isoleucyl-tRNA synthetase (IARS) - coding DNA reference sequence

(used for variant description)

(last modified November 8, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_002161.5 in the IARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering IARS transcript NM_002161.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            cggtgcggagcctgtctccttcactggatcccg       c.-121

 .         .         .         .         .         .                g.5093
 cattttcagcgcgttgcatcacctccgtgcgcccggttgcagcgtggacgccggatgagt       c.-61

 .         .         .         .         .         .   | 02         g.9337
 tgcttttaggcttgctggcccgcggggctgtccaggcacgcgaggcccctcag | caacaaa    c.-1

          .         .         .         .         .         .       g.9397
 ATGCTTCAACAAGTTCCAGAAAACATAAATTTTCCTGCTGAAGAAGAGAAAATCTTGGAG       c.60
 M  L  Q  Q  V  P  E  N  I  N  F  P  A  E  E  E  K  I  L  E         p.20

          .         .         .         .         .          | 03    g.10475
 TTTTGGACTGAATTTAATTGTTTTCAGGAATGCTTAAAGCAATCAAAACATAAACCAAA | A    c.120
 F  W  T  E  F  N  C  F  Q  E  C  L  K  Q  S  K  H  K  P  K  |      p.40

          .         .         .         .         .         .       g.10535
 TTTACCTTCTATGATGGTCCTCCTTTTGCAACTGGACTGCCTCACTATGGACATATACTT       c.180
 F  T  F  Y  D  G  P  P  F  A  T  G  L  P  H  Y  G  H  I  L         p.60

          .         .         .         .         .         .       g.10595
 GCGGGTACAATTAAAGATATAGTTACAAGATATGCTCACCAGAGTGGGTTTCATGTTGAC       c.240
 A  G  T  I  K  D  I  V  T  R  Y  A  H  Q  S  G  F  H  V  D         p.80

          .         .         .       | 04 .         .         .    g.10870
 AGAAGATTTGGATGGGATTGCCATGGCTTACCTGTG | GAATATGAAATTGATAAGACACTG    c.300
 R  R  F  G  W  D  C  H  G  L  P  V   | E  Y  E  I  D  K  T  L      p.100

          .         .         .         .         .         .       g.10930
 GGAATCAGAGGACCAGAGGATGTGGCCAAAATGGGGATTACAGAGTATAACAATCAGTGC       c.360
 G  I  R  G  P  E  D  V  A  K  M  G  I  T  E  Y  N  N  Q  C         p.120

          .         .         .       | 05 .         .         .    g.12162
 CGAGCAATTGTGATGAGATATTCTGCTGAGTGGAAG | TCTACTGTTAGCAGACTTGGCCGA    c.420
 R  A  I  V  M  R  Y  S  A  E  W  K   | S  T  V  S  R  L  G  R      p.140

          .         .         .         .         .          | 06    g.12918
 TGGATTGACTTTGACAATGACTATAAAACTCTGTATCCACAATTCATGGAATCAGTCTG | G    c.480
 W  I  D  F  D  N  D  Y  K  T  L  Y  P  Q  F  M  E  S  V  W  |      p.160

          .         .         .         .         .         .       g.12978
 TGGGTCTTCAAACAACTCTATGATAAAGGCCTTGTTTATAGAGGTGTGAAAGTCATGCCC       c.540
 W  V  F  K  Q  L  Y  D  K  G  L  V  Y  R  G  V  K  V  M  P         p.180

          .         .         .         .         .        | 07.    g.17866
 TTCTCTACGGCATGTAACACTCCACTTTCCAACTTCGAGTCACACCAGAATTATAAG | GAT    c.600
 F  S  T  A  C  N  T  P  L  S  N  F  E  S  H  Q  N  Y  K   | D      p.200

          .         .         .         .         .         .       g.17926
 GTTCAAGATCCTTCAGTATTTGTAACTTTCCCTTTGGAAGAAGATGAAACTGTATCTTTA       c.660
 V  Q  D  P  S  V  F  V  T  F  P  L  E  E  D  E  T  V  S  L         p.220

          .         .         .         .         .         .       g.17986
 GTTGCTTGGACAACCACTCCCTGGACTCTACCTAGTAACCTTGCTGTGTGTGTTAATCCA       c.720
 V  A  W  T  T  T  P  W  T  L  P  S  N  L  A  V  C  V  N  P         p.240

