5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled (HTR1A) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000524.3 in the HTR1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032816.1, covering HTR1A transcript NM_000524.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            agagggataaataaagggaagtgaggaggaaga       c.-541

 .         .         .         .         .         .                g.5093
 gggagactgaaagggaaggcaggtggggagaagggggacgaaagaggcagaagagagaga       c.-481

 .         .         .         .         .         .                g.5153
 agagaggaggagagagggggagagagggaaggaaggaaatagggagaggagggtcacaga       c.-421

 .         .         .         .         .         .                g.5213
 gtgaccgtggaggatggggcttctcggttctagatatttctgggattggagactgtttgc       c.-361

 .         .         .         .         .         .                g.5273
 tagtggggagactccagctccggcagccagttcgggagcggcaaagtaaaatggacagcg       c.-301

 .         .         .         .         .         .                g.5333
 acagacagacgttccagccacctctccgccgccgggagatcctggagctgctttcaggcc       c.-241

 .         .         .         .         .         .                g.5393
 aactccagtttcccagctggagcttctgaacgcgctggactgcgagagcccagggagcgc       c.-181

 .         .         .         .         .         .                g.5453
 ctgaaagctgctcctcggagatacccttcgccgaagcagtaagaacttcctgcttgggtc       c.-121

 .         .         .         .         .         .                g.5513
 tctgcattcccttcctccgaaacttcccaggagaagggcggaagaccccaggggaagggg       c.-61

 .         .         .         .         .         .                g.5573
 cgaggcgaatcttcgcgctgctttttcttccctcccccttcccgcgccgggcgcgcaggc       c.-1

          .         .         .         .         .         .       g.5633
 ATGGATGTGCTCAGCCCTGGTCAGGGCAACAACACCACATCACCACCGGCTCCCTTTGAG       c.60
 M  D  V  L  S  P  G  Q  G  N  N  T  T  S  P  P  A  P  F  E         p.20

          .         .         .         .         .         .       g.5693
 ACCGGCGGCAACACTACTGGTATCTCCGACGTGACCGTCAGCTACCAAGTGATCACCTCT       c.120
 T  G  G  N  T  T  G  I  S  D  V  T  V  S  Y  Q  V  I  T  S         p.40

          .         .         .         .         .         .       g.5753
 CTGCTGCTGGGCACGCTCATCTTCTGCGCGGTGCTGGGCAATGCGTGCGTGGTGGCTGCC       c.180
 L  L  L  G  T  L  I  F  C  A  V  L  G  N  A  C  V  V  A  A         p.60

          .         .         .         .         .         .       g.5813
 ATCGCCTTGGAGCGCTCCCTGCAGAACGTGGCCAATTATCTTATTGGCTCTTTGGCGGTC       c.240
 I  A  L  E  R  S  L  Q  N  V  A  N  Y  L  I  G  S  L  A  V         p.80

          .         .         .         .         .         .       g.5873
 ACCGACCTCATGGTGTCGGTGTTGGTGCTGCCCATGGCCGCGCTGTATCAGGTGCTCAAC       c.300
 T  D  L  M  V  S  V  L  V  L  P  M  A  A  L  Y  Q  V  L  N         p.100

          .         .         .         .         .         .       g.5933
 AAGTGGACACTGGGCCAGGTAACCTGCGACCTGTTCATCGCCCTCGACGTGCTGTGCTGC       c.360
 K  W  T  L  G  Q  V  T  C  D  L  F  I  A  L  D  V  L  C  C         p.120

          .         .         .         .         .         .       g.5993
 ACCTCATCCATCTTGCACCTGTGCGCCATCGCGCTGGACAGGTACTGGGCCATCACGGAC       c.420
 T  S  S  I  L  H  L  C  A  I  A  L  D  R  Y  W  A  I  T  D         p.140

          .         .         .         .         .         .       g.6053
 CCCATCGACTACGTGAACAAGAGGACGCCCCGGCGCGCCGCTGCGCTCATCTCGCTCACT       c.480
 P  I  D  Y  V  N  K  R  T  P  R  R  A  A  A  L  I  S  L  T         p.160

          .         .         .         .         .         .       g.6113
 TGGCTTATTGGCTTCCTCATCTCTATCCCGCCCATGCTGGGCTGGCGCACCCCGGAAGAC       c.540
 W  L  I  G  F  L  I  S  I  P  P  M  L  G  W  R  T  P  E  D         p.180

          .         .         .         .         .         .       g.6173
 CGCTCGGACCCCGACGCATGCACCATTAGCAAGGATCATGGCTACACTATCTATTCCACC       c.600
 R  S  D  P  D  A  C  T  I  S  K  D  H  G  Y  T  I  Y  S  T         p.200

