heparan sulfate (glucosamine) 3-O-sulfotransferase 6 (HS3ST6) - coding DNA reference sequence

(used for variant description)

(last modified March 13, 2025)

This file was created to facilitate the description of sequence variants on transcript NM_001009606.2 in the HS3ST6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering HS3ST6 transcript NM_001009606.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGCTGCTCGTGGCCCTGGTGCTCGGCGCCTACTGCCTCTGCGCCCTCCCCGGCCGCTGC       c.60
 M  L  L  V  A  L  V  L  G  A  Y  C  L  C  A  L  P  G  R  C         p.20

          .         .         .         .         .         .       g.120
 CCGCCGGCCGCCCGCGCCCCCGCGCCGGCCCCCGCGCCCTCCGAGCCGTCCAGCTCCGTC       c.120
 P  P  A  A  R  A  P  A  P  A  P  A  P  S  E  P  S  S  S  V         p.40

          .         .         .         .         .         .       g.180
 CACCGCCCGGGAGCACCCGGCCTGCCTTTGGCCAGCGGTCCCGGCCGCCGGCGCTTCCCG       c.180
 H  R  P  G  A  P  G  L  P  L  A  S  G  P  G  R  R  R  F  P         p.60

          .         .         .         .         .         .       g.240
 CAAGCGCTCATCGTTGGCGTGAAGAAGGGCGGCACGCGCGCCCTGCTGGAGTTTCTGCGG       c.240
 Q  A  L  I  V  G  V  K  K  G  G  T  R  A  L  L  E  F  L  R         p.80

          .         .         .         .         .         .       g.300
 CTGCACCCCGACGTCCGCGCGCTGGGCTCTGAGCCCCACTTCTTCGACAGGTGCTACGAG       c.300
 L  H  P  D  V  R  A  L  G  S  E  P  H  F  F  D  R  C  Y  E         p.100

          .         . | 02       .         .         .         .    g.6065
 CGCGGCCTCGCCTGGTACCG | GAGTCTGATGCCCCGAACCCTGGATGGGCAGATCACCATG    c.360
 R  G  L  A  W  Y  R  |  S  L  M  P  R  T  L  D  G  Q  I  T  M      p.120

          .         .         .         .         .         .       g.6125
 GAGAAGACCCCCAGCTACTTCGTGACGCGAGAGGCCCCCCGCCGCATCCACGCCATGTCC       c.420
 E  K  T  P  S  Y  F  V  T  R  E  A  P  R  R  I  H  A  M  S         p.140

          .         .         .         .         .         .       g.6185
 CCGGACACGAAGCTGATCGTGGTGGTGCGGAACCCCGTGACCCGGGCCATCTCCGACTAC       c.480
 P  D  T  K  L  I  V  V  V  R  N  P  V  T  R  A  I  S  D  Y         p.160

          .         .         .         .         .         .       g.6245
 GCCCAGACGCTCTCCAAGACCCCGGGCCTGCCCAGCTTCCGCGCCCTGGCCTTCCGCCAC       c.540
 A  Q  T  L  S  K  T  P  G  L  P  S  F  R  A  L  A  F  R  H         p.180

          .         .         .         .         .         .       g.6305
 GGCCTGGGCCCCGTGGACACAGCCTGGAGCGCCGTCCGCATCGGCCTGTACGCCCAGCAC       c.600
 G  L  G  P  V  D  T  A  W  S  A  V  R  I  G  L  Y  A  Q  H         p.200

          .         .         .         .         .         .       g.6365
 CTGGACCACTGGCTGCGCTACTTCCCCCTGTCCCACTTCCTGTTCGTCAGCGGGGAGCGT       c.660
 L  D  H  W  L  R  Y  F  P  L  S  H  F  L  F  V  S  G  E  R         p.220

          .         .         .         .         .         .       g.6425
 CTGGTCAGCGACCCGGCCGGAGAGGTCGGCCGCGTGCAGGACTTCCTGGGCCTGAAACGG       c.720
 L  V  S  D  P  A  G  E  V  G  R  V  Q  D  F  L  G  L  K  R         p.240

          .         .         .         .         .         .       g.6485
 GTCGTCACGGACAAGCACTTCTACTTCAACGCCACCAAGGGCTTCCCCTGCCTCAAGAAG       c.780
 V  V  T  D  K  H  F  Y  F  N  A  T  K  G  F  P  C  L  K  K         p.260

          .         .         .         .         .         .       g.6545
 GCCCAGGGCGGCAGCCGTCCCCGCTGCCTGGGCAAGTCCAAGGGCCGGCCACACCCACGC       c.840
 A  Q  G  G  S  R  P  R  C  L  G  K  S  K  G  R  P  H  P  R         p.280

          .         .         .         .         .         .       g.6605
 GTGCCCCAGGCCCTGGTCCGGCGCCTGCAGGAGTTCTACCGGCCCTTCAACCGCAGGTTC       c.900
 V  P  Q  A  L  V  R  R  L  Q  E  F  Y  R  P  F  N  R  R  F         p.300

          .         .         .                                     g.6641
 TACCAGATGACGGGCCAGGACTTCGGCTGGGGCTGA                               c.936
 Y  Q  M  T  G  Q  D  F  G  W  G  X                                 p.311

          .         .         .         .         .         .       g.6701
 gcggcaccctggggatgctcagcaccttgattgacacccgctcgcctggccagagcgggc       c.*60

          .         .         .         .         .         .       g.6761
 tgcgtgcacatgctgggcagagaggaatatttaagaaataaagcttggacccagattttt       c.*120

                                                                    g.6768
 ccacaaa                                                            c.*127

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Heparan sulfate (glucosamine) 3-O-sulfotransferase 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.