          .         .      | 08  .         .         .         .    g.20505
 GAAATGCAATATGTGAAAATTAAAG | ATGTTGCCAGAGGACGATTACTCATTTTAATGGAA    c.780
 E  M  Q  Y  V  K  I  K  D |   V  A  R  G  R  L  L  I  L  M  E      p.260

          .         .         .         .         .    | 09    .    g.20840
 GCCAGATTGTCAGCCCTCTATAAATTGGAGAGTGACTATGAGATCCTTGAAAG | ATTTCCT    c.840
 A  R  L  S  A  L  Y  K  L  E  S  D  Y  E  I  L  E  R  |  F  P      p.280

          .         .         .         .         .     | 10   .    g.24241
 GGTGCCTATCTTAAAGGCAAGAAGTACAGGCCCCTGTTTGACTATTTCCTGAAG | TGTAAA    c.900
 G  A  Y  L  K  G  K  K  Y  R  P  L  F  D  Y  F  L  K   | C  K      p.300

          .         .         .         .         .         .       g.24301
 GAGAATGGCGCTTTCACTGTGCTTGTTGACAACTATGTGAAGGAAGAAGAAGGCACAGGG       c.960
 E  N  G  A  F  T  V  L  V  D  N  Y  V  K  E  E  E  G  T  G         p.320

          .         .         . | 11       .         .         .    g.27131
 GTTGTCCACCAAGCTCCTTACTTCGGTGCT | GAGGACTATCGGGTCTGTATGGACTTTAAC    c.1020
 V  V  H  Q  A  P  Y  F  G  A   | E  D  Y  R  V  C  M  D  F  N      p.340

          .         .         .         .         .         .       g.27191
 ATTATTCGGAAAGACTCACTCCCTGTTTGCCCTGTGGATGCTTCAGGCTGCTTCACAACG       c.1080
 I  I  R  K  D  S  L  P  V  C  P  V  D  A  S  G  C  F  T  T         p.360

          .         .         .    | 12    .         .         .    g.27707
 GAGGTGACAGATTTCGCAGGACAGTATGTGAAG | GATGCTGACAAAAGTATCATCAGGACT    c.1140
 E  V  T  D  F  A  G  Q  Y  V  K   | D  A  D  K  S  I  I  R  T      p.380

          .         .         .         .         .         .       g.27767
 TTGAAGGAACAAGGCCGACTTCTGGTTGCCACCACCTTCACTCACAGCTACCCTTTTTGC       c.1200
 L  K  E  Q  G  R  L  L  V  A  T  T  F  T  H  S  Y  P  F  C         p.400

       | 13  .         .         .         .         .         .    g.28828
 TGGAG | ATCAGACACTCCTCTAATTTACAAAGCAGTGCCCAGCTGGTTTGTGCGAGTGGAG    c.1260
 W  R  |  S  D  T  P  L  I  Y  K  A  V  P  S  W  F  V  R  V  E      p.420

          .         .         .         .     | 14   .         .    g.30472
 AACATGGTGGACCAGCTCCTAAGGAACAATGACCTGTGCTACTG | GGTCCCAGAGTTGGTA    c.1320
 N  M  V  D  Q  L  L  R  N  N  D  L  C  Y  W  |  V  P  E  L  V      p.440

          .         .         .         .         .         .       g.30532
 CGAGAAAAACGATTTGGAAATTGGCTGAAAGATGCACGTGACTGGACAATTTCCAGAAAC       c.1380
 R  E  K  R  F  G  N  W  L  K  D  A  R  D  W  T  I  S  R  N         p.460

          .         .         .         .         .  | 15      .    g.33212
 AGATACTGGGGCACCCCCATCCCACTGTGGGTCAGCGATGACTTTGAGGAG | GTGGTATGC    c.1440
 R  Y  W  G  T  P  I  P  L  W  V  S  D  D  F  E  E   | V  V  C      p.480

          .         .         .         .         .         .       g.33272
 ATTGGGTCAGTGGCGGAACTTGAAGAACTGTCAGGAGCAAAGATCTCAGATCTCCACAGA       c.1500
 I  G  S  V  A  E  L  E  E  L  S  G  A  K  I  S  D  L  H  R         p.500

       | 16  .         .         .         .         .         .    g.33688
 GAGAG | TGTTGACCACCTGACCATTCCTTCACGCTGTGGGAAGGGATCCTTGCACCGCATC    c.1560
 E  S  |  V  D  H  L  T  I  P  S  R  C  G  K  G  S  L  H  R  I      p.520

          .         .         .         .         .         .       g.33748
 TCTGAAGTGTTTGACTGTTGGTTTGAGAGTGGCAGCATGCCCTATGCTCAGGTTCATTAC       c.1620
 S  E  V  F  D  C  W  F  E  S  G  S  M  P  Y  A  Q  V  H  Y         p.540

          .         .         .         .         .         .       g.33808
 CCGTTTGAAAACAAGAGGGAGTTTGAGGATGCTTTTCCTGCAGATTTCATTGCCGAGGGC       c.1680
 P  F  E  N  K  R  E  F  E  D  A  F  P  A  D  F  I  A  E  G         p.560

          .         . | 17       .         .         .         .    g.35741
 ATCGACCAAACCAGAGGATG | GTTTTATACCCTGCTGGTGCTGGCCACGGCCCTCTTTGGA    c.1740
 I  D  Q  T  R  G  W  |  F  Y  T  L  L  V  L  A  T  A  L  F  G      p.580

          .         .         .         .        | 18.         .    g.38535
 CAACCGCCTTTCAAGAACGTAATTGTGAATGGGCTTGTCCTGGCAAG | TGATGGCCAAAAA    c.1800
 Q  P  P  F  K  N  V  I  V  N  G  L  V  L  A  S  |  D  G  Q  K      p.600

          .         .         .         .         .         .       g.38595
 ATGAGCAAACGGAAAAAGAATTATCCAGATCCAGTTTCCATCATCCAGAAGTATGGTGCT       c.1860
 M  S  K  R  K  K  N  Y  P  D  P  V  S  I  I  Q  K  Y  G  A         p.620

          .  | 19      .         .         .         .         .    g.39807
 GATGCCCTCAG | ATTATATCTGATTAACTCCCCTGTGGTGAGAGCAGAAAACCTCCGCTTT    c.1920
 D  A  L  R  |  L  Y  L  I  N  S  P  V  V  R  A  E  N  L  R  F      p.640

          .         .         .         .         .         .       g.39867
 AAAGAAGAGGGTGTGCGGGACGTCCTTAAGGATGTACTGCTCCCATGGTACAATGCCTAT       c.1980
 K  E  E  G  V  R  D  V  L  K  D  V  L  L  P  W  Y  N  A  Y         p.660

          .         .         .       | 20 .         .         .    g.41980
 CGCTTCTTAATCCAGAACGTTCTGAGGCTCCAGAAG | GAGGAAGAAATAGAATTTCTCTAC    c.2040
 R  F  L  I  Q  N  V  L  R  L  Q  K   | E  E  E  I  E  F  L  Y      p.680

          .         .         .         .         .         .       g.42040
 AATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATCCTGTCCTTCATG       c.2100
 N  E  N  T  V  R  E  S  P  N  I  T  D  R  W  I  L  S  F  M         p.700

          .         .         .        | 21.         .         .    g.45326
 CAGTCTCTCATTGGCTTCTTTGAGACTGAAATGGCAG | CTTATAGGCTTTATACTGTGGTG    c.2160
 Q  S  L  I  G  F  F  E  T  E  M  A  A |   Y  R  L  Y  T  V  V      p.720

          .         .         .         .         .         .       g.45386
 CCTCGCCTGGTCAAGTTTGTAGATATTCTGACCAATTGGTATGTTAGAATGAACCGCAGA       c.2220
 P  R  L  V  K  F  V  D  I  L  T  N  W  Y  V  R  M  N  R  R         p.740

           | 22        .         .         .         .         .    g.46922
 AGATTAAAG | GGTGAAAATGGGATGGAGGATTGTGTCATGGCCCTAGAAACCTTGTTTAGT    c.2280
 R  L  K   | G  E  N  G  M  E  D  C  V  M  A  L  E  T  L  F  S      p.760

          .         .        | 23.         .         .         .    g.47955
 GTTCTGCTTTCTCTTTGCAGACTTATG | GCTCCCTACACACCTTTTCTCACTGAATTGATG    c.2340
 V  L  L  S  L  C  R  L  M   | A  P  Y  T  P  F  L  T  E  L  M      p.780

          .         .         .         .         .         .       g.48015
 TACCAGAATCTAAAGGTGCTGATTGACCCTGTTTCTGTTCAGGACAAGGACACACTCAGC       c.2400
 Y  Q  N  L  K  V  L  I  D  P  V  S  V  Q  D  K  D  T  L  S         p.800

          .         .          | 24        .         .         .    g.48498
 ATTCACTACCTCATGCTGCCCCGTGTTCG | AGAAGAATTGATTGACAAGAAAACAGAGAGT    c.2460
 I  H  Y  L  M  L  P  R  V  R  |  E  E  L  I  D  K  K  T  E  S      p.820

          .         .         .         .         .         .       g.48558
 GCAGTATCTCAGATGCAGTCTGTGATTGAACTTGGAAGAGTGATCAGAGACCGAAAAACT       c.2520
 A  V  S  Q  M  Q  S  V  I  E  L  G  R  V  I  R  D  R  K  T         p.840

          .   | 25     .         .         .         .         .    g.48863
 ATTCCCATAAAG | TATCCTTTGAAAGAAATTGTGGTTATCCATCAAGATCCAGAAGCTCTT    c.2580
 I  P  I  K   | Y  P  L  K  E  I  V  V  I  H  Q  D  P  E  A  L      p.860

          .         .         .       | 26 .         .         .    g.51229
 AAAGATATCAAGTCTTTGGAGAAGTATATCATTGAG | GAACTCAATGTTCGAAAAGTTACA    c.2640
 K  D  I  K  S  L  E  K  Y  I  I  E   | E  L  N  V  R  K  V  T      p.880

          .         .         .         .         .         .       g.51289
 CTGTCTACAGATAAAAACAAGTATGGCATTCGGCTAAGGGCAGAACCAGATCACATGGTC       c.2700
 L  S  T  D  K  N  K  Y  G  I  R  L  R  A  E  P  D  H  M  V         p.900

          .         .         .         .         .         .       g.51349
 CTGGGGAAGCGTCTGAAGGGAGCCTTTAAGGCAGTGATGACGTCCATCAAGCAGTTGAGC       c.2760
 L  G  K  R  L  K  G  A  F  K  A  V  M  T  S  I  K  Q  L  S         p.920

          .         .         .  | 27      .         .         .    g.53714
 AGTGAGGAGCTGGAGCAGTTCCAGAAGACTG | GGACCATTGTTGTGGAAGGCCATGAATTG    c.2820
 S  E  E  L  E  Q  F  Q  K  T  G |   T  I  V  V  E  G  H  E  L      p.940

          .         .         .         .         .         .       g.53774
 CACGATGAAGACATCCGCCTCATGTACACCTTTGATCAGGCCACAGGTGGGACTGCGCAA       c.2880
 H  D  E  D  I  R  L  M  Y  T  F  D  Q  A  T  G  G  T  A  Q         p.960

          .         .     | 28   .         .         .         .    g.55481
 TTTGAAGCACACTCAGATGCTCAG | GCTTTGGTCCTCTTAGATGTCACTCCTGACCAGTCA    c.2940
 F  E  A  H  S  D  A  Q   | A  L  V  L  L  D  V  T  P  D  Q  S      p.980

          .         .         .         .         .         .       g.55541
 ATGGTAGATGAAGGAATGGCTCGGGAAGTCATCAATCGCATACAGAAACTTCGCAAAAAG       c.3000
 M  V  D  E  G  M  A  R  E  V  I  N  R  I  Q  K  L  R  K  K         p.1000

  | 29       .         .         .         .         .         .    g.56486
  | TGCAATCTGGTTCCAACTGATGAAATCACAGTGTACTATAAAGCAAAGTCTGAAGGAACA    c.3060
  | C  N  L  V  P  T  D  E  I  T  V  Y  Y  K  A  K  S  E  G  T      p.1020

          .         .         .         .         .         .       g.56546
 TATCTGAATAGTGTTATTGAAAGCCACACAGAGTTCATATTTACCACCATAAAGGCTCCC       c.3120
 Y  L  N  S  V  I  E  S  H  T  E  F  I  F  T  T  I  K  A  P         p.1040

          .         .         .         .         .        | 30.    g.57798
 TTGAAACCATATCCAGTTTCTCCATCGGATAAAGTCCTTATTCAAGAAAAAACACAG | TTG    c.3180
 L  K  P  Y  P  V  S  P  S  D  K  V  L  I  Q  E  K  T  Q   | L      p.1060

          .         .         .         .         .         .       g.57858
 AAGGGATCTGAACTGGAAATTACACTCACCAGAGGATCTTCCCTTCCTGGTCCTGCTTGT       c.3240
 K  G  S  E  L  E  I  T  L  T  R  G  S  S  L  P  G  P  A  C         p.1080

          .         .         .         .    | 31    .         .    g.69647
 GCATATGTCAATCTTAACATTTGTGCAAATGGCAGTGAACAAG | GTGGAGTATTGCTCCTG    c.3300
 A  Y  V  N  L  N  I  C  A  N  G  S  E  Q  G |   G  V  L  L  L      p.1100

          .         .         .         .         .         .       g.69707
 GAAAATCCAAAAGGTGACAATAGGTTGGACCTTTTAAAGCTGAAGAGTGTTGTCACTAGC       c.3360
 E  N  P  K  G  D  N  R  L  D  L  L  K  L  K  S  V  V  T  S         p.1120

          .         .         .         .          | 32        .    g.75278
 ATTTTTGGTGTGAAAAATACAGAGCTGGCTGTCTTCCATGATGAAACAG | AAATACAAAAC    c.3420
 I  F  G  V  K  N  T  E  L  A  V  F  H  D  E  T  E |   I  Q  N      p.1140

          .         .         .         .         .         .       g.75338
 CAAACTGACTTACTGAGTCTTAGTGGAAAAACACTTTGTGTGACTGCAGGATCGGCTCCC       c.3480
 Q  T  D  L  L  S  L  S  G  K  T  L  C  V  T  A  G  S  A  P         p.1160

          .         .         .         .         .         .       g.75398
 TCTCTGATCAACAGTTCTAGTACTCTTCTTTGTCAGTATATCAACCTACAGCTCCTGAAT       c.3540
 S  L  I  N  S  S  S  T  L  L  C  Q  Y  I  N  L  Q  L  L  N         p.1180

          .    | 33    .         .         .         .         .    g.76131
 GCAAAGCCACAAG | AGTGTTTAATGGGGACAGTGGGCACTCTCCTGCTTGAAAACCCACTT    c.3600
 A  K  P  Q  E |   C  L  M  G  T  V  G  T  L  L  L  E  N  P  L      p.1200

          .         .         .         .         .         .       g.76191
 GGGCAGAATGGACTCACCCACCAAGGTCTTCTGTATGAAGCAGCCAAGGTGTTTGGCCTT       c.3660
 G  Q  N  G  L  T  H  Q  G  L  L  Y  E  A  A  K  V  F  G  L         p.1220

          .         .         .         .       | 34 .         .    g.87881
 CGGAGCAGGAAGCTAAAGCTGTTTCTGAATGAGACCCAAACGCAGG | AAATTACAGAAGAC    c.3720
 R  S  R  K  L  K  L  F  L  N  E  T  Q  T  Q  E |   I  T  E  D      p.1240

          .         .         .         .         .         .       g.87941
 ATCCCCGTGAAGACTTTGAATATGAAGACTGTGTATGTTTCTGTGTTACCAACAACAGCA       c.3780
 I  P  V  K  T  L  N  M  K  T  V  Y  V  S  V  L  P  T  T  A         p.1260

                                                                    g.87950
 GACTTCTAG                                                          c.3789
 D  F  X                                                            p.1262

          .         .         .         .         .         .       g.88010
 catgtacttatcaatgttgttcggtcagcccttccctaattacacctatcccctacacat       c.*60

          .         .         .         .         .         .       g.88070
 acatgcacatagacacacacatgaacacactgaagatatttccttcaggtgtgtgtaaaa       c.*120

          .         .         .         .         .         .       g.88130
 tatgctgcttggattgaaattcaaatgggattgattagtcaagtaacttgagacctcaca       c.*180

          .         .         .         .         .         .       g.88190
 gtaatcttcacacttaaccttagacacctatgcagtcatgttgggagcaggttacaatgt       c.*240

          .         .         .         .         .         .       g.88250
 tacttcagcccacagtttatttctatacttgagttcttaagtacagaagatagaagtgat       c.*300

          .         .         .         .         .         .       g.88310
 ttaaatggcatagtatatatatcattttctggccttttaaaatttatttgagacctcttg       c.*360

          .         .         .         .         .         .       g.88370
 atgaaatggacatattatatatttctgccacctggattttcctggataatttgatggaat       c.*420

          .         .         .         .         .         .       g.88430
 attttaagtttcagtaaatcagaacaataaacaaactcagatataaatgtgttgaaagta       c.*480

          .         .         .         .         .         .       g.88490
 attcattctcccatagataaatgaaacttgaaatgtgtaaactttgaagaacataaaaac       c.*540

          .         .         .         .         .         .       g.88550
 ttcatggtggtttcttattaagacagtggactagacatctaataaaacttctttccaaaa       c.*600

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Isoleucyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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