 cttttatctttctctgtgtattaaatgctgctctcacgagatttaagttttgtttatttt       c.*2460

          .         .         .                                     g.783799
 ttagttaataaaaggaagagggaattactgaaattta                              c.*2497

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Heparanase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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