heat shock transcription factor 4 (HSF4) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001040667.2 in the HSF4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009294.1, covering HSF4 transcript NM_001040667.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        agatg       c.-961

 .         .         .         .         .         .                g.5065
 cacgcgcgtccccgctgcccaacgaagcctgggtcgcgttgcgccgccgccaccctgggc       c.-901

 .         .         .         .         .         .                g.5125
 tggcagtggagctggagctggagcccgcgctgcccgctgagagcgtgacgcgcgtcctgc       c.-841

 .         .         .         .         .         .                g.5185
 agccagccgtccccgtggctgcgctgcgcctcaacctctcaggcgacaccgtaggcccag       c.-781

 .         .         .         .         .         .                g.5245
 tgcgcttcgcagcacaccactacgccgcaaccctgtgcgcgctcgaggtgcgcgcagccg       c.-721

 .         .         .         .         .         .                g.5305
 cttcggccgagctgaacgccgcgctggaggagctggcggcgcgctgcgcggccctgcgcg       c.-661

 .         .         .         .         .         .                g.5365
 aggtgcattgtttctgcgtggtgagccactcggtgctggacgccttccgcgcgcactgcc       c.-601

 .         .         .         .         .         .                g.5425
 cgcgcctgcgcacctataccctcaagctcacgcgcgagccgcatccctggaggcctacgc       c.-541

 .         .         .         .         .   | 02     .             g.5651
 tcgtggcgtgattgggcgacttctctcccccgtccccgtggac | acgccccacccgctcgg    c.-481

 .         .         .         .         .         .                g.5711
 tcctggacacactgcccccctctcttgcctccacccctctgcggactctgcagctccgcg       c.-421

 .         .         .         .         .         | 03             g.6067
 gccccggcgcagggagagggagggcacgggcgcgggccgggcctcaagg | gacttgcccag    c.-361

 .         .         .         .         .         .                g.6127
 cccacaccaggtcgcgcaccggcgatttctcctgtagaacaaagaaggaaatagagggac       c.-301

 .         .         .         .         .         .                g.6187
 cgagaggggtgggactcgaacccaagtctcccactcatctcaccccaccccaccccactc       c.-241

 .         .         .         .         .         .                g.6247
 caccccaccccacccctccactccactccactccacacatcccatccagccagccttttc       c.-181

 .         .         .         .         .         .                g.6307
 tgcctgctggtgcctcggccgctgtccgagccccgccccgcgggcttgcacgtggccccc       c.-121

 .         .         .         .         .         .                g.6367
 gcctgacccggcgccccggggcggagtagggcggagcgggcggcaaacgcagcactttcc       c.-61

 .         .         .         .         .         .                g.6427
 gcggctttgacgagcccgcagcggccgggcccgagcgcagagccgggccgagactgcacc       c.-1

          .         .         .         .         .         .       g.6487
 ATGCAGGAAGCGCCAGCTGCGCTGCCCACGGAGCCAGGCCCCAGCCCCGTGCCTGCCTTC       c.60
 M  Q  E  A  P  A  A  L  P  T  E  P  G  P  S  P  V  P  A  F         p.20

          .         .         .         .         .         .       g.6547
 CTCGGCAAGCTATGGGCGCTGGTGGGGGACCCAGGCACAGACCACCTGATCCGCTGGAGC       c.120
 L  G  K  L  W  A  L  V  G  D  P  G  T  D  H  L  I  R  W  S         p.40

     | 04    .         .         .         .         .         .    g.7194
 CCG | AGCGGGACCAGTTTCCTCGTAAGCGACCAGAGCCGTTTCGCCAAGGAAGTGCTGCCC    c.180
 P   | S  G  T  S  F  L  V  S  D  Q  S  R  F  A  K  E  V  L  P      p.60

          .         .         .         .         .   | 05     .    g.7342
 CAGTATTTCAAGCATAGCAACATGGCGAGCTTCGTGCGCCAACTCAACATGT | ACGGTTTT    c.240
 Q  Y  F  K  H  S  N  M  A  S  F  V  R  Q  L  N  M  Y |   G  F      p.80

          .         .         .         .         .         .       g.7402
 CGGAAGGTGGTGAGCATCGAGCAGGGCGGCCTGCTTAGGCCGGAGCGCGACCACGTCGAG       c.300
 R  K  V  V  S  I  E  Q  G  G  L  L  R  P  E  R  D  H  V  E         p.100

          .         .         .         .         .         .       g.7462
 TTCCAGCACCCGAGCTTCGTGCGCGGCCGCGAGCAGCTACTGGAGCGCGTGCGGCGCAAG       c.360
 F  Q  H  P  S  F  V  R  G  R  E  Q  L  L  E  R  V  R  R  K         p.120

  | 06       .         .         .         .         .         .    g.7621
  | GTGCCCGCGCTGCGCGGCGACGACGGCCGCTGGCGCCCGGAGGACCTGGGTCGACTACTG    c.420
  | V  P  A  L  R  G  D  D  G  R  W  R  P  E  D  L  G  R  L  L      p.140

          .         .         .         .         .         .       g.7681
 GGCGAGGTGCAGGCTTTGCGGGGAGTGCAGGAGAGCACCGAGGCGCGGCTGCGGGAGCTC       c.480
 G  E  V  Q  A  L  R  G  V  Q  E  S  T  E  A  R  L  R  E  L         p.160

       | 07  .         .         .         .         .         .    g.7990
 AGGCA | GCAGAACGAGATCTTGTGGCGGGAGGTGGTGACACTTCGGCAGAGCCACGGTCAG    c.540
 R  Q  |  Q  N  E  I  L  W  R  E  V  V  T  L  R  Q  S  H  G  Q      p.180