          .         .         .         .         .         .       g.6233
 TTTGGAGCTTTCTACATCCCGCTGCTGCTCATGCTGGTTCTCTATGGGCGCATATTCCGA       c.660
 F  G  A  F  Y  I  P  L  L  L  M  L  V  L  Y  G  R  I  F  R         p.220

          .         .         .         .         .         .       g.6293
 GCTGCGCGCTTCCGCATCCGCAAGACGGTCAAAAAGGTGGAGAAGACCGGAGCGGACACC       c.720
 A  A  R  F  R  I  R  K  T  V  K  K  V  E  K  T  G  A  D  T         p.240

          .         .         .         .         .         .       g.6353
 CGCCATGGAGCATCTCCCGCCCCGCAGCCCAAGAAGAGTGTGAATGGAGAGTCGGGGAGC       c.780
 R  H  G  A  S  P  A  P  Q  P  K  K  S  V  N  G  E  S  G  S         p.260

          .         .         .         .         .         .       g.6413
 AGGAACTGGAGGCTGGGCGTGGAGAGCAAGGCTGGGGGTGCTCTGTGCGCCAATGGCGCG       c.840
 R  N  W  R  L  G  V  E  S  K  A  G  G  A  L  C  A  N  G  A         p.280

          .         .         .         .         .         .       g.6473
 GTGAGGCAAGGTGACGATGGCGCCGCCCTGGAGGTGATCGAGGTGCACCGAGTGGGCAAC       c.900
 V  R  Q  G  D  D  G  A  A  L  E  V  I  E  V  H  R  V  G  N         p.300

          .         .         .         .         .         .       g.6533
 TCCAAAGAGCACTTGCCTCTGCCCAGCGAGGCTGGTCCTACCCCTTGTGCCCCCGCCTCT       c.960
 S  K  E  H  L  P  L  P  S  E  A  G  P  T  P  C  A  P  A  S         p.320

          .         .         .         .         .         .       g.6593
 TTCGAGAGGAAAAATGAGCGCAACGCCGAGGCGAAGCGCAAGATGGCCCTGGCCCGAGAG       c.1020
 F  E  R  K  N  E  R  N  A  E  A  K  R  K  M  A  L  A  R  E         p.340

          .         .         .         .         .         .       g.6653
 AGGAAGACAGTGAAGACGCTGGGCATCATCATGGGCACCTTCATCCTCTGCTGGCTGCCC       c.1080
 R  K  T  V  K  T  L  G  I  I  M  G  T  F  I  L  C  W  L  P         p.360

          .         .         .         .         .         .       g.6713
 TTCTTCATCGTGGCTCTTGTTCTGCCCTTCTGCGAGAGCAGCTGCCACATGCCCACCCTG       c.1140
 F  F  I  V  A  L  V  L  P  F  C  E  S  S  C  H  M  P  T  L         p.380

          .         .         .         .         .         .       g.6773
 TTGGGCGCCATAATCAATTGGCTGGGCTACTCCAACTCTCTGCTTAACCCCGTCATTTAC       c.1200
 L  G  A  I  I  N  W  L  G  Y  S  N  S  L  L  N  P  V  I  Y         p.400

          .         .         .         .         .         .       g.6833
 GCATACTTCAACAAGGACTTTCAAAACGCGTTTAAGAAGATCATTAAGTGTAAGTTCTGC       c.1260
 A  Y  F  N  K  D  F  Q  N  A  F  K  K  I  I  K  C  K  F  C         p.420

                                                                    g.6842
 CGCCAGTGA                                                          c.1269
 R  Q  X                                                            p.422

          .         .         .         .         .         .       g.6902
 tgacggaggagtagccggccagtcgaggctacaggatccgtcccattcactatgcttccc       c.*60

          .         .         .         .         .         .       g.6962
 ccaaccctagggaatcaacacttaagataattcgccacttctcctctttctctctgctcc       c.*120

          .         .         .         .         .         .       g.7022
 gctcacggcttgcagacctggtcccctccccacttcctgctccacggcagggccctttgt       c.*180

          .         .         .         .         .         .       g.7082
 gcaaaggagacccagcggaggagcgttgagagcccaggaaattcagagagtttgtgagaa       c.*240

          .         .         .         .         .         .       g.7142
 gcgacattggctcagacttcgcctgtatcatcagttttgatcccagtaattgcctcttct       c.*300

          .         .         .         .         .         .       g.7202
 ctcttctatctcctaaatctttgcggtggatgtttaatgcttagttcaaggcagaaaatc       c.*360

          .         .         .         .                           g.7245
 caaaaaataaataaactgtacacacagccgccgcgcccactaa                        c.*403

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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