isoleucyl-tRNA synthetase 2, mitochondrial (IARS2) - coding DNA reference sequence

(used for variant description)

(last modified April 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_018060.3 in the IARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041799.1, covering IARS2 transcript NM_018060.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 ggagcgcgtgcgccctcttactcggctccccttggtttcctggg       c.-61

 .         .         .         .         .         .                g.5104
 gtcctgccccttcaagctggggcgggagcggaggaccccgctctcaggggttgccggacc       c.-1

          .         .         .         .         .         .       g.5164
 ATGCGTTGGGGGCTGCGCCCTCGCGGGCCGGGCGCGGCCGCCCTGGCCACTGCCCGAAGT       c.60
 M  R  W  G  L  R  P  R  G  P  G  A  A  A  L  A  T  A  R  S         p.20

          .         .         .         .         .         .       g.5224
 TTGTGGGGGACGCCCCGCCTTCCCTGCAGCCCGGGATGGCAAGGGGCGACGAAGAGGCTT       c.120
 L  W  G  T  P  R  L  P  C  S  P  G  W  Q  G  A  T  K  R  L         p.40

          .         .         .         .         .         .       g.5284
 CTGGTGCGGTCGGTCTCCGGGGCCAGTAACCACCAGCCGAACTCGAATAGTGGCAGATAC       c.180
 L  V  R  S  V  S  G  A  S  N  H  Q  P  N  S  N  S  G  R  Y         p.60

          .         .         .         .         .         .       g.5344
 CGGGACACGGTGCTGCTGCCGCAGACGAGCTTCCCCATGAAGCTGCTGGGCCGCCAGCAG       c.240
 R  D  T  V  L  L  P  Q  T  S  F  P  M  K  L  L  G  R  Q  Q         p.80

          .         .        | 02.         .         .         .    g.7024
 CCGGACACGGAGCTGGAGATCCAGCAG | AAATGTGGATTTTCAGAACTTTATTCATGGCAA    c.300
 P  D  T  E  L  E  I  Q  Q   | K  C  G  F  S  E  L  Y  S  W  Q      p.100

          .         .         .         .         .         .       g.7084
 AGAGAAAGAAAAGTAAAGACAGAATTTTGCCTTCATGATGGACCTCCTTATGCAAACGGT       c.360
 R  E  R  K  V  K  T  E  F  C  L  H  D  G  P  P  Y  A  N  G         p.120

          .         .         . | 03       .         .         .    g.11407
 GACCCTCATGTTGGACATGCTTTAAATAAG | ATTTTGAAAGACATAGCCAATCGATTCCAT    c.420
 D  P  H  V  G  H  A  L  N  K   | I  L  K  D  I  A  N  R  F  H      p.140

          .         .         .         .         .         .       g.11467
 ATGATGAATGGCTCCAAAATACATTTTGTGCCCGGCTGGGATTGTCATGGGTTGCCCATT       c.480
 M  M  N  G  S  K  I  H  F  V  P  G  W  D  C  H  G  L  P  I         p.160

          .         .         .         .         .         .       g.11527
 GAAATAAAAGTATTATCAGAACTTGGTAGAGAAGCTCAGAATCTTTCAGCTATGGAAATT       c.540
 E  I  K  V  L  S  E  L  G  R  E  A  Q  N  L  S  A  M  E  I         p.180

          . | 04       .         .         .         .         .    g.13066
 AGAAAGAAAG | CTAGATCATTTGCTAAAGCAGCCATTGAGAAACAGAAATCAGCATTTATT    c.600
 R  K  K  A |   R  S  F  A  K  A  A  I  E  K  Q  K  S  A  F  I      p.200

          .         .         .         .         .         .       g.13126
 CGTTGGGGAATAATGGCAGATTGGAATAATTGCTACTATACATTTGATGGGAAGTATGAA       c.660
 R  W  G  I  M  A  D  W  N  N  C  Y  Y  T  F  D  G  K  Y  E         p.220

          .         .         .          | 05        .         .    g.13271
 GCCAAACAGTTGAGAACTTTTTACCAAATGTATGATAAG | GGCTTGGTTTATCGATCTTAC    c.720
 A  K  Q  L  R  T  F  Y  Q  M  Y  D  K   | G  L  V  Y  R  S  Y      p.240

          .         .          | 06        .         .         .    g.13413
 AAACCTGTGTTTTGGTCTCCGTCATCTAG | GACTGCATTGGCTGAAGCAGAACTTGAATAT    c.780
 K  P  V  F  W  S  P  S  S  R  |  T  A  L  A  E  A  E  L  E  Y      p.260

          .         .         .         .         .         .       g.13473
 AATCCTGAGCATGTCAGTCGTTCAATATATGTAAAATTTCCTCTCTTAAAGCCTTCTCCA       c.840
 N  P  E  H  V  S  R  S  I  Y  V  K  F  P  L  L  K  P  S  P         p.280

          .          | 07        .         .         .         .    g.13615
 AAATTGGCATCTCTTATAG | ATGGTTCATCTCCTGTTAGTATTTTGGTCTGGACCACACAA    c.900
 K  L  A  S  L  I  D |   G  S  S  P  V  S  I  L  V  W  T  T  Q      p.300

          .         .         .         .         . | 08       .    g.14344
 CCTTGGACGATTCCAGCCAATGAAGCTGTTTGCTATATGCCTGAATCAAA | GTATGCTGTT    c.960
 P  W  T  I  P  A  N  E  A  V  C  Y  M  P  E  S  K  |  Y  A  V      p.320

          .         .         .         .         .         .       g.14404
 GTGAAATGTTCTAAGTCTGGAGACCTCTACGTACTGGCGGCAGATAAAGTAGCATCTGTT       c.1020
 V  K  C  S  K  S  G  D  L  Y  V  L  A  A  D  K  V  A  S  V         p.340

          .         .         .         .       | 09 .         .    g.16792
 GCTTCTACTTTGGAAACAACATTTGAGACTATTTCAACACTTTCAG | GTGTAGATTTGGAA    c.1080
 A  S  T  L  E  T  T  F  E  T  I  S  T  L  S  G |   V  D  L  E      p.360

          .         .         .         .         .         .       g.16852
 AATGGTACTTGCAGTCATCCATTAATTCCTGATAAAGCCTCTCCTCTTTTACCTGCAAAT       c.1140
 N  G  T  C  S  H  P  L  I  P  D  K  A  S  P  L  L  P  A  N         p.380

          .         .         .         .         .         .       g.16912
 CATGTGACCATGGCAAAAGGAACGGGATTGGTTCACACAGCCCCAGCTCATGGTATGGAA       c.1200
 H  V  T  M  A  K  G  T  G  L  V  H  T  A  P  A  H  G  M  E         p.400

          .         .         .       | 10 .         .         .    g.17972
 GACTACGGTGTAGCGTCTCAGCACAACCTGCCCATG | GATTGTCTAGTGGACGAAGATGGA    c.1260
 D  Y  G  V  A  S  Q  H  N  L  P  M   | D  C  L  V  D  E  D  G      p.420

          .         .         .         .         .         .       g.18032
 GTTTTCACAGATGTTGCAGGTCCTGAACTTCAAAACAAGGCTGTCCTTGAAGAGGGAACT       c.1320
 V  F  T  D  V  A  G  P  E  L  Q  N  K  A  V  L  E  E  G  T         p.440

         | 11.         .         .         .         .         .    g.21726
 GATGTGG | TTATAAAGATGCTTCAGACTGCAAAGAATTTGTTGAAAGAGGAGAAATTGGTG    c.1380
 D  V  V |   I  K  M  L  Q  T  A  K  N  L  L  K  E  E  K  L  V      p.460

          .         .         .         .         .         .       g.21786
 CATAGCTATCCGTATGACTGGAGGACCAAGAAACCTGTGGTTATTCGTGCCAGCAAGCAG       c.1440
 H  S  Y  P  Y  D  W  R  T  K  K  P  V  V  I  R  A  S  K  Q         p.480

          .         .         .          | 12        .         .    g.25222
 TGGTTTATAAACATCACGGATATTAAGACTGCAGCCAAG | GAATTGTTAAAAAAGGTGAAA    c.1500
 W  F  I  N  I  T  D  I  K  T  A  A  K   | E  L  L  K  K  V  K      p.500

          .         .         .         .         .         .       g.25282
 TTTATTCCTGGATCAGCACTGAATGGCATGGTTGAAATGATGGACAGGCGGCCATATTGG       c.1560
 F  I  P  G  S  A  L  N  G  M  V  E  M  M  D  R  R  P  Y  W         p.520