          .         .  | 08      .         .         .         .    g.8212
 CAGCACCGGGTCATTGGCAAG | CTGATCCAGTGTCTCTTTGGGCCACTTCAGGCGGGGCCG    c.600
 Q  H  R  V  I  G  K   | L  I  Q  C  L  F  G  P  L  Q  A  G  P      p.200

          .         .       | 09 .         .         .         .    g.8769
 AGCAATGCAGGAGGCAAGAGAAAGCT | GTCCCTGATGCTGGATGAGGGGAGCTCATGCCCA    c.660
 S  N  A  G  G  K  R  K  L  |  S  L  M  L  D  E  G  S  S  C  P      p.220

          .         .         .         .         .         .       g.8829
 ACACCTGCCAAGTTCAACACCTGCCCTCTACCTGGTGCCCTTCTGCAGGACCCCTACTTC       c.720
 T  P  A  K  F  N  T  C  P  L  P  G  A  L  L  Q  D  P  Y  F         p.240

           | 10        .         .         .         .         .    g.9141
 ATCCAGTCG | CCTCTCCCAGAGACAAATTTGGGCCTTAGCCCTCACAGGGCCAGGGGCCCC    c.780
 I  Q  S   | P  L  P  E  T  N  L  G  L  S  P  H  R  A  R  G  P      p.260

          .         .         .         .         .         .       g.9201
 ATCATCTCTGACATCCCAGAAGACTCTCCATCCCCTGAGGGGACCAGGCTTTCTCCCTCC       c.840
 I  I  S  D  I  P  E  D  S  P  S  P  E  G  T  R  L  S  P  S         p.280

          .     | 11   .         .         .         .         .    g.9381
 AGTGATGGCAGGAG | GGAGAAGGGCCTGGCACTGCTCAAAGAAGAGCCGGCCAGTCCAGGG    c.900
 S  D  G  R  R  |  E  K  G  L  A  L  L  K  E  E  P  A  S  P  G      p.300

          .         .         .         .         .         .       g.9441
 GGGGATGGCGAGGCCGGGCTGGCCCTGGCCCCAAACGAGTGTGACTTCTGCGTGACAGCC       c.960
 G  D  G  E  A  G  L  A  L  A  P  N  E  C  D  F  C  V  T  A         p.320

          .         .         .         .         .         .       g.9501
 CCCCCGCCACTGCCTGTGGCTGTGGTGCAGGCCATCCTGGAAGGGAAAGGGAGCTTCAGC       c.1020
 P  P  P  L  P  V  A  V  V  Q  A  I  L  E  G  K  G  S  F  S         p.340

          .         .         .         .         .         .       g.9561
 CCCGAGGGGCCCAGGAATGCCCAACAGCCTGAACCAGGGGATCCCAGGGAGATACCTGAC       c.1080
 P  E  G  P  R  N  A  Q  Q  P  E  P  G  D  P  R  E  I  P  D         p.360

    | 12     .         .         .         .         .         .    g.10504
 AG | GGGGCCTCTGGGCCTGGAAAGCGGGGACAGGAGCCCAGAGAGTCTGCTGCCTCCGATG    c.1140
 R  |  G  P  L  G  L  E  S  G  D  R  S  P  E  S  L  L  P  P  M      p.380

          .         .         .         .         | 13         .    g.10663
 CTGCTTCAGCCCCCTCAAGAAAGTGTGGAACCTGCAGGGCCTCTAGAT | GTGCTGGGCCCC    c.1200
 L  L  Q  P  P  Q  E  S  V  E  P  A  G  P  L  D   | V  L  G  P      p.400

          .         .         .         .         .     | 14   .    g.10900
 AGTCTCCAAGGGCGAGAATGGACCCTGATGGACTTGGACATGGAGCTGTCCTTG | ATGCAG    c.1260
 S  L  Q  G  R  E  W  T  L  M  D  L  D  M  E  L  S  L   | M  Q      p.420

          .         .         .         .         .         .       g.10960
 CCCTTGGTTCCAGAGCGGGGTGAGCCTGAGCTGGCGGTCAAGGGGTTAAATTCTCCAAGC       c.1320
 P  L  V  P  E  R  G  E  P  E  L  A  V  K  G  L  N  S  P  S         p.440

      | 15   .         .         .         .         .         .    g.11302
 CCAG | GGAAGGACCCCACGCTCGGGGCCCCACTCCTGCTGGATGTCCAGGCGGCCTTGGGA    c.1380
 P  G |   K  D  P  T  L  G  A  P  L  L  L  D  V  Q  A  A  L  G      p.460

          .         .         .         .         .         .       g.11362
 GGCCCAGCCCTGGGCCTGCCTGGGGCTTTAACCATTTATAGCACTCCTGAGAGCCGGACT       c.1440
 G  P  A  L  G  L  P  G  A  L  T  I  Y  S  T  P  E  S  R  T         p.480

          .         .         .                                     g.11401
 GCCTCCTACTTGGGCCCGGAAGCCAGTCCCTCCCCCTAA                            c.1479
 A  S  Y  L  G  P  E  A  S  P  S  P  X                              p.492

          .         .         .         .         .         .       g.11461
 gaccccgcgcctctgaaggggcttggaaccagtccgccgctgcacatccttcttggcttc       c.*60

          .         .         .         .         .         .       g.11521
 ctggcgccccctatcgggggtgagcgaagcccccactactaaatggcctctctccactac       c.*120

          .         .         .         .                           g.11561
 cccgactatccctgcacataaactccgttttttttttttc                           c.*160

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Heat shock transcription factor 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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