          .         .         .         .         .         .       g.25342
 TGTATATCAAGGCAAAGAGTTTGGGGTGTTCCAATTCCTGTGTTTCATCATAAGACCAAG       c.1620
 C  I  S  R  Q  R  V  W  G  V  P  I  P  V  F  H  H  K  T  K         p.540

          .         . | 13       .         .         .         .    g.36164
 GATGAATACTTGATCAACAG | CCAAACCACTGAGCATATTGTTAAACTAGTGGAACAACAC    c.1680
 D  E  Y  L  I  N  S  |  Q  T  T  E  H  I  V  K  L  V  E  Q  H      p.560

          .         .         .         .         .         .       g.36224
 GGCAGTGATATCTGGTGGACTCTTCCCCCTGAACAACTTCTTCCAAAAGAAGTCTTATCT       c.1740
 G  S  D  I  W  W  T  L  P  P  E  Q  L  L  P  K  E  V  L  S         p.580

     | 14    .         .         .         .         .         .    g.37694
 GAG | GTTGGTGGCCCTGATGCCTTGGAATATGTGCCAGGTCAGGATATTTTGGACATCTGG    c.1800
 E   | V  G  G  P  D  A  L  E  Y  V  P  G  Q  D  I  L  D  I  W      p.600

          .         .         .        | 15.         .         .    g.45312
 TTTGATAGCGGAACTTCATGGTCTTATGTTCTTCCAG | GTCCTGACCAAAGAGCAGATTTG    c.1860
 F  D  S  G  T  S  W  S  Y  V  L  P  G |   P  D  Q  R  A  D  L      p.620

          .         .         .         .         .         .       g.45372
 TACTTGGAAGGAAAAGACCAGCTCGGGGGTTGGTTTCAGTCATCCTTATTAACAAGTGTG       c.1920
 Y  L  E  G  K  D  Q  L  G  G  W  F  Q  S  S  L  L  T  S  V         p.640

          .         .       | 16 .         .         .         .    g.47730
 GCAGCAAGGAAGAGAGCACCTTATAA | GACAGTGATTGTTCATGGATTTACCCTTGGAGAA    c.1980
 A  A  R  K  R  A  P  Y  K  |  T  V  I  V  H  G  F  T  L  G  E      p.660

          .         .         .         .         .         .       g.47790
 AAGGGAGAAAAGATGTCCAAGTCTCTTGGGAATGTCATTCATCCTGATGTTGTCGTTAAT       c.2040
 K  G  E  K  M  S  K  S  L  G  N  V  I  H  P  D  V  V  V  N         p.680

           | 17        .         .         .         .         .    g.48856
 GGAGGACAA | GATCAAAGCAAAGAGCCTCCGTATGGTGCTGATGTCCTTCGCTGGTGGGTA    c.2100
 G  G  Q   | D  Q  S  K  E  P  P  Y  G  A  D  V  L  R  W  W  V      p.700

          .         .         .         .         .         .       g.48916
 GCTGATTCCAATGTCTTCACCGAAGTTGCAATTGGCCCATCCGTGCTCAATGCTGCCAGA       c.2160
 A  D  S  N  V  F  T  E  V  A  I  G  P  S  V  L  N  A  A  R         p.720

          .      | 18  .         .         .         .         .    g.49940
 GATGATATTAGCAAG | CTTAGGAATACACTTCGCTTTCTTTTGGGAAATGTGGCTGATTTC    c.2220
 D  D  I  S  K   | L  R  N  T  L  R  F  L  L  G  N  V  A  D  F      p.740

          .         .         .         .         .         .       g.50000
 AACCCAGAAACAGATTCCATCCCTGTAAACGATATGTATGTCATAGACCAGTACATGCTA       c.2280
 N  P  E  T  D  S  I  P  V  N  D  M  Y  V  I  D  Q  Y  M  L         p.760

          .         .        | 19.         .         .         .    g.51103
 CACTTACTGCAGGATTTGGCAAACAAG | ATTACCGAATTATACAAACAATATGATTTTGGA    c.2340
 H  L  L  Q  D  L  A  N  K   | I  T  E  L  Y  K  Q  Y  D  F  G      p.780

          .         .         .         .         .         .       g.51163
 AAAGTTGTTCGGCTGTTACGGACGTTTTATACCAGAGAGCTCTCTAACTTTTATTTCAGT       c.2400
 K  V  V  R  L  L  R  T  F  Y  T  R  E  L  S  N  F  Y  F  S         p.800

          .     | 20   .         .         .         .         .    g.52736
 ATAATCAAAGATAG | GCTCTATTGTGAAAAGGAAAATGACCCCAAACGACGCTCTTGTCAG    c.2460
 I  I  K  D  R  |  L  Y  C  E  K  E  N  D  P  K  R  R  S  C  Q      p.820

          .         .         .         .         .         .       g.52796
 ACTGCATTAGTTGAAATTTTGGATGTAATAGTTCGTTCTTTTGCTCCCATTCTTCCTCAC       c.2520
 T  A  L  V  E  I  L  D  V  I  V  R  S  F  A  P  I  L  P  H         p.840

          .         .         .         . | 21       .         .    g.53851
 CTGGCTGAAGAGGTGTTCCAGCACATACCTTATATTAAAG | AGCCCAAGAGTGTTTTCCGT    c.2580
 L  A  E  E  V  F  Q  H  I  P  Y  I  K  E |   P  K  S  V  F  R      p.860

          .         .         .         .         .         .       g.53911
 ACTGGGTGGATTAGTACTAGTTCTATCTGGAAAAAGCCCGGGTTGGAAGAAGCTGTGGAG       c.2640
 T  G  W  I  S  T  S  S  I  W  K  K  P  G  L  E  E  A  V  E         p.880

          .         .         .         .         .         .       g.53971
 AGTGCGTGTGCAATGCGAGACTCATTTCTTGGAAGCATCCCTGGCAAAAATGCAGCTGAG       c.2700
 S  A  C  A  M  R  D  S  F  L  G  S  I  P  G  K  N  A  A  E         p.900

          .         .         .         .         .  | 22      .    g.56405
 TACAAGGTTATCACTGTGATAGAACCTGGACTGCTTTTTGAGATAATAGAG | ATGCTGCAG    c.2760
 Y  K  V  I  T  V  I  E  P  G  L  L  F  E  I  I  E   | M  L  Q      p.920

          .         .         .         .         .         .       g.56465
 TCTGAAGAGACTTCCAGCACCTCTCAGTTGAATGAATTAATGATGGCTTCTGAGTCAACT       c.2820
 S  E  E  T  S  S  T  S  Q  L  N  E  L  M  M  A  S  E  S  T         p.940

          .         .         .         .         .         .       g.56525
 TTACTGGCTCAGGAACCACGAGAGATGACTGCAGATGTAATCGAGCTTAAAGGGAAATTC       c.2880
 L  L  A  Q  E  P  R  E  M  T  A  D  V  I  E  L  K  G  K  F         p.960

          .       | 23 .         .         .         .         .    g.58424
 CTCATCAACTTAGAAG | GTGGTGATATTCGTGAAGAGTCTTCCTATAAAGTAATTGTCATG    c.2940
 L  I  N  L  E  G |   G  D  I  R  E  E  S  S  Y  K  V  I  V  M      p.980

          .         .         .         .         .         .       g.58484
 CCGACTACGAAAGAAAAATGCCCCCGTTGTTGGAAGTATACAGCGGAGTCTTCAGATACA       c.3000
 P  T  T  K  E  K  C  P  R  C  W  K  Y  T  A  E  S  S  D  T         p.1000

          .         .         .                                     g.58523
 CTGTGTCCTCGATGTGCAGAAGTTGTCAGTGGAAAATAG                            c.3039
 L  C  P  R  C  A  E  V  V  S  G  K  X                              p.1012

          .         .         .         .         .         .       g.58583
 tattaacagctcactcgagcaagaaccctcctgacagtactggctagaagtttggatgga       c.*60

          .         .         .         .         .         .       g.58643
 ttatttacaatataggaaagaaagccaagatttaggtaatgagtggatgagtaaatggtg       c.*120

          .         .         .         .         .         .       g.58703
 gaggatgggagtcaaaatcagaattatagaagaagtatttcctgtaactatagaaagaat       c.*180

          .         .         .         .         .         .       g.58763
 tatgtatatatacatgcagaaatatatatgtgtgtgtgtatctgtggatggatatatgta       c.*240

          .         .         .         .         .         .       g.58823
 tatctcttcctatatatatccatagtggacttattcagaacatagatatgtattcagctt       c.*300

          .         .         .         .         .         .       g.58883
 gtcttcaaatacggccaagcagaaaatgttttatattttataaatcatcttttgactctg       c.*360

          .         .         .         .                           g.58929
 tatttaaattctatgatactgaaaataaaggcattctggaaaaata                     c.*406

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isoleucyